Journal of Intensive Care Medicine最新文献

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Determining Reintubation Risk Factors and Effects on Outcomes in the Surgical ICU. 外科ICU患者再插管危险因素及其对预后的影响。
IF 2.3 3区 医学
Journal of Intensive Care Medicine Pub Date : 2026-09-18 DOI: 10.1177/08850666261488846
Ethan Hollar, Ryan D Conrardy, Kai Yang, Thomas Carver
{"title":"Determining Reintubation Risk Factors and Effects on Outcomes in the Surgical ICU.","authors":"Ethan Hollar, Ryan D Conrardy, Kai Yang, Thomas Carver","doi":"10.1177/08850666261488846","DOIUrl":"https://doi.org/10.1177/08850666261488846","url":null,"abstract":"<p><p>PurposeReintubation (RI) in surgical intensive care unit (SICU) patients is associated with significant morbidity and mortality. Reported RI rates are lower in surgical populations (6-9%) than in medical populations. This study evaluated the rate, risk factors, and outcomes associated with RI in a SICU cohort.MethodsA retrospective cohort study of adults admitted to a Level-1 trauma center SICU who received mechanical ventilation between 2019 and 2020 was performed. Exclusion criteria included age <18 years, self-extubation, tracheostomy before extubation, admission to a nonsurgical service, or death before extubation. RI was defined as unplanned intubation within 96 h of extubation. Demographic, clinical, and peri-extubation variables were analyzed using multivariable logistic regression. Post hoc exploratory analyses evaluated operative and nonoperative intubation subgroups.ResultsOf 667 patients, 52 (7.8%) experienced RI. In the full-cohort model, atrial fibrillation, spinal cord injury, alcohol withdrawal, ventilator-associated pneumonia (VAP), combined propofol-dexmedetomidine sedation, and admitting service were independently associated with RI; VAP timing relative to RI was uncertain. RI occurred in 5.8% of patients intubated for an operative procedure and 11.2% of those intubated for a nonoperative indication (<i>P</i> = .011). Compared with successful extubation, RI was associated with longer mechanical ventilation (11 vs 1 day), intensive care unit (ICU) stay (15 vs 2 days) and hospital stay (25 vs 10 days), as well as higher rates of tracheostomy (63% vs 2%), delirium (77% vs 33%), VAP (29% vs 2%), and in-hospital mortality (23% vs 1%, all <i>P</i> < .001).ConclusionsThe incidence of RI in this SICU was 7.8% and was associated with markedly worse outcomes. Patient-specific risk assessment may help guide risk-stratified post-extubation monitoring and respiratory support. The exploratory subgroup findings require prospective validation.</p>","PeriodicalId":16307,"journal":{"name":"Journal of Intensive Care Medicine","volume":" ","pages":"8850666261488846"},"PeriodicalIF":2.3,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148990243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Critical Care and Transplant Decision-Making in Acute and Acute-on-Chronic Liver Failure: A Scoping Review. 急性和急性慢性肝衰竭的重症监护和移植决策:一项范围综述。
IF 2.3 3区 医学
Journal of Intensive Care Medicine Pub Date : 2026-09-18 DOI: 10.1177/08850666261487160
Mehsa Hashim, Zohair Karim, Abiha Abdullah, Frank Spitz, Maham Sarfaraz, Berkay Demirors, Vrishketan Sethi, Jason Mial-Anthony, Stalin Dharmayan, Shwe P Han, Timothy Fokken, Michele Molinari
{"title":"Critical Care and Transplant Decision-Making in Acute and Acute-on-Chronic Liver Failure: A Scoping Review.","authors":"Mehsa Hashim, Zohair Karim, Abiha Abdullah, Frank Spitz, Maham Sarfaraz, Berkay Demirors, Vrishketan Sethi, Jason Mial-Anthony, Stalin Dharmayan, Shwe P Han, Timothy Fokken, Michele Molinari","doi":"10.1177/08850666261487160","DOIUrl":"https://doi.org/10.1177/08850666261487160","url":null,"abstract":"<p><p>BackgroundAcute liver failure (ALF) and acute-on-chronic liver failure (ACLF) are distinct, rapidly progressive conditions associated with high short-term mortality. For selected patients, liver transplantation (LT) is the only definitive therapy that requires timely referral and expert multidisciplinary assessment.ObjectivesThis scoping review synthesizes contemporary evidence guiding the decision between LT and conservative management in ALF and