Journal of neurogenetics最新文献_第7页

Identification and characterization of GAL4 drivers that mark distinct cell types and regions in the Drosophila adult gut. 在果蝇成年肠道中标记不同细胞类型和区域的GAL4驱动因子的鉴定和表征。

IF 1.9 4区医学

Journal of neurogenetics Pub Date : 2021-03-01 Epub Date: 2020-12-16 DOI: 10.1080/01677063.2020.1853722

Seung Yeon Lim, Hyejin You, Jinhyeong Lee, Jaejin Lee, Yoojin Lee, Kyung-Ah Lee, Boram Kim, Ji-Hoon Lee, JiHyeon Jeong, Sooin Jang, Byoungsoo Kim, Hyungjun Choi, Gayoung Hwang, Min Sung Choi, Sung-Eun Yoon, Jae Young Kwon, Won-Jae Lee, Young-Joon Kim, Greg S B Suh

{"title":"Identification and characterization of GAL4 drivers that mark distinct cell types and regions in the Drosophila adult gut.","authors":"Seung Yeon Lim, Hyejin You, Jinhyeong Lee, Jaejin Lee, Yoojin Lee, Kyung-Ah Lee, Boram Kim, Ji-Hoon Lee, JiHyeon Jeong, Sooin Jang, Byoungsoo Kim, Hyungjun Choi, Gayoung Hwang, Min Sung Choi, Sung-Eun Yoon, Jae Young Kwon, Won-Jae Lee, Young-Joon Kim, Greg S B Suh","doi":"10.1080/01677063.2020.1853722","DOIUrl":"https://doi.org/10.1080/01677063.2020.1853722","url":null,"abstract":"The gastrointestinal tract in the adult Drosophila serves as a model system for exploring the mechanisms underlying digestion, absorption and excretion, stem cell plasticity, and inter-organ communication, particularly through the gut-brain axis. It is also useful for studying the cellular and adaptive responses to dietary changes, alterations in microbiota and immunity, and systematic and endocrine signals. Despite the various cell types and distinct regions in the gastrointestinal tract, few tools are available to target and manipulate the activity of each cell type and region, and their gene expression. Here, we report 353 GAL4 lines and several split-GAL4 lines that are expressed in enteric neurons (ENs), progenitors (ISCs and EBs), enterocytes (ECs), enteroendocrine cells (EEs), or/and other cell types that are yet to be identified in distinct regions of the gut. We had initially collected approximately 600 GAL4 lines that may be expressed in the gut based on RNA sequencing data, and then crossed them to UAS-GFP to perform immunohistochemistry to identify those that are expressed selectively in the gut. The cell types and regional expression patterns that are associated with the entire set of GAL4 drivers and split-GAL4 combinations are annotated online at http://kdrc.kr/index.php (K-Gut Project). This GAL4 resource can be used to target specific populations of distinct cell types in the fly gut, and therefore, should permit a more precise investigation of gut cells that regulate important biological processes.","PeriodicalId":16491,"journal":{"name":"Journal of neurogenetics","volume":"35 1","pages":"33-44"},"PeriodicalIF":1.9,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01677063.2020.1853722","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38379238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

A journey to 'tame a small metazoan organism', ^‡ seen through the artistic eyes of C. elegans researchers. 从 elegans 研究人员的艺术视角看 "驯服小型后生动物 "之旅‡。

IF 1.9 4区医学

Journal of neurogenetics Pub Date : 2020-09-01 Epub Date: 2020-12-08 DOI: 10.1080/01677063.2020.1839449

Eleni Gourgou, Alexandra R Willis, Sebastian Giunti, Maria J De Rosa, Amanda G Charlesworth, Mirella Hernandez Lima, Elizabeth Glater, Sonja Soo, Bianca Pereira, Kübra Akbaş, Anushka Deb, Madhushree Kamak, Mark W Moyle, Annika Traa, Aakanksha Singhvi, Surojit Sural, Eugene Jennifer Jin

引用次数: 4

Nature's gift to neuroscience. 大自然给神经科学的礼物

IF 1.9 4区医学

Journal of neurogenetics Pub Date : 2020-09-01 DOI: 10.1080/01677063.2020.1841760

