Alan Rozanski MD , Heidi Gransar MS , Robert J.H. Miller MD , Donghee Han MD , Sean Hayes MD , John Friedman MD, MPH , Louise Thomson MD , Daniel Berman MD
{"title":"Clinical correlates of a single-item physical activity questionnaire among patients undergoing stress SPECT myocardial perfusion imaging","authors":"Alan Rozanski MD , Heidi Gransar MS , Robert J.H. Miller MD , Donghee Han MD , Sean Hayes MD , John Friedman MD, MPH , Louise Thomson MD , Daniel Berman MD","doi":"10.1016/j.nuclcard.2024.102066","DOIUrl":"10.1016/j.nuclcard.2024.102066","url":null,"abstract":"<div><h3>Background</h3><div>There has been an increasing call for employing ultrashort exercise activity questionnaires as a clinical “vital sign”. To-date, this has not been applied to patients undergoing cardiac stress testing.</div></div><div><h3>Methods</h3><div>We evaluated 1136 patients who completed a one-item exercise questionnaire before undergoing stress SPECT myocardial perfusion imaging (MPI). This question asked patients to grade how much they exercise during daily life on a 11-point scale (0 = none, 10 = always). Patients were divided into four exercise activity groups based on their response: no, low, moderate, and high exercise activity. The results of this questionnaire were compared with patients’ clinical risk profile, mode of stress testing (exercise vs pharmacologic), and exercise treadmill duration.</div></div><div><h3>Results</h3><div>We noted a stepwise inverse relationship between exercise activity and patients’ frequency of hypertension, diabetes, and obesity (<em>P</em> < .001 for each). Patients with no reported exercise activity were more likely to complain of dyspnea. There was a stepwise increase in the number of patients performing treadmill exercise with increasing reported exercise activity (<em>P</em> < .001). The duration on treadmill exercise increased in stepwise fashion with higher patient reported exercise activity (<em>P</em> < .001).</div></div><div><h3>Conclusion</h3><div>Our single-item, self-reported questionnaire was correlated with patients’ risk profiles, their mode of stress testing, and cardiorespiratory fitness. These correlates, along with the pragmatic nature of this ultrashort questionnaire, and its built-in identification of patients who may warrant exercise counseling, augurs for adopting ultrashort questionnaires regarding exercise activity among patients undergoing stress MPI, and other cardiac imaging tests where functional capacity is not routinely assessed.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"41 ","pages":"Article 102066"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Slow or fast infusion profiles for Rubidium-82–What is the fuzz about?","authors":"Martin Lyngby Lassen PhD, Philip Hasbak MD, DMSc","doi":"10.1016/j.nuclcard.2024.102068","DOIUrl":"10.1016/j.nuclcard.2024.102068","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"41 ","pages":"Article 102068"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"How to differentiate obstructive from non-obstructive CAD with quantitative PET MPI using coronary flow capacity","authors":"Nils P. Johnson MD, MS, K. Lance Gould MD","doi":"10.1016/j.nuclcard.2024.102039","DOIUrl":"10.1016/j.nuclcard.2024.102039","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"41 ","pages":"Article 102039"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joseph C. Lee MBBS, FRACP, FAANMS , Jia Wen Chong B Med Sci, MBBS, Grad Dip Clin Ed , William W. Chik MBBS, FRACP, FCSANZ
{"title":"Assessing vasodilator stress","authors":"Joseph C. Lee MBBS, FRACP, FAANMS , Jia Wen Chong B Med Sci, MBBS, Grad Dip Clin Ed , William W. Chik MBBS, FRACP, FCSANZ","doi":"10.1016/j.nuclcard.2024.102034","DOIUrl":"10.1016/j.nuclcard.2024.102034","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"41 ","pages":"Article 102034"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical risk stratification and myocardial perfusion imaging: Could a questionnaire give the answer?","authors":"Roberta Assante MD, PhD, Wanda Acampa MD, PhD","doi":"10.1016/j.nuclcard.2024.102069","DOIUrl":"10.1016/j.nuclcard.2024.102069","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"41 ","pages":"Article 102069"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mouaz Al-Mallah MD, MSc , Maria Alwan MD , Mahmoud Al Rifai MD, MPH , Ahmed Sayed MBBS