ACLF, focusing on prognostic models, clinical thresholds, futility criteria, ethical considerations, and emerging decision-support tools.MethodsPRISMA-ScR guidelines were used to conduct this review. PubMed, Scopus, Web of Science, and Google Scholar were searched for English-language clinical trials, observational studies, guidelines, and reviews published through September 1, 2025 addressing LT decision-making, prognostication, or critical care in ALF and ACLF. Data were charted and thematically synthesized.ResultsIn ALF, early referral to a transplant center is recommended. Prognostic tools such as King's College Criteria and the ALFSG Index assist risk stratification but must be interpreted alongside dynamic clinical assessments. In ACLF, early transplant evaluation is advised, particularly for grade 3 disease. Scores including CLIF-C ACLF, NACSELD-ACLF, and TAM inform mortality risk, while persistent hyperlactatemia (>9 mmol/L), vasopressor dependence (norepinephrine >1 μg/kg/min), and severe hypoxemia (PaO<sub>2</sub>/FiO<sub>2</sub> < 150 mm Hg) signal limited transplant benefit. Conservative management may suit patients with reversible precipitants or contraindications to LT. Post-transplant outcomes are generally favorable but depend on pre-transplant severity and frailty. Pregnant patients, children, and older adults require individualized decision-making, and marked racial, socioeconomic, and regional disparities in transplant access persist.ConclusionPrognostic scores in ALF reliably identify patients who will die without LT but not those who will recover, so referral to transplant centers should precede certainty. In ACLF-3, days 3-7 after stabilization are decisive. The same physiological thresholds should delay transplantation when reversible and deny it only when refractory; serial trajectory predicts outcome better than any single measurement.</p>","PeriodicalId":16307,"journal":{"name":"Journal of Intensive Care Medicine","volume":" ","pages":"8850666261487160"},"PeriodicalIF":2.3,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148990115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence, Prevalence, Risk Factors, and Outcomes of ICU-Acquired Weakness Among Critically Ill Children: A Systematic Review and Meta-Analysis. 重症儿童重症监护下获得性虚弱的发生率、流行率、危险因素和结局:系统回顾和荟萃分析。
IF 2.3 3区 医学
Journal of Intensive Care Medicine Pub Date : 2026-09-15 DOI: 10.1177/08850666261488013
Nattasit Katchamat, Sudhathai Sirithepmontree, Hyekyun Rhee
{"title":"Incidence, Prevalence, Risk Factors, and Outcomes of ICU-Acquired Weakness Among Critically Ill Children: A Systematic Review and Meta-Analysis.","authors":"Nattasit Katchamat, Sudhathai Sirithepmontree, Hyekyun Rhee","doi":"10.1177/08850666261488013","DOIUrl":"10.1177/08850666261488013","url":null,"abstract":"<p><p>BackgroundICU-acquired weakness (ICUAW) is a common neuromuscular complication affecting both short- and long-terms health outcomes in critically ill children. To date, no comprehensive systematic review has synthesized evidence on ICUAW in pediatric populations. This systematic review aims to identify the incidence, prevalence, risk factors, and outcomes for ICUAW among critically ill children.MethodsThe review was conducted following JBI systematic review methodology and reported following the PRISMA guidelines. PubMed, CINAHL, Embase, and Scopus were searched for English-language original studies published from January 1, 2010, to October 14, 2025, including children aged 1 month-18 years in PICU/ICU settings diagnosed with ICUAW. Pooled incidence and prevalence were estimated using a random-effects meta-analysis. Risk factors and outcomes were narratively synthesized. Three ICUAW subtypes, including critical illness myopathy (CIM), critical illness polyneuropathy (CIP), and critical illness neuromyopathy (CINM), were synthesized separately. The JBI critical appraisal tools were used to apprise the quality of included studies.ResultsOf 2686 articles, 14 met inclusion criteria. The pooled incidence and prevalence were 2% (95% CI: 0.00-0.87), and 52% (95% CI: 0.32-0.70), respectively, with substantial between-study heterogeneity. Data synthesis identified 