Journal of Nepal Health Research Council最新文献

Immunogenicity and Safety Profile of Typhoid Conjugate Vaccine (Vi-DT) Among Nepali Children. 尼泊尔儿童伤寒结合疫苗的免疫原性和安全性

Journal of Nepal Health Research Council Pub Date : 2025-06-29 DOI: 10.33314/jnhrc.v23i01.5251

Santosh Adhikari, Ganesh Kumar Rai, Ram Hari Chapagain, Bishnu Rath Giri, Prakash Joshi, Nisha Jyoti Shrestha, Bina Prajapati Manandhar, Suresh Man Tamang, Jessica Maharjan, Bibesh Thapaliya, Birendra Prasad Gupta, Deok Ryun Kim, Sridhar Vemula, Sushant Sahastrabuddhe, Tarun Saluja

{"title":"Immunogenicity and Safety Profile of Typhoid Conjugate Vaccine (Vi-DT) Among Nepali Children.","authors":"Santosh Adhikari, Ganesh Kumar Rai, Ram Hari Chapagain, Bishnu Rath Giri, Prakash Joshi, Nisha Jyoti Shrestha, Bina Prajapati Manandhar, Suresh Man Tamang, Jessica Maharjan, Bibesh Thapaliya, Birendra Prasad Gupta, Deok Ryun Kim, Sridhar Vemula, Sushant Sahastrabuddhe, Tarun Saluja","doi":"10.33314/jnhrc.v23i01.5251","DOIUrl":"10.33314/jnhrc.v23i01.5251","url":null,"abstract":"Background: Typhoid fever remains a major concern in tropical countries. The availability of an effective vaccine could be an important inclusion to currently available interventions. We reported on our evaluation of the immunogenicity and safety of the typhoid conjugate vaccine (Vi-DT) among Nepali children.Methods: The study was an observer blinded, active controlled, randomized phase III clinical trial in children above 6 months and less than 18 years old. Three different lots of Vi-DT(Vi- Diptheria Toxoid); test vaccine and Vi-TT ( Vi-Tetanus Toxoid); comparator vaccines were administered to eligible children. Seroconversion was assessed with blood samples collected at baseline and 4 weeks after the vaccination. A rise of at least 4-fold vi-antibody titer from the baseline was used to indicate positive seroconversion. Data on solicited and unsolicited adverse events were collected.Results: Four hundred and eighty-eight children participated in the study. Seroconversion rate was 98.61% and 98.36% among participants who received Vi-DT and Vi-TT vaccines respectively. One immediate adverse event was observed only for Vi-DT group. One hundred forty-two and 66 solicited AEs within 7 days were observed with test and comparator vaccine respectively. Unsolicited AEs within 28 days were 125 for test vaccine compared and 77 for the comparator vaccine. Two SAEs were reported which were Not- related to study vaccine.Conclusions: The overall seroconversion in Vi DT vaccine was non inferior to the comparator vaccine and the safety profile of the vaccine was good without any life-threatening events.","PeriodicalId":16380,"journal":{"name":"Journal of Nepal Health Research Council","volume":"23 1","pages":"82-88"},"PeriodicalIF":0.0,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seroprevelance of Dengue Among Healthy Blood Donors in Blood bank: Comment. 血库健康献血者登革热血清阳性率分析

Journal of Nepal Health Research Council Pub Date : 2025-06-29 DOI: 10.33314/jnhrc.v23i01.5569

Hinpetch Daungsupawong, Viroj Wiwanitkit

引用次数: 0

Determination of strategies used for the prevention of mosquito bites. 确定预防蚊虫叮咬的策略。

Journal of Nepal Health Research Council Pub Date : 2025-06-29 DOI: 10.33314/jnhrc.v23i01.5144

