Journal of Nuclear Cardiology最新文献

{"title":"Quantitative assessment of cardiac 123iodo-metaiodobenzylguanidine SPECT/CT in patients with arrhythmogenic right ventricular cardiomyopathy: Novel insight in disease monitoring","authors":"Johannes M. Hagen ,&nbsp;Mathias J. Zacherl MD ,&nbsp;Matthias Brendel MD ,&nbsp;Sebastian Clauß MD ,&nbsp;Stefan Kääb MD ,&nbsp;Peter Bartenstein MD ,&nbsp;Andrei Todica MD ,&nbsp;Guido Böning PhD ,&nbsp;Maximilian Fischer MD","doi":"10.1016/j.nuclcard.2024.101911","DOIUrl":"10.1016/j.nuclcard.2024.101911","url":null,"abstract":"<div><h3>Background</h3><div>The heart-to-mediastinum ratio (H/M-Ratio) of ¹²³iodo-metaiodobenzylguanidine (¹²³I-MIBG) represents state-of-the-art assessment for sympathetic dysfunction in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). This study aims to evaluate quantitative reconstruction of ¹²³I-MIBG uptake and to demonstrate its correlation with echocardiographic parameters.</div></div><div><h3>Methods</h3><div>Cardiac innervation was assessed in 23 patients diagnosed with definite ARVC or borderline ARVC and 12 patients with other cardiac disease presenting arrhythmia, using quantitative ¹²³I-MIBG Single Photon Emission Computed Tomography/Computed Tomography (SPECT/CT) imaging. Tracer uptake was evaluated in the left (LV) and right ventricle (RV) based on a CT scan after quantitative image reconstruction. The relationship between tracer uptake and echocardiographic parameter data was examined.</div></div><div><h3>Results</h3><div>Absolute quantification of ¹²³I-MIBG uptake in the LV and RV is feasible and correlates accurately with the gold standard H/M Ratio. When comparing sensitivity and specificity, the area under the curve (AUC) favors standardized uptake value (SUV) of the RV over the right-ventricle-to-mediastinum-ratio (RV/M-Ratio) for diagnosing ARVC. A reduced RV-SUV in patients with definite ARVC is associated with reduced RV function. RV polar maps revealed globally reduced ¹²³I-MIBG uptake without segment-specific reduction in the RV.</div></div><div><h3>Conclusions</h3><div>Quantitative ¹²³I-MIBG SPECT in ARCV patients offers robust potential for clinical reporting and demonstrates a significant correlation with RV function. Segmental RV analysis needs to be evaluated in larger samples. In summary, cardiac ¹²³I-MIBG imaging using SUV could facilitate image-guided therapy in patients diagnosed with ARVC.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"39 ","pages":"Article 101911"},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141620141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a dedicated cardiac protocol on diagnosis of infective endocarditis in patients undergoing [18F]-FDG-thoracic digital-PET/CT – Effects of expertise level","authors":"Susan Notohamiprodjo MD ,&nbsp;Klemens Scheidhauer MD ,&nbsp;Matthias Eiber MD ,&nbsp;Igor Yakushev MD ,&nbsp;Alberto Villagran Asiares MSc ,&nbsp;Julia Kraus-Deuringer MD ,&nbsp;Helge W.A. Krebs-Fleischmann MD ,&nbsp;Sebastian Kleiner MD ,&nbsp;Robert Eggerstedt MD ,&nbsp;Bettina Eglseder MD ,&nbsp;Wolfgang A. Weber MD ,&nbsp;Stephan G. Nekolla PhD","doi":"10.1016/j.nuclcard.2024.102010","DOIUrl":"10.1016/j.nuclcard.2024.102010","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to assess the impact of dedicated cardiac protocol (DCP) on diagnostic accuracy of state-of-the-art digital [¹⁸F]-FDG-PET/CT in infective endocarditis (IE) and the intra-individual comparison of the performance with that of conventional whole-body approach (WBA) and to analyze the effects of the expertise level of the investigators.</div></div><div><h3>Methods</h3><div>44 patients suspected for IE underwent digital-FDG-PET/CT after overnight fasting. Each three consultants and trainees reread PET images blinded to the examination approach and clinical information. Visual and semiquantitative analyses were performed.</div></div><div><h3>Results</h3><div>Digital-FDG-PET/CT with DCP revealed sensitivity, specificity, and accuracy of 89%, 93%, and 91% for native valve endocarditis (NVE) and 93%, 86%, and 91% for prosthetic valve endocarditis. Compared to WBA, substantial improvement of the diagnostic performance for NVE in DCP was evident, especially in trainees, but not as high compared to consultants. Digital-FDG-PET/CT enabled 79.5% reclassification of modified-Duke-Clinical-Criteria (mDC) with 34.1% upgrading and 45.4% downgrading.</div></div><div><h3>Conclusions</h3><div>This study provides new data using state-of-the-art digital-FDG-PET/CT with DCP improving the diagnostic accuracy in challenging cases of possible IE, particularly in NVE, provided that the investigators involved have the necessary expertise. These findings may have a significant impact on IE-related morbidity, mortality, and patient's management and might be meaningful for updates on the prevailing opinion regarding the value of FDG PET/CT in NVE.