Journal of Medical pharmaceutical and allied sciences最新文献

{"title":"Characterization and molecular docking studies of Erucic acid","authors":"Bhawna Sharma","doi":"10.55522/jmpas.v13i1.5486","DOIUrl":"https://doi.org/10.55522/jmpas.v13i1.5486","url":null,"abstract":"Neuro degenerative diseases (NDs) are a wide range of neurological conditions\u0000 characterized by the deterioration of neurons, glial cells, synapses, and other\u0000 networks. Parkinson’s disease is one of the second most common neuro degenerative\u0000 disorders after Alzheimer’s disease. Erucic acid, an omega-9 monounsaturated fatty acid,\u0000 was reported to be commonly present in mustard oil. Erucic acid was also reported to\u0000 have neuro protective and antioxidant benefits in a number of pre-clinical trials\u0000 conducted in the past. In the present study, erucic acid, linoleic acid, and Riluzole\u0000 were evaluated using a molecular docking-based technique based on their binding\u0000 affinities and other physico-chemical characteristics of the compounds. PYRX 0.8 was\u0000 used for molecular docking between ligands and the various antioxidant and\u0000 neurotransmitter-associated proteins, and Discovery Studio Visualizer 2020 was used to\u0000 create the visualization. Additionally, Lipinski's rule of five was used to forecast\u0000 whether these compounds would be drug-like. Further absorption, distribution,\u0000 metabolism, excretion, and Toxicity (ADME-T) profile of the compounds were studied using\u0000 the pkCSM tool. According to drug-likeness analysis, all of the compounds i.e. erucic\u0000 acid, linoleic acid, and Riluzole fell within Lipinski's rule of five's acceptable\u0000 range. The docking studies implied that erucic acid might have anti-parkinsonian effects\u0000 by binding to molecular targets superoxide dismutase (SOD1) enzyme protein i.e. 5YTU and\u0000 to 5-Hydroxytrytamine (5H2TC) receptor protein i.e. 6BQH when compared to Riluzole along\u0000 with good ADME-T properties. However, more research is needed to evaluate the efficacy\u0000 of erucic acid against additional targets of Parkinson’s disease and other neuro\u0000 degenerative illnesses.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"35 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140411724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative morpho-anatomical studies of Albizia lebbeck (L.) Benth and in vitro\u0000 micro propagated plantlets","authors":"Md. Nazneen Bobby","doi":"10.55522/jmpas.v13i1.5928","DOIUrl":"https://doi.org/10.55522/jmpas.v13i1.5928","url":null,"abstract":"The current investigation was characterizing the pharmacognostical screening of\u0000 the mother plant Albizia lebbeck and its in vitro propagated plantlets. The macroscopic\u0000 analysis showed the presence of various parts of the plants and the anatomical studies\u0000 revealed the presence of paracytic stomata of equal subsidiary cells; dendroid vein\u0000 terminations; Thick–walled epidermal cells and parenchymatous ground tissue; cuticular\u0000 projections with striations in the epidermal cells of a leaf; smaller vascular bundles\u0000 with lateral veins; thick-walled bundle sheath fibers with thick vascular strands;\u0000 irregularly lobed sclereids and tannin cells in the upper epidermis of lamina; druse\u0000 idioblasts in the mesophyll of the leaf; accessory vascular bundles in the petiole were\u0000 observed in the mother plant, which was compared with the in-vitro micro propagated\u0000 plantlet with the presence of thick and wide midrib with lamina; Thick leaf margin with\u0000 thin Phloem; short xylem; vascular showed reduced in size; Reduce palisade tissue; Thick\u0000 and compact parenchyma; Squamish and papillate epidermal cells were observed in\u0000 epidermal and stromata region. The current studies contribute as a standard monograph\u0000 for the identification and evaluation of plants.