{"title":"Uterine Artery Embolization Before Myomectomy: Is It Worth the Trouble?","authors":"Diane Bula Ibula MD , Ambre Balestra MD , Panayiotis Tanos MD , Michelle Nisolle MD, PhD , Stavros Karampelas MD","doi":"10.1016/j.jmig.2024.11.009","DOIUrl":"10.1016/j.jmig.2024.11.009","url":null,"abstract":"<div><h3>Objectives</h3><div>This study compared patients who underwent myomectomy with preoperative uterine artery embolization (UAE) to those who underwent surgery without UAE. The primary objective was to analyze whether preoperative embolization reduces perioperative blood loss and other related complications. The secondary objective was to analyze the long-term outcomes of the 2 techniques in terms of fertility and obstetrical complications.</div></div><div><h3>Design</h3><div>Observational cohort retrospective study approved by the Brugmann University Hospital's ethics committee (CE2023/79).</div></div><div><h3>Setting</h3><div>The department of gynecology database was used to extract all myomectomy cases between January 2011 and December 2021. Hysteroscopic myomectomies were excluded.</div></div><div><h3>Patients</h3><div>192 patients were included.</div></div><div><h3>Interventions</h3><div>The population was divided according to the presence or absence of preoperative UAE. The UAE and myomectomy group comprised 95 cases between 2011 and 2020, while the myomectomy-only group consisted of 97 cases between 2014 and 2021.</div></div><div><h3>Measurements and Main Results</h3><div>Blood loss was significantly lower when preoperative UAE was performed (175.9 [308.5] mL versus 623.3 [697.5] mL, p-value <.0001). However, there was no significant difference in postoperative haemoglobin, blood transfusion rate or emergent hysterectomy conversions compared to myomectomy as the only treatment. UAE was associated with complications that may result in infertility, such as adhesions (15.3% UAE group vs. 2.2% non-UAE group, p-value .02) and an increased incidence of miscarriage in pregnancies (53.5% UAE group vs. 22.3% non-UAE group, p-value = .01). Furthermore, in cases where a pregnancy did progress following UAE, later obstetrical complications such as abnormal placentation or uterine rupture were common in the series (21.7% UAE group vs. 0% non-UAE group, p-value = .03).</div></div><div><h3>Conclusion</h3><div>The findings of our study indicate that, other than a lower estimated blood loss (EBL), preoperative UAE does not appear to improve the outcome of myomectomies, while potentially increasing the risk of fertility and pregnancy related complications.</div></div>","PeriodicalId":16397,"journal":{"name":"Journal of minimally invasive gynecology","volume":"32 4","pages":"Pages 386-394"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Robotic Sentinel Lymph Node Dissection for Presumed Early-Stage Epithelial Ovarian Cancer Stadification by Transperitoneal and Retroperitoneal Approaches","authors":"Blanca Valenzuela-Méndez MD, PhD , Enrica Bentivegna MD , Anne-Sophie Bats MD, PhD , Henri Azaïs MD, PhD","doi":"10.1016/j.jmig.2024.12.017","DOIUrl":"10.1016/j.jmig.2024.12.017","url":null,"abstract":"<div><h3>Introduction</h3><div>Epithelial ovarian cancer (EOC) is a significant global health concern. Early detection remains rare, with only 20% of cases identified at an early stage, highlighting the critical need for effective staging interventions [<span><span>1</span></span>]. Traditional extensive lymphadenectomy, associated with considerable morbidity, has led to the exploration of selective sentinel lymph node biopsy (SLNB), which is still under study [<span><span>1</span></span>, <span><span>2</span></span>, <span><span>3</span></span>, <span><span>4</span></span>].</div></div><div><h3>Methods</h3><div>SLNB, enhanced by robotic technology, is demonstrated through two clinical case studies studies that show how robotic systems are used to meticulously identify and map sentinel nodes, focusing on procedural specifics and fluorescence-guided node identification. The article synthesizes insights from recent studies [<span><span>1</span></span>, <span><span>2</span></span>, <span><span>3</span></span>, <span><span>4</span></span>], emphasizing the integration of robotic technology with SLNB to enhance surgical precision, improve recovery, and reduce morbidity.