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"39 ","pages":"Article 102010"},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In search of the answers to the viability questions","authors":"Mehmet Onur Omaygenc MD ,&nbsp;Holly Morgan PhD ,&nbsp;Lisa Mielniczuk MD, FRCPC, FCCS ,&nbsp;Divaka Perera MA, MD, FRCP ,&nbsp;Julio A. Panza MD","doi":"10.1016/j.nuclcard.2024.101912","DOIUrl":"10.1016/j.nuclcard.2024.101912","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"39 ","pages":"Article 101912"},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary cardiac angiosarcoma confirmed by immunophenotype of pericardial fluid and multimodal imaging modalities","authors":"","doi":"10.1016/j.nuclcard.2024.101887","DOIUrl":"10.1016/j.nuclcard.2024.101887","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"39 ","pages":"Article 101887"},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141235337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to the Editor","authors":"Alexander Liu MBBS MRCP,&nbsp;Kshama Wechalekar MBBS, DRM, DNB","doi":"10.1016/j.nuclcard.2024.102033","DOIUrl":"10.1016/j.nuclcard.2024.102033","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"39 ","pages":"Article 102033"},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of positron emission tomography for the diagnosis of immune-checkpoint inhibitor| myocarditis","authors":"Abdelrahman Ali MD ,&nbsp;Yang Lu MD, PhD ,&nbsp;Shaden Khalaf ,&nbsp;Cezar Iliescu MD ,&nbsp;Efstratios Koutroumpakis MD ,&nbsp;Syed Wamique Yusuf MBBS ,&nbsp;Bilal A. Siddiqui MD ,&nbsp;Sumit K. Subudhi MD, PhD ,&nbsp;Anita Deswal MD, MPH ,&nbsp;Nicolas L. Palaskas MD MPH","doi":"10.1016/j.nuclcard.2024.101909","DOIUrl":"10.1016/j.nuclcard.2024.101909","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"39 ","pages":"Article 101909"},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translational molecular imaging: Thrombosis imaging with positron emission tomography","authors":"","doi":"10.1016/j.nuclcard.2024.101848","DOIUrl":"10.1016/j.nuclcard.2024.101848","url":null,"abstract":"<div><div>A key focus of cardiovascular medicine is the detection, treatment, and prevention of disease, with a move towards more personalized and patient-centred treatments. To achieve this goal, novel imaging approaches that allow for early and accurate detection of disease and risk stratification are needed. At present, the diagnosis, monitoring, and prognostication of thrombotic cardiovascular diseases are based on imaging techniques that measure changes in structural anatomy and biological function. Molecular imaging is emerging as a new tool for the non-invasive detection of biological processes, such as thrombosis, that can improve identification of these events above and beyond current imaging modalities. At the forefront of these evolving techniques is the use of high-sensitivity radiotracers in conjunction with positron emission tomography imaging that could revolutionise current diagnostic paradigms by improving our understanding of the role and origin of thrombosis in a range of cardiovascular diseases.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"39 ","pages":"Article 101848"},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140153057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caravan of dreams: Precision quantitative imaging shaping the future of nuclear cardiology","authors":"Marcelo F. Di Carli MD, MASNC","doi":"10.1016/j.nuclcard.2024.102044","DOIUrl":"10.1016/j.nuclcard.2024.102044","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"39 ","pages":"Article 102044"},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does digital positron emission tomography/computed tomography represent a step forward in the diagnostic accuracy of infective endocarditis?","authors":"Maria Nazarena Pizzi MD, PhD","doi":"10.1016/j.nuclcard.2024.102024","DOIUrl":"10.1016/j.nuclcard.2024.102024","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"39 ","pages":"Article 102024"},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deeper insights from deep learning: Enhanced myocardial perfusion assessments using multimodal artificial intelligence","authors":"Michael T. Lu MD, MPH,&nbsp;Ahmed Tawakol MD","doi":"10.1016/j.nuclcard.2024.102014","DOIUrl":"10.1016/j.nuclcard.2024.102014","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"38 ","pages":"Article 102014"},"PeriodicalIF":3.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}