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140413137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-silico approach: predictive ADME/T properties and ACE inhibitory action of\u0000 isolated compounds of Aspidopterys sps","authors":"Udaya Chandrika P","doi":"10.55522/jmpas.v13i1.5903","DOIUrl":"https://doi.org/10.55522/jmpas.v13i1.5903","url":null,"abstract":"The current research study aimed to study Isolated phytocompounds of Aspidopterys\u0000 sps (A. indica and A.cordata) by invitro antihypertensive activity, in-silico molecular\u0000 docking, and ADME/T analysis. The preceding reports had revealed a fact of polyphenols\u0000 and triterpenoids have an ability to control blood pressure by inhibition of Angiotensin\u0000 converting enzyme (ACE). The isolated ligands Catechin, Isoorientin, Fisetin, and\u0000 Ursolic acid (A , B, C and D) tested for ACE inhibition, docked with target Human\u0000 Angiotensin-converting enzyme employing Autodock 4.2, drug-likeliness, physicochemical\u0000 nature, toxicity prediction by Swiss ADME, ProTox tools available online. All\u0000 phytoconstituents showed optimistic dose-responsive inhibition, Compounds exhibited\u0000 magnificent IC50 (15.38 ± 0.53) μg/ml, B (20.21± 0.34 μg/ml), C (17.62 ± 0.78 μg/ml), D\u0000 (23.98 ± 0.65 μg/ml), Captopril (15.86±0.32 μg/ml). Molecule A showed utmost binding\u0000 energy (-7.3 K.cal/mol) significant alignment with target protein and good interactions\u0000 compared to Captopril (-6.7) and Lisinopril (-7.38 K.cal/mol). Prediction of ADME/T and\u0000 ligands showed good pharmacokinetic properties characterized by high absorption in the\u0000 gastrointestinal tract, oral bioavailability, and minimal toxicity and high binding\u0000 energies, so these bioactive compounds could be further explored as possible\u0000 antihypertensive drugs.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"12 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140413960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of infusions of phenylephrine, norepinephrine, and mephentermine on\u0000 maternal hemodynamics and neonatal outcomes in caesarean section under spinal\u0000 anaesthesia","authors":"Laxman K Senapati","doi":"10.55522/jmpas.v13i1.5919","DOIUrl":"https://doi.org/10.55522/jmpas.v13i1.5919","url":null,"abstract":"Although the subarachnoid block is the preferred anesthetic technique for the\u0000 caesarean section, on the downside it is often associated with complications like\u0000 maternal hypotension. We compared phenylephrine, norepinephrine, and mephentermine\u0000 infusions to maintain blood pressure during the caesarian section under subarachnoid\u0000 block. Our study included 240 parturients with singleton-term pregnancies undergoing a\u0000 caesarian section under spinal anesthesia. Following spinal anesthesia till the delivery\u0000 of the baby, parturients randomly assigned to three groups received phenylephrine,\u0000 norepinephrine, and mephentermine infusions.Heart rate, blood pressure, intra-operative\u0000 nausea and vomiting, neonatal Apgar score, and total rescue vasopressors required were\u0000 analyzed. Except at 4 min (p=0.006), ANOVA revealed no statistically significant\u0000 difference in systolic blood pressure between the groups across all time points.\u0000 Systolic blood pressure showed a significant difference between the mephentermine group\u0000 versus the phenylephrine group (p=0.013) and the norepinephrine group versus the\u0000 phenylephrine group (p=0.022) at four minutes post hoc Bonferroni. Except at 15 and 60\u0000 minutes (p=0.02 and p=0.001, Refer This Article Amit Pradhan, Rasulata Swain,\u0000 Priyadarsini Samanta, Laxman K Senapati, Ganesh C Satapathy, 2024. Comparison of\u0000 infusions of phenylephrine, norepinephrine, and Mephentermine on maternal hemodynamics\u0000 and neonatal outcomes in caesarean section under spinal anaesthesia. . Journal of\u0000 medical pharmaceutical and allied sciences, V 13 - I 1, Pages- 6392 – 6400. Doi:\u0000 https://doi.org/10.55522/jmpas.V13I1.5919.respectively), the mean heart rate was\u0000 comparable among the three groups. The Chi-square test revealed no statistically\u0000 significant difference in the requirement of rescue drugs among the groups (ϰ2=1.57,\u0000 p=0.45) except at the time point of 4 minutes (p=0.01) when the highest requirement was\u0000 observed in the phenylephrine group. The Apgar scores amongst the groups were comparable\u0000 at 1 min (p=0.99) and 5 min (p=0.98). In the lower segment caesarian section under the\u0000 subarachnoid block, infusions of phenylephrine, norepinephrine, and mephentermine were\u0000 equally effective in managing maternal hypotension and achieving favorable neonatal\u0000 outcomes.