Journal of Nephrology最新文献

{"title":"Fanconi syndrome induced by topical cidofovir in an otherwise healthy young woman.","authors":"Birgit Korinek, Ursula Thiem, Florian Pfaff, Afschin Soleiman, Bernhard Kirsch","doi":"10.1007/s40620-025-02343-0","DOIUrl":"https://doi.org/10.1007/s40620-025-02343-0","url":null,"abstract":"","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The \"Diary of William Harvey\" written by the father of modern Nephrology Jean Hamburger.","authors":"Giovanni Battista Fogazzi, Beatrice Descamps-Latscha, Carmine Zoccali","doi":"10.1007/s40620-025-02317-2","DOIUrl":"https://doi.org/10.1007/s40620-025-02317-2","url":null,"abstract":"<p><p>This review explores Jean Hamburger's \"The Diary of William Harvey,\" a novel published in 1983 that imaginatively reconstructs the life and thoughts of William Harvey, the pioneering scientist who discovered blood circulation. Hamburger, a prominent figure in nephrology, crafts a narrative that spans from 1647 to 1654, offering a fictional diary that delves into Harvey's reflections on his scientific achievements and the turbulent political landscape of 17th-century England. The book provides insights into Harvey's interactions with notable contemporaries, including King Charles I and Thomas Hobbes, while highlighting his challenges against prevailing medical doctrines. Hamburger's portrayal emphasizes Harvey's commitment to empirical evidence and his philosophical musings on life and the human condition. The novel captures Harvey's struggle against the entrenched beliefs of his time, particularly the Galenic doctrine, and his dedication to scientific inquiry despite resistance from figures like James Primrose and Jean Riolan. Through vivid imagery, Hamburger explores Harvey's innovative research approach, including his studies on the heart and his analogy of the heart to a bagpipe. The book also reflects on Harvey's personal life and loyalty to King Charles I. Hamburger's work transcends mere historical fiction, offering a profound meditation on the essence of scientific inquiry and the human spirit. \"The Diary of William Harvey\" serves as a testament to the enduring impact of those who challenge conventional wisdom and pursue knowledge with courage and compassion, making it relevant to contemporary discussions in medicine, philosophy, and ethics.</p>","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crescentic glomerulonephritis associated with myelodysplatic syndrome and visceral leishmaniasis.","authors":"Antoine Decaestecker, Adrien Daniel, Zoé Malbranque, Nicolas Wayolle, Amandine Ydee","doi":"10.1007/s40620-025-02329-y","DOIUrl":"10.1007/s40620-025-02329-y","url":null,"abstract":"<p><p>Membranoproliferative glomerulonephritis (MPGN) can be secondary to infections, autoimmune diseases, or hematological disorders. MPGN is uncommon and has a poor renal prognosis. We report the case of a patient with a myelodysplastic syndrome, presenting with autoimmune inflammatory manifestations and rapidly progressing kidney failure. The kidney biopsy revealed MPGN with extracapillary proliferation. The patient's condition rapidly improved under corticosteroid therapy, with normalization of the kidney function. However, during corticosteroid treatment, the patient developed severe visceral leishmaniasis with cutaneous, splenic, and osteo-medullary involvement. Upon review, we found that parasites were already present in minimal quantities in the bone marrow biopsy performed three months prior to corticosteroid treatment. We cannot conclusively determine whether the kidney lesions are linked to the autoimmune inflammatory manifestations of the myelodysplastic syndrome or to leishmaniasis. This case may be noteworthy due to the combination of two diseases that could be responsible for the histological lesions, and emphasizes the importance of a thorough evaluation in the case of MPGN.</p>","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of the Kidney Failure Risk Equation according to diabetic status in the CKD-CAREMEAU cohort of patients with chronic kidney disease.","authors":"Julien Prouvot, Pascal Reboul, Pedram Ahmadpoor, Edouard Clemmer, Marion Gerbal, Florian Garo, Sylvain Cariou, Emilie Pambrun, Ziyad Messikh, Olivier Moranne","doi":"10.1007/s40620-025-02286-6","DOIUrl":"https://doi.org/10.1007/s40620-025-02286-6","url":null,"abstract":"<p><strong>Background: </strong>The Kidney Failure Risk Equation (KFRE) estimates the risk of kidney replacement therapy (KRT) at 5 years. Patients with diabetes mellitus are at high risk of KRT and death, a competing event. This study assesses the performance of the 5-year KFRE in patients with diabetes mellitus, compared to non-diabetic patients and considering age, in a cohort of patients evaluated by a nephrologist at a tertiary care center.</p><p><strong>Methods: </strong>The CKD-CAREMEAU cohort included all patients who visited a nephrologist for chronic kidney disease (CKD) before KRT between 2008 and 2017. The 5-year KFRE was calculated for each patient, based on their baseline characteristics. The study evaluated performance regarding discrimination and calibration, taking the patient's diabetic status and age into account.