Journal of Medical pharmaceutical and allied sciences最新文献_第9页

Current advances in dry eye disease diagnosis and treatment 干眼病诊断与治疗的最新进展

Journal of Medical pharmaceutical and allied sciences Pub Date : 2023-04-30 DOI: 10.55522/jmpas.v12i2.4952

M. Venkatesh

引用次数: 0

Protective effect of ethanolic leaf extract of myrianthus arboreus on indomethacin induced gastric ulcer in adult male wistar rats 豆蔻叶乙醇提取物对吲哚美辛致成年雄性wistar大鼠胃溃疡的保护作用

Journal of Medical pharmaceutical and allied sciences Pub Date : 2023-04-30 DOI: 10.55522/jmpas.v12i2.4699

A. Agu

{"title":"Protective effect of ethanolic leaf extract of myrianthus arboreus on indomethacin induced gastric ulcer in adult male wistar rats","authors":"A. Agu","doi":"10.55522/jmpas.v12i2.4699","DOIUrl":"https://doi.org/10.55522/jmpas.v12i2.4699","url":null,"abstract":"Gastric ulcers are a common gastrointestinal disease with a complex etiology. It manifests with various signs and symptoms, which, in severe cases, could be life-threatening, especially in developing countries. Medicinal plants have been known to exhibit therapeutic potential with minimal adverse effects and thus have been employed in treating various diseases. This study evaluated the effect of ethanolic Myrianthus arboreus leaf extract on indomethacin-induced gastric ulcers in adult male Wistar rats. Twenty-five rats were divided into five groups of five rats each: group A received distilled water; group B received distilled water for 14 days, and 30 mg/kg body weight of indomethacin after 24 hours of fasting. Group C received 20 mg/kg of omeprazole for 14 days and 30 mg/kg of indomethacin after 24 hours of fasting. Groups D and E received 50 mg/kg and 100 mg/kg of M. arboreus, respectively, for 14 days and 30 mg/kg of indomethacin each after 24 hours of fasting. The ulcer index, antioxidant parameters, gastric pH, and histopathology of the stomach were evaluated after the laboratory experiment. The results showed a significant increase in ulcer index and malondialdehyde caused by the indomethacin, while there was a reduction in glutathione, superoxide dismutase, and hydrogen ion concentration (pH), as well as extensive damage to the gastric mucosa. In contrast, both the extract and the omeprazole significantly improved these damages. The results revealed that the leaf extract of M. arboreus has a significant gastro-protective effect comparable to that of omeprazole on the indomethacin-induced gastric ulcer.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85581679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Morphology and Nottingham prognostic index in triple-negative breast carcinomas 三阴性乳腺癌的形态学和诺丁汉预后指数

Journal of Medical pharmaceutical and allied sciences Pub Date : 2023-01-31 DOI: 10.55522/jmpas.v12i1.3800

Anisha Tirumala Sudarshan

{"title":"Morphology and Nottingham prognostic index in triple-negative breast carcinomas","authors":"Anisha Tirumala Sudarshan","doi":"10.55522/jmpas.v12i1.3800","DOIUrl":"https://doi.org/10.55522/jmpas.v12i1.3800","url":null,"abstract":"Triple-negative breast carcinomas are defined by a lack of expression of the steroid hormone receptors i.e., Estrogen Receptor, Progesterone Receptor, and Human epidermal growth factor Receptor-2. They are characterized by distinct molecular, histological, and clinical features. With higher mortality and early relapse, management of these tumors relies on clinicopathologic prognostic factors. Nottingham's prognostic index is a widely used prognostic tool that integrates three independent prognostic factors, namely tumor size, lymph node status, and histologic grade. It is a sensitive index of clinical aggressiveness in breast carcinomas. This study aims to evaluate morphologic features of Triple negative breast carcinomas and correlate them with Nottingham prognostic index. 22 modified radical mastectomies with triple-negative status were considered for this study. Tumor size, histologic type, grade, node involvement, necrosis, lymphovascular invasion, and Nottingham prognostic index were assessed. All 22 Triple negative breast carcinomas were invasive ductal carcinomas [NOS]. One involved skin and six were larger than 5cms. 10 cases (45%) were histologic grade III, and 9 cases (41%) were grade II. 2 cases had more than 10 positive nodes. Nottingham's prognostic index ranged from 2 to 9.4. Lymphovascular invasion and necrosis in 16 cases (73%) and perineural invasion in 3 cases were noted. Prognostication of breast carcinomas using Nottingham prognostic index helps clinicians in decision-making, stratifying risks, and tailoring individual treatment plans. Including Nottingham's prognostic index routinely in breast carcinoma reporting offers a meaningful integrated indicator for clinicians to assess tumor behavior and aggressiveness.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79761578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Holistic care management for diabetes mellitus: A futuristic approach 糖尿病的整体护理管理:未来的方法