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140416086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osseo-densification for preservation and compaction of alveolar bone in enhancing\u0000 stability of dental implants: A systematic review","authors":"Arshad Jamal Sayed","doi":"10.55522/jmpas.v13i1.5741","DOIUrl":"https://doi.org/10.55522/jmpas.v13i1.5741","url":null,"abstract":"A higher implant failure rate may be associated with a lack of primary stability.\u0000 Primary stability is a stationary, entirely mechanical parameter that determines when an\u0000 implant is placed. Several methods have been developed to improve the primary implant's\u0000 level of stability. However, Osseo-densification (OD) is a revolutionary implant\u0000 preparation approach that addresses these issues and enhances the main stability of\u0000 implants inserted into low-density bones. In light of this, the present systematic\u0000 review was conducted to understand the Osseo-densification for preservation and\u0000 compaction of alveolar bone in enhancing the stability of the dental implant. Research\u0000 papers from PubMed, CINAHL, Web of Science, and Web of Science, Medline searched. The\u0000 most recent literature suggests that using the Osseo-densification drilling protocol\u0000 increases the overall value of implant insertion torque and, consequently, increases the\u0000 primary stability of implants. To evaluate the caliber of the contained research, CARE,\u0000 ARRIVE, and modified CONSORT checklists were employed. 133 full texts were chosen for\u0000 further investigation after duplicates were removed and titles and abstracts were\u0000 reviewed of these, 27 entire texts met the inclusion criteria. The thorough literature\u0000 search identified 6 Case Studies & Case Series, 11 in vivo animal studies, and ten\u0000 /experimental animal studies that noted the use of the Osseo-densification technique.\u0000 The data from most recent animal in vivo/in vitro studies and case reports / case series\u0000 suggest that Osseo-densification drilling protocol increases the overall value of\u0000 implant insertion torque and, as a result, increases implant primary stability.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140415267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classification of celiac disease using novel approach of three-level DWT\u0000 decomposition and linear support vector machine","authors":"Nisha Ms","doi":"10.55522/jmpas.v13i1.6039","DOIUrl":"https://doi.org/10.55522/jmpas.v13i1.6039","url":null,"abstract":"In the medical field, the requirement for automated medical diagnosis software has\u0000 risen as the application uses machine learning to facilitate health analysis from\u0000 different data points from a patient comparing it with massive amounts of medical data\u0000 to diagnose and prevent disease. The automated system can run multiple tests\u0000 simultaneously and thus resulting to faster turnaround time and enables timely patient\u0000 care along with higher accuracy and reliability. The irregularities in the small\u0000 intestine villi’s structure cause various autoimmune disorders. So, this work aims to\u0000 find a novel technique for the feature extraction of upper endoscopy images of celiac\u0000 disease. We employed CLAHE (Contrast Limited Adaptive Histogram Equalization) for the\u0000 preprocessing step and the Sobel operator with gradient magnitude for the segmentation\u0000 of the enhanced image. In this manuscript, we have proposed a novel approach by\u0000 calculating texture features through gray level co-occurrence matrix and frequency\u0000 analysis using 3-level discrete wavelet transform decomposition on endoscopy images that\u0000 renders novelty to the work. Thereafter, linear SVM (support vector machine) with PCA\u0000 (Principal Component Analysis) is used for classification. The ensemble approach attains\u0000 accuracy, sensitivity, and specificity of 78.49 %, 90.32 %, and 77.27% respectively. The\u0000 outcomes achieved with the suggested approach are compared with some state-of-the-art\u0000 methods using the same dataset. The results are promising due to high sensitivity for\u0000 the treatment of untreated celiac disease and can prove boom to the medical industry by\u0000 assisting clinicians to diagnose the disease at an early stage.