</p><p><strong>Results: </strong>The study included 2935 patients with a median age of 73 [65-80] years, 1800 of whom were men (61%), and 1249 (43%) who were affected by diabetes. The incidence of KRT was higher in diabetic patients (167 (13%)) than in non-diabetic patients (184 (11%))(p = 0.04). Additionally, the death rate within five years after inclusion was not statistically higher for diabetic patients (351 (28%)) than non-diabetic patients (443 (26%))(p = 0.3). Diabetic status affected neither discrimination nor calibration. However, the equation overestimated the risk for higher-risk patients, especially among the elderly.</p><p><strong>Conclusions: </strong>Our study found no difference in the 5-year KFRE performance between diabetic and non-diabetic patients. However, performance was worse for patients over 75 years old.</p>","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney transplant arteriopathy revisited.","authors":"Katharina Wirths, Michael Thomas, Georg Dieplinger, Tristan Wagner, Wolfgang Arns, Hans Schlösser, Rabi Raj Datta, Francesco Pesce, Vanessa Ditt, Ulrich Lang, Michael Ströhlein, Ulrike Bauernfeind, Christine Kurschat, Lutz Thorsten Weber, Dirk Stippel, Jan U Becker","doi":"10.1007/s40620-025-02308-3","DOIUrl":"https://doi.org/10.1007/s40620-025-02308-3","url":null,"abstract":"<p><strong>Background: </strong>Transplant arteriopathy involves a spectrum of Leukocyte Common Antigen-positive, hypoelastotic, foam cell intimal fibrosis. Transplant arteriopathy has been associated with both Chronic Active T Cell-Mediated Rejection and Antibody-Mediated Rejection chronicity. Aim of this study was to find clinicopathological correlates of transplant arteriopathy in a single centre retrospective cohort.</p><p><strong>Methods: </strong>We retrieved 46 biopsies showing transplant arteriopathy from 33 patients, out of a total of 784 biopsies carried out between 2005 and 2014. We retrospectively evaluated Banff Lesion Scores and Additional Diagnostic Parameters as well as the transplant arteriopathy descriptors Leukocyte Common Antigen-positive, hypoelastotic, foam cell, and correlated these findings with clinical data and death-censored transplant survival.</p><p><strong>Results: </strong>Transplant arteriopathy was frequently associated with antibody-mediated rejection-associated Banff Lesions Scores and Additional Diagnostic Parameters. Hypoelastotic, leukocyte common antigen-positive and foam cell lesions were often combined, with hypoelastotic lesion being the most frequent finding in transplant arteriopathy. Leukocyte common antigen-positive lesion appeared earlier and was associated with Banff Lesion Score v ≥ 1. About half were positive for donor-specific antibodies, about a third had concurrent transplant glomerulopathy, and about a sixth were C4d-positive. Twelve of thirty-three transplants were lost during follow-up, concurrent transplant glomerulopathy was associated with shorter transplant survival.</p><p><strong>Conclusions: </strong>The frequent coincidence of transplant arteriopathy and indicators of antibody-mediated rejection suggests that this arterial remodelling could indeed be antibody-mediated rejection chronicity. The transplant community should re-examine transplant arteriopathy with an expanded definition including the previously ignored hypoelastotic lesion in order to re-confirm or reject with confidence transplant arteriopathy as Additional Diagnostic Parameter of Antibody-Mediated Rejection chronicity, and to learn about its prognostic and therapeutic implications.</p>","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The complexity of kidney disease secondary to collagen IV variants: insights into phenotypic variability from a large Sicilian pedigree.","authors":"Elisa Longhitano, Giulia Margherita Brach Del Prever, Claudia Spinella, Valeria Bracciamà, Vincenzo Calabrese, Antonio Amoroso, Giovanni Conti, Giuseppe Remuzzi, Thorsten Wiech, Marina Noris, Silvia Deaglio, Domenico Santoro","doi":"10.1007/s40620-025-02321-6","DOIUrl":"https://doi.org/10.1007/s40620-025-02321-6","url":null,"abstract":"<p><strong>Background: </strong>Collagen type IV (COL IV) is a crucial component of basement membranes, including the glomerular basement membrane (GBM), essential for kidney function. COL4A3, COL4A4, and COL4A5 variants lead to a broad spectrum of kidney disorders. This paper investigates the clinical and genetic characteristics of a large Sicilian family with COL4A gene abnormalities.</p><p><strong>Methods: </strong>Starting from a male patient with digenic Alport Syndrome, we collected clinical data through genealogical research and performed genetic analyses on nineteen members of his family. Kidney biopsies were available for three of them.</p><p><strong>Results: </strong>We identified variants in COL4A5 and COL4A3 genes. Clinical and histological manifestations varied widely, even among individuals with the same variant, highlighting the remarkable phenotypic heterogeneity of collagen IV-related nephropathies.</p><p><strong>Conclusions: </strong>Our findings underscore the pivotal role of genetic testing in guiding clinical management and advancing the understanding of collagen IV-related kidney diseases. Moreover, this study emphasizes the need for further research to elucidate the intricate interplay between genetic variants and histological and clinical phenotypes, thereby paving the way for personalized therapeutic approaches in collagen IV-associated nephropathies.