Joy Alcedo, Yishi Jin, Douglas S Portman, Veena Prahlad, David Raizen, Georgia Rapti, X Z Shawn Xu, Yun Zhang, Chun-Fang Wu

引用次数: 1

Studying neural circuits of decision-making in Drosophila larva. 果蝇幼虫决策神经回路的研究。

IF 1.9 4区医学

Journal of neurogenetics Pub Date : 2020-03-01 Epub Date: 2020-02-13 DOI: 10.1080/01677063.2020.1719407

Tihana Jovanic

引用次数: 3

Studying complex brain dynamics using Drosophila. 用果蝇研究复杂的大脑动力学。

IF 1.9 4区医学

Journal of neurogenetics Pub Date : 2020-03-01 Epub Date: 2019-12-26 DOI: 10.1080/01677063.2019.1706092

Sophie Aimon, Ilona C Grunwald Kadow

引用次数: 4

Understanding neurobehavioral genetics of zebrafish. 了解斑马鱼的神经行为遗传学。

IF 1.9 4区医学

Journal of neurogenetics Pub Date : 2020-03-01 Epub Date: 2020-01-05 DOI: 10.1080/01677063.2019.1698565

Sergey V Cheresiz, Andrey D Volgin, Alexandra Kokorina Evsyukova, Alim A O Bashirzade, Konstantin A Demin, Murilo S de Abreu, Tamara G Amstislavskaya, Allan V Kalueff

{"title":"Understanding neurobehavioral genetics of zebrafish.","authors":"Sergey V Cheresiz, Andrey D Volgin, Alexandra Kokorina Evsyukova, Alim A O Bashirzade, Konstantin A Demin, Murilo S de Abreu, Tamara G Amstislavskaya, Allan V Kalueff","doi":"10.1080/01677063.2019.1698565","DOIUrl":"https://doi.org/10.1080/01677063.2019.1698565","url":null,"abstract":"Due to its fully sequenced genome, high genetic homology to humans, external fertilization, fast development, transparency of embryos, low cost and active reproduction, the zebrafish (Danio rerio) has become a novel promising model organism in biomedicine. Zebrafish are a useful tool in genetic and neuroscience research, including linking various genetic mutations to brain mechanisms using forward and reverse genetics. These approaches have produced novel models of rare genetic CNS disorders and common brain illnesses, such as addiction, aggression, anxiety and depression. Genetically modified zebrafish also foster neuroanatomical studies, manipulating neural circuits and linking them to different behaviors. Here, we discuss recent advances in neurogenetics of zebrafish, and evaluate their unique strengths, inherent limitations and the rapidly growing potential for elucidating the conserved roles of genes in neuropsychiatric disorders.","PeriodicalId":16491,"journal":{"name":"Journal of neurogenetics","volume":"34 2","pages":"203-215"},"PeriodicalIF":1.9,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01677063.2019.1698565","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37511775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

The Unc13A isoform is important for phasic release and olfactory memory formation at mushroom body synapses. un13a异构体在蘑菇体突触的相释放和嗅觉记忆形成中起重要作用。

IF 1.9 4区医学

Journal of neurogenetics Pub Date : 2020-03-01 Epub Date: 2020-01-24 DOI: 10.1080/01677063.2019.1710146

Jennifer Woitkuhn, Anatoli Ender, Christine B Beuschel, Marta Maglione, Tanja Matkovic-Rachid, Sheng Huang, Martin Lehmann, Joerg R P Geiger, Stephan J Sigrist