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140412818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-vitro evaluation of Epherda Foemenia for anti-oxidant and anti-cancer\u0000 properties","authors":"Kamal Eldin Ahmed Abdelsalam","doi":"10.55522/jmpas.v13i1.5767","DOIUrl":"https://doi.org/10.55522/jmpas.v13i1.5767","url":null,"abstract":"Ephedra foeminea has been increasingly recognized for its anti-cancer properties.\u0000 The current study evaluated the anti-oxidant and anti-cancer activities of the methanol\u0000 extract of E. foeminea (EFME). The extract was evaluated for cytotoxic effects against\u0000 mouse breast cancer 4T1 cells, and camptothecin was used as a standard anti-cancer drug\u0000 for comparison. The anti-oxidant activity was determined by the\u0000 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging effect while the\u0000 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay, cell\u0000 invasion assay, scratch assay and cell cycle analysis were used for evaluation of its\u0000 anti-cancer potential. In the MTT assay on 4T1 cells, viability was preserved at ≥86%\u0000 when treated at 12.5 μg/ml, with an IC50 concentration of 40.09 μg/ml. Further, the\u0000 extract increased the cell invasion in the invasion assay, while a reduced cell\u0000 migration was observed in the scratch assay. Cell cycle analysis using flow cytometry\u0000 demonstrated a good anti-cancer effect of EFME with cell cycle arrest in the G2/M phase.\u0000 Moreover, a remarkable anti-oxidant effect was observed in the DPPH assay. These\u0000 findings indicated the EFME exhibits significant anti-cancer, and anti-oxidant\u0000 properties but the effects were observed at a higher concentration of 40.09\u0000 μg/ml.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"47 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140411691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant and α-Glucosidase inhibitory activity of various solvent fractions from\u0000 Amaranthus viridis L., Amaranthus tricolor L., and Amaranthus spinosus L.","authors":"Bich Ngoc Giau Lu","doi":"10.55522/jmpas.v13i1.5986","DOIUrl":"https://doi.org/10.55522/jmpas.v13i1.5986","url":null,"abstract":"Amaranthus tricolor L., Amaranthus spinosus L., and Amaranthus viridis L. are\u0000 well-known for flavoring food products and traditional medicine. This study investigated\u0000 the antioxidant and α-glucosidase inhibitory activity of various solvent fractions from\u0000 the whole plant of A. tricolor, A. spinosus, and A. viridis in Vietnam. The total\u0000 extract and solvent fractions of petroleum ether (PE), chloroform (CF), ethyl acetate\u0000 (EA), n-butanol (B), and water (W) were tested for antioxidant activity using the DPPH\u0000 assay and α-glucosidase inhibition. The results showed that the three species of\u0000 Amaranthus had relatively low antioxidant activity, and the total extract of A. spinosus\u0000 L. had the highest antioxidant activity with an IC50 value of 324.96 μg/mL. The EA\u0000 fraction of A. tricolor had outstanding α-glucosidase inhibitory activity with an IC50\u0000 value of 95.94 μg/mL. It is recommended to continue isolation research to find active\u0000 ingredients with α-glucosidase inhibition potential in the EA extract of A. tricolor.\u0000 Additionally, an in vivo assay might be conducted to evaluate the activity and toxicity\u0000 of this EA fraction.