Journal of Neonatology最新文献_第3页

Bronchopulmonary Dysplasia in a Tertiary Level Neonatal Unit of North India: Risk Factors and Outcome: A Case-control Study 印度北部一家三级医院新生儿科的支气管肺发育不良：风险因素和结果：病例对照研究

Journal of Neonatology Pub Date : 2024-03-22 DOI: 10.1177/09732179241234519

Pragya Mishra, Shalini Tripathi, Akhil Sharma, G. Sonkar, Mala Kumar, S.N. Singh

{"title":"Bronchopulmonary Dysplasia in a Tertiary Level Neonatal Unit of North India: Risk Factors and Outcome: A Case-control Study","authors":"Pragya Mishra, Shalini Tripathi, Akhil Sharma, G. Sonkar, Mala Kumar, S.N. Singh","doi":"10.1177/09732179241234519","DOIUrl":"https://doi.org/10.1177/09732179241234519","url":null,"abstract":"Background: Bronchopulmonary dysplasia (BPD) in preterm neonates is a dreadful complication that increases the length of neonatal intensive care unit (NICU) stay, increases the cost of treatment, and poses long-term respiratory morbidity. Methods: This was a case-control study to determine risk factors for BPD among preterm neonates (gestational age <32 weeks). Also, the proportion of BPD neonates developing secondary pulmonary arterial hypertension (PAH), vitamin D levels, and their outcomes were studied. Results: Of 70 neonates with a mean birth weight of 1392 ± 544.28 grams and a mean gestational age of 30.14 ± 1.12 weeks, 35 cases of BPD (mild 42%, moderate 27%, severe 31%) and 35 controls were enrolled. After multivariate analysis, SGA (adjusted odds ratio [AOR] 12.6 with 95% CI 1.5-109.3; 0.022), lack of antenatal steroids (AOR 9.4 with 95% CI 1.8-50.7; 0.009), mechanical ventilation [MV] within the first 48 hours of life (AOR 8.7 with 95% CI 1.4-54.1; 0.021), and lack of surfactant administration (AOR 16.5% CI 3-89.1; 0.005) were independent risk factors. No significant difference was reported in vitamin D levels between BPD and non-BPD neonates (33.89 ± 22.50 ng/mL vs. 27.00 ± 8.17 ng/mL; 0.356). 14.3 % of BPD neonates expired, and 23% developed PAH. Neonates had a longer NICU stay than controls (46.66 ± 7.96 vs. 21 ± 8.82 days; <0.001) Conclusion: We found SGA, lack of antenatal steroids, MV, and lack of surfactant administration to be independent risk factors for BPD. BPD neonates had dismal outcomes (one-fourth expired and left against medical advice), and one-fifth had PAH among survivors, increasing the length of their NICU stay.","PeriodicalId":16516,"journal":{"name":"Journal of Neonatology","volume":" 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140216764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasound Gel as a Source of Burkholderia cepacia Sepsis Outbreak in Preterm Neonates 超声凝胶是早产新生儿伯克霍尔德氏菌败血症爆发的源头

Journal of Neonatology Pub Date : 2024-03-19 DOI: 10.1177/09732179241234188

Raunak Raj, Radhika Sujatha, Sahira Haneefa, Vishnu Vasantha Sundaresan, Aswathy Rahul

{"title":"Ultrasound Gel as a Source of Burkholderia cepacia Sepsis Outbreak in Preterm Neonates","authors":"Raunak Raj, Radhika Sujatha, Sahira Haneefa, Vishnu Vasantha Sundaresan, Aswathy Rahul","doi":"10.1177/09732179241234188","DOIUrl":"https://doi.org/10.1177/09732179241234188","url":null,"abstract":"Background: In the middle of 2018, we noticed an outbreak of sepsis due to Burkholderia cepacia complex among inborn babies, and this continued till December 2020. These babies were not responding to conventional antibiotic therapy. Aim: To study the clinical profile of neonates with Burkholderia septicemia, to determine its antimicrobial susceptibility patterns, and to identify the source of infection. Materials and methods: This was a retrospective descriptive study conducted in the inborn nursery of the Government Medical College, Thiruvananthapuram for a period of 30 months, from June 2018 to December 2020. All babies whose blood culture was positive for Burkholderia were identified from the records. Microbiological surveillance was done for source identification. Results: Out of the total 2264 neonates admitted during the study period, 84 (3.7%) had Burkholderia cepacia sepsis. The mean gestational age was 31(2) weeks. The most common clinical presentation was feed intolerance (64%) and 12% had a liver abscess. The highest antimicrobial sensitivity was observed for ceftazidime and cotrimoxazole (100%) followed by cefoperazone-sulbactam (98%) and meropenem (94%). The outbreak was controlled by the withdrawal of contaminated muti-use USG gel and the implementation of the practice of single-use sterile USG gel. Conclusions: Gastrointestinal manifestations are predominantly a manifestation in Burkholderia cepacia sepsis and a strong suspicion of liver abscess should be kept in mind. cotrimoxazole and ceftazidime are the best choice of antibiotics. Unsterile ultrasound gel use in the labor room and NICU can be a source of infection","PeriodicalId":16516,"journal":{"name":"Journal of Neonatology","volume":"3 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140230517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perfusion Index as a Predictor of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Newborns 灌注指数作为早产新生儿血流动力学显著性动脉导管未闭的预测指标