Journal of Medical pharmaceutical and allied sciences Pub Date : 2023-01-31 DOI: 10.55522/jmpas.v12i1.4588

K. Bora

{"title":"Holistic care management for diabetes mellitus: A futuristic approach","authors":"K. Bora","doi":"10.55522/jmpas.v12i1.4588","DOIUrl":"https://doi.org/10.55522/jmpas.v12i1.4588","url":null,"abstract":"The public health concern is very important for the growing burden of chronic metabolic disease like Diabetes mellitus. It is foreseeable that by 2045 India would reach rank first in Type-2 Diabetes Mellitus which contributes to 90% of diabetes. Therefore, more care or attention should be given to this disease. There are so many medications available in the market including herbal drugs. But due to more side effects of oral hypoglycemic agents, attention grabs more towards the alternative of synthetic drugs or using Nano-carriers to avoid side effects. Presently, many novel drug delivery systems for oral hypoglycemic agents are available in the market. But herbal drugs grab more attention due to lesser side effects, efficacy and cost-effective. However, there is very less work is reported on nanotechnology like liposomes, nanoparticles/microparticles, gold nanoparticles, noisome, and nano-capsules/microcapsules of herbal drugs, which is currently emerging therapy for diabetes. Nanotechnology or a novel drug delivery system for herbal medicine can be used to overcome the challenges like poor bioavailability, efficacy and stability problems. The current review emphasizes current epidemiology, its types, complications and management of different treatment strategies for diabetes mellitus. Furthermore, the problems related to herbal medicine with immense hope for herbal medicine using nanotechnology are discussed.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88038807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of reference dose levels for nuclear medicine center in Jordan 约旦核医学中心参考剂量水平的评估

Journal of Medical pharmaceutical and allied sciences Pub Date : 2023-01-31 DOI: 10.55522/jmpas.v12i1.3446

T. Alayed

引用次数: 0

Holistic care management for diabetes mellitus: A futuristic approach 糖尿病的整体护理管理:未来的方法

Journal of Medical pharmaceutical and allied sciences Pub Date : 2023-01-31 DOI: 10.55522/jmpas.v12i1.458

Kundan Singh Bora

{"title":"Holistic care management for diabetes mellitus: A futuristic approach","authors":"Kundan Singh Bora","doi":"10.55522/jmpas.v12i1.458","DOIUrl":"https://doi.org/10.55522/jmpas.v12i1.458","url":null,"abstract":"The public health concern is very important for the growing burden of chronic metabolic disease like Diabetes mellitus. It is foreseeable that by 2045 India would reach rank first in Type-2 Diabetes Mellitus which contributes to 90% of diabetes. Therefore, more care or attention should be given to this disease. There are so many medications available in the market including herbal drugs. But due to more side effects of oral hypoglycemic agents, attention grabs more towards the alternative of synthetic drugs or using Nano-carriers to avoid side effects. Presently, many novel drug delivery systems for oral hypoglycemic agents are available in the market. But herbal drugs grab more attention due to lesser side effects, efficacy and cost-effective. However, there is very less work is reported on nanotechnology like liposomes, nanoparticles/microparticles, gold nanoparticles, noisome, and nano-capsules/microcapsules of herbal drugs, which is currently emerging therapy for diabetes. Nanotechnology or a novel drug delivery system for herbal medicine can be used to overcome the challenges like poor bioavailability, efficacy and stability problems. The current review emphasizes current epidemiology, its types, complications and management of different treatment strategies for diabetes mellitus. Furthermore, the problems related to herbal medicine with immense hope for herbal medicine using nanotechnology are discussed.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"182 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135395090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Swotting effective hypertension therapy: Ramipril versus telmisartan 有效的高血压治疗:雷米普利与替米沙坦

Journal of Medical pharmaceutical and allied sciences Pub Date : 2023-01-31 DOI: 10.55522/jmpas.v12i1.4280