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"26 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140413931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network ethnopharmacological and molecular docking based evaluation of the\u0000 anti-breast cancer activity for ayurvedic botanicals acting on hypoxia-inducible\u0000 factor-1","authors":"N. Bhatia","doi":"10.55522/jmpas.v13i1.5888","DOIUrl":"https://doi.org/10.55522/jmpas.v13i1.5888","url":null,"abstract":"The recognized root causes of breast cancer aggressiveness, resistance to therapy,\u0000 and poor prognosis encompass hypoxia-inducible factors (HIFs), the HIF-dependent cancer\u0000 hallmarks angiogenesis and metabolic reconfiguration.There is enough evidence to suggest\u0000 that HIF is involved in the progression of breast cancer.Information for the network was\u0000 gathered from the following databases: Dr. Duke's, IMPPAT, PubChem, Binding DB, UniProt,\u0000 and DisGeNET. The network was created using the Cytoscapeprogramme. Screened bioactives\u0000 having similarity index more than 0.6 from polypharmacology approach were subjected to\u0000 docking studies with HIF-1 (PDB ID: 1H2K) with PyRx software and the ligands with good\u0000 docking score was further explored for molecular docking interaction analysis. The\u0000 number of bioactives having interaction with HIF-1, equal to or greater than 0.6 from\u0000 Ashwagandh, Shatavari, Neem, Alsi seeds, Methi, Haldi, Ghritkumari, Yashtimadhu, and\u0000 KadiPatta was 12, 9, 2, 6, 12, 11, 5, 10, and 3, respectively. On performing the docking\u0000 against the target HIF-1for top molecules with Araboglycyrrhizin (-10.1kcal/mol),\u0000 Asparanin-A (-9.2 kcal/mol), Shatavarin-I (-9.2 kcal/mol), Shatavarin-X (-9.1 kcal/mol),\u0000 Somniferanolide (-9.1 kcal/mol), Somniferawithanolide (-9.7 kcal/mol), Trigofoenoside-A\u0000 (-9.2 kcal/mol), Trigofoenoside-F (-9.4 kcal/mol), Trillin (-9.9 kcal/mol), and\u0000 Withanolide (-9.2 kcal/mol), the binding energies and molecular interactions of the\u0000 ligands were fairly good as compared with standard synthetic ligand Acriflavine (-7.6\u0000 kcal/mol). The study elucidated an in silico molecular mechanism of HIF-1 inhibition by\u0000 various bioactive phytoconstituents from selected plants. Comprehending the logic behind\u0000 anti-breast cancer action was made easier with the help of experimental evidence of the\u0000 network findings.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140413879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation of nano spray preparation from Purslane Leaf Extract (Portulaca\u0000 oleracea l.) as sunscreen","authors":"Elmiawati Latifah","doi":"10.55522/jmpas.v13i1.5890","DOIUrl":"https://doi.org/10.55522/jmpas.v13i1.5890","url":null,"abstract":"Purslane plant (Portulaca oleracea L.) is a type of wild plant that grows\u0000 abundantly, but its benefits are rarely known. Purslane contains saponins, which have\u0000 high antioxidant and biological activity. Skin that is sensitive to sun exposure is the\u0000 issue this nanospray is targeting. The aim of this research is to determine the optimal\u0000 formulation of herbal nanospray products with Purslane sunscreen to treat skin problems\u0000 caused by sun exposure. The research method used was an experimental method with\u0000 research stages starting from plant determination, extract making, nanospray formulation\u0000 determination, preparation evaluation, in vivo UV protection activity test, and in vitro\u0000 SPF test. Quantitative descriptive analysis was carried out using Microsoft Excel and\u0000 SPSS Version 24. There were significant differences in erythema (lesions on the skin)\u0000 between the 4 treatment groups, with significant differences in the negative control and\u0000 positive control groups, as well as the group given dose treatment (the amount of\u0000 extract in the nanoparticles) of 0.8 g and 0.4 g of purslane extract with the negative\u0000 control. So, it can be concluded that doses of 0.8 g (SPF value: 9.9) and 0.4 g (SPF\u0000 value: 8.43) of purslane extract have the potential to be sunscreens with maximum\u0000 category and extra protective power. Purslane extract nanospray sunscreen has the\u0000 advantage of being made from herbal ingredients, which have less potential for\u0000 irritation than chemical sunscreen products.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"19 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140411658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}