Raj Kumar Thapa

{"title":"Determination of strategies used for the prevention of mosquito bites.","authors":"Raj Kumar Thapa","doi":"10.33314/jnhrc.v23i01.5144","DOIUrl":"https://doi.org/10.33314/jnhrc.v23i01.5144","url":null,"abstract":"Background: Vector borne diseases are one of the prevailing global healthcare problems caused by mosquito bites. The main objective of this study was to determine the strategies used for the prevention of mosquito bites by general public of Kaski district, a mosquito bite prone area of Western Nepal, as evidenced by rising dengue cases.Methods: A cross-sectional study with 435 households were surveyed, for the strategies used for mosquito bite prevention, in representative 15 wards of one metropolitan and four rural municipalities of Kaski district, selected by simple random sampling technique. The survey was conducted during a period of November, 2022 - February, 2023. Data was analyzed using Statistical Package for Social Science (SPSS).Results: Approximately 4% of study participants used traditional methods such as smoke from burnt medicinal plants, burnt clothes and grass, and the application of mustard oil for the prevention of mosquito bites. Majority (92%) of participants used non-traditional methods like mosquito net, mosquito incense, mosquito bat and mosquito repellent for the prevention of mosquito bites. Only 13% of study participants used some kind of personal use mosquito repellent; cream being the most commonly used one. Age, ethnicity, residence, education and income were found to be significantly associated with the use of mosquito bite prevention strategy. Majority of the respondents were unaware of the governmental plans and their implementation for mosquito control and bite prevention strategies.Conclusion: This study summarises the strategies used for the prevention of mosquito bites by the residents of Kaski district of Nepal. Future interventional studies are warranted to enhance the awareness about the effective strategies for the prevention of mosquito bites.","PeriodicalId":16380,"journal":{"name":"Journal of Nepal Health Research Council","volume":"23 1","pages":"47-58"},"PeriodicalIF":0.0,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Altitude on Metabolic Syndrome. 海拔对代谢综合征的影响。

Journal of Nepal Health Research Council Pub Date : 2025-06-29 DOI: 10.33314/jnhrc.v23i01.5525

Mahendra Prasad Bhatt, Manavi Poudel, Sushant Pokhrel, Anuradha Kadel, Mukesh Joshi

{"title":"Effect of Altitude on Metabolic Syndrome.","authors":"Mahendra Prasad Bhatt, Manavi Poudel, Sushant Pokhrel, Anuradha Kadel, Mukesh Joshi","doi":"10.33314/jnhrc.v23i01.5525","DOIUrl":"https://doi.org/10.33314/jnhrc.v23i01.5525","url":null,"abstract":"Background: Metabolic syndrome is a constellation of overweight/obesity, hypertension, and disturbances in lipid and carbohydrate metabolism. Hypoxic and hypobaric conditions of high altitude alter the use of energy producing metabolic fuels which may secondarily affect lipid and blood glucose concentrations. Thus, this study aims to assess prevalence and risk factors of the metabolic syndrome in high and low altitude inhabitants of Nepal.Methods: A hospital based descriptive cross-sectional study was carried out including 58 individuals from high altitude and 58 individuals from low altitude attending Manmohan Memorial Teaching Hospital, Kathmandu. Anthropometric measurements and blood pressure were recorded and blood samples were obtained for laboratory analysis. The samples were analyzed for fasting glucose, triglycerides, total cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol as per the standard guidelines.Results: Among the study group, 31.8% of high altitude and 68.2% of low altitude are found to have metabolic syndrome according to National Cholesterol Education Program Adult Treatment PlanIII and 35.5% of high altitude and 64.5% of low altitude are found to have metabolic syndrome according to HJSS criteria. The most prevalent defining components were low high density lipoprotein cholesterol (38.8%), high triglyceride (36.2%), elevated fasting blood sugar (33.6%) and Hypertension (34.4%). Among the lifestyle factors, alcohol consumption, unhealthy diet and physical inactivity were found to be an independent risk factors for MetS.Conclusions: High altitude inhabitants have significantly lower metabolic syndrome than that of low altitude inhabitants because of less physical activities in their work and sedentary. Thus, encouragement of food habit, healthy lifestyle, and timely health screening and monitoring help in prevention of metabolic syndrome.","PeriodicalId":16380,"journal":{"name":"Journal of Nepal Health Research Council","volume":"23 1","pages":"145-151"},"PeriodicalIF":0.0,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Association Between ABO Blood Groups and Adenomyosis. ABO血型与bbb的关系。

