Journal of Nephrology最新文献

{"title":"Disseminated cryptococcosis with renal involvement as the initial presentation of HIV infection.","authors":"Karen F Haddad, Avi Z Rosenberg, Elias C Ghandour, Bernard G Jaar","doi":"10.1007/s40620-025-02314-5","DOIUrl":"https://doi.org/10.1007/s40620-025-02314-5","url":null,"abstract":"","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainable reuse of hemodialysis reject water for potato farming: a large-scale feasibility study in Morocco.","authors":"Faissal Tarrass, Meryem Benjelloun, Aziz Razkaoui, Omar Benjelloun, Younes Ouahel, Ayachi Kaoukabi, Mostapha Habib Allah","doi":"10.1007/s40620-025-02295-5","DOIUrl":"https://doi.org/10.1007/s40620-025-02295-5","url":null,"abstract":"<p><strong>Background: </strong>Hemodialysis consumes huge volumes of water and produces large quantities of wastewater.</p><p><strong>Aim: </strong>This study explored how to sustainably reuse hemodialysis reject water for large-scale potato farming in Morocco. With the increasing demand for water resources in agriculture and the challenges posed by water scarcity, this project explored the potential benefits of using this wastewater, its impact on potato yields, and the possible economic aspects.</p><p><strong>Methods: </strong>The AquaCrop-FAO model was used to simulate potato growth in a hot, semi-arid area with drip irrigation. The model was calibrated using data concerning five potato varieties. Validation included information from experimental studies in similar climates and soil conditions.</p><p><strong>Results: </strong>Morocco produces about 1.1 million cubic meters of hemodialysis reject water each year. The simulated potato yield is estimated at 29.37-47.67 t/ha depending on the potato variety (- 8.8 < Dev < - 2.5). The model revealed a good fit for potato yield with 0.941 ≤ R2 ≤ 0.998, 1.345 ≤ RMSE ≤ 3.324, 0.05 ≤ NRMSE ≤ 0.092, 0.443 ≤ EF ≤ 0.887 and 0.855 ≤ d ≤ 0.974. Cost evaluation showed that using reject water in agriculture could save about $638,000 USD each year in water costs. The financial benefit from potato farming with this type of water could reach $7000 to $10,000 USD per hectare, depending on the farm size, with an overall gross benefit from this water of $5-9 million USD per year.</p><p><strong>Conclusion: </strong>Reusing hemodialysis wastewater could save water and create extra income for dialysis facilities.</p>","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Follow up of patients with cystine and brushite stones-should we do more?","authors":"Ilan Klein, Alex Blinzovski, Ilona Pilosov Solomon, Yuval Freifeld, Yoram Dekel","doi":"10.1007/s40620-025-02310-9","DOIUrl":"https://doi.org/10.1007/s40620-025-02310-9","url":null,"abstract":"","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective study of kidney disease in Alport syndrome during and after pregnancy.","authors":"Xinxin Kong, Jan Boeckhaus, Fang Wang, Chunyan Shi, Hongwen Zhang, Oliver Gross, Jie Ding, Yanqin Zhang","doi":"10.1007/s40620-025-02252-2","DOIUrl":"https://doi.org/10.1007/s40620-025-02252-2","url":null,"abstract":"<p><strong>Background: </strong>During pregnancy, hyperfiltration and other factors are hypothesized to contribute to the progression of kidney disease in women with Alport syndrome. To evaluate the status of kidney disease, clinical data from mothers with Alport syndrome in China and Europe over the pregnancy were analyzed.</p><p><strong>Methods: </strong>This retrospective observational study collected data to evaluate proteinuria, kidney function and Alport stage prior to, during, and after pregnancy, respectively.