{"title":"Cardiac positron emission tomography and other modalities for coronary artery disease assessment: A snapshot from the medicare data","authors":"Mouaz Al-Mallah MD, MSc , Maria Alwan MD , Mahmoud Al Rifai MD, MPH , Ahmed Sayed MBBS","doi":"10.1016/j.nuclcard.2024.102030","DOIUrl":"10.1016/j.nuclcard.2024.102030","url":null,"abstract":"<div><h3>Background</h3><div>Positron emission tomography (PET) is an important tool for assessing coronary artery disease (CAD), but its widespread utilization is limited due to various factors, including limited local champion availability. This study aims to compare the frequency of PET procedures and their interpreters with other common CAD assessment modalities.</div></div><div><h3>Methods</h3><div>Using Medicare data, we examined the number of cardiac PET procedures billed and compared them with single-photon emission computed tomography (SPECT), coronary computed tomography angiography (CCTA), stress magnetic resonance imaging (MRI), and stress echocardiography. Healthcare Common Procedure Coding System codes were used to identify procedures. We calculated the total number of PET myocardial perfusion imaging (MPI) procedures, the proportion of PET/CT and myocardial blood flow (MBF) assessments, and the median number of studies read per physician. We also analyzed the trends in the use of different CAD assessment modalities between 2018 and 2022. Descriptive statistics summarized the data.</div></div><div><h3>Results</h3><div>In 2022, Medicare billed for 212,106 PET MPI scans. SPECT was six times more frequent (1,343,519), whereas stress echocardiography (201,676) and CCTA (118,734) had similar or lower use. Stress MRI (3,932) was least used. Of the PET MPI scans, 46% were PET/CT, and 39% included MBF measurements. Cardiologists interpreted 86% of PET scans, with a median of 58 studies per reader; 23% interpreted ≤25 studies annually. SPECT had a median of 63 studies per reader, and CCTA, stress MRI, and stress echocardiography had medians of 27, 20, and 24, respectively. PET, CT, and MRI use increased from 2018 to 2022, whereas SPECT and stress echocardiography declined.</div></div><div><h3>Conclusion</h3><div>In the Medicare population, radionuclide perfusion imaging (SPECT and PET) remained the preferred method for assessment of CAD, with SPECT being the most frequently used modality and PET being the second most frequently used modality for this application. However, PET/CT and MBF are underutilized, limiting diagnostic and prognostic capabilities. Efforts to enhance education and awareness of PET's advantages and to address barriers to its wider adoption are essential to maximize its clinical benefits and improve patient outcomes.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"41 ","pages":"Article 102030"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Robert M. Bober MD , Richard V. Milani MD , Nadia I. Abelhad MD , Cruz Velasco-Gonzalez PhD , Merrill H. Stewart MD , Daniel P. Morin MD, MPH
{"title":"Fast vs slow rubidium-82 infusion profiles and test-retest precision of myocardial perfusion using contemporary 3D cardiac analog positron emission tomography-computed tomography imaging","authors":"Robert M. Bober MD , Richard V. Milani MD , Nadia I. Abelhad MD , Cruz Velasco-Gonzalez PhD , Merrill H. Stewart MD , Daniel P. Morin MD, MPH","doi":"10.1016/j.nuclcard.2024.102059","DOIUrl":"10.1016/j.nuclcard.2024.102059","url":null,"abstract":"<div><h3>Background</h3><div>On legacy 2D positron emission tomography (PET) systems utilizing a 50 mL/min Rb-82 profile, test-retest precision of quantitative perfusion is ∼10%. It is unclear whether Rb-82 infusion rate significantly impacts quantitative perfusion and/or image quality on modern analog 3D PET-CT systems. We aimed to determine whether the Rb-82 infusion profile significantly impacts test-retest precision of quantitative perfusion, perfusion metrics, and/or image quality on a modern analog 3D PET-CT scanner.