Journal of Nepal Health Research Council Pub Date : 2025-06-29 DOI: 10.33314/jnhrc.v23i01.5621

Sunita Pun, Neebha Ojha, Poonam Koirala

{"title":"The Association Between ABO Blood Groups and Adenomyosis.","authors":"Sunita Pun, Neebha Ojha, Poonam Koirala","doi":"10.33314/jnhrc.v23i01.5621","DOIUrl":"https://doi.org/10.33314/jnhrc.v23i01.5621","url":null,"abstract":"Background: Several studies have investigated the relationships between female reproductive diseases and ABO blood groups. However, evidence regarding the potential association between ABO blood groups and adenomyosis remains limited. The aim of the study, thus, was to investigate the association between ABO blood groups and the risk of developing adenomyosis in Nepalese women.Methods: A cross-sectional study was conducted at the department of obstetrics and gynecology, Tribhuvan University Teaching Hospital, Maharajgunj, from 2016 to 2017. Statistical analysis was done using Statistical Package for Social Sciences (SPSS, 29). Odd ratio with their corresponding 95% confidence intervals, and P-value were calculated and analyzed. A P-value equal or < 0.05 was considered statistically significant. Results: A total of 249 with recorded ABO groups were included in this study. Of these, 85 cases (34%) were histologically confirmed to have adenomyosis. The most frequent ABO blood group was B (43%), while the least frequent group was AB (6%). Women with blood group B had a significantly increased risk of developing adenomyosis, with an odds ratio of 2.3 (95% CI: 1.22-4.43, P value = 0.01). Conversely, blood group A was associated with a significantly reduced risk of adenomyosis, with an odds ratio of 0.41 (95% CI: 0.19-0.89, P value= 0.03). Conclusions: This study demonstrated that women with blood group B have a 2.3-fold higher risk of developing adenomyosis, whereas those with blood group A may have a protective effect. Multicenter studies with larger sample sizes and diverse demographics groups are needed to substantiate these findings.Key words: Adenomyosis; ABO blood group; risk factors.","PeriodicalId":16380,"journal":{"name":"Journal of Nepal Health Research Council","volume":"23 1","pages":"176-179"},"PeriodicalIF":0.0,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Menstrual Hygiene among Female Prisoners of Jhapa and Morang Districts of Nepal. 尼泊尔Jhapa和Morang地区女性囚犯的月经卫生状况。

Journal of Nepal Health Research Council Pub Date : 2025-06-29 DOI: 10.33314/jnhrc.v23i01.5394

Laxmi Gautam, Mamata Regmi, Amrit Bist

{"title":"Menstrual Hygiene among Female Prisoners of Jhapa and Morang Districts of Nepal.","authors":"Laxmi Gautam, Mamata Regmi, Amrit Bist","doi":"10.33314/jnhrc.v23i01.5394","DOIUrl":"10.33314/jnhrc.v23i01.5394","url":null,"abstract":"Background: Female prisoners constitute a minority of prison population and their special health care needs are often neglected. This study aims to assess the knowledge of menstruation and menstrual hygiene practices of female prisoners of Jhapa and Morang.Methods: A cross sectional study was conducted among 140 female prisoners of Jhapa and Morang District Prison of Eastern Nepal through a pretested semi structured questionnaire and face to face interview. Logistic regression model was used to assess the factors associated with the outcome variable using an adjusted odds ratio with a 95% CI, and p-value <0.05 was considered statistically significant.Results: The study showed that 65% of the female prisoners had adequate knowledge about menstruation. Half of the respondents (50%) had good menstrual hygiene practice. Majority of the respondents (67.9%) used sanitary pad and nearly one third (32.9%) used clothes as absorbent material during menstruation. Dysmenorrhea was the major health problem (31.9%) reported by prisoners. Respondent's knowledge on menstruation was significantly associated with educational status (AOR: 6.775, 95% CI: 2.089-21.87), marital status (AOR: 3.375, 95% CI: 1.979- 11.63) and former residence (AOR: 5.014, 95% CI: 2.196-11.44) in multivariate analysis.Conclusions: More than one third of female prisoners had inadequate knowledge about menstruation and half menstrual hygiene practices were unsatisfactory. This demonstrates a need to design health education programme and foster advocacy to improve the knowledge and promote safe hygienic practice of female prisoners during menstruation.","PeriodicalId":16380,"journal":{"name":"Journal of Nepal Health Research Council","volume":"23 1","pages":"114-120"},"PeriodicalIF":0.0,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and Risk Factors of High Blood Pressure among Elderly People. 老年人高血压患病率及危险因素分析。

