Journal of NeuroEngineering and Rehabilitation最新文献

{"title":"Hands-free Atalante exoskeleton in post-stroke gait and balance rehabilitation: a safety study.","authors":"Thierry Lejeune, Dijana Nuic, Stéphanie Dehem, Jean-Gabriel Previnaire, Céline Cuenot, Thierry Debugne, Jerome Kaps, Bérénice Paul, Vincent Pean, Sergi Sanz Perez, Fanny Juhel, Soultana Tatsidou, Jacques Kerdraon","doi":"10.1186/s12984-025-01621-z","DOIUrl":"https://doi.org/10.1186/s12984-025-01621-z","url":null,"abstract":"<p><strong>Background: </strong>Stroke often results in gait dysfunction, impairing daily activities and quality of life. Overground robotic exoskeletons hold promise for post-stroke rehabilitation. This study primarily aimed to assess the safety of hands-free Atalante exoskeleton training in post-stroke subjects, with a secondary aim to assess gait and balance.</p><p><strong>Methods: </strong>Forty subjects (10.2 ± 12.1 months post-stroke) with gait dysfunction (Functional Ambulation Category [FAC] score ≤ 3) underwent five training sessions over three weeks with a hands-free exoskeleton (Atalante, Wandercraft, France). Safety, the primary outcome, was evaluated by the number and severity of adverse events (AEs), judged by an independent clinical evaluation committee (CEC). A usability test was performed during the fifth training session followed by the exoskeleton use questionnaire. Gait and balance were assessed pre/post-training via walking capacity score (FAC), gait speed by 10-meter walk test (10MWT), walked distance by 6-minute walk test (6MWT), and balance by Berg Balance Scale (BBS). Spasticity was assessed with the Modified Ashworth scale. Anxiety and depression were quantified using the Hospital Anxiety and Depression Scale. Safety outcomes were analyzed using the Wilson, Lee and Dubin methods for proportions, and occurrence rates were computed. Within-group differences were compared using Wilcoxon, McNemar, and Friedman tests, with significance set at P < 0.05.</p><p><strong>Results: </strong>Thirty-one subjects completed the training sessions, while nine discontinued. The study reported two serious adverse events (SAE) (vertigo, dysarthria) and six AEs, with the CEC concluding that no SAE was linked to the device/study procedure. The average AE rate per session was 2.5 ± 1.4%, including four events possibly linked to the device/study procedure (knee pain [n = 1], skin lacerations [n = 3]), classified as negligible or minor by the CEC. A high proportion (82.6%) successfully completed the usability test and reported satisfaction (90%) on the exoskeleton use questionnaire. For gait and balance, favorable changes were observed in FAC, 10MWT, 6MWT, and BBS scores Post-training (p < 0.05, respectively). Spasticity, anxiety, and depression remained unchanged.</p><p><strong>Conclusions: </strong>This study indicates that the hands-free Atalante exoskeleton is safe, feasible, and well-tolerated for gait and balance rehabilitation in post-stroke subjects, warranting larger randomized controlled trials to assess its efficacy.</p><p><strong>Trial registration: </strong>Evaluation of the Use of the Atalante Exoskeleton in Patients Presenting an Hemiplegia Due to Cerebrovascular Accident (INSPIRE) trial was registered at ClinicalTrials.gov (NCT04694001, registered on 20201231).</p>","PeriodicalId":16384,"journal":{"name":"Journal of NeuroEngineering and Rehabilitation","volume":"22 1","pages":"82"},"PeriodicalIF":5.2,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posturographic sensory ratios provide evidence for neuroplasticity after computerized vestibular rehabilitation therapy in a single group interventional trial.","authors":"Eytan A David, Navid Shahnaz","doi":"10.1186/s12984-025-01608-w","DOIUrl":"10.1186/s12984-025-01608-w","url":null,"abstract":"<p><strong>Background: </strong>Vestibular deficits are common and debilitating. Many patients do not achieve satisfactory resolution of their symptoms with standard rehabilitation techniques. This study seeks to measure changes in computerized dynamic posturography sensory ratio information after computerized vestibular retraining therapy (CVRT).