Journal of Neuro-Ophthalmology最新文献

{"title":"Purtscher-Like Retinopathy: An Unusual Ocular Finding After an Intracranial Endovascular Procedure.","authors":"Azyadeh Camacho-Ordonez, Roberto Rodríguez-Rivas, Alonso Gutierrez-Romero, Hector Alfredo Montenegro-Rosales, Antonio Arauz-Gongora","doi":"10.1097/WNO.0000000000002202","DOIUrl":"10.1097/WNO.0000000000002202","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"255-256"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Neuroradiologic Findings in Idiopathic Intracranial Hypertension-A Population-Based Study.","authors":"Yael N Steinberg, Gregory J Parnes, Nilesh K Raval, Fernando M Pellerano Sosa, Afshin Parsikia, Joyce N Mbekeani","doi":"10.1097/WNO.0000000000002248","DOIUrl":"10.1097/WNO.0000000000002248","url":null,"abstract":"<p><strong>Background: </strong>Idiopathic intracranial hypertension (IIH) has been associated with several MRI features. We assessed types of MRI findings and clinical-radiologic correlations in patients with IIH from one hospital system.</p><p><strong>Methods: </strong>A retrospective chart review of IIH and control patients was conducted. Brain MRI/magnetic resonance venogram features were enumerated and assessed for correlation with body mass index (BMI) and lumbar puncture opening pressure (LPOP). Sensitivity, specificity, positive predictive value (PPV), and likelihood ratios (LRs) were calculated for each MRI sign. Significance was set at P < 0.05.</p><p><strong>Results: </strong>One hundred one patients diagnosed with IIH, and 119 control patients had complete files and were included. Patients with IIH were predominantly female (92.8% vs 59.7%; P = <0.001), younger (30.6 years vs 46.4 years; P < 0.001), and more obese (mean BMI = 35.2 vs 29.3; P < 0.001) than controls. Mean (SD) number of MRI findings was 2.21 (1.8) in IIH and 0.6 (1.2) in controls; ( P < 0.001). Vertical nerve tortuosity (44.1%; P < 0.001), TVSS (37.8%; P < 0.001), sheath expansion (36.0%; P < 0.001), globe flattening (22.5%; P < 0.001), slit ventricles (18.9%; P < 0.001), optic disc protrusion (9.9%; P = 0.007), and complete empty sella (12.6%; P < 0.042) were observed more in patients with IIH than control patients. In the IIH group, mean (SD) LPOP was 33.6 (11.11) cmH 2 O and weakly correlated with number of MRI findings (rho = 0.182, P = 0.057). TVSS (sensitivity 37.84%; confidence interval [CI] 29.3%-47.2%, specificity 98.32%; CI 93.5%-99.6%) had the highest PPV (95.45%) and positive LR (22.51) for IIH diagnosis.</p><p><strong>Conclusions: </strong>These results are consistent with IIH predominance in young, obese females. In patients with IIH, the number of MRI findings exceeded controls and positively correlated with LPOP. TVSS was most predictive of IIH.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"183-189"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preserved Ganglion Cell Analysis in a Case of Longstanding Leber Hereditary Optic Neuropathy: A Sign of Hibernating Neurons?","authors":"Armin Handzic, Laura Donaldson, Edward Margolin","doi":"10.1097/WNO.0000000000002165","DOIUrl":"10.1097/WNO.0000000000002165","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"e119-e121"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140863285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment: Ultrasound vs Biopsy for Giant Cell Arteritis: Discussion in Point Counter-Point in the June 2024 Issue of Journal of Neuro-Ophthalmology.","authors":"Jagannadha Avasarala","doi":"10.1097/WNO.0000000000002313","DOIUrl":"10.1097/WNO.0000000000002313","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"e162"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Optic Disc Pit and Optic Nerve Cyst on MRI.","authors":"Joshua Pasol","doi":"10.1097/WNO.0000000000002352","DOIUrl":"10.1097/WNO.0000000000002352","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"e164-e166"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonarteritic Anterior Ischemic Optic Neuropathy After Recreational PDE5 Inhibitor Use in a Healthy Patient: More Evidence for Causation.","authors":"Natalie Brossard-Barbosa, Zoë R Williams","doi":"10.1097/WNO.0000000000002159","DOIUrl":"10.1097/WNO.0000000000002159","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"e109-e111"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrence-Independent Progressive Inner-Retinal Thinning After Optic Neuritis: A Longitudinal Study.","authors":"Yeji Moon, Yujin Gim, Kyung-Ah Park, Hee Kyung Yang, Seong-Joon Kim, Sung-Min Kim, Jae Ho Jung","doi":"10.1097/WNO.0000000000002244","DOIUrl":"10.1097/WNO.0000000000002244","url":null,"abstract":"<p><strong>Background: </strong>Longitudinal changes in the inner retina in patients with optic neuritis (ON) may be helpful in monitoring patients and determining maintenance treatment. The aim of this study was to investigate longitudinal changes in the inner retina after subsiding of acute demyelinating ON and to identify the factors associated with such changes.