Journal of Muscle Research and Cell Motility最新文献

The role of melatonin in attenuation of vascular endothelin-1 reactivity via calcium channels and endothelial derived relaxing factors in STZ-induced diabetic aortic rats. 褪黑素在stz诱导的糖尿病主动脉大鼠血管内皮素-1反应性钙通道和内皮源性舒张因子衰减中的作用。

IF 1.7 3区生物学

Journal of Muscle Research and Cell Motility Pub Date : 2026-04-22 DOI: 10.1007/s10974-026-09730-5

Chrakhan J Khdhir, Ridha H Hussein, Ismail M Maulood

引用次数: 0

Smooth muscle contractile cytoskeleton in health and disease. 平滑肌收缩细胞骨架在健康和疾病。

IF 1.7 3区生物学

Journal of Muscle Research and Cell Motility Pub Date : 2026-04-22 DOI: 10.1007/s10974-026-09731-4

Glenn Carrington, Malika Zahedi, Michelle Peckham

引用次数: 0

Effects of culture media glucose concentration on LHCN-M2 skeletal muscle cell viability, differentiation and metabolic phenotype: a proof-of-concept study. 培养基葡萄糖浓度对LHCN-M2骨骼肌细胞活力、分化和代谢表型的影响：一项概念验证研究

IF 1.7 3区生物学

Journal of Muscle Research and Cell Motility Pub Date : 2026-03-30 DOI: 10.1007/s10974-026-09729-y

Ryan Brett, Leanne Hodson, Derek Renshaw, Mark C Turner

{"title":"Effects of culture media glucose concentration on LHCN-M2 skeletal muscle cell viability, differentiation and metabolic phenotype: a proof-of-concept study.","authors":"Ryan Brett, Leanne Hodson, Derek Renshaw, Mark C Turner","doi":"10.1007/s10974-026-09729-y","DOIUrl":"https://doi.org/10.1007/s10974-026-09729-y","url":null,"abstract":"In vitro skeletal muscle culture models provide important insight into the cellular mechanisms which underpin skeletal muscle physiology and metabolism in health and disease. The establishment of a model that can be cultured in physiological concentrations of glucose is an important factor in its translatability to more complex models and systems. Using the human skeletal muscle cell line, LHCN-M2 myoblasts, we aimed to determine the effects of different concentrations of glucose in culture media on cell viability, proliferation, ATP production and differentiation. LHCN-M2 myoblasts were cultured in NORM (1 g· L- 1) or HIGH (3.8 g· L- 1) glucose growth media, and cell viability, ATP production, and proliferation were measured. Immunofluorescence microscopy was used to determine LHCN-M2 differentiation into multinucleated myotubes with increasing concentrations of human serum (0.5%, 1% and 2% v/v). There were no differences in the viability, proliferation or basal ATP production rates of LHCN-M2 cells grown in NORM compared to HIGH glucose (P > 0.05). Morphological analysis revealed that myotube area was greater when differentiated in 2% compared to 0.5% human serum (P = 0.02), but myotube number and fusion index were unaffected (P > 0.05). These findings demonstrate that LHCN-M2 cells are capable of proliferating and differentiating into multinucleated myotubes under normal glucose concentrations in the culture media. Further work is required to determine the implications of media glucose concentration on the wider metabolic function and phenotype of LHCN-M2 myoblasts cells and myotubes.","PeriodicalId":16422,"journal":{"name":"Journal of Muscle Research and Cell Motility","volume":"47 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amiodarone disrupts thyroid hormone homeostasis and impairs myogenic progression and locomotor function in zebrafish embryos. 胺碘酮破坏斑马鱼胚胎的甲状腺激素稳态并损害肌肉生成进展和运动功能。

IF 1.7 3区生物学

Journal of Muscle Research and Cell Motility Pub Date : 2026-03-21 DOI: 10.1007/s10974-026-09728-z

