Journal of Nephrology最新文献

{"title":"Estimation of age and sex-specific Glomerular Filtration Rate and its association with mortality and atherosclerotic cardiovascular outcomes in the Abu Dhabi population; A Retrospective Cohort Study.","authors":"Latifa Mohammad Baynouna AlKetbi, Yousef Boobes, Bachar Afandi, Hamda Aleissaee, Noura AlShamsi, Mohammed AlMansoori, Ahmed Hemaid, Muna Jalal AlDobaee, Noura AlAlawi, Rudina Mubarak AlKetbi, Toqa Fahmawee, Basil AlHashaikeh, AlYazia AlAzeezi, Fatima Shuaib, Jawaher Alnuaimi, Esraa Mahmoud, Nayla AlAhbabi, Nico Nagelkerke","doi":"10.1007/s40620-025-02347-w","DOIUrl":"10.1007/s40620-025-02347-w","url":null,"abstract":"<p><strong>Background: </strong>The impact of reduced kidney function quantified by estimated Glomerular Filtration Rate (eGFR) on various adverse clinical outcomes has been extensively studied. This study aims to estimate the age and sex-specific eGFR in the Abu Dhabi population and its association with adverse outcomes.</p><p><strong>Methods: </strong>This is a retrospective cohort study conducted in 8699 participants enrolled in a national cardiovascular disease screening program from 2011 to 2013. A reference eGFR percentile was estimated from healthy cohort members who had no comorbidities. The  LMS (Lambda, Mu, and Sigma) method was used to determine these percentiles. The cohort was reassessed in 2023 for mortality and cardiovascular outcomes.</p><p><strong>Results: </strong>The reference percentiles of normal eGFR values showed a marked decrease with age, with small sex differences in the reference percentile distribution. Subjects in the two categories within the higher eGFR threshold range, the 95th and 97th percentiles were older, had a significantly higher prevalence of diabetes, were more frequently smokers, and had higher body mass index, higher HbA1c, higher HDL, lower vitamin D, and were more likely to be males, with higher physical activity and a lower prevalence of coronary heart disease. Older age, female sex, history of atherosclerotic cardiovascular disease, history of hypertension, being treated for hypertension, lower diastolic blood pressure, higher systolic blood pressure, lower HDL, higher HbA1c, and higher vitamin D were significantly associated with lower eGFR percentiles.</p><p><strong>Conclusions: </strong>These ethnicity-specific eGFR reference values are valuable for the early identification of patients with chronic kidney disease, allowing for early qualification for beneficial preventive medication, evaluations, and nephrologist referrals. A prognostic definition of the higher eGFR threshold, as renal hyperfiltration, is suggested since the 97th percentile had a significantly higher incidence of atherosclerotic cardiovascular disease.</p>","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":"1957-1967"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crescentic glomerulonephritis associated with myelodysplatic syndrome and visceral leishmaniasis.","authors":"Antoine Decaestecker, Adrien Daniel, Zoé Malbranque, Nicolas Wayolle, Amandine Ydee","doi":"10.1007/s40620-025-02329-y","DOIUrl":"10.1007/s40620-025-02329-y","url":null,"abstract":"<p><p>Membranoproliferative glomerulonephritis (MPGN) can be secondary to infections, autoimmune diseases, or hematological disorders. MPGN is uncommon and has a poor renal prognosis. We report the case of a patient with a myelodysplastic syndrome, presenting with autoimmune inflammatory manifestations and rapidly progressing kidney failure. The kidney biopsy revealed MPGN with extracapillary proliferation. The patient's condition rapidly improved under corticosteroid therapy, with normalization of the kidney function. However, during corticosteroid treatment, the patient developed severe visceral leishmaniasis with cutaneous, splenic, and osteo-medullary involvement. Upon review, we found that parasites were already present in minimal quantities in the bone marrow biopsy performed three months prior to corticosteroid treatment. We cannot conclusively determine whether the kidney lesions are linked to the autoimmune inflammatory manifestations of the myelodysplastic syndrome or to leishmaniasis. This case may be noteworthy due to the combination of two diseases that could be responsible for the histological lesions, and emphasizes the importance of a thorough evaluation in the case of MPGN.</p>","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":"1999-2004"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intermediate and long-term AKI outcomes in a public health system.","authors":"Ana Muñoz-Sánchez, Leyre Martín-Rodríguez, Paula López-Sánchez, Maria Valdenebro, Maria Luisa Serrano-Salazar, Maria Marques, Jose Portoles","doi":"10.1007/s40620-025-02367-6","DOIUrl":"10.1007/s40620-025-02367-6","url":null,"abstract":"<p><strong>Background: </strong>Acute Kidney Injury (AKI) is frequent and is associated with adverse outcomes.</p><p><strong>Aims: </strong>To analyze the impact of community-acquired and hospital-acquired AKI on in-hospital and five-year post-discharge kidney replacement therapy (KRT) requirement in the pre-COVID era.