4 personal-, 13 disease-, and 17 treatment-related factors, and 11 biomarkers associated with ICUAW. ICUAW was associated with seven physical and hospital-related outcomes during hospitalization, whereas only reduced physical functioning and quality of life were identified as post-discharge outcomes.ConclusionThis review provides pooled estimates of ICUAW incidence and prevalence and identifies risk factors, and outcomes in children. Findings underscore the need for early detection and timely prevention of pediatric ICUAW. Clinicians should assess risk factors for and identify ICUAW using standardized diagnostic methods, specifying affected muscles and ICUAW subtypes. Future research is needed to develop and validate standardized criteria to enhance diagnostic precision and comparability across studies of ICUAW.</p>","PeriodicalId":16307,"journal":{"name":"Journal of Intensive Care Medicine","volume":" ","pages":"8850666261488013"},"PeriodicalIF":2.3,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148969403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic Disease Management Using Big Data and Predictive Models (Big Data & Predictive Analytics). 使用大数据和预测模型的慢性疾病管理(大数据和预测分析)。
IF 2.3 3区 医学
Journal of Intensive Care Medicine Pub Date : 2026-09-12 DOI: 10.1177/08850666261487154
Joseph Hegenbart
{"title":"Chronic Disease Management Using Big Data and Predictive Models (Big Data & Predictive Analytics).","authors":"Joseph Hegenbart","doi":"10.1177/08850666261487154","DOIUrl":"https://doi.org/10.1177/08850666261487154","url":null,"abstract":"<p><p>Accurate prediction of thirty-day hospital readmissions in large clinical cohorts depends on data quality, the integrity of pre-processing, and the choice of learning strategy. The aim of this study was to develop and empirically validate an artificial-intelligence-based method for generating clinically coherent medical data in order to improve the precision, stability, and real-world applicability of models forecasting adverse outcomes in patients with chronic diseases. The analysis used the full Diabetes 130-Hospitals dataset (n = 101,766), applying multi-stage pre-processing, diffusion-based generation of synthetic records, three learning regimes based on real, synthetic, and combined data. The results show that pre-processing markedly strengthened dataset integrity: up to 18% of missing laboratory values were fully reconstructed, numerical ranges were stabilised, and the minority class representing 11.2% of cases was rebalanced to 45-50% while preserving correlation structures. Synthetic data demonstrated close correspondence to real distributions, with similarity values of 0.97 and correlation alignment of 0.95. In all comparisons, the combined learning regime was the strongest: gradient-boosting models achieved the highest discrimination, neural-network models offered the most accurate probability calibration, and synthetic-only learning consistently produced the weakest outcomes. Models trained on combined data maintained 95% of baseline performance under noise and simulated missingness, compared with 88% for real-only learning and 84% for synthetic-only learning. The findings suggest that synthetic augmentation, when integrated with real clinical data, can improve predictive discrimination, calibration, and robustness. However, the modest F1-scores indicate that further threshold optimisation and prospective external validation are required before clinical deployment.</p>","PeriodicalId":16307,"journal":{"name":"Journal of Intensive Care Medicine","volume":" ","pages":"8850666261487154"},"PeriodicalIF":2.3,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Survival Determinants in Hypoxic Hepatitis Among Critically Ill Patients: A Systematic Review and Meta-Analysis. 危重患者缺氧性肝炎的生存决定因素:系统回顾和荟萃分析。
IF 2.3 3区 医学
Journal of Intensive Care Medicine Pub Date : 2026-09-11 DOI: 10.1177/08850666261477382
Yeison Cruz Castillo, Carlos David Trevilla Martínez, Mariela Denise Fermin Madera, Brenda Tatiana Camacho Ramirez, Laura A Gray, Supritha Chintamaneni, Gabriela Flores Monar, Bansi Sutariya, Camila Sanchez Cruz, Ernesto Calderón-Martinez, Rashmi Advani, Sushovan Guha