Juhi Vaishnav, Abhinav Upadhyay, Arya Bhatt, Suresh Balakrishnan

引用次数: 0

High-intensity interval training alleviates COPD-induced gastrocnemius muscle dysfunction via the BRD4/PGC-1α axis through restoring mitochondrial function and oxidative fiber composition. 高强度间歇训练通过恢复线粒体功能和氧化纤维组成，通过BRD4/PGC-1α轴缓解copd诱导的腓肠肌功能障碍。

IF 1.7 3区生物学

Journal of Muscle Research and Cell Motility Pub Date : 2026-03-21 DOI: 10.1007/s10974-026-09723-4

Chunjiao Zhu, Wenna Peng, Liting Yang, Wanwan Zhang

引用次数: 0

Resistance-based exercise restores muscle health in dialysis patients. 基于阻力的运动可以恢复透析患者的肌肉健康。

IF 1.7 3区生物学

Journal of Muscle Research and Cell Motility Pub Date : 2026-03-14 DOI: 10.1007/s10974-026-09727-0

Piush Srivastava, Sunil Kumar Singh, Rakesh Sathish Nair, Saket Jha, Navin Viswakarma, Deepti Srivastava, Greg Hachaj, Stephen T Bartlett, Ilaria Santi, Aslam Ejaz, Robert W Motl, Enrico Benedetti, Sandeep Kumar, Ajay Rana

{"title":"Resistance-based exercise restores muscle health in dialysis patients.","authors":"Piush Srivastava, Sunil Kumar Singh, Rakesh Sathish Nair, Saket Jha, Navin Viswakarma, Deepti Srivastava, Greg Hachaj, Stephen T Bartlett, Ilaria Santi, Aslam Ejaz, Robert W Motl, Enrico Benedetti, Sandeep Kumar, Ajay Rana","doi":"10.1007/s10974-026-09727-0","DOIUrl":"10.1007/s10974-026-09727-0","url":null,"abstract":"Chronic kidney disease (CKD) and end-stage renal disease (ESRD) are serious health concerns worldwide that require regular dialysis before a kidney transplant for a better quality of life. Due to aging and frailty, dialysis patients are often limited in physical activity, which can lead to multiple health complications and sometimes result in patient death. Therefore, maintaining muscle health is crucial for individuals undergoing dialysis. We recently reported that personalized resistance-based exercise can improve frailty in dialysis patients; however, the molecular mechanisms underlying its effects on muscle health remain unknown. RNA-Seq analysis revealed that exercise upregulates genes associated with muscle stemness, regeneration, and differentiation. Furthermore, our study demonstrated that exercise upregulates mitochondrial proteins involved in the oxidation of organic compounds and mitochondrial function in muscle. Moreover, we observed that exercise increased energy production via glucose uptake, glycogenesis, and fatty acid metabolism. These results suggest that personalized resistance-based muscle therapy in dialysis patients restores the expression of genes and proteins associated with muscle stemness, regeneration, differentiation, and energy generation.","PeriodicalId":16422,"journal":{"name":"Journal of Muscle Research and Cell Motility","volume":"47 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12989000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147458165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stair-climbing resistance exercise, with or without oral turmeric (Curcuma longa L.) supplementation, relieves symptoms and promotes musculoskeletal repair in experimental rheumatoid arthritis in rats. 在实验性类风湿性关节炎大鼠中，口服或不口服姜黄（Curcuma longa L.）补充剂进行爬楼梯阻力运动，可缓解症状并促进肌肉骨骼修复。

IF 1.7 3区生物学

Journal of Muscle Research and Cell Motility Pub Date : 2026-03-13 DOI: 10.1007/s10974-026-09726-1

Mikael Gerson Kuhn, Leticia Massochim da Silva, Flávia Heloísa da Silva, Maiara Cristina Lima de Jesus, Michele Gossler, Gabriella Lopes Cappellaro, Gladson Ricardo Flor Bertolini, Lucinéia de Fátima Chasko Ribeiro, Ana Tereza Bittencourt Guimarães, Marcia Miranda Torrejais