</p><p><strong>Methods: </strong>This prospective, single group, interventional study enrolled adult participants with stable, unilateral vestibular deficits. Before and after twelve twice weekly sessions of CVRT, and 4-6 and 10-12 months post-treatment, participants completed the Sensory Organization Test, from which sensory ratios (somatosensory - SOM, visual - VIS, vestibular - VEST, and visual preference - PREF) were calculated.</p><p><strong>Results: </strong>13 participants completed the intervention and post-retraining assessment; 9 completed the 4-6 and 10-12 month assessments. After CVRT, VIS increased by 11.6 (1.6 to 21.7) and VEST increased by 9.5 (0.6 to 18.3) and both remained significantly above baseline 10-12 months after treatment. The SOM and PREF ratios changed negligibly. Participants with mild disability (DHI ≤ 30) showed no change while participants with moderate-to-severe disability (DHI > 30) had significantly greater improvements in VIS (P = 0.0006) and VEST (P = 0.02) across all three post-treatment assessments.</p><p><strong>Conclusions: </strong>CVRT was associated with durable improvement in VIS and VEST sensory ratios and improved postural control under conditions that favour use of vestibular information, consistent with increased weighting of vestibular information over vision.</p><p><strong>Trial registration: </strong>Clinicaltrials.gov registration NCT04875013; 04/27/2021.</p>","PeriodicalId":16384,"journal":{"name":"Journal of NeuroEngineering and Rehabilitation","volume":"22 1","pages":"81"},"PeriodicalIF":5.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is physical therapy recommended for people with parkinson's disease treated with subthalamic deep brain stimulation? a delphi consensus study.","authors":"Matteo Guidetti, Sara Marceglia, Tommaso Bocci, Ryan Duncan, Alfonso Fasano, Kelly D Foote, Clement Hamani, Joachim K Krauss, Andrea A Kühn, Francesco Lena, Patricia Limousin, Andres M Lozano, Natale V Maiorana, Nicola Modugno, Elena Moro, Michael S Okun, Serena Oliveri, Marco Santilli, Alfons Schnitzler, Yasin Temel, Lars Timmermann, Veerle Visser-Vandewalle, Jens Volkmann, Alberto Priori","doi":"10.1186/s12984-025-01616-w","DOIUrl":"https://doi.org/10.1186/s12984-025-01616-w","url":null,"abstract":"<p><strong>Background: </strong>Although deep brain stimulation of the subthalamic nucleus (STN-DBS) induces motor benefits in people with Parkinson's disease (PwPD), its effect on motor axial symptoms (e.g., postural instability, trunk posture alterations) and gait impairments (e.g., freezing of gait) is still ambiguous. Physical therapy (PT) effectively complements pharmacological treatment to improve postural stability, gait performance, and other dopamine-resistant symptoms (e.g. freezing of gait) in the general population with PD. Despite the positive potential of combined PT and STN-DBS surgery, scientific results are still lacking. We therefore involved worldwide leading experts on DBS and motor rehabilitation in PwPD in a consensus Delphi panel to define the current level of PT recommendation following STN-DBS surgery.</p><p><strong>Methods: </strong>After summarizing the few available findings through a systematic scoping review, we identified clinically and academically experienced DBS clinicians (n = 21) to discuss the challenges related to PT following STN-DBS. A 5-point Likert scale questionnaire was used and based on the results of the systematic review, thirty-nine questions were designed and submitted to the panel-half related to general considerations on PT following STN-DBS, and half related to PT treatments.</p><p><strong>Results: </strong>Despite the low-to-moderate quality of data, the few available rehabilitation studies suggested that PT could improve dynamic and static balance, gait performance and posture in the population with PD receiving STN-DBS. Similarly, the panellists strongly agreed that PT might help improve motor symptoms and quality of life, and it may be prescribed to maximize the effects of stimulation. The experts agreed that physical therapists could be part of the multidisciplinary team taking care of the patients. Also, they agreed that conventional PT, but not massage or manual therapy, should be prescribed because of the specificity of STN-DBS implantation.