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Nanotechnology Standardisation Policies-Where do we stand? 纳米技术标准化政策——我们在哪里?
Journal of Nanomedicine Research Pub Date : 2016-10-18 DOI: 10.15406/JNMR.2016.04.00085
A. Mohanty
{"title":"Nanotechnology Standardisation Policies-Where do we stand?","authors":"A. Mohanty","doi":"10.15406/JNMR.2016.04.00085","DOIUrl":"https://doi.org/10.15406/JNMR.2016.04.00085","url":null,"abstract":"","PeriodicalId":16465,"journal":{"name":"Journal of Nanomedicine Research","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86572547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation and Characterization of Atenolol Laden Nanoparticles 负载阿替洛尔纳米颗粒的制备与表征
Journal of Nanomedicine Research Pub Date : 2016-10-18 DOI: 10.15406/JNMR.2016.04.00084
D. Archana, J. Divya
{"title":"Preparation and Characterization of Atenolol Laden Nanoparticles","authors":"D. Archana, J. Divya","doi":"10.15406/JNMR.2016.04.00084","DOIUrl":"https://doi.org/10.15406/JNMR.2016.04.00084","url":null,"abstract":"In the present study, an attempt was made to develop nanoparticles of Atenolol for effective treatment of Glaucoma. By developing the nanoparticulated delivery the required action of drug at the target site i.e. at eye can be provided. The nanoparticles were prepared by nano precipitation method. The formulation was subjected to different evaluation parameters like particle size, zeta potential, drug content uniformity, entrapment efficiency, in-vitro drug release study.                \u0000 \u0000 The particle size range of nanoparticles was found to be 100-256 nm. The zeta potential of nanoparticles was found to be 55.87 to 64.87 mV. The drug content of different formulations F1 to F8 was calculated and the content was found to be in range of 95.98 TO 102.14 %. The entrapment efficiency was found to be in range of 45.76 to 72.98%. From the in-vitro drug release studies, it was found that the cumulative percent drug release for optimised formulation F5 found to be between 12.56 to 88.15 % respectively.","PeriodicalId":16465,"journal":{"name":"Journal of Nanomedicine Research","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88544015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Nanoneurobiophysics: The Leading Highway for Neurodegenerative Diseases Research 纳米神经生物物理学:神经退行性疾病研究的主要途径
Journal of Nanomedicine Research Pub Date : 2016-10-07 DOI: 10.15406/JNMR.2016.04.00082
M. Hausen, G. S. Oliveira, F. L. Leite
{"title":"Nanoneurobiophysics: The Leading Highway for Neurodegenerative Diseases Research","authors":"M. Hausen, G. S. Oliveira, F. L. Leite","doi":"10.15406/JNMR.2016.04.00082","DOIUrl":"https://doi.org/10.15406/JNMR.2016.04.00082","url":null,"abstract":"Submit Manuscript | http://medcraveonline.com A thunderous deep inside advancement in medicine science has impacted all fields in the last decades. Nanotechnology (Nt) has consolidated their progress in biology, physics, mathematics and chemistry. In human diseases, Nt introduces new perspectives to the investigation of the mechanisms pathways involved in neurodegenerative diseases, (e.g, multiple sclerosis, Parkinson’s and Alzheimer’s disease) [5,6]. Additionally, the development and characterization of nanostructured materials simplify disease investigation.","PeriodicalId":16465,"journal":{"name":"Journal of Nanomedicine Research","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86418629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Plasmonic Silver Nanoparticles with Atomically Precise Composition 具有原子精确组成的等离子体银纳米粒子
Journal of Nanomedicine Research Pub Date : 2016-10-05 DOI: 10.15406/JNMR.2016.04.00083
Yangwei Liu