R. Das

{"title":"Swotting effective hypertension therapy: Ramipril versus telmisartan","authors":"R. Das","doi":"10.55522/jmpas.v12i1.4280","DOIUrl":"https://doi.org/10.55522/jmpas.v12i1.4280","url":null,"abstract":"One of the most important, globally controllable risk factors for cardiovascular diseases and early mortality is hypertension. Angiotensinconverting enzyme inhibitors and angiotensin receptor blockers, both of which inhibit the renin-angiotensin system, are becoming more common as initial treatments for the management of hypertension patients with which ramipril and telmisartan being the most frequently used. Telmisartan has the highest affinity for the AT1 receptor of all the ARBs.Ramipril and telmisartan both are found to provide a variety of therapeutic advantages. In this study, a detailed comparative analysis has been done between ramipril and telmisartan regarding their efficacy, safety, monotherapy as well as combination therapy outcome and measures to be taken while considering both drugs. This study focused on which one is more successful in treating hypertension individuals, while also having a superior safety profile and combining the two medications which one is linked to more side effects, additional benefits, or other important information to eliminate the hazards connected to blood pressure increase while minimizing negative effects on quality of life.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82127226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liquid infused silicon based urinary catheters: A simple laboratory model to study bacterial biofilm formation 液体输注硅基导尿管:研究细菌生物膜形成的简单实验室模型

Journal of Medical pharmaceutical and allied sciences Pub Date : 2023-01-31 DOI: 10.55522/jmpas.v12i1.4154

V. Palanimuthu

{"title":"Liquid infused silicon based urinary catheters: A simple laboratory model to study bacterial biofilm formation","authors":"V. Palanimuthu","doi":"10.55522/jmpas.v12i1.4154","DOIUrl":"https://doi.org/10.55522/jmpas.v12i1.4154","url":null,"abstract":"Biofilms are organized communities of micro-organisms buried firmly on an extra polymeric matrix attached to the living surface. The matrix which is formed surrounding the bacteria makes them tolerant to harsh environmental conditions as well as resistant to antibacterial treatment. The development of biofilms in clinical or hospital settings is the major reason for several infections. They have a negative impact when they are formed on medical devices as it is difficult to eradicate them using disinfectants or antibiotics available. Several in vitro models have been implemented in the last decade to evaluate antimicrobial activity on bacterial biofilms. Although well-established static biofilm methods are available; there is a lack of simple dynamic biofilm models to replicate the clinical settings of biofilm development. In this scenario, considering the importance of this research area, we planned to design laboratory-scale working models to study biofilms. We used Pseudomonas aeruginosa as a model organism. We divided the biofilm models into two categories namely static and dynamic models. The dynamic model of biofilm, that we used for mimicking the clinical setting, was a silicone-based catheter model. This new model will contribute to deeper knowledge about the physiology, structure, formation, and composition of biofilms. This method can be used as an appropriate and up-to-date technique to study biofilms in laboratory settings.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82456615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extraction and identification of bioactive compound embelin from embelia ribes fruits 枸杞果实中生物活性化合物栓塞素的提取与鉴定

Journal of Medical pharmaceutical and allied sciences Pub Date : 2023-01-31 DOI: 10.55522/jmpas.v12i1.4226

Thirupataiah Boini

{"title":"Extraction and identification of bioactive compound embelin from embelia ribes fruits","authors":"Thirupataiah Boini","doi":"10.55522/jmpas.v12i1.4226","DOIUrl":"https://doi.org/10.55522/jmpas.v12i1.4226","url":null,"abstract":"Embelia ribes is the most widely used plant in numerous Ayurvedic preparations to treat various disorders. The most commonly used plant parts like leaves and fruit are in the Indian traditional system for CNS (Central Nervous System) disease, Anti-bacterial Anthelmintic, and Anti-ulcer activity. The proposed work aimed to optimize different extraction parameters (Part of Crude drug, Solvent and Temperature) to increase the extraction yield of the Embelin from Embelia ribes fruits. Extraction was done by using Chloroform as a solvent, and extraction yield was optimized by using independent variables, such as solvent, drug parts, time and temperature, with the help of the design of expert software. One part of the crude drug kept in 3 parts of Chloroform for 34 mins at 49 oC temperature gives the maximum yield (38.73±1.13%) of Embelin. HPTLC was done by using the mobile phase of Chloroform: Ethyl acetate: Formic acid (5:4:0.5 v/v/v). A single band appeared in the TLC plate exhibiting the Isolation of a Single compound, further the Isolated compound was identified and characterized by using Ultraviolet Spectroscopy (UV), Fourier Transform Infra-Red (FTIR), and Nuclear Magnetic Resonance Spectroscopy (NMR). The results obtained from the analytical techniques reveal that the Isolated compound was Embelin.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78629538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of anti-psychotic drug utilisation in psychiatry ward of tertiary care hospital 三级医院精神科病房抗精神病药物使用情况评估

Journal of Medical pharmaceutical and allied sciences Pub Date : 2023-01-31 DOI: 10.55522/jmpas.v12i1.3823

Manish Kumar

引用次数: 0