Journal of Neonatology Pub Date : 2024-03-19 DOI: 10.1177/09732179241234182

Lalitha Rajalakshmi S, Lakshmi Venugopalan, Gnanasambandam Subramaniyam, N. Krishnamoorthy

{"title":"Perfusion Index as a Predictor of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Newborns","authors":"Lalitha Rajalakshmi S, Lakshmi Venugopalan, Gnanasambandam Subramaniyam, N. Krishnamoorthy","doi":"10.1177/09732179241234182","DOIUrl":"https://doi.org/10.1177/09732179241234182","url":null,"abstract":"Aim: To assess the value of perfusion index (PI) and arrive at the ideal cut-off value of delta PI (DPI) (pre and postductal difference in PI) in identifying hemodynamically significant patent ductus arteriosus (HsPDA). Methods: Prospective observational study was conducted on 156 preterm newborns of <37 weeks in the NICU of tertiary care center, from August 2019 to March 2020 after ethical clearance. 156 preterm babies were classified into noPDA, HsPDA and Non-HsPDA based on echocardiogram findings and compared with DPI value on Day 1 to 3 of life. Receiver operating characteristic (ROC) curve was constructed to establish cut-offs for DPI in diagnosing HsPDA. A P value <.05 is considered for statistical significance. Results: There was a significantly lower PI in both preductal and post ductal limbs with HsPDA compared to other groups. A DPI Cut-off of 0.75 on day 2 of life has a sensitivity of 75%, specificity of 100% and positive predictive value (PPV) of 100% and a negative predictive value of 89%. Conclusion: PI is a simple non-invasive bedside index predict the presence of a HsPDA in preterm newborns and DPI of >0.75 indicates for presence of HsPDA.","PeriodicalId":16516,"journal":{"name":"Journal of Neonatology","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140228572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the Downside of Glucagon Therapy for Neonatal Hypoglycemia: A Case Report 揭开胰高血糖素治疗新生儿低血糖的弊端：病例报告

Journal of Neonatology Pub Date : 2024-03-19 DOI: 10.1177/09732179241234177

Geethanjali Rupnagudi, Anil Mathew, P. Bendapudi

引用次数: 0

A New Formula for Estimating Insertion Length of Umbilical Catheters in Neonates: An Observational Study 估算新生儿脐带导管插入长度的新公式：观察研究

Journal of Neonatology Pub Date : 2024-03-19 DOI: 10.1177/09732179241234515

Jennifer Webb, Sian Elliott, W. J. Watkins, Laura Stuttaford, Sujoy Banerjee, Babatunde Kayode-Adedeji, Gautam Bagga, Neha Sharma, M. Chakraborty