{"title":"Plasmonic Silver Nanoparticles with Atomically Precise Composition","authors":"Yangwei Liu","doi":"10.15406/JNMR.2016.04.00083","DOIUrl":"https://doi.org/10.15406/JNMR.2016.04.00083","url":null,"abstract":"Submit Manuscript | http://medcraveonline.com and Ag374 species protected by 4-tert-butylbenzenethiolate were chemically synthesized and structurally resolved by X-ray crystallography. It is noteworthy that, although these silver nanoparticles (Ag NPs) were identified with atomically precise composition, these species showed plasmonic optical characteristics [10]. Atomically precise silver species, taking Ag44 as an example, typically possess characteristic optical absorption peaks and thus were initially described as intensely and broadly absorbing nanoparticles (IBANs) [11] before structurally ressolved [12]. The ultraviolet–visible absorption (UV-vis) of Ag136 and Ag374 reported in this work was nowhere close to molecular species and showed clear metallic features.","PeriodicalId":16465,"journal":{"name":"Journal of Nanomedicine Research","volume":"654 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76840436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Zinc Oxide Nanoparticles Fortified Biscuits as a Nutritional Supplement for Zinc Deficient Rats 氧化锌纳米颗粒强化饼干对缺锌大鼠的营养补充作用
Journal of Nanomedicine Research Pub Date : 2016-08-31 DOI: 10.15406/JNMR.2016.04.00081
S. A. Raya, M. Hassan, K. Farroh, Shimaa A Hashim, T. Salaheldin
{"title":"Zinc Oxide Nanoparticles Fortified Biscuits as a Nutritional Supplement for Zinc Deficient Rats","authors":"S. A. Raya, M. Hassan, K. Farroh, Shimaa A Hashim, T. Salaheldin","doi":"10.15406/JNMR.2016.04.00081","DOIUrl":"https://doi.org/10.15406/JNMR.2016.04.00081","url":null,"abstract":"Zinc deficiency is a global nutritional disorder affecting majority of healthy people rather than those suffering from chronic diseases, affects about one third of people around the worldand thereby causing clinical manifestations. This work represents new modality to increase the intestinal absorptivity and bioavailability of zinc from the diet by replacing traditional bulk form by zinc nanoparticles to be used in preparations of zinc fortified biscuits as a nutritional supplement for zinc deficiency disease in rats. Zinc oxide nanoparticles of 25 ± 5 nm sizes were synthesized by co-precipitation approach and characterized by Transmission Electron Microscope and X-Ray Diffraction. Zinc deficient rats model was performed by nourishing on zinc deficient diet for five weeks to acquire zinc deficiency. Three levels nano zinc oxide Fortified Biscuits (13.5 ppm, 27 ppm and 54 ppm) were prepared to be compared with bulk form of zinc oxide. Results showed that, rapid enhancement of body growth rate, appetite and hair growth was recorded for nano zinc treated groups that might be attributed to the increased intestinal absorptivity and bioavailability of the nano scaled zinc oxide as a result of its ultra-small sizes compared to the regular bulky zinc oxide form. The toxicological evaluation of the applied nano zinc oxide concentrations didn’t cause any apparent toxicity and the lethal dose (LD50) cannot be established within the applied doses, where no mortality during the designed experiment period. Histopathological examination support the capability of the nano zinc oxide formulation to replace the traditional bulk forms of oral zinc supplements for rapid and efficient recovery with no significant histopathological abnormalities in Liver, Kidneys and Testis. The present work recommend dose of 13.5 ppm nano zinc fortified biscuits for managing mild zinc deficiency and the dose of 27 ppm for more sever conditions.","PeriodicalId":16465,"journal":{"name":"Journal of Nanomedicine Research","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87469444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
A Short Review on the Delivery of Breast Anticancer Drug Tamoxifen and its Metabolites by Serum Proteins 乳腺癌药物他莫昔芬及其代谢物经血清蛋白传递的研究进展
Journal of Nanomedicine Research Pub Date : 2016-08-24 DOI: 10.15406/JNMR.2016.04.00080
P. Bourassa, Thomas Tj, Tajmir Riahi Ha