</div></div><div><h3>Discussion</h3><div>We examine SLNB through retroperitoneal and transperitoneal approaches, highlighting technical aspects and the benefits of robotic assistance over conventional laparoscopy, such as improved precision and ergonomics. A recent analysis and meta-analysis [<span><span>1</span></span>] showed a high pooled detection rate, though the evidence quality is low. Recently, the MELISA [<span><span>3</span></span>] and SELLY [<span><span>2</span></span>] studies were published, with MELISA showing higher detection, sensitivity, and specificity rates than SELLY. Sentinel lymph nodes vary in location, requiring meticulous exploration [<span><span>1</span></span>]. The retroperitoneal approach might offer an advantage for para-aortic dissection, particularly in obese patients, however, in sentinel lymph node biopsy, the need for extensive dissection could potentially limit its use [<span><span>5</span></span>]. Key technique aspects include injection zones and using combined tracers [<span><span>2</span></span>]. Limitations include variable detection rates, lack of standardized protocols, accessibility to robotic technology, and the need for advanced surgical skills [<span><span>1</span></span>].</div></div><div><h3>Conclusion</h3><div>SLNB, particularly with robotic assistance, shows promise for improving accuracy and reducing morbidity in epithelial ovarian cancer. However, its use remains limited to clinical trials. Future studies should focus on developing standardized protocols to achieve consistent results and provide sufficient evidence for its integration into routine clinical practice.</div></div>","PeriodicalId":16397,"journal":{"name":"Journal of minimally invasive gynecology","volume":"32 4","pages":"Pages 316-317"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Audrey Astruc MD, Constance Rio MD, Pierre Emmanuel Bouet MD, PhD, Guillaume Legendre MD, PhD
{"title":"The SYNAPPH Study: Uterine Synechiae Prevalence After a Postpartum Hemorrhage, a Pilot Study","authors":"Audrey Astruc MD, Constance Rio MD, Pierre Emmanuel Bouet MD, PhD, Guillaume Legendre MD, PhD","doi":"10.1016/j.jmig.2024.10.025","DOIUrl":"10.1016/j.jmig.2024.10.025","url":null,"abstract":"<div><h3>Study Objective</h3><div>To prospectively assess the prevalence of intrauterine synechia following medically treated postpartum hemorrhage (PPH) and to evaluate the association between synechiae formation and PPH management techniques.</div></div><div><h3>Design</h3><div>A prospective observational cohort study.</div></div><div><h3>Setting</h3><div>Angers University Hospital.</div></div><div><h3>Participants</h3><div>A total of 83 women presenting with medically treated PPH from January to December 2021 were included in the study.</div></div><div><h3>Intervention</h3><div>Diagnostic hysteroscopy was performed twelve weeks postpartum to assess for the presence of uterine synechiae. Detailed data on PPH management techniques were collected for analysis.</div></div><div><h3>Measurements and Main Results</h3><div>The majority of participants were primiparous and had undergone vaginal delivery. Only 7% required intrauterine balloon tamponade (IUBT), and 4% underwent uterine artery embolization. Uterine synechiae were identified in 20 women during diagnostic hysteroscopy, yielding a prevalence of 24% at 12 weeks postpartum; all classified as type I according to the ESGE classification system. IUBT was used in 15% of women with synechiae compared to 5% in the nonsynechiae group, although this difference was not statistically significant (OR 3.52, 95% CI 0.65–19.10, p = .123). Multivariate analysis identified second manual uterine examination (OR 5.00, 95% CI 1.50–16.66, p = .009) and bimanual uterine massage (OR 3.50, 95% CI 1.12–10.09, p = .020) as independent risk factors for synechiae formation.