Journal of Nephropathology最新文献_第8页

Pregnant kidney transplant recipients with COVID-19; a report of two cases and literature review 感染COVID-19的妊娠肾移植受者;二例报告及文献复习

Journal of Nephropathology Pub Date : 2022-02-02 DOI: 10.34172/jnp.2022.17291

A. Domingos, A. Braga, D. Gonçalves, S. Pedroso, L. Martins, J. Braga

引用次数: 0

Refractory diffuse podocytopathy 难治性弥漫性足细胞病

Journal of Nephropathology Pub Date : 2022-02-01 DOI: 10.34172/jnp.2022.17314

João Oliveira, I. Sala, Joana Freitas, J. Tavares, S. Santos, Andreia Campos, Josefina Santos Lascasas, T. Mendonça, A. Cabrita

引用次数: 1

Membranous nephropathy with collapse in a HIV negative patient; a case report with a 34-month follow-up 1例HIV阴性患者膜性肾病伴塌陷病例报告，随访34个月

Journal of Nephropathology Pub Date : 2022-01-30 DOI: 10.34172/jnp.2022.17337

L. Costa, Anabela S Rodrigues, C. Ferreira, Carla Pereira Lima, Tânia, Couto Sousa, H. Viana, M. Góis, Sérgio Silva Lemos

引用次数: 0

"Double whammy" to the kidneys: an unusual etiology of acute kidney disease 对肾脏的“双重打击”：急性肾脏疾病的一种罕见病因

Journal of Nephropathology Pub Date : 2022-01-20 DOI: 10.34172/jnp.2022.17252

V. Jayaprakash, Muthukaruppaiah Suganya, Dhanasekaran Karthick, A. Kurien, Raghavan Padmanabhan

引用次数: 1

An unusual cause of acute kidney injury "inhalation of diazinon" 急性肾损伤的一个特殊原因“吸入二嗪农”

Journal of Nephropathology Pub Date : 2022-01-12 DOI: 10.34172/jnp.2022.17227

Mohammadreza Rahimi Majd, Maliheh Yarmohamadi, M. Parvin, Soheila Mirjan

引用次数: 0

Ameliorative impact of ezetimibe on gentamicin-induced kidney damage; A histopathological perspective 依折麦布对庆大霉素所致肾损害的改善作用组织病理学的观点

Journal of Nephropathology Pub Date : 2022-01-10 DOI: 10.34172/jnp.2022.17341

Elham Emami, A. Hasanpour Dehkordi, A. Maghsoudi, H. Nasri, Alireza Vahedi

{"title":"Ameliorative impact of ezetimibe on gentamicin-induced kidney damage; A histopathological perspective","authors":"Elham Emami, A. Hasanpour Dehkordi, A. Maghsoudi, H. Nasri, Alireza Vahedi","doi":"10.34172/jnp.2022.17341","DOIUrl":"https://doi.org/10.34172/jnp.2022.17341","url":null,"abstract":"\u0000 Introduction: Gentamicin, despite its beneficial effects, has significant nephrotoxic effects that are observed in 20% of the patients. Ezetimibe is recognized as an inhibitor of cholesterol absorption. Objectives: The present study aimed to investigate the histopathological effects of ezetimibe on gentamicin-induced kidney damage. Material and Methods: Twenty male Wistar rats were randomly divided into five groups and treated as the following; group 1 (normal group), group 2 [gentamicin group, daily 80 mg/kg, intraperitoneal (i.p.) for seven days], group 3-5 (gentamicin 80 + ezetimibe at doses of 2.5, 12.5, and 37.5 mg/kg, respectively). Kidney sections were examined for histopathological parameters including vacuolization of the tubular renal cells, degeneration, necrosis, flattening of the tubular cells and debris in the tubular lumen. Results: Gentamicin injection significantly induced histopathological alterations (P< 0.05). Ezetimibe therapy significantly decreased the levels of vacuolization, degeneration, necrosis, flattening of the tubular cells and debris in the nephrotoxic rats (P< 0.05). Conclusion: The results illustrated that treatment with ezetimibe can improve kidney damage caused by gentamicin injection.","PeriodicalId":16515,"journal":{"name":"Journal of Nephropathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46249980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spectrum of histopathological findings in pediatric renal biopsies; a five-year single center experience in Egypt 儿童肾活检的组织病理学表现谱在埃及一个中心工作了五年

Journal of Nephropathology Pub Date : 2022-01-08 DOI: 10.34172/jnp.2022.17247

W. Hamza, Ahmed Fayed, A. Shaker, M. E. El Nokeety

{"title":"Spectrum of histopathological findings in pediatric renal biopsies; a five-year single center experience in Egypt","authors":"W. Hamza, Ahmed Fayed, A. Shaker, M. E. El Nokeety","doi":"10.34172/jnp.2022.17247","DOIUrl":"https://doi.org/10.34172/jnp.2022.17247","url":null,"abstract":"Introduction: Medical renal diseases stand as one of the major health problems in pediatric age group considering its morbidity/mortality and the subsequent management plans. Objectives: In this manuscript, the spectrum of histopathological patterns of medical nephropathic lesions in Egyptian pediatric patients over duration of five years is reported with clinical indications. Patients and Methods: We conducted a retrospective study for analysis of our pathological reports of renal needle biopsies during the period from January 2014 until January 2019. One hundred and sixteen cases were included. Results: The most commonly encountered pediatric renal pathology was minimal change disease (27.59%), followed by congenital glomerular diseases (22.41%), focal segmental glomerulosclerosis (12.93%), and thrombotic microangiopathy (7.76%). The most common clinical indication for biopsy was nephrotic syndrome (37.07%) followed by impaired renal functions with elevated serum creatinine (21.55%). In addition, we report very rare histological findings in few cases including infantile nephropathic cystinosis, Barakat syndrome and C3 glomerulopathy. Conclusion: Minimal change disease and congenital glomerular diseases accounted for half of pediatric renal pathologies in the study population. The most common clinical indication for renal biopsy was nephrotic syndrome. Electron microscopic examination and genetic studies are mandatory for proper evaluation of pediatric nephropathies.","PeriodicalId":16515,"journal":{"name":"Journal of Nephropathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43103463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The predictive value of serum uric acid in development of acute kidney injury and mortality in patients with sepsis 血清尿酸对脓毒症患者急性肾损伤和死亡率的预测价值