{"title":"A Short Review on the Delivery of Breast Anticancer Drug Tamoxifen and its Metabolites by Serum Proteins","authors":"P. Bourassa, Thomas Tj, Tajmir Riahi Ha","doi":"10.15406/JNMR.2016.04.00080","DOIUrl":"https://doi.org/10.15406/JNMR.2016.04.00080","url":null,"abstract":"The loading of tamoxifen (Tam), 4-hydroxytamoxifen (4-OH-Tam) and endoxifen (End) by carrier proteins, human serum albumin (HSA) and bovine serum albumin (BSA) was reviewed in aqueous solution at physiological pH. The binding study is directly related to the conjugation of tamoxifen and its metabolites with serum proteins. Tamoxifen and its metabolites bind serum proteins via hydrophobic, hydrophilic and H-bonding contacts. The loading efficacy (LE) was 45-52% for drug-protein conjugates. Modeling showed the presence of H-bonding, which stabilized drug-protein complexation with the free binding energy of -11.79 to -11.25 Kcal/mol for drug-HSA and -13.79 to -12.72 Kcal/mol for drug-BSA conjugates. Drug conjugation induced major perturbations on the conformation of serum proteins. Our studies indicate that serum proteins can transport tamoxifen and its metabolites to target tissues in the human body.","PeriodicalId":16465,"journal":{"name":"Journal of Nanomedicine Research","volume":"10 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90218544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Protein Nanoparticle as a Versatile Drug Delivery System in Nanotechnology 蛋白质纳米颗粒作为纳米技术中多功能的给药系统
Journal of Nanomedicine Research Pub Date : 2016-08-01 DOI: 10.15406/JNMR.2016.04.00077
Dongmei Ren
{"title":"Protein Nanoparticle as a Versatile Drug Delivery System in Nanotechnology","authors":"Dongmei Ren","doi":"10.15406/JNMR.2016.04.00077","DOIUrl":"https://doi.org/10.15406/JNMR.2016.04.00077","url":null,"abstract":"Protein nanoparticles are extensively investigated as versatile drug delivery systems, due to their nanoscale size, container-like shape, natural source, biocompatibility, and biodegradability. They provide three distinct interfaces: internal, external, and inter-subunit interfaces for modifications. Chemistry and genetic engineering provide powerful tools to functionalize protein nanoparticles. Through modifications to the three interfaces, protein nanoparticles can be functionalized with drug encapsulation, controlled drug release, controlled disassembly, and tumor targeting capabilities. This mini review introduced the fundamentals of protein nanoparticles as drug delivery systems, focused on modifications to the three different interfaces, and elucidated different strategies and mechanisms used in integrating multiple functionalities in protein nanoparticles.","PeriodicalId":16465,"journal":{"name":"Journal of Nanomedicine Research","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78449156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Pequiá-Based Nanoemulsion Highlights an Important Amazon Fruit (Caryocar villosum (Aubl.) Pers.) Pequiá-Based纳米乳揭示了一种重要的亚马逊水果(Caryocar villosum (Aubl.))珀耳斯)。
Journal of Nanomedicine Research Pub Date : 2016-08-01 DOI: 10.15406/jnmr.2016.04.00079
Jacqueline D. S. Leal, J. L. Duarte, J. C. Vilhena, Àlex, ro C Florentino, D. Bereau, Jean-Charles Robinson, José C. T. Carvalho, R. A. Cruz, C. Fern, Es, Anna E.M.F.M. Oliveira
{"title":"Pequiá-Based Nanoemulsion Highlights an Important Amazon Fruit (Caryocar villosum (Aubl.) Pers.)","authors":"Jacqueline D. S. Leal, J. L. Duarte, J. C. Vilhena, Àlex, ro C Florentino, D. Bereau, Jean-Charles Robinson, José C. T. Carvalho, R. A. Cruz, C. Fern, Es, Anna E.M.F.M. Oliveira","doi":"10.15406/jnmr.2016.04.00079","DOIUrl":"https://doi.org/10.15406/jnmr.2016.04.00079","url":null,"abstract":"The fruits from pequia (Caryocar villosum) are an important source of antioxidant substances. However, despite the great potential of this natural product for pharmaceutical