</p><p><strong>Conclusions: </strong>Although RCT evidence is lacking, upon Delphi panel, PT for PwPD receiving STN-DBS can be potentially useful to maximize clinical improvement. However, more research is needed, with RCTs and well-designed studies. The rehabilitation and DBS community should expand this area of research to create guidelines for PT following STN-DBS.</p>","PeriodicalId":16384,"journal":{"name":"Journal of NeuroEngineering and Rehabilitation","volume":"22 1","pages":"80"},"PeriodicalIF":5.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare practitioners and robotic-assisted rehabilitation: understanding needs and barriers.","authors":"Giovanna Nicora, Enea Parimbelli, Maria Cristina Mauro, Francesca Falchini, Marco Germanotta, Alessio Fasano, Giuseppina Sgandurra, Elena Beani, Emanuele Gruppioni, Francesca Bugané, Irene Giovanna Aprile, Silvana Quaglini","doi":"10.1186/s12984-025-01593-0","DOIUrl":"https://doi.org/10.1186/s12984-025-01593-0","url":null,"abstract":"<p><strong>Backgrounds: </strong>In recent years, numerous robotic devices, together with allied technologies, have been developed to support rehabilitation, both in research settings and industry. Although robotic-assisted rehabilitation and related technologies hold significant promise for supporting healthcare practitioners and enhancing patient care, their use in clinical practice remains limited. One of the motivations could be that final users' needs have not been given due consideration so far. As a matter of fact, understanding user needs and perceptions is crucial for designing these technological devices and for creating new organizational models within hospitals aiming to establish and maintain robotics-assisted rehabilitation gyms.</p><p><strong>Methods: </strong>We developed and distributed an online survey to the Italian community of healthcare practitioners working in rehabilitation, to depict the current landscape of robotic-assisted rehabilitation and to understand their opinions and demands across various domains and diseases. The questionnaire is divided into two main parts. The first section pertains to the respondents' demographics and professional experience. The second part includes questions about eight different categories of rehabilitative devices. For each category, practitioners can indicate whether they use a device in their practice, their perceptions, and any perceived barriers. Additionally, they can fill out a System Usability Scale for a specific device in that category.</p><p><strong>Results: </strong>We collected answers from 423 Italian rehabilitation professionals, including various clinical roles, that revealed significant insights into the use of robotics in rehabilitation. Gender distribution shows a high prevalence of female professionals. 40% of respondents reported being unfamiliar with any robotics devices. Advanced treadmills are the most known and used robots. Generally, usage and experience with devices are associated with positive attitudes towards robotics-assisted rehabilitation. Lack of financial resources and scientific evidence, as well as lack of opportunities and training, are the most reported barriers.</p><p><strong>Conclusions: </strong>Despite a general positivity towards technology, there is a substantial lack of awareness about rehabilitation devices among professionals. The survey highlights the need for enhanced training and education on robotics in rehabilitation programs. Additionally, the limited focus on home rehabilitation is noted. The study emphasizes the importance of verifying both the effectiveness and economic sustainability of robotic devices in clinical practice.</p>","PeriodicalId":16384,"journal":{"name":"Journal of NeuroEngineering and Rehabilitation","volume":"22 1","pages":"78"},"PeriodicalIF":5.2,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11983797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review of AI/ML applications in multi-domain robotic rehabilitation: trends, gaps, and future directions.","authors":"Giovanna Nicora, Samuele Pe, Gabriele Santangelo, Lucia Billeci, Irene Giovanna Aprile, Marco Germanotta, Riccardo Bellazzi, Enea Parimbelli, Silvana Quaglini","doi":"10.1186/s12984-025-01605-z","DOIUrl":"10.1186/s12984-025-01605-z","url":null,"abstract":"<p><p>Robotic technology is expected to transform rehabilitation settings, by