{"title":"A New Formula for Estimating Insertion Length of Umbilical Catheters in Neonates: An Observational Study","authors":"Jennifer Webb, Sian Elliott, W. J. Watkins, Laura Stuttaford, Sujoy Banerjee, Babatunde Kayode-Adedeji, Gautam Bagga, Neha Sharma, M. Chakraborty","doi":"10.1177/09732179241234515","DOIUrl":"https://doi.org/10.1177/09732179241234515","url":null,"abstract":"Objective: Current formulae used by clinicians to estimate the insertion length of umbilical catheters are inaccurate. We aimed to derive a new model that could improve accuracy in estimating the insertion length of umbilical catheters. Study design: This was a multi-centre prospective observational study of neonates admitted to neonatal units and needing umbilical line(s) inserted for clinical reasons. Demographic data, catheter-related measurements and a new external length measurement—sternal notch to the umbilicus, were collected at three tertiary-level neonatal units in South Wales, UK. Generalised linear models were used to estimate the fit of the external length, birthweight, gestation and head circumference with catheter length and to derive a formula. The best fit was estimated by comparing r 2 values for each equation. Results: Data from 113 infants for each venous and arterial line were analysed for the new mathematical formulae. For both umbilical arterial catheterisation [[Formula: see text] and umbilical venous catheter (UVC) [[Formula: see text]], a quadratic model based on birthweight was found to have the best fit for predicting the insertion length of the catheters. However, the overall fit for UVCs was poorer for all explanatory variables ( y = estimated insertion length of the umbilical catheter in cm, x = birthweight in kg). Conclusion: Our prospective multi-centre observational study identified a quadratic model based on birthweight as the best fit for estimating the insertion length of umbilical lines in neonates. This is a new finding and further development on earlier birthweight-based linear models.","PeriodicalId":16516,"journal":{"name":"Journal of Neonatology","volume":"59 44","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140230541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SARS CoV-2 Antibodies in Cord Blood of Neonates Delivered to Pregnant Mothers Vaccinated for COVID-19 接种 COVID-19 疫苗的孕妇所生新生儿脐带血中的 SARS CoV-2 抗体

Journal of Neonatology Pub Date : 2024-03-14 DOI: 10.1177/09732179241234520

Priyanka Tank, Suraj Chawla, Rakesh Tank, A. Dhingra, Jyoti Sangwan

{"title":"SARS CoV-2 Antibodies in Cord Blood of Neonates Delivered to Pregnant Mothers Vaccinated for COVID-19","authors":"Priyanka Tank, Suraj Chawla, Rakesh Tank, A. Dhingra, Jyoti Sangwan","doi":"10.1177/09732179241234520","DOIUrl":"https://doi.org/10.1177/09732179241234520","url":null,"abstract":"Background: The recent novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) pandemic has been responsible for millions of deaths globally. Several vaccines against the SARS-CoV-2 virus have been developed. Objective: To estimate the proportion of newborns who acquire IgG anti-SARS-CoV-2 antibodies from mothers vaccinated against COVID-19. Methods: Eligible study subjects seeking care in the Obstetrics & Gynecology department for delivery were recruited in this cross-sectional analytic study. Demographic and clinical characteristics of the study subjects were noted and around 3–5 mL venous blood was collected from each study participant duo (mother and newborn) to detect IgG antibodies to SARS-CoV2 “S” protein. Results: Over the entire study period, 125 pregnant ladies who were vaccinated with two doses of any COVID-19 vaccine were included in the study. A sizeable proportion (44.0%) of vaccinated pregnant women were seropositive for IgG antibodies to SARS-CoV2 “S” protein. A significantly high number of seropositive newborns (82.8%) were delivered to seropositive mothers as compared to seronegative mothers (OR 41.1; 95% confidence interval 14.6–116.1, p < .0001). Conclusions: The present study reveals that a substantial proportion of newborns acquired SARS-CoV-2 antibodies from their vaccinated seropositive mothers through transplacental transfer.","PeriodicalId":16516,"journal":{"name":"Journal of Neonatology","volume":"18 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140244278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From the pen of the President NNF… 从 NNF 主席的笔下...

Journal of Neonatology Pub Date : 2024-03-01 DOI: 10.1177/09732179241236661

Sushma Nangia

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Ma Ka Doodh Amrut [मां का दूध अमृत] Ma Ka Doodh Amrut [मां का दूध अमृत]

Journal of Neonatology Pub Date : 2024-03-01 DOI: 10.1177/09732179231215887

Vijayanand Jamalpuri

引用次数: 0

Pressure Data from Neonatalie Live Manikin to Determine Appropriate Ventilation During Simulation Training of Undergraduate Students in Neonatal Resuscitation 在对本科生进行新生儿复苏模拟训练时，利用新生儿活体模拟人的压力数据确定适当的通气量

Journal of Neonatology Pub Date : 2024-02-18 DOI: 10.1177/09732179241228065

S. Nimbalkar, Anish Sinha, Purvi Patel, Reshma Pujara, Dipti Shah, Jaimin Patel, Swati Sethi, Rashmi Aradhya, Mayur K Shinde, D. Patel