and food industries, to our knowledge, no study was carried out in order to obtain novel nanoformulation with this raw material. Our results suggested that required Hydrophyle-Lipophile Balance (HLB) of pequia oil is around 12.0 and nanoemulsion with low mean droplet size (191.3 ± 0.8 nm) and Polydispersity Index (0.290 ± 0.040) was obtained. Thus, our studies contribute to valorization of an Amazon fruit, providing for the first time valuable information about nanoemulsion formation using pequia fruits oil.","PeriodicalId":16465,"journal":{"name":"Journal of Nanomedicine Research","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83928772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Multifunctional Magnetic Nanoparticles-A Promising Approach for Cancer Treatment 多功能磁性纳米粒子——一种很有前途的癌症治疗方法
Journal of Nanomedicine Research Pub Date : 2016-08-01 DOI: 10.15406/JNMR.2016.04.00078
Maulick Chopra, K. Ganeshlenin, asamy, D. Maity
{"title":"Multifunctional Magnetic Nanoparticles-A Promising Approach for Cancer Treatment","authors":"Maulick Chopra, K. Ganeshlenin, asamy, D. Maity","doi":"10.15406/JNMR.2016.04.00078","DOIUrl":"https://doi.org/10.15406/JNMR.2016.04.00078","url":null,"abstract":"Nanomedicine plays an important role for treating cancer over the conventional treatments or techniques and has marked over in the past few decades. This can be attributed to the studies between cancer and magnetic nanoparticles, established and reported over the past few years. The magnetic nanoparticles exhibit unique characteristics which make them an ideal candidate for the treatment of cancer under the biomedical applications. Magnetic Nanoparticles can be attracted magnetically by an external applied magnetic field and they act as drug carriers to the cancer cells. Magnetic nanoparticles are able to generate the heat in an alternating magnetic field, as the temperature increases (42-45 °C) it can be used to eradicate or inhibit cancer cell activities locally or even to release drugs in a precisely controlled manner and this effect of magnetic nanoparticles is called hyperthermia. Moreover, with the help of magnetic resonance imaging (MRI), magnetic nanoparticles can also be used as a diagnostic tool by using contrast agents. This opinion provides the snapshot on the properties and application of magnetic nanoparticles in the treatment of cancer.","PeriodicalId":16465,"journal":{"name":"Journal of Nanomedicine Research","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77586394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Recent Advancement in PGLA Nano Polymer Synthesis and its Applications PGLA纳米聚合物的合成及其应用研究进展
Journal of Nanomedicine Research Pub Date : 2016-07-21 DOI: 10.15406/JNMR.2016.04.00076
H. Mehta, Jayeeta, Shastri, H. Muthurajan
{"title":"Recent Advancement in PGLA Nano Polymer Synthesis and its Applications","authors":"H. Mehta, Jayeeta, Shastri, H. Muthurajan","doi":"10.15406/JNMR.2016.04.00076","DOIUrl":"https://doi.org/10.15406/JNMR.2016.04.00076","url":null,"abstract":"Poly lactic-glycol acid (PGLA) plays vital role in pharma industry especially as encapsulation material. Considering importance of polymeric material especially PLGA. In the PubMed searched we found total 937 articles were reported in the year of 2015 (01-01-2015 to 31-12-2015).In these articles we focused on reviewing advancement of PLGA nanoparticle synthesis method, characterization and applications of PLGA mediated Nano polymer ranging from drug delivery to in vivo imaging arena. The review ends with a concluding outlook on the possibilities and future challenges presented to PLGA polymer-based nanotechnologies in healthcare.","PeriodicalId":16465,"journal":{"name":"Journal of Nanomedicine Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80571238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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