引用次数: 0

The effect of nimesulide on skeletal muscle hypertrophy and load progression after 8 weeks of resistance training in wistar rats. 尼美舒利对wistar大鼠8周阻力训练后骨骼肌肥大及负荷进展的影响。

IF 1.7 3区生物学

Journal of Muscle Research and Cell Motility Pub Date : 2026-03-04 DOI: 10.1007/s10974-026-09724-3

Ayron Motta da Fonseca, Ronaldo André Castelo Dos Santos de Almeida, Emerson Lopes Olivares, Anderson Luiz Bezerra da Silveira

{"title":"The effect of nimesulide on skeletal muscle hypertrophy and load progression after 8 weeks of resistance training in wistar rats.","authors":"Ayron Motta da Fonseca, Ronaldo André Castelo Dos Santos de Almeida, Emerson Lopes Olivares, Anderson Luiz Bezerra da Silveira","doi":"10.1007/s10974-026-09724-3","DOIUrl":"10.1007/s10974-026-09724-3","url":null,"abstract":"Resistance training is currently a widely targeted practice due to its ability to induce vital adaptations resulting from increased muscle strength (MS) and hypertrophy. There are reports of the concomitant use of nonsteroidal anti-inflammatory drugs with this practice for pain relief, which arises from the adaptive signaling of training. Based on this, the present study aimed to investigate whether the use of nimesulide concomitant with training could interfere with MS and hypertrophy. The sample consisted of 18 male Wistar rats, aged 91 days, with a body mass of 331 ± 20 g, divided into three groups: Control (CTRL, n = 4); Trained (TR, n = 7); and Trained and Treated with nimesulide (COMB, n = 7). The training protocol followed the ladder-climbing model. Nimesulide was administered orally at a dose of 2.5 mg/kg every day after training. Tissue collection of the Flexor Hallucis Longus (FHL) muscle was performed two days after the last training session. After eight weeks of the training protocol, a significant increase in MS was observed in TR and COMB compared to CTRL (p < 0.05). A significant increase in FHL muscle volume was observed in COMB compared to CTRL and TR only when muscle mass was normalized to body mass (p < 0.05), whereas no significant differences were detected among groups for absolute FHL mass. Additionally, there were no differences in training load or volume between COMB and TR (p ≥ 0.05). Therefore, based on the results, it is concluded that the administration of nimesulide during eight weeks of training promoted a greater hypertrophic response of the FHL muscle in rats.","PeriodicalId":16422,"journal":{"name":"Journal of Muscle Research and Cell Motility","volume":"47 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12960334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147355584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methodological framing in muscle morphology and mechanics: aligning experimental protocols with scientific questions. 肌肉形态学和力学的方法学框架：将实验方案与科学问题对齐。

IF 1.7 3区生物学

Journal of Muscle Research and Cell Motility Pub Date : 2026-02-26 DOI: 10.1007/s10974-026-09725-2

Leonardo Cesanelli, Petras Minderis, Andrej Fokin, Berta Ylaite, Nerijus Eimantas, Marius Brazaitis, Danguole Satkunskiene, Aivaras Ratkevicius, Hans Degens

引用次数: 0

Short-duration electrical pulse stimulation induces myokines and mitochondrial adaptations in C2C12 myotubes. 短时间电脉冲刺激诱导C2C12肌管中的肌因子和线粒体适应。

IF 1.7 3区生物学

Journal of Muscle Research and Cell Motility Pub Date : 2026-02-13 DOI: 10.1007/s10974-026-09722-5

Shih-Hua Fang, Ming-Ru Chiang, Chia-Yang Li, Pei-Ying Li, Zong-Jia Wu, Hsin-Hua Li

引用次数: 0