</p><p><strong>Methods: </strong>In this multicenter retrospective observational study, we reviewed the medical records of 77 patients with ON, including 23 with neuromyelitis optica spectrum disorder with aquaporin 4 (AQP4)-immunoglobulin G (IgG) (AQP4 group), 23 with myelin oligodendrocyte glycoprotein (MOG)-antibody-associated disease (MOG group), 18 with multiple sclerosis (MS group), and 13 with idiopathic ON (iON group). We measured the thickness of the peripapillary retinal nerve fiber layer (pRNFL) and the macular ganglion cell-inner plexiform layer (mGCIPL) using optical coherence tomography (OCT) at baseline and at follow-up examinations (mean follow-up duration, 29.6 ± 8.6 months; mean number of OCT, 4.2 ± 1.2) in the absence of ON recurrence.</p><p><strong>Results: </strong>The estimated rate of pRNFL thinning in the AQP4, MOG, MS, and iON groups was 0.66 (95% confidence interval, 0.35-0.97), 0.35 (0.04-0.66), 0.53 (0.16-0.90), and 0.25 (-0.18 to 0.68) μm/year, respectively, indicating that, in the iON group in contrast to the other groups, there was no significant decrease of pRNFL thickness. Among the AQP4, MOG, and MS groups, there was no significant difference in the rate of pRNFL thinning ( P = 0.560). The rate of mGCIPL thinning in the AQP4 and MOG groups was 0.25 (0.04-0.46) μm/year and 0.38 (0.23-0.53) μm/year, respectively. Meanwhile, the rate of mGCIPL change in the MS and iON groups was 0.04 (-0.12 to 0.19) and 0.00 (-0.17 to 0.16) μm/year, respectively, which indicates that there was no significant mGCIPL thinning in the latter 2 groups. Between the AQP4 and MOG groups, meanwhile, the rate of mGCIPL change did not significantly differ ( P = 0.295). Age older than 40 years was associated with significant progression of mGCIPL thinning ( P = 0.005).</p><p><strong>Conclusions: </strong>We noted inner retina thinning progression independent of relapse activity in AQP4-ON, MOG-ON, and MS-ON. Because subclinical neuroaxonal damage continues to be incurred after an acute attack of ON subsides despite suppression of new attacks, long-term follow-up and neuroprotection should be considered to be integral to the treatment of patients with ON.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"190-196"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"12th Asian Neuro-Ophthalmology Society (ASNOS) Congress, December 6-8, 2024, Hong Kong, China.","authors":"Carmen K M Chan, Noel C Y Chan","doi":"10.1097/WNO.0000000000002365","DOIUrl":"10.1097/WNO.0000000000002365","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"e265-e266"},"PeriodicalIF":2.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microcystic Changes in the Retinal Inner Nuclear layer following Optic Tract Trauma.","authors":"Raquel Félix, Henrique C Queirós, Miguel Raimundo, Pedro Fonseca","doi":"10.1097/WNO.0000000000002335","DOIUrl":"10.1097/WNO.0000000000002335","url":null,"abstract":"","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"388-390"},"PeriodicalIF":2.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optic Nerve and Optic Nerve Sheath Biopsy Indications and Outcomes.","authors":"Reilly A Coombs, John J Chen, Diva R Salomão, Deena A Tajfirouz, Eric R Eggenberger, Marie A DiNome, Jacqueline A Leavitt, Misha L Pless, James A Garrity, Sasha A Mansukhani","doi":"10.1097/WNO.0000000000002329","DOIUrl":"10.1097/WNO.0000000000002329","url":null,"abstract":"<p><strong>Background: </strong>This study describes the clinical presentation, diagnostic yield, and outcomes of patients who have undergone optic nerve or nerve sheath biopsies.</p><p><strong>Methods: </strong>A total of 72 patients undergoing an optic nerve or optic nerve sheath biopsy at Mayo Clinic, Rochester, MN; Jacksonville, FL; or Scottsdale, AZ were included. Patients were identified by searching the pathology database between January 1, 2000, and December 31, 2023. Charts were reviewed to confirm the site of biopsy and review the patient's presentation, clinical course, and indication for biopsy. The main outcome measure was the diagnostic yield.</p><p><strong>Results: </strong>Of the 72 patients included, 32 underwent optic nerve and 40 optic nerve sheath biopsies. The median age at biopsy was 34 years (range, 1-81 years), and 44 patients (61%) were female. The median preoperative visual acuity was no light perception (NLP) (range, 20/20 to NLP). Prebiopsy optic disc appearance was pallor in 32 (44%), edema in 18 (25%), normal in 11 (15%), and edema with pallor in 5 (7%) patients. Surgical approach was by orbitotomy in 43 (60%), craniotomy in 25 (35%), and trans-nasal in 4 (5%) patients. A definitive diagnosis was achieved on 48 biopsies of 72 patients with an unexplained optic neuropathy, thus giving a diagnostic yield of 67%, higher in optic nerve biopsies (81%) compared with nerve sheath biopsies (55%). The most common diagnoses were meningioma in 23 (32%), glioma in 9 (13%), and sarcoidosis in 6 (8%) patients. For all patients, postbiopsy complications occurred in 11 patients (18%), including strabismus in 5 (7%) patients and acute unexpected vision loss in 4 (6%) patients. The patients in this cohort were followed for a median of 3.3 years, and visual acuity at most recent visit was NLP (range, 20/20 to NLP).</p><p><strong>Conclusions: </strong>Based on our study, the diagnostic yield of optic nerve and optic nerve sheath biopsies was 67%. The potential diagnostic benefits of an optic nerve and optic nerve sheath biopsies may be offset by the possible permanent postsurgical complications.</p>","PeriodicalId":16485,"journal":{"name":"Journal of Neuro-Ophthalmology","volume":" ","pages":"267-272"},"PeriodicalIF":2.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}