血清尿酸对脓毒症患者急性肾损伤和死亡率的预测价值

Q4 Medicine
Doaa Atef Moubarez
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引用次数: 1

摘要

引言:急性肾损伤(AKI)和败血症是重症监护室发病率和死亡率的重要原因。因此,对高危个体进行早期筛查对于预防AKI和改善结果至关重要。目的:探讨尿酸在脓毒症患者AKI和死亡率预测中的可能作用。患者和方法:一项前瞻性研究根据快速顺序器官衰竭评估(qSOFA)标准招募了400名在重症监护室(ICU)住院的败血症患者。根据患者的尿酸水平将其分为两组;血清尿酸≥7mg/dL的患者和血清尿酸<7mg/dL的患者。结果:本研究共纳入了400名败血症患者。其中,52.5%(210/400)的患者在入住ICU期间出现高尿酸血症。共有177/400名(44.2%)患者出现AKI。高尿酸血症合并AKI的可能性为65.6%,尿酸水平低于7 mg/dL与AKI相关的可能性为23.9%(P<0.001)。高尿酸血症组的死亡率明显高于正常尿酸水平组(P<0.001曲线显示,尿酸对败血症患者的AKI和ICU死亡率具有很高的预测价值。结论:血清尿酸可作为预测败血症患者AKI和死亡率的指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The predictive value of serum uric acid in development of acute kidney injury and mortality in patients with sepsis
Introduction: Acute kidney injury (AKI) and sepsis are significant causes of morbidity and mortality in intensive care units. Therefore, early screening of high-risk individuals is critical for preventing AKI and improving outcomes. Objectives: To examine the possible involvement of uric acid in predicting AKI and mortality in septic patients. Patients and Methods: A prospective study recruited 400 patients with sepsis based on the quick Sequential Organ Failure Assessment (qSOFA) criteria who were hospitalized in the intensive care unit (ICU). Patients were categorized into two groups depending on their uric acid levels; those with a serum uric acid ≥7 mg/dL and those with a serum uric acid <7 mg/dL. Results: A total of 400 septic patients were included in this study. Among them, 52.5% (210/400) patients had hyperuricemia during admission to the ICU. A total of 177/400 (44.2%) patients developed AKI. The likelihood of having hyperuricemia in association with AKI was 65.6%. Meanwhile, the likelihood of having a uric acid level of less than 7 mg/dL in association with AKI was 23.9% (P<0.001). The mortality rate in the hyperuricemia group was substantially greater than in the normal uric acid level group (P<0.001). Uric acid levels higher than 7 mg/dL were significantly associated with AKI by multivariate logistic regression (P= 0.002). Receiver operating characteristic (ROC) curves revealed that uric acid has a high predictive value for AKI and ICU mortality in patients with sepsis. Conclusion: Serum uric acid could be a marker to predict AKI and mortality in patients with sepsis.
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来源期刊
Journal of Nephropathology
Journal of Nephropathology Medicine-Nephrology
CiteScore
1.30
自引率
0.00%
发文量
35
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