</div></div><div><h3>Methods</h3><div>Ninety-eight volunteers from 3 distinct groups: healthy volunteers (Normals), patients with risk factors, and/or coronary disease (Clinicals) and patients with prior transmural myocardial infarctions (Infarcts), underwent cardiac stress testing on an analog 3D PET-CT. Participants received 3 consecutive resting scans and 2 consecutive stress scans, minutes apart, with two randomly assigned Rb-82 infusion profiles: 50 mL/min (fast [F]) and 20 mL/min (slow [S]). Perfusion metrics (resting (rMBF) and stress myocardial blood flow (sMBF)) were calculated using HeartSee software. Coefficients of variance (COV), repeatability (RC), MBF, and image quality metrics were compared.</div></div><div><h3>Results</h3><div>rMBF correlated well between F and S profiles, with intraclass correlation coefficients (ICC) ranging .91-.93. sMBF was highly correlated between F and S profiles (ICC = .97). Fast and slow profiles were associated with similar same-day test-retest precision (COV 11.5% vs 11.3% (<em>P</em> = .77); RC 21.5% vs 22.6%, for F–F vs S–S). There were no clinically significant differences in MBF values between F and S profiles. Image quality metrics were similar between the 2 profiles.</div></div><div><h3>Conclusions</h3><div>There are no clinically significant differences in precision, perfusion metrics, or image quality between Rb-82 fast and slow infusions using a contemporary analog 3D PET-CT.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"41 ","pages":"Article 102059"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Caseous calcification as a cause of false positive FDG-PET/CT in native valve endocarditis.","authors":"Yousef Kamel, Donato Terrone, Matthieu Pelletier-Galarneau","doi":"10.1016/j.nuclcard.2024.102058","DOIUrl":"10.1016/j.nuclcard.2024.102058","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102058"},"PeriodicalIF":3.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jorge Dahdal MD , Ruurt A. Jukema MD , Hendrik J. Harms PhD , Maarten J. Cramer MD, PhD , Pieter G. Raijmakers MD, PhD , Paul Knaapen MD, PhD , Ibrahim Danad MD, PhD
{"title":"PET myocardial perfusion imaging: Trends, challenges, and opportunities","authors":"Jorge Dahdal MD , Ruurt A. Jukema MD , Hendrik J. Harms PhD , Maarten J. Cramer MD, PhD , Pieter G. Raijmakers MD, PhD , Paul Knaapen MD, PhD , Ibrahim Danad MD, PhD","doi":"10.1016/j.nuclcard.2024.102011","DOIUrl":"10.1016/j.nuclcard.2024.102011","url":null,"abstract":"<div><div>Various non-invasive images are used in clinical practice for the diagnosis and prognostication of chronic coronary syndromes. Notably, quantitative myocardial perfusion imaging (MPI) through positron emission tomography (PET) has seen significant technical advancements and a substantial increase in its use over the past two decades. This progress has generated an unprecedented wealth of clinical information, which, when properly applied, can diagnose and fine-tune the management of patients with different types of ischemic syndromes. This state-of-art review focuses on quantitative PET MPI, its integration into clinical practice, and how it holds up at the eyes of modern cardiac imaging and revascularization clinical trials, along with future perspectives.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"40 ","pages":"Article 102011"},"PeriodicalIF":3.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"18F-FDG PET-CT for diagnosing cutaneous fistulas secondary to retained lead fragments: A rare and challenging complication after pacemaker extraction","authors":"","doi":"10.1016/j.nuclcard.2024.101794","DOIUrl":"10.1016/j.nuclcard.2024.101794","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"40 ","pages":"Article 101794"},"PeriodicalIF":3.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139391947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}