Journal of Nepal Health Research Council Pub Date : 2025-06-29 DOI: 10.33314/jnhrc.v23i01.5223

Keshab Parajuli, Mahendra Prasad Sharma, Raju Ghimire, Kshitij Karki

{"title":"Prevalence and Risk Factors of High Blood Pressure among Elderly People.","authors":"Keshab Parajuli, Mahendra Prasad Sharma, Raju Ghimire, Kshitij Karki","doi":"10.33314/jnhrc.v23i01.5223","DOIUrl":"https://doi.org/10.33314/jnhrc.v23i01.5223","url":null,"abstract":"Background: High Blood Pressure, a prevalent condition exacerbated by population growth, disproportionately affects the elderly, with over two-thirds of individuals aged 65 and above affected. This study aimed to evaluate the prevalence and risk factors of high blood pressure among elderly residents of Chandragiri Municipality in Kathmandu.Methodology: A cross-sectional was applied, and the respondents were selected from randomly chosen wards of Chandragiri Municipality. Elderly individuals aged over 60 years residing in the area, regardless of permanency, were included. Data analysis was conducted using SPSS software, with the Chi-square test employed to assess associations between high blood pressure and various risk factors at a significance level of 5%.Results: The study included 418 individuals, of whom 48.8% were currently suffering from high blood pressure. The majority was male 55.5% and married 73.7%, with Chhetri 45.2% and Brahmin 40.7% being the most prevalent ethnic groups. Most respondents were illiterate 44.3% and resided in joint families 68.4%. Reported risk factors for high blood pressure included tobacco smoking 37.3%, alcohol consumption 36.1%, and non-vegetarian diets 85.9%.Conclusion: Significant relationships were observed between blood pressure and age, sex, marital status, tobacco smoking, and alcohol consumption. Conversely, religion, ethnicity, education level, family type, BMI, diet type, and physical activity did not exhibit noteworthy associations with high blood pressure in this sample. These findings underscore the multifactorial nature of high blood pressure and its diverse risk factors.","PeriodicalId":16380,"journal":{"name":"Journal of Nepal Health Research Council","volume":"23 1","pages":"65-72"},"PeriodicalIF":0.0,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Vitamin B12 Level in Children with Type 1 Diabetes. 1型糖尿病儿童血清维生素B12水平

Journal of Nepal Health Research Council Pub Date : 2025-06-29 DOI: 10.33314/jnhrc.v23i01.4726