</p><p><strong>Methods: </strong>We linked the regional health system database of 419,851 admissions to the regional KRT registry. We grouped all admissions into 3 categories: community-acquired AKI, where AKI was the primary diagnosis, and hospital-acquired AKI, where AKI was an additional diagnosis alongside another primary condition. Admissions without this code were grouped into a third category (no AKI). We excluded patients aged under 18 years old, those with previous KRT, and pregnant women. The study was approved by the ethics committee. Patients were followed up for five years after discharge.</p><p><strong>Results: </strong>Community-acquired AKI accounted for 0.6% of all admissions, associated prolonged average hospital stays, and increased mortality rates. In-hospital KRT administration was required in 3.1% of cases, and after a mean follow-up time of 459 days, 7.2% of these patients began chronic KRT. Hospital-acquired AKI represented 6.1% of all admissions and was associated with the highest mortality rate (22.9% vs 14.4% in the community-acquired AKI group) and the longest average hospital stay (12.6 days vs 7.1 in the no AKI group). Only 0.5% of hospital-acquired AKI cases required KRT during the AKI episode, while 2% of these patients initiated chronic KRT after a mean follow-up time of 594 days.</p><p><strong>Conclusions: </strong>AKI continues to be a frequent problem in clinical practice, negatively influencing patient morbidity and mortality, and increasing the risk of starting KRT in the medium-long term.</p>","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":"1985-1994"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotype-genotype correlations in patients with Alport syndrome from the Polish population.","authors":"Maria Malarska, Hanna Moczulska, Paulina Pachniak, Karolina Gadzalska, Paulina Jakiel, Monika Gorządek, Ewa Juścińska, Michał Pietrusiński, Marcin Mazerant, Agnieszka Pukajło-Marczyk, Katarzyna Kiliś-Pstrusińska, Alicja Majos, Michał Podgórski, Agnieszka Zmysłowska","doi":"10.1007/s40620-025-02251-3","DOIUrl":"10.1007/s40620-025-02251-3","url":null,"abstract":"<p><strong>Background: </strong>Alport syndrome (AS) is a rare inherited kidney disease associated with progressive renal failure and visual and hearing disorders. The purpose of this study was to find genetic variants in patients with suspected Alport syndrome from Central and Southwestern Poland and their association with the clinical course of the disease, and to evaluate the impact of Alport syndrome on pregnancy.</p><p><strong>Methods: </strong>Initially, 90 patients with suspected Alport syndrome were evaluated by molecular-based testing. Clinical analyses, including urinalysis, evaluation of serum parameters, ultrasound, ophthalmologic, cardiovascular and audiology examination, and genetic testing were performed using next-generation sequencing and the Sanger method.</p><p><strong>Results: </strong>Seventy-seven patients (40.26% male; 59.74% female) with a median age of 6 years were included in the study group, after receiving a diagnosis of Alport syndrome. Twenty pathogenic/potentially pathogenic variants within the COL4A3, COL4A4 and COL4A5 genes were identified in these patients. The c.1871G > A variant in the COL4A5 gene was the most common (53.25%). Isolated hematuria was the most common initial sign of Alport syndrome (70.8%). Genetic testing confirmed Alport syndrome in 85% of symptomatic patients and in 15% of asymptomatic patients. Sensorineural hearing loss (17%) and ocular abnormalities (6%) were also detected in patients in the study group. Isolated hematuria showed a significant association with COL4A5 gene variants (p < 0.001). Genetic variants showed an association with initial clinical symptoms and age at Alport syndrome manifestation.</p><p><strong>Conclusions: </strong>Regular urinalysis and genetic testing should be considered in suspected cases of Alport syndrome for rapid diagnosis and effective patient management.</p>","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":"1831-1839"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol consumption and incidence of decline in glomerular filtration rate and of proteinuria: the Osaka Kenko Innovation (TOKI) study.","authors":"Yuko Nakamura, Naoko Otsuki, Qinyan Li, Maki Shinzawa, Isao Matsui, Miyae Yamakawa, Asuka Oyama, Hiroshi Toki, Ryohei Yamamoto","doi":"10.1007/s40620-025-02339-w","DOIUrl":"10.1007/s40620-025-02339-w","url":null,"abstract":"<p><strong>Background: </strong>Although excessive alcohol consumption is a critical factor for non-communicable diseases, its clinical relevance to chronic kidney disease is controversial.</p><p><strong>Methods: </strong>This retrospective cohort study, including 80,765 men and 88,507 women aged 40-74 years who underwent annual health checkups in Japan between April 2012 and March 2017, assessed a dose-dependent association between alcohol consumption (rare, occasional, and daily drinkers with ≤ 19, 20-39, 40-59, and ≥ 60 g/day) and incidence of ≥ 30% decline in estimated glomerular filtration rate (eGFR), eGFR < 60 ml/min/1.73 m² and presence of proteinuria (dipstick urinary protein ≥ 1 +), using Cox proportional hazards models adjusted for clinically relevant factors.