providing precise, repetitive, and task-specific interventions, thereby potentially improving patients' clinical outcomes. Artificial intelligence (AI) and machine learning (ML) have been widely applied in different areas to support robotic rehabilitation, from controlling robot movements to real-time patient assessment. To provide an overview of the current landscape and the impact of AI/ML use in robotics rehabilitation, we performed a systematic review focusing on the use of AI and robotics in rehabilitation from a broad perspective, encompassing different pathologies and body districts, and considering both motor and neurocognitive rehabilitation. We searched the Scopus and IEEE Xplore databases, focusing on the studies involving human participants. After article retrieval, a tagging phase was carried out to devise a comprehensive and easily-interpretable taxonomy: its categories include the aim of the AI/ML within the rehabilitation system, the type of algorithms used, and the location of robots and sensors. The 201 selected articles span multiple domains and diverse aims, such as movement classification, trajectory prediction, and patient evaluation, demonstrating the potential of ML to revolutionize personalized therapy and improve patient engagement. ML is reported as highly effective in predicting movement intentions, assessing clinical outcomes, and detecting compensatory movements, providing insights into the future of personalized rehabilitation interventions. Our analysis also reveals pitfalls in the current use of AI/ML in this area, such as potential explainability issues and poor generalization ability when these systems are applied in real-world settings.</p>","PeriodicalId":16384,"journal":{"name":"Journal of NeuroEngineering and Rehabilitation","volume":"22 1","pages":"79"},"PeriodicalIF":5.2,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11984262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical peripheral stimulation for the treatment of gait disorders in patients with Parkinson's disease: a multi-centre, double-blind, crossover randomized controlled trial.","authors":"Maria Francesca De Pandis, Carlo Tomino, Stefania Proietti, Rossella Rotondo, Maria Gaglione, Miriam Casali, Massimo Corbo, Lazzaro di Biase, Manuela Galli, Michela Goffredo, Fabrizio Stocchi","doi":"10.1186/s12984-025-01574-3","DOIUrl":"10.1186/s12984-025-01574-3","url":null,"abstract":"<p><strong>Background: </strong>Pharmacological, surgical and physical therapies ameliorate motor and non-motor symptoms in Parkinson's disease (PD). Unfortunately, the progression of the disease induces deterioration in daily activities, especially in gait and balance. Invasive and non invasive medical devices have been developed to alleviate drug-resistant symptoms in patients with advanced PD, and automated mechanical peripheral stimulation (AMPS) has been proposed as a new rehabilitative approach.</p><p><strong>Methods: </strong>This multicentre, double-blind, crossover randomized controlled trial included 83 participants with PD assigned to two groups: AMPS treatment (Gondola^® group, n = 40) and placebo treatment (SHAM group, n = 43). The intervention consisted of 6 sessions of stimulation over 3 weeks (AMPS or SHAM), interspersed with a wash-out period of 6 weeks, before switching groups. The aim of this study was to evaluate the effects of AMPS treatment on gait speed and gait-related disorders in subjects with PD.</p><p><strong>Results: </strong>The Gondola^® device resulted in a moderate clinical impact on gait speed in people with PD since the improvement in walking speed exceeded the cut-off of 0.14 m/s in both treatments. The improvement in walking velocity was accompanied by a significantly longer stride length and a prominent increase in % stride length without altering gait cadence in the Gondola^® group compared with the SHAM group.</p><p><strong>Conclusions: </strong>AMPS stimulation improved gait speed in people with PD. Trial registration ClinicalTrials.gov identifier: NCT03843268. Date of registration: 12 Feb 2019, retrospectively registered.