</div></div><div><h3>Conclusion</h3><div>This is the first study to evaluate the risk of intrauterine synechiae following medically treated PPH. Mild uterine synechiae were observed in one in four women in the cohort. The need for a second manual uterine examination and bimanual uterine massage were significantly associated with the development of synechiae. Further research is warranted to explore the long-term clinical consequences, including fertility outcomes, and to determine the potential role of diagnostic hysteroscopy in postpartum follow-up after PPH.</div></div><div><h3>Summation</h3><div>The study prospectively investigates the prevalence of uterine synechiae following nonsurgical postpartum hemorrhage, revealing a 24% occurrence, with second manual uterine examination and bimanual massage identified as independent risk factors.</div></div>","PeriodicalId":16397,"journal":{"name":"Journal of minimally invasive gynecology","volume":"32 4","pages":"Pages 365-371.e1"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wanlin Zhang MD , Ruonan Tang MM , Xifeng Xiao MD , Jin Liu MD , Mao Li MM , Xiaohong Wang MD
{"title":"A Comparative Study on the Efficacy of Subendometrial Versus Intrauterine Platelet-Rich Plasma Injections for Treating Intrauterine Adhesions: A Retrospective Cohort Study","authors":"Wanlin Zhang MD , Ruonan Tang MM , Xifeng Xiao MD , Jin Liu MD , Mao Li MM , Xiaohong Wang MD","doi":"10.1016/j.jmig.2024.11.007","DOIUrl":"10.1016/j.jmig.2024.11.007","url":null,"abstract":"<div><h3>Objective</h3><div>Comparison of the clinical efficacy of hysteroscopic subendometrial injection of platelet-rich plasma (PRP) and intrauterine instillation of PRP for the treatment of intrauterine adhesions.</div></div><div><h3>Design</h3><div>A Retrospective Cohort Study.</div></div><div><h3>Setting</h3><div>University hospital.</div></div><div><h3>Patients</h3><div>Patients who underwent hysteroscopic transcervical excision of adhesions from September 1, 2020, to July 31, 2023, and were treated with PRP in the postoperative period were included.</div></div><div><h3>Interventions</h3><div>Subendometrial PRP injection group (referred to as SE-PRP group) and intrauterine PRP infusion group (referred to as IU-PRP group)</div></div><div><h3>Measures and main results</h3><div>A total of 299 patients with moderate-to-severe IUA treated with PRP after Transcervical resection of adhesions (TCRA) were included. The primary outcome metric was the clinical pregnancy rate, and the secondary outcome metrics were the rate of menstrual improvement and the AFS score. The results showed that: the AFS reduction scores was greater in the SE-PRP group than in the IU-PRP group (8 vs 7, p = 0.019); the menstrual improvement rate in the SE-PRP group was higher than that in the IU-PRP group (77.0% vs 52.9%, p < 0.001); and the clinical pregnancy rate in the SE-PRP group was similar than that in the clinical pregnancy rate in the IU-PRP group (28.4% vs 20.4%, p = 0.208). The results of multifactorial logistic regression analysis showed that the clinical pregnancy rate in the SE-PRP group was significantly higher than that in the IU-PRP group (OR = 2.020, 95% CI = 1.050–3.889, p = 0.035). The results of the propensity score matching (PSM) analysis showed that: the median postoperative AFS score reduction was significantly higher in the SE-PRP group than in the IU-PRP group (p = 0.015); and the rate of improvement in menstruation was significantly higher in the matched SE-PRP group (75.0% vs 58.1%, p = 0.027) and clinical pregnancy rates were higher in the SE-PRP group (29.4% vs 16.2%, p = 0.043).</div></div><div><h3>Conclusions</h3><div>Hysteroscopic intrauterine PRP injection is more clinically effective than intrauterine PRP infusion for patients with moderate to severe intrauterine adhesions, resulting in greater reduction in adhesion scores, improvement in menstrual rate, and increased clinical pregnancy rate.</div></div>","PeriodicalId":16397,"journal":{"name":"Journal of minimally invasive gynecology","volume":"32 4","pages":"Pages 378-385.e1"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}