</p><p><strong>Results: </strong>The incidence of ≥ 30% eGFR decline was observed in 1231 (1.5%) men and 1291 (1.5%) women during the median observation period of 2.8 and 2.9 years, respectively. In men, daily drinkers consuming ≥ 40 g/day of ethanol were at significantly high risk for ≥ 30% eGFR decline (adjusted hazard ratio [95% confidence interval] of rare, occasional, and daily drinkers with ≤ 19, 20-39, 40-59, and ≥ 60 g/day: 1.00 [reference], 1.05 [0.87, 1.27], 0.99 [0.80, 1.21], 1.05 [0.88, 1.26], 1.23 [1.01, 1.51], 1.61 [1.22, 2.11], respectively). Similar dose-dependent associations with incidence of eGFR < 60 ml/min/1.73 m² and proteinuria were observed in men. Contrary to men, alcohol consumption was not associated with eGFR decline and proteinuria in women.</p><p><strong>Conclusion: </strong>Men with alcohol consumption ≥ 40 g/day were at a high risk of eGFR decline and development of proteinuria.</p>","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":"1937-1946"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144618633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body water distribution, early malnutrition and sarcopenia in ADPKD: insights from a cross sectional study.","authors":"Maria Teresa Sciarrone Alibrandi, Matteo Brambilla Pisoni, Rodolfo Fernando Rivera, Martina Catania, Marta Vespa, Liliana Italia De Rosa, Romina Bucci, Kristiana Kola, Sara Farinone, Lorena Citterio, Maria Vittoria Vergani, Paolo Manunta, Giuseppe Vezzoli","doi":"10.1007/s40620-025-02327-0","DOIUrl":"10.1007/s40620-025-02327-0","url":null,"abstract":"<p><strong>Background: </strong>Bioelectrical impedance analysis is a non-invasive method used to assess body composition and nutritional status in patients with chronic kidney disease (CKD). However, its reliability in autosomal dominant polycystic kidney disease (ADPKD) remains uncertain due to altered fluid distribution caused by cystic organ enlargement. This cross-sectional study compared bioelectrical impedance analysis-derived body composition and nutritional parameters between patients with ADPKD and those with non-ADPKD CKD.</p><p><strong>Methods: </strong>A total of 218 CKD patients (71 with ADPKD and 147 with non-ADPKD CKD, stages 1-5D) were enrolled. To control for baseline differences, 1:1 propensity score matching was applied. All participants underwent bioelectrical impedance analysis to assess body water compartments, skeletal muscle mass, fat mass, and phase angle. In the ADPKD group, parameters were further analyzed based on the presence of organomegaly, defined as nephromegaly (total kidney volume > 750 mL or kidney length > 16 cm) or hepatomegaly (liver transverse diameter > 25 cm).</p><p><strong>Results: </strong>After matching, two balanced groups of 71 patients each were compared. ADPKD patients showed significantly higher total and extracellular water than controls, both as absolute values normalized to height squared and as a percentage of body weight. Among ADPKD patients, the 41 with organomegaly had significantly lower phase angle, fat mass, fat-free mass, and skeletal muscle mass than the 30 without organomegaly-despite a paradoxical increase in body mass index (BMI). These changes were independent of kidney function.</p><p><strong>Conclusions: </strong>Bioelectrical impedance analysis detected altered fluid distribution and early signs of malnutrition and sarcopenia in ADPKD, supporting the need for proactive nutritional monitoring, especially in patients with organomegaly.</p>","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":"1917-1925"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leptospiral casts in the urinary sediment.","authors":"Mateja Kraljevic, José Antonio T Poloni, Florian Buchkremer","doi":"10.1007/s40620-025-02270-0","DOIUrl":"10.1007/s40620-025-02270-0","url":null,"abstract":"","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":"1995-1997"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANCA renal risk score to predict kidney outcomes in an Australian cohort: a single-centre experience.","authors":"Lisa Paxton, Emily Schembri, Benjamin Hunt, Anthony Longano, Lawrence P McMahon, Limy Wong","doi":"10.1007/s40620-025-02276-8","DOIUrl":"10.1007/s40620-025-02276-8","url":null,"abstract":"","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":"2005-2007"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening for Fabry disease in patients on kidney replacement therapy at Padua University Hospital Nephrology Unit.","authors":"Gianni Carraro, Valentina Di Vico, Dorella Del Prete, Lucia Federica Stefanelli, Martina Cacciapuoti, Nicola Vitturi, Giorgia Gugelmo, Lorenzo A Calò, Federico Nalesso","doi":"10.1007/s40620-025-02312-7","DOIUrl":"10.1007/s40620-025-02312-7","url":null,"abstract":"","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":"2013-2015"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunotherapy-induced acute interstitial nephritis with neutrophil infiltrate, looking like pyelonephritis.","authors":"Mathis Michel, Adrien Flahault, Antoine Max, Jerome Olagne, Hervé Sartelet","doi":"10.1007/s40620-025-02332-3","DOIUrl":"10.1007/s40620-025-02332-3","url":null,"abstract":"","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":"2017-2019"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}