</p>","PeriodicalId":16384,"journal":{"name":"Journal of NeuroEngineering and Rehabilitation","volume":"22 1","pages":"77"},"PeriodicalIF":5.2,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11978199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring balance control mechanisms in people with multiple sclerosis in virtual reality environment: a systematic review.","authors":"Badriah Alayidi, Emad Al-Yahya, Donal McNally, Stephen P Morgan","doi":"10.1186/s12984-025-01612-0","DOIUrl":"10.1186/s12984-025-01612-0","url":null,"abstract":"<p><strong>Background: </strong>Multiple sclerosis (MS) impairs balance control, affecting mobility and quality of life. Virtual reality (VR) offers a novel way to study balance mechanisms and potential rehabilitation. This review examines balance control in MS patients using VR, comparing responses in VR and non-VR settings with those of healthy controls.</p><p><strong>Methods: </strong>This systematic review adhered to PRISMA guidelines. Comprehensive searches were conducted across databases including PubMed, Web of Science, Scopus, CINAHL, and ScienceDirect. Studies involving individuals with MS were analyzed to explore population characteristics and types of VR environments employed. Data extraction focused on participant demographics, clinical profiles, VR configurations, and reported outcomes.</p><p><strong>Results: </strong>The potential value of VR training in this population was explored via systematic review. 23 studies highlighted the potential of VR environments to explore balance mechanisms in MS. Diverse VR types, ranging from immersive to semi-immersive systems, were used to assess postural control, functional balance outcomes, gait, and mobility. Despite variability in methodologies and reported outcomes, changes in functional measures such as gait and balance were frequently observed. This variability underscores the need for standardized protocols to enhance the comparability and application of VR in MS rehabilitation.</p><p><strong>Conclusion: </strong>This systematic review highlights the variability in assessed balance response outcomes in PwMS.</p>","PeriodicalId":16384,"journal":{"name":"Journal of NeuroEngineering and Rehabilitation","volume":"22 1","pages":"75"},"PeriodicalIF":5.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision neuroregulation combining liquid metal and magnetic stimulation.","authors":"Yuheng Wang, Junjie Lin, Kai Zhu, Yuhui Nie, Mengyuan Wang, Xiaoxu Ma, Xu Liu, Ruru Wang, Wenshu Mai, Fangxuan Chu, Ruixu Liu, Jiankang Wu, Jingna Jin, Xiaoqing Zhou, Ren Ma, Xin Wang, Tao Yin, Zhipeng Liu, Shunqi Zhang","doi":"10.1186/s12984-025-01575-2","DOIUrl":"10.1186/s12984-025-01575-2","url":null,"abstract":"<p><strong>Background: </strong>Electromagnetic field-based neuroregulation technology is a crucial technique for treating central nervous system and peripheral nervous system disorders. However, the use of invasive electrodes has unavoidable problems such as the risk of inflammation due to high hardness, electrical connections and the need for batteries. On the other hand, non-invasive magnetic stimulation has limitations such as centimeter-level focal areas and shallow stimulation depth.</p><p><strong>Methods: </strong>To enhance the precision and effectiveness of wireless magnetic stimulation, we employed a figure-8 magnetic stimulation coil (8-coil) to generate a magnetic field, combined with an injectable, highly conductive, and flexible liquid metal (LM) to produce a millimeter-scale focused electric field. A coaxial electric field measurement electrode was used to establish an agar phantom-based electric field measurement platform. The sciatic nerve of C57 mice was stimulated under acute anesthesia conditions, and electromyography (EMG) signals were collected to evaluate the enhancement of stimulation effects. Long-term safety was assessed through four weeks of implantation.</p><p><strong>Results: </strong>Theoretical analysis and finite element simulations demonstrated that the combination of LM and the 8-coil generated a millimeter-scale enhanced vector electric field within the tissue. Measured electric field distributions closely aligned with theoretical and simulation results. In the sciatic nerve experiments on mice, 1 µL of LM under a 0.45 T magnetic field significantly increased EMG signals and leg movement amplitude by approximately 500%. Long-term implantation under magnetic stimulation revealed no adverse effects.