Journal of Nephropathology Pub Date : 2022-01-08 DOI: 10.34172/jnp.2022.17307

Doaa Atef Moubarez

{"title":"The predictive value of serum uric acid in development of acute kidney injury and mortality in patients with sepsis","authors":"Doaa Atef Moubarez","doi":"10.34172/jnp.2022.17307","DOIUrl":"https://doi.org/10.34172/jnp.2022.17307","url":null,"abstract":"\u0000 Introduction: Acute kidney injury (AKI) and sepsis are significant causes of morbidity and mortality in intensive care units. Therefore, early screening of high-risk individuals is critical for preventing AKI and improving outcomes. Objectives: To examine the possible involvement of uric acid in predicting AKI and mortality in septic patients. Patients and Methods: A prospective study recruited 400 patients with sepsis based on the quick Sequential Organ Failure Assessment (qSOFA) criteria who were hospitalized in the intensive care unit (ICU). Patients were categorized into two groups depending on their uric acid levels; those with a serum uric acid ≥7 mg/dL and those with a serum uric acid <7 mg/dL. Results: A total of 400 septic patients were included in this study. Among them, 52.5% (210/400) patients had hyperuricemia during admission to the ICU. A total of 177/400 (44.2%) patients developed AKI. The likelihood of having hyperuricemia in association with AKI was 65.6%. Meanwhile, the likelihood of having a uric acid level of less than 7 mg/dL in association with AKI was 23.9% (P<0.001). The mortality rate in the hyperuricemia group was substantially greater than in the normal uric acid level group (P<0.001). Uric acid levels higher than 7 mg/dL were significantly associated with AKI by multivariate logistic regression (P= 0.002). Receiver operating characteristic (ROC) curves revealed that uric acid has a high predictive value for AKI and ICU mortality in patients with sepsis. Conclusion: Serum uric acid could be a marker to predict AKI and mortality in patients with sepsis.","PeriodicalId":16515,"journal":{"name":"Journal of Nephropathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49197432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A rare case of adenovirus infection in post renal transplant patient 肾移植术后罕见腺病毒感染病例

Journal of Nephropathology Pub Date : 2022-01-02 DOI: 10.34172/jnp.2022.17226

G. Kottangal, S. V. Nalumakkal, Smitha Nalumakkal Vijayan

引用次数: 0

Kidney outcomes of immune-complex associated mesangiocapillary glomerulonephritis in patients with and without HIV HIV患者和非HIV患者免疫复合物相关的血管毛细血管肾小球肾炎的肾脏预后

Journal of Nephropathology Pub Date : 2022-01-02 DOI: 10.34172/jnp.2022.17269

Abdul-Jalil Inusah, L. Coetzee, W. Bates, M. Chothia

{"title":"Kidney outcomes of immune-complex associated mesangiocapillary glomerulonephritis in patients with and without HIV","authors":"Abdul-Jalil Inusah, L. Coetzee, W. Bates, M. Chothia","doi":"10.34172/jnp.2022.17269","DOIUrl":"https://doi.org/10.34172/jnp.2022.17269","url":null,"abstract":"Introduction: HIV-associated kidney diseases continue to be a major problem in South Africa. Objectives: We aimed to determine the kidney outcomes of immune-complex associated mesangiocapillary glomerulonephritis (MCGN) in patients with and without HIV. Patients and Methods: A retrospective cohort study was conducted on all adult patients with a kidney biopsy diagnosis of immune-complex associated MCGN from 1 January 2000 to 31 December 2016. We compared the proportion of HIV-positive and HIV-negative patients that reached the composite endpoint of either doubling of the serum creatinine or end-stage kidney disease. Cox proportional hazards models were employed to examine the association between the composite endpoint and predictor variables. Results: A total of 79 patients were included of which 20 (25.3%) were HIV-positive. Twentyfour patients (30.4%) reached the composite endpoint. The cumulative proportions reaching the composite endpoint at one and four years were 25.3% and 30.4% with no difference between HIVpositive and HIV-negative patients (45.0% versus 25.4%, respectively; P= 0.10). Multivariable Cox proportional hazards model identified estimated glomerular filtration rate at biopsy (hazard ratio [HR] = 0.92; 95% confidence interval [CI]: 0.84-1.00, P=0.04) and proteinuria at follow-up (HR = 1.60; 95% CI: 1.21-2.11, P<0.01) as predictors of the composite endpoint at one-year. On survival analysis, there was no difference in the composite endpoint for HIV status (P=0.09; log-rank). Conclusion: Immune-complex associated MCGN continues to be a common histopathological pattern of injury at our center. Due to late presentation, kidney outcomes remain poor, regardless of HIV status.","PeriodicalId":16515,"journal":{"name":"Journal of Nephropathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44185818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1