Santosh Pradhan, Subhana Thapa, Pradeep Krishna Shrestha, Bharat Jha

{"title":"Serum Vitamin B12 Level in Children with Type 1 Diabetes.","authors":"Santosh Pradhan, Subhana Thapa, Pradeep Krishna Shrestha, Bharat Jha","doi":"10.33314/jnhrc.v23i01.4726","DOIUrl":"https://doi.org/10.33314/jnhrc.v23i01.4726","url":null,"abstract":"Background: Type 1 Diabetes Mellitus is known to be associated with multiple co-morbidities. Vitamin B12 deficiency is a potential co- morbidity that might have been overlooked in these patients. The aim of this study is to evaluate the serum level of vitamin B 12 in a well-defined population of Type 1 diabetes.Methods: The cross sectional study carried out on 40 patients with Type 1 Diabetes Mellitus visiting endocrinology unit in Kanti children's Hospital, Kathmandu, Nepal. Thirty healthy non diabetics were also selected. Serum C-peptide, vitamin B12, creatinine, blood glucose level and glycosylated hemoglobin were assessed in both groups. SPSS ver. 22 was used to analyze the data.Results: The mean serum vitamin B12 level of the diabetic group was 206.92±82.18 pmol/L. Among the population 40.0% i.e. 16 out of 40 were found to be deficient and 37.5 % i.e. 15 out of 40 were subclinically deficient. Whereas the mean serum vitamin B12 level of the non diabetic group was 340.71±136.02pmol/L. Out of 30 only 2(6.7%) were deficient, 8 (26.75%) were found to be subclinically deficient. Significant difference was noticed in the mean serum level of vitaminB12 between these two groups.Conclusions: This study shows the presence of low serum vitamin B12 levels in Type 1 Diabetics. The routine screening for this condition along with confirmatory test and detail clinical examination could benefit the patients with Type 1 diabetes.","PeriodicalId":16380,"journal":{"name":"Journal of Nepal Health Research Council","volume":"23 1","pages":"14-20"},"PeriodicalIF":0.0,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Crigler-Najjar Syndrome Type 2. 罕见的Crigler-Najjar综合征2例。

Journal of Nepal Health Research Council Pub Date : 2025-06-29 DOI: 10.33314/jnhrc.v23i01.5352

Anil Kumar Shrestha, Sangay Chultim Sherpa, Asmita Karki, Sumit Agrawal, Deepak Raj Paudel

引用次数: 0

The Level of Serum Enzymes and Hormones in Patients with Miscarriage. 流产患者血清酶和激素水平的变化。

Journal of Nepal Health Research Council Pub Date : 2025-06-29 DOI: 10.33314/jnhrc.v23i01.5154

Rupesh Kumar Shreewastav, Munzal Yadav

{"title":"The Level of Serum Enzymes and Hormones in Patients with Miscarriage.","authors":"Rupesh Kumar Shreewastav, Munzal Yadav","doi":"10.33314/jnhrc.v23i01.5154","DOIUrl":"https://doi.org/10.33314/jnhrc.v23i01.5154","url":null,"abstract":"Background: The level of various enzymes and thyroid hormones in blood get altered during miscarriage, which can have predictive value or importance as a biomarker for the diagnosis. The aim of the present study is to validate the alteration in the level of serum enzymes and thyroid hormones in patients suffering with miscarriage in a tertiary care hospital in Nepal.Methods: A descriptive cross-sectional study was carried out on patients suffering with miscarriage and admitted for treatment in Nobel Medical College Teaching Hospital. Demographic data were recorded in a predesigned performa. The level of various enzymes and thyroid hormones were estimated from the blood sample of patients in the department of biochemistry laboratory. Data were entered in MS excel and analyzed by statistical package for the social sciences Version version 20.0 Results: The total number of patients suffering from miscarriage and enrolled in the study was 86. The mean value of serum gamma glutamyl transferase, lactate dehydrogenase and adenosine deaminase in these patients were 22.67±8.22, 289.6±126.9 and 21.3±9.9 IU/ml respectively, which were significantly higher (p=<0.0001, 0.0004, 0.0179 respectively) when compared to healthy pregnant women. Thyroid dysfunction was noted in 15 (17.44%) patients, out of that Subclinical hypothyroidism was most common and affected 8(9.3%) individuals.Conclusions: The mean value of serum gamma glutamyl transferase, lactate dehydrogenase and adenosine deaminase in case of miscarriage was found to be elevated significantly and thyroid dysfunction was also noted to small fraction of patients suffering from miscarriage with Subclinical hypothyroidism being the most common.","PeriodicalId":16380,"journal":{"name":"Journal of Nepal Health Research Council","volume":"23 1","pages":"59-64"},"PeriodicalIF":0.0,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0