Journal of Nuclear Cardiology最新文献

{"title":"Amyloidosis imaging in focus: The evolution of bone-avid cardiac scintigraphy in the era of disease-modifying therapies","authors":"Marcelo F. Di Carli MD, MASNC","doi":"10.1016/j.nuclcard.2025.102150","DOIUrl":"10.1016/j.nuclcard.2025.102150","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"44 ","pages":"Article 102150"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing motion in the estimation of myocardial blood flow with [F-18] flurpiridaz positron emission tomography","authors":"Jonathon A. Nye, Sameer V. Tipnis","doi":"10.1016/j.nuclcard.2024.102123","DOIUrl":"10.1016/j.nuclcard.2024.102123","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"44 ","pages":"Article 102123"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143403501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automatic motion correction for myocardial blood flow estimation improves diagnostic performance for coronary artery disease in 18F-flurpiridaz positron emission tomography-myocardial perfusion imaging","authors":"Valerie Builoff BS ,&nbsp;Cathleen Huang BA ,&nbsp;Keiichiro Kuronuma MD, PhD ,&nbsp;Chih-Chun Wei MS ,&nbsp;Hidesato Fujito MD, PhD ,&nbsp;Yuka Otaki MD, PhD ,&nbsp;Serge D. Van Kriekinge PhD ,&nbsp;Paul Kavanagh MS ,&nbsp;Mark Lemley BS ,&nbsp;Mark C. Hyun CNMT ,&nbsp;Marcelo Di Carli MD ,&nbsp;Daniel S. Berman MD ,&nbsp;Piotr J. Slomka PhD","doi":"10.1016/j.nuclcard.2024.102072","DOIUrl":"10.1016/j.nuclcard.2024.102072","url":null,"abstract":"<div><h3>Background</h3><div>Motion correction (MC) is critical for accurate quantification of myocardial blood flow (MBF) and flow reserve (MFR) from ¹⁸F-flurpiridaz positron emission tomography (PET) myocardial perfusion imaging (MPI). However, manual correction is time consuming and introduces inter-observer variability. We aimed to validate an automatic MC algorithm for ¹⁸F-flurpiridaz PET-MPI in terms of diagnostic performance for predicting coronary artery disease (CAD).</div></div><div><h3>Methods</h3><div>In total, 231 patients who underwent invasive coronary angiography and rest/pharmacologic stress ¹⁸F-flurpiridaz PET-MPI from the phase III Flurpiridaz trial (NCT01347710) were enrolled. For manual MC, two operators (Reader 1 and Reader 2) shifted each frame's images in three directions. The automatic MC algorithm, initially developed for ⁸²Rb-chloride PET-MPI, was optimized for ¹⁸F-flurpiridaz. Diagnostic performance was compared using minimal segmental MBF/MFR with and without MC to predict obstructive CAD by invasive coronary angiography.</div></div><div><h3>Results</h3><div>Manual MC took 10 minutes per case (both stress and rest) on average, while automatic MC required &lt;10 seconds. The area under the receiver operating characteristic curves (AUCs) for significant CAD using minimal segmental MBF were comparable between automatic and manual MC (AUC = 0.877 automatic, AUC = 0.888 Reader 1 and AUC = 0.892 Reader 2; all <em>P</em> &gt; 0.05). AUCs of minimal segmental MBF with manual and automatic MC were significantly higher than without MC (<em>P</em> &lt; 0.05 for both). Similar findings were observed with minimal segmental MFR.</div></div><div><h3>Conclusions</h3><div>Automatic MC can be performed rapidly, with diagnostic performance for predicting obstructive CAD comparable to manual MC. This method could be utilized for analysis of MBF/MFR in patients undergoing ¹⁸F-flurpiridaz PET-MPI.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"44 ","pages":"Article 102072"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between technetium-99m pyrophosphate myocardial uptake and extracellular volume on cardiac magnetic resonance imaging in patients with transthyretin cardiac amyloidosis","authors":"Chun-Yuan Khoo MBBS ,&nbsp;Jennifer Maning DO ,&nbsp;Richard Weinberg MD, PhD ,&nbsp;Ryan Avery MD ,&nbsp;Vinesh Appadurai MD ,&nbsp;Sanjiv Shah MD ,&nbsp;Korosh Sharain MD ,&nbsp;Scott M. Leonard BSc ,&nbsp;Logan Robert Linscheid BSc ,&nbsp;Chen Chen MD ,&nbsp;Anahita Iyer BSc ,&nbsp;Susan Lehrer BSc ,&nbsp;Ike S. Okwuosa MD ,&nbsp;Paul C. Cremer MD, MS","doi":"10.1016/j.nuclcard.2024.102083","DOIUrl":"10.1016/j.nuclcard.2024.102083","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"44 ","pages":"Article 102083"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient ischemic dilatation in cardiac amyloidosis","authors":"Bethlehem Mengesha MD,&nbsp;Gary Small MD,&nbsp;David Ian Paterson MD,&nbsp;Benjamin Chow MD","doi":"10.1016/j.nuclcard.2024.102042","DOIUrl":"10.1016/j.nuclcard.2024.102042","url":null,"abstract":"<div><div>Myocardial perfusion abnormalities and altered myocardial blood flow have been described in cardiac amyloidosis. Transient ischemic dilatation (TID) on perfusion imaging has been seen in the presence of multivessel coronary artery disease (CAD), hypertrophic cardiomyopathy, significant LV systolic dysfunction and hypertensive cardiomyopathy. But to our knowledge this phenomenon has not been described in cardiac amyloidosis. We present a case of cardiac amyloidosis presenting with transient ischemic dilatation on myocardial perfusion imaging.