{"title":"The Unc13A isoform is important for phasic release and olfactory memory formation at mushroom body synapses.","authors":"Jennifer Woitkuhn, Anatoli Ender, Christine B Beuschel, Marta Maglione, Tanja Matkovic-Rachid, Sheng Huang, Martin Lehmann, Joerg R P Geiger, Stephan J Sigrist","doi":"10.1080/01677063.2019.1710146","DOIUrl":"https://doi.org/10.1080/01677063.2019.1710146","url":null,"abstract":"The cellular analysis of mushroom body (MB)-dependent memory forming processes is far advanced, whereas, the molecular and physiological understanding of their synaptic basis lags behind. Recent analysis of the Drosophila olfactory system showed that Unc13A, a member of the M(Unc13) release factor family, promotes a phasic, high release probability component, while Unc13B supports a slower tonic release component, reflecting their different nanoscopic positioning within individual active zones. We here use STED super-resolution microscopy of MB lobe synapses to show that Unc13A clusters closer to the active zone centre than Unc13B. Unc13A specifically supported phasic transmission and short-term plasticity of Kenyon cell:output neuron synapses, measured by combining electrophysiological recordings of output neurons with optogenetic stimulation. Knockdown of unc13A within Kenyon cells provoked drastic deficits of olfactory aversive short-term and anaesthesia-sensitive middle-term memory. Knockdown of unc13B provoked milder memory deficits. Thus, a low frequency domain transmission component is probably crucial for the proper representation of memory-associated activity patterns, consistent with sparse Kenyon cell activation during memory acquisition and retrieval. Notably, Unc13A/B ratios appeared highly diversified across MB lobes, leaving room for an interplay of activity components in memory encoding and retrieval.","PeriodicalId":16491,"journal":{"name":"Journal of neurogenetics","volume":"34 1","pages":"106-114"},"PeriodicalIF":1.9,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01677063.2019.1710146","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37577409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Experimental psychology meets behavioral ecology: what laboratory studies of learning polymorphisms mean for learning under natural conditions, and vice versa. 实验心理学符合行为生态学:学习多态性的实验室研究对自然条件下的学习意味着什么，反之亦然。

IF 1.9 4区医学

Journal of neurogenetics Pub Date : 2020-03-01 Epub Date: 2020-02-06 DOI: 10.1080/01677063.2020.1718674

Brian H Smith, Chelsea N Cook

引用次数: 5

A biographical sketch of Troy D. Zars (1967-2018). 特洛伊·d·扎尔斯(1967-2018)的传记小品。

IF 1.9 4区医学

Journal of neurogenetics Pub Date : 2020-03-01 DOI: 10.1080/01677063.2020.1716749

Bertram Gerber, Elizabeth G King, Divya Sitaraman

引用次数: 0

Oxytocin ameliorates bone cancer pain by suppressing toll-like receptor 4 and proinflammatory cytokines in rat spinal cord. 催产素通过抑制大鼠脊髓toll样受体4和促炎细胞因子改善骨癌疼痛。

IF 1.9 4区医学

Journal of neurogenetics Pub Date : 2020-03-01 Epub Date: 2020-03-02 DOI: 10.1080/01677063.2019.1711077

Xiaping Mou, Ji Fang, An Yang, Gang Du

{"title":"Oxytocin ameliorates bone cancer pain by suppressing toll-like receptor 4 and proinflammatory cytokines in rat spinal cord.","authors":"Xiaping Mou, Ji Fang, An Yang, Gang Du","doi":"10.1080/01677063.2019.1711077","DOIUrl":"https://doi.org/10.1080/01677063.2019.1711077","url":null,"abstract":"Bone cancer pain is considered to be mechanistically unique compared with inflammatory or neuropathic pain states. Toll-like receptor 4 (TLR4) is a transmembrane receptor protein which has been reported to be involved in neuropathic pain. However, the role of TLR4 in bone cancer pain is still unclear. Therefore, the aim of this study is to investigate the hypothesis that oxytocin may ameliorate bone cancer pain by suppressing TLR4 in spinal cord. Behavioral analysis and molecular biological experiments were carried out. Our data demonstrated that intrathecally delivery of oxytocin significantly ameliorated the mechanical allodynia and thermal hyperalgesia in bone cancer pain rats. Moreover, oxytocin suppressed the up-regulation of TLR4 and proinflammatory cytokines TNFα and IL-1β in spinal cord of bone cancer pain rats. Therefore, we concluded that intrathecal administration of oxytocin relieves bone cancer pain by suppressing the up-regulation of TLR4, TNFα and IL-1β in spinal cord. Oxytocin possesses analgesic efficacy against bone cancer pain and deserves further to confirm its effectiveness in clinically relevant of cancer pain.","PeriodicalId":16491,"journal":{"name":"Journal of neurogenetics","volume":"34 2","pages":"216-222"},"PeriodicalIF":1.9,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01677063.2019.1711077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37692128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11