{"title":"Pressure Data from Neonatalie Live Manikin to Determine Appropriate Ventilation During Simulation Training of Undergraduate Students in Neonatal Resuscitation","authors":"S. Nimbalkar, Anish Sinha, Purvi Patel, Reshma Pujara, Dipti Shah, Jaimin Patel, Swati Sethi, Rashmi Aradhya, Mayur K Shinde, D. Patel","doi":"10.1177/09732179241228065","DOIUrl":"https://doi.org/10.1177/09732179241228065","url":null,"abstract":"Background: Neonatalie Live (NL) was developed as a part of the Safer Births project with collaboration between Laerdal Global Health and Tanzanian, Norwegian, and international research institutions. Its features allow instructors to determine the time of starting ventilation, the percentage of valid ventilations, etc. NL generated real-time data during the assessment. Aim: To evaluate whether undergraduate students trained on Neonatalie and NL manikins had equivalent ventilation skills on NL. Study design: Randomized Control Trial. Methods: Final-year MBBS students were randomly assigned to Neonatalie (72 students) or NL (71 students) groups after providing written and informed consent and assessed on NL. Live data generated by NL was analyzed. Outcome: To assess the success rate at bag and mask ventilation (BMV), as evidenced by objective data from NL. Results: A total of 142 students (assessed only on NL) participated in the study before and after four months. Total time from initiation of BMV to spontaneous breathing did not differ significantly between the Neonatalie and NL [127.6 sec (57.4) vs. 115.1 sec (48.3), p = .16]. “Try to ventilate the baby continuously without pauses” was the most common feedback to all students 70 (49.2%), but no statistical significance between the Neonatalie and NL groups [34 (47.2%) vs. 36 (51.43%)] was found. Conclusion: Undergraduate students trained on either manikin had similar success at BMV, as evidenced by independent objective data generated from within the manikin.","PeriodicalId":16516,"journal":{"name":"Journal of Neonatology","volume":"7 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139959565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extrauterine Growth Restriction and Catch-up Growth Following NICU Discharge: A Tale of two Standards 宫外生长受限和新生儿重症监护室出院后的追赶生长：两种标准的故事

Journal of Neonatology Pub Date : 2024-02-16 DOI: 10.1177/09732179241228421

Lena F. Olgun, Andrea S. Weintraub, Robert S. Green

{"title":"Extrauterine Growth Restriction and Catch-up Growth Following NICU Discharge: A Tale of two Standards","authors":"Lena F. Olgun, Andrea S. Weintraub, Robert S. Green","doi":"10.1177/09732179241228421","DOIUrl":"https://doi.org/10.1177/09732179241228421","url":null,"abstract":"Aim: Extrauterine growth restriction (EUGR) is common in premature infants, but the progression after neonatal intensive care unit (NICU) discharge is not well described. We aimed to assess EUGR after NICU discharge and to identify factors associated with catch-up growth (CUG) and neurodevelopmental outcomes at 2 years of age. Methods: Growth parameters at birth, 36 weeks postmenstrual age (PMA), and two neurodevelopmental follow-up visits for preterm graduates of our NICU were reviewed. EUGR was assessed using Fenton and Intergrowth-21 standards. Factors associated with outpatient growth and neurodevelopmental outcomes at 2 years of age were evaluated using logistic and linear regression. Results: 369 infants born at 24–32 weeks gestation comprised the cohort. EUGR prevalence was 14.9% for Intergrowth-21 versus 56.4% for Fenton ( p < .001). Although there was a significant decrease in weight z-score from birth to 36 weeks PMA, weight z-scores returned to their birth weight values at the second clinic visit (86 weeks PMA). Infants who received formula as opposed to human milk (HM) showed faster CUG. Higher scores in the Bayley-III scale at 2 years of age were associated with HM feeding. Discussion/Conclusion: Fewer infants were identified as EUGR when Intergrowth-21 versus Fenton growth standards were used, which categorizes infants with adverse clinical courses and poorer neurodevelopmental outcomes more distinctly. While growth failure during the birth hospitalization is common in preterm infants, outpatient CUG was demonstrated, with return to birth weight z-score. Our findings suggest that HM feeding may have a positive impact on cognitive, language, and motor developmental outcomes for preterm infants despite less rapid CUG.","PeriodicalId":16516,"journal":{"name":"Journal of Neonatology","volume":"57 49","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139960804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0