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"44 ","pages":"Article 102042"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of metabolic activity in the evaluation of cardiac sarcoidosis","authors":"Christiane Wiefels MD ,&nbsp;Kevin Boczar MD ,&nbsp;David Birnie MBChB ,&nbsp;Rob Beanlands MD ,&nbsp;Panithaya Chareonthaitawee MD","doi":"10.1016/j.nuclcard.2024.102088","DOIUrl":"10.1016/j.nuclcard.2024.102088","url":null,"abstract":"<div><div>Sarcoidosis is a systemic disorder characterized by non-necrotizing granulomatous inflammation and fibrosis affecting multiple organs, notably the lungs and lymph nodes. Cardiac sarcoidosis (CS), a subset of the disease predominantly involving the heart, significantly heightens the associated morbidity and mortality of sarcoidosis. Early detection of CS is crucial for optimal management. Positron emission tomography/computed tomography (PET/CT) using 18F-fluorodeoxyglucose (18F-FDG) has emerged as an important diagnostic, prognostic, and monitoring tool for CS. Guidelines emphasize a combined approach of visual interpretation and adjunctive quantitative metrics to enhance diagnostic accuracy and treatment monitoring. Various quantitative parameters including maximum standardized uptake value (SUVmax), coefficient of variation, and texture analysis show promise as auxiliary tools diagnosing and prognosticating CS. However, standardization and validation of these quantitative methods remain challenging due to inter-center variability and technological differences. Further validation through large-scale, multi-center studies is needed to optimize their use and better delineate their role in CS diagnosis, prognostication, and therapy monitoring.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"43 ","pages":"Article 102088"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart rate and blood pressure response to vasodilator stress: A trip back to the future","authors":"Ahmed Aljizeeri MBBS ,&nbsp;Mouaz H. Al-Mallah MD, MSc","doi":"10.1016/j.nuclcard.2024.102085","DOIUrl":"10.1016/j.nuclcard.2024.102085","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"43 ","pages":"Article 102085"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidentally detected diaphragmatic eventration as para-cardiac thoracic activity on myocardial perfusion imaging","authors":"Hardik Veerwal MD,&nbsp;Komal Preet MBBS,&nbsp;Ashwani Sood DNB,&nbsp;Harpreet Singh MD,&nbsp;Madan Parmar MSc,&nbsp;Bhagwant R. Mittal MD, DNB","doi":"10.1016/j.nuclcard.2024.101817","DOIUrl":"10.1016/j.nuclcard.2024.101817","url":null,"abstract":"<div><div>Diaphragmatic eventration<span><span> is the elevation of hemi-diaphragm without any disruption to diaphragmatic continuity which can be congenital or acquired. The most common acquired cause is phrenic nerve paralysis<span> due to traumatic causes and is usually incidentally diagnosed on chest radiograph or </span></span>computed tomography<span><span>. We hereby report a case of a patient who had road traffic accident with fracture of the left proximal femur<span>. Stress Myocardial Perfusion Imaging (MPI) done for pre-operative clearance showed an incidental </span></span>tracer<span><span> avidity adjoining to left myocardium in the </span>thorax. It was confirmed on anatomical imaging to be gastric cavity uptake due to diaphragm eventration.</span></span></span></div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"43 ","pages":"Article 101817"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139672026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"I can see clearly now the blur has gone: Deep learning efficiencies in single-photon emission computed tomography myocardial perfusion imaging","authors":"Manish Motwani MB ChB, PhD","doi":"10.1016/j.nuclcard.2024.102091","DOIUrl":"10.1016/j.nuclcard.2024.102091","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"43 ","pages":"Article 102091"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac motion correction with a deep learning network for perfusion defect assessment in single-photon emission computed tomography myocardial perfusion imaging","authors":"Xirang Zhang MS ,&nbsp;Yongyi Yang PhD ,&nbsp;P. Hendrik Pretorius PhD ,&nbsp;Piotr J. Slomka PhD ,&nbsp;Michael A. King PhD","doi":"10.1016/j.nuclcard.2024.102071","DOIUrl":"10.1016/j.nuclcard.2024.102071","url":null,"abstract":"<div><h3>Background</h3><div>In myocardial perfusion imaging (MPI) with single-photon emission computed tomography (SPECT), ungated studies are used for evaluation of perfusion defects despite motion blur. We investigate the potential benefit of motion correction using a deep-learning (DL) network for evaluating perfusion defects.</div></div><div><h3>Methods</h3><div>We employed a DL network for cardiac motion correction in ECG-gated SPECT-MPI images, wherein the image data from different cardiac phases are combined with respect to a reference gate to reduce motion blur. For training the DL network, 197 cases were used. Given the variability of gated images during the cardiac cycle, we investigated the detectability of perfusion defects in two distinct reference gates. To assess perfusion defect detection, we performed receiver-operating characteristic (ROC) analyses on the motion-corrected images using a separate test dataset of clinical 194 subjects, in which studies were created from actual patient data with inserted simulated-lesions as ground truth. The reconstructed images were assessed by the quantitative-perfusion SPECT (QPS) software. We also evaluated the performance on reduced-count studies (by two and four folds).</div></div><div><h3>Results</h3><div>The quantitative results, measured by area-under-the-ROC curve (AUC), demonstrated that DL motion correction improves the detectability of perfusion defects significantly on both standard- and reduced-count studies, and that the detectability can vary with reference cardiac phases. A joint assessment from two reference phases achieved AUC = 0.841 on the quarter-count data, higher than with ungated full-count data (AUC = 0.795, <em>P</em>-value = 0.0054).</div></div><div><h3>Conclusions</h3><div>DL motion correction can benefit assessment of perfusion defects in standard- and reduced-count SPECT-MPI studies. It can also be beneficial to evaluate perfusion images over multiple cardiac phases.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"43 ","pages":"Article 102071"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}