</p><p><strong>Results: </strong>A total of 74 women were enrolled, 82% of them with X-linked Alport syndrome and 11% with autosomal Alport syndrome (unknown in 5 patients). Detailed information on the course of pregnancy was available for 62 pregnancies from 52 different women. No fetal malformations were observed. Mean gestational age was 37.9 ± 2.7 weeks (n = 55). Complications included high blood pressure (n = 8), abortion (n = 5), preeclampsia (n = 5), gestational diabetes (n = 3), nephrotic syndrome (n = 2), cervical insufficiency with fetal growth delay (n = 2), premature rupture of membranes (n = 1) and acute intrauterine fetal distress (n = 1). Median proteinuria was 350 (30-2465) mg/day prior to pregnancy, 2390 (450-11,450) mg/day during pregnancy, and 590 (40-2650) mg/day at a mean postpartum follow-up time of 4.5 ± 2.1 years. Mean estimated glomerular filtration rate (eGFR) decreased by 17.2 ± 16.7 ml/min/1.73 m², from 96.1 ± 32.9 to 78.9 ± 37 ml/min/1.73 m² after pregnancy (n = 15; p = 0.003). The eGFR loss was higher in women with eGFR < 90 ml/min/1.73 m² prior to pregnancy compared to women with normal renal function (- 21.5 ± 9.8 vs. - 14 ± 20 ml/min/1.73 m²), and in women with severe variants compared to women with less severe variants (- 21.5 ± 20.2 vs. - 11.3 ± 19.0 ml/min/1.73 m²). Progression of Alport stage after pregnancy was observed in 42% of the women, 31% remained in stage 0-1, and 23% remained in stage 2.</p><p><strong>Conclusions: </strong>This study provides important data on the natural history of Alport syndrome in women who have undergone  a pregnancy. Women with severe variants of Alport syndrome, and women with eGFR below 90 ml/min/1.73 m² face greater risks of kidney disease progression after pregnancy. Further prospective studies are required to confirm these findings.</p>","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contributing factors and clinical usefulness of spot urine glucose-to-creatinine ratio by sodium glucose cotransporter 2 inhibitors: a cross-sectional study.","authors":"Kojiro Nagai, Keisuke Morita, Ken Matsuo, Satoshi Tanaka","doi":"10.1007/s40620-025-02305-6","DOIUrl":"https://doi.org/10.1007/s40620-025-02305-6","url":null,"abstract":"","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening for Fabry disease in patients on kidney replacement therapy at Padua University Hospital Nephrology Unit.","authors":"Gianni Carraro, Valentina Di Vico, Dorella Del Prete, Lucia Federica Stefanelli, Martina Cacciapuoti, Nicola Vitturi, Giorgia Gugelmo, Lorenzo A Calò, Federico Nalesso","doi":"10.1007/s40620-025-02312-7","DOIUrl":"https://doi.org/10.1007/s40620-025-02312-7","url":null,"abstract":"","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adenine phosphoribosyltransferase deficiency as a rare cause of rapidly progressive chronic kidney disease.","authors":"Hannes Alder, Ariana Gaspert, Daniel G Fuster","doi":"10.1007/s40620-025-02304-7","DOIUrl":"https://doi.org/10.1007/s40620-025-02304-7","url":null,"abstract":"","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunosuppressive treatment patterns in kidney transplant recipients in France: an insurance claims database study (OISTER) over a 12 year period.","authors":"Dany Anglicheau, Antoine Durrbach, Isabelle Bardoulat, Mickael Arnaud, François-Emery Cotté, Radu Vadanici, Mélanie Chartier, Denis Glotz","doi":"10.1007/s40620-025-02296-4","DOIUrl":"https://doi.org/10.1007/s40620-025-02296-4","url":null,"abstract":"<p><strong>Background: </strong>The impact of new immunosuppressive strategies to prevent graft rejection on prescribing patterns is poorly documented. The objective of this study was to describe immunosuppressive medication use and survival outcomes in patients undergoing kidney transplantation in France between 2009 and 2020.</p><p><strong>Methods: </strong>This retrospective cohort study was performed using data from the French national healthcare database. All adult patients undergoing kidney transplantation between 2009 and 2020 were identified, and followed from transplantation until study end, death or graft failure. All immunosuppressive drug deliveries from pharmacies were documented. Survival and death-censored graft failure were estimated using Kaplan-Meier analysis.