</p><p><strong>Conclusions: </strong>This method utilizes focused electric fields to improve the precision and effectiveness of neuro-magnetic stimulation. It holds promise as a novel approach for precise stimulation. Preliminary evidence was provided for the safety of in vivo LM implantation under external magnetic fields.</p>","PeriodicalId":16384,"journal":{"name":"Journal of NeuroEngineering and Rehabilitation","volume":"22 1","pages":"76"},"PeriodicalIF":5.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Distinct and additive effects of visual and vibratory feedback for motor rehabilitation: an EEG study in healthy subjects.","authors":"Ahmed Adham, Hugo Bessaguet, Lucas Struber, Diana Rimaud, Etienne Ojardias, Pascal Giraux","doi":"10.1186/s12984-025-01615-x","DOIUrl":"10.1186/s12984-025-01615-x","url":null,"abstract":"","PeriodicalId":16384,"journal":{"name":"Journal of NeuroEngineering and Rehabilitation","volume":"22 1","pages":"74"},"PeriodicalIF":5.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between lower extremity movement patterns and ACL loading in CAI patients across varied ankle sprain frequencies within a year.","authors":"Zeyi Zhang, Shengmeng Wei, Hanlin Shi, Youping Sun","doi":"10.1186/s12984-025-01552-9","DOIUrl":"10.1186/s12984-025-01552-9","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the relationship between the biomechanical characteristics of lower extremity and anterior cruciate ligament (ACL) loading during single-leg landing in patients with chronic ankle instability (CAI) who have different ankle sprain frequencies within a year.</p><p><strong>Study design: </strong>Cross-sectional study; Level of evidence, 3.</p><p><strong>Methods: </strong>The incidence of ankle sprains among 74 male participants was meticulously documented over a one-year period. The participants had an average age of 21.78 years, a height of 176.37 cm, and a weight of 72.61 kg. Subsequently, a one-year monitoring period was implemented to assess the incidence of ankle sprains among the participants. The participants were classified into five groups according to their documented frequency of ankle sprains. The categories were as follows: The 2, 3, 4, 5, and 6 or more ankle sprain groups. Kinematic, kinetic, and electromyographic data were collected while participants performed a single-leg landing task. Lower extremity muscle force and ACL loading were modeled using OpenSim software.</p><p><strong>Results: </strong>CAI patients with more than four ankle sprains had higher peak ACL loading during single-leg landing than those with only two or three ankle sprains (P < 0.05). Additionally, CAI patients with more than four ankle sprains exhibited a limited range of ankle dorsiflexion and biceps femoris muscle force, which was significantly correlated with ACL loading (P < 0.05). CAI patients with more than 5 ankle sprains had greater ankle inversion angle, inversion angular velocity, vertical ground reaction force (GRF), rectus femoris muscle strength, and lower gastrocnemius, soleus muscle force during single-leg landing, and these biomechanical indices were significantly correlated with ACL strain (P < 0.05).</p><p><strong>Conclusion: </strong>Based on these findings, it appears that experiencing four ankle sprains within a year might be a threshold for the development of knee compensation in CAI patients. This compensation could result in a significant increase in ACL loading. The study also found that CAI patients with more than four ankle sprains commonly exhibited altered motor characteristics such as limited ankle dorsiflexion angle, increased ankle inversion angle, excessive vertical GRF, and insufficient gastrocnemius and soleus muscle force during the landing phase. These characteristics might be responsible for the observed increase in ACL loading. In the future, clinical practice and scientific research may benefit from targeted interventions to prevent ACL injuries in CAI patients with different sprain histories, in accordance with the findings of this study.</p>","PeriodicalId":16384,"journal":{"name":"Journal of NeuroEngineering and Rehabilitation","volume":"22 1","pages":"72"},"PeriodicalIF":5.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}