</p>","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health professional and transplant recipient perspectives of kidney transplantation in regional, rural, and remote Australia - a survey study.","authors":"Tara K Watters, Nicole J Scholes-Robertson, Beverley D Glass, Andrew J Mallett","doi":"10.1007/s40620-025-02331-4","DOIUrl":"https://doi.org/10.1007/s40620-025-02331-4","url":null,"abstract":"<p><strong>Background: </strong>Despite higher rates of chronic kidney disease and kidney failure in rural and remote populations, these patients are less likely to receive a kidney transplant. Additional barriers to kidney transplantation are associated with the need to travel to metropolitan areas where medical testing and transplantation facilities are located. We determined the opinions, attitudes, and experiences of both health professionals and recent kidney transplant recipients regarding kidney transplantation processes in Australia for patients residing in regional, rural, and remote areas.</p><p><strong>Methods: </strong>A cross-sectional survey containing closed and open-ended questions was administered, with kidney transplant recipients from northern Queensland and Australian kidney transplant health professionals surveyed. Quantitative data were analysed using descriptive and inferential statistics, while a descriptive thematic method was used to analyse qualitative data.</p><p><strong>Results: </strong>Australian transplant health professionals (82) and recent kidney transplant recipients (77) participated. Almost all (97%) health professional participants agreed that receiving psychosocial support from peers would be beneficial for potential transplant recipients. Kidney transplant recipients rated information prior to transplant, potential medication side effects, high financial costs incurred related to treatment, and access to ongoing medication supply as the most important aspects in relation to their own experience. Prevalent themes around improving transplant experiences included enabling timely and flexible access to transplant assessment, reducing financial hardship, and fostering comprehensive psychosocial support.</p><p><strong>Conclusions: </strong>Multiple aspects of current kidney transplant processes in Australia, and particularly northern Australia, could be optimised to improve patient experiences and clinical outcomes for regional, rural, and remote kidney transplant recipients.</p>","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roots of strength: a life shaped by kidney challenges.","authors":"Amna Alsayed Jaffar Majed","doi":"10.1007/s40620-025-02311-8","DOIUrl":"https://doi.org/10.1007/s40620-025-02311-8","url":null,"abstract":"","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Against the odds: Nivedita's fight for survival and hope.","authors":"Mythri Shankar","doi":"10.1007/s40620-025-02300-x","DOIUrl":"https://doi.org/10.1007/s40620-025-02300-x","url":null,"abstract":"","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the impact of Arteriovenous Fistula (AVF) creation on kidney function.","authors":"Sri Ram Ramasamy Muthuraman, Emma Aitken","doi":"10.1007/s40620-025-02316-3","DOIUrl":"https://doi.org/10.1007/s40620-025-02316-3","url":null,"abstract":"<p><strong>Background: </strong>Arteriovenous fistula (AVF) creation may slow down the decline of kidney function as shown in few previous studies. Our aim was to evaluate the effect of AVF creation on kidney function and dialysis initiation in predialysis patients.</p><p><strong>Methods: </strong>Predialysis patients with AVFs and estimated glomerular filtration rate (eGFR) recorded on day of AVF creation and at 12 and 6 months pre- and post-AVF creation were identified. Rate of decline (RoD) of eGFR and Kidney Failure Risk Equation Score (KFRE) was recorded pre- and post-AVF creation at 6 and 12 months. Patients with non-functioning AVFs were identified and RoD was compared to functioning AVFs. Patients undergoing haemodialysis pre- and post-AVF creation were identified.</p><p><strong>Results: </strong>Overall, 368 patients and 435 patients were identified for the 12-month and 6-month group, respectively. Rate of decline of eGFR 6 months pre-AVF creation was -0.33 ml/min/1.73m2/month which slowed down to -0.23 ml/min/1.73m2/month in the 6 months post-AVF creation. Rate of decline of eGFR 12 months pre-AVF creation was -0.37 ml/min/1.73m2/month and slowed down to -0.19 ml/min/1.73m2/month in the 12 months post-AVF creation. KFRE increased at a slower rate at 6 and 12 months post-AVF. One hundred sixty-two patients had functioning AVFs while 29 patients had non-functioning AVFs at 6 months post-AVF creation. Rate of decline of eGFR in patients with functioning AVF was -0.22 ml/min/1.73m2/month compared to -0.32 ml/min/1.73m2/month in patients with non-functioning AVF; 246 patients (62.3%) were commenced on haemodialysis in the 12 months pre- and post- AVF creation.</p><p><strong>Conclusion: </strong>AVF creation was associated with a slower rate of decline of kidney function. However, this is unlikely to delay the commencement of haemodialysis in predialysis patients.</p>","PeriodicalId":16542,"journal":{"name":"Journal of Nephrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}