{"title":"Survival Determinants in Hypoxic Hepatitis Among Critically Ill Patients: A Systematic Review and Meta-Analysis.","authors":"Yeison Cruz Castillo, Carlos David Trevilla Martínez, Mariela Denise Fermin Madera, Brenda Tatiana Camacho Ramirez, Laura A Gray, Supritha Chintamaneni, Gabriela Flores Monar, Bansi Sutariya, Camila Sanchez Cruz, Ernesto Calderón-Martinez, Rashmi Advani, Sushovan Guha","doi":"10.1177/08850666261477382","DOIUrl":"https://doi.org/10.1177/08850666261477382","url":null,"abstract":"<p><p>BackgroundHypoxic hepatitis (HH), also termed ischemic hepatitis or shock liver, is an acute hepatocellular injury caused by an imbalance between hepatic oxygen supply and demand. It develops secondary to cardiac, circulatory, or respiratory failure through reduced hepatic blood flow, systemic hypoxemia, hepatic venous congestion, or impaired cellular oxygen utilization. Although its recognition in critical care has increased, the clinical and biochemical factors distinguishing survivors from non-survivors remain poorly defined. This analysis aimed to characterize these differences among critically ill adults diagnosed with HH.MethodsThis systematic review and meta-analysis followed PRISMA guidelines and was pre-registered in PROSPERO (CRD420251180238). A comprehensive search of PubMed, Scopus, Web of Science, EMBASE, Cochrane, LILACS, CNKI, CINAHL, and Google Scholar was conducted on July 4, 2025. Eligible studies included critically ill patients diagnosed with HH. Random-effects meta-analyses were performed in R.ResultsOf 3236 identified records, five cohort studies comprising 107,346 participants were included. The pooled mean difference in age between survivors and non-survivors was -5.1 years (p = 0.03; I<sup>2</sup> = 23.1%). Mechanical ventilation was associated with lower survival (RR = 0.76; p < 0.01; I<sup>2</sup> = 0.7%), and norepinephrine or other hemodynamic support was associated with lower odds of survival (OR = 0.4; p < 0.01; I<sup>2</sup> = 5.5%). In contrast, lactate, bilirubin, and INR were not significantly associated with survival.ConclusionHypoxic hepatitis should be interpreted primarily as a secondary marker of severe cardiac, circulatory, or respiratory failure rather than as an isolated primary driver of mortality. Its occurrence may be associated with increased mortality in critically ill patients; however, the available evidence is limited by the small number of eligible studies and heterogeneity. Further standardized, prospective studies are needed to clarify its independent prognostic significance.</p>","PeriodicalId":16307,"journal":{"name":"Journal of Intensive Care Medicine","volume":" ","pages":"8850666261477382"},"PeriodicalIF":2.3,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148945094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early Hyperoxia and 28-day Mortality in Adult Postcardiotomy Extracorporeal Membrane Oxygenation: A Two-Center Retrospective Cohort Study. 成人心脏切开术后早期高氧和28天死亡率体外膜氧合:一项双中心回顾性队列研究。
IF 2.3 3区 医学
Journal of Intensive Care Medicine Pub Date : 2026-09-08 DOI: 10.1177/08850666261477389
Chuang Liu, Shujie Yan, Xingxing Li, Hui Zhao, Zhenzhen Li, Bingyang Ji
{"title":"Early Hyperoxia and 28-day Mortality in Adult Postcardiotomy Extracorporeal Membrane Oxygenation: A Two-Center Retrospective Cohort Study.","authors":"Chuang Liu, Shujie Yan, Xingxing Li, Hui Zhao, Zhenzhen Li, Bingyang Ji","doi":"10.1177/08850666261477389","DOIUrl":"https://doi.org/10.1177/08850666261477389","url":null,"abstract":"<p><p>ObjectivesTo evaluate the association between early arterial hyperoxia and 28-day mortality in postcardiotomy VA-ECMO (PC-ECMO) adult patients.MethodsWe conducted a retrospective cohort study including 209 adults who received PC-ECMO across two tertiary centers between January 2019 and December 2024. The primary exposure was the 24-h mean arterial oxygen partial pressure (24h-mean PaO<sub>2</sub>) after ECMO support. The primary outcome was 28-day all-cause mortality. Cox proportional hazards models were used to assess associations between oxygen metrics and mortality, with adjustment for confounders.ResultsThe cohort had a median age of 59 