</p><p><strong>Results: </strong>Thirty four thousand six hundred kidney transplantation patients were eligible. Median follow-up duration was 4.0 years [IQR: 1.6-7.0 years]. Five-year survival probability was 0.890 [0.885-0.895], and death-censored graft survival was 0.850 [0.844-0.856]. Overall survival, but not graft survival was age-dependent. Calcineurin inhibitors were delivered to 29,573 patients (91.3%), antimetabolites to 29,318 (90.5%), corticosteroids to 28,536 (88.1%), mTOR inhibitors to 5231 (16.1%) and belatacept to 1272 (3.9%). The use of tacrolimus, everolimus and belatacept increased over time, while the use of corticosteroids, ciclosporin and sirolimus declined. Immunosuppressive treatment was maintained by 22,963 patients (76.5%) throughout follow-up.</p><p><strong>Conclusions: </strong>In this comprehensive study of kidney transplant recipients in France, we observed high rates of overall patient and graft survival. Over the study period, immunosuppressive treatment patterns were relatively stable and dominated by the use of calcineurin inhibitors. These results provide important insights into the state of post-transplant care and the potential implications of increased availability of innovative therapies.</p>","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pivotal role for typing of renal infiltrates: kidney localisation of a lymphoma presenting as pembrolizumab-associated nephritis. A lesson for the clinical nephrologist.","authors":"Rayane Benyahia, Olivier Roques, Loïc Ysebaert, Yann Bergé, Julien Mazières, Charlotte Syrykh, Magali Colombat, Julie Belliere","doi":"10.1007/s40620-025-02246-0","DOIUrl":"https://doi.org/10.1007/s40620-025-02246-0","url":null,"abstract":"","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development, validation, and reliability of a questionnaire to assess risk-factors of chronic kidney disease of unknown etiology.","authors":"Asha K Rajan, Nisha Abdul Khader, Pooja Gopal Poojari, Ravindra Prabhu Attur, Veena G Kamath, Shobha U Kamath, Shankar Prasad Nagaraju, Surulivel Rajan Mallayasamy, Muhammed Rashid, Girish Thunga","doi":"10.1007/s40620-025-02297-3","DOIUrl":"https://doi.org/10.1007/s40620-025-02297-3","url":null,"abstract":"<p><strong>Background: </strong>Chronic Kidney Disease of unknown aetiology (CKDu) is an emerging global health issue, yet research on risk factors is limited. This study addresses the gap by developing, validating, and evaluating the reliability of a questionnaire to assess the risk factors of CKDu.</p><p><strong>Methods: </strong>A draft version of the questionnaire was prepared based on thorough literature review and experts' discussion. Six experts validated it for content validity, incorporating items with an item level content validity index ≥ 0.78. The reliability of the developed questionnaire was assessed using the test-retest method. Sample size for reliability was calculated using a tool by ArifinWN; 2018. Subjects were recruited by purposive sampling after obtaining informed consent. Data were analysed for reliability using Statistical-Package for the Social-Sciences (SPSS) version 20.0.</p><p><strong>Results: </strong>A 10-domain questionnaire was developed to assess CKDu risk factors. Six experts, comprised of three associate professors, two nephrologists and one renal pharmacist, validated the questionnaire. All items had an item level content validity index > 0.78, and the scale level content validity index of the questionnaire was 0.98. The questionnaire was administered to 165 subjects with a mean age of 50.65 ± 12.5 years, comprising 53.9% males. Most of them were labourers (38.2%) followed by farmers (21.8%). Among the risk factors, 57% of subjects were exposed to long hours of sunlight during work, 52.7% burned garbage waste and 46.1% were exposed to insecticides and pesticides. The questionnaire was re-administered after two weeks for reliability. All items under each domain fulfilled the minimum internal consistency of > 0.7.</p><p><strong>Conclusions: </strong>The questionnaire demonstrated its validity and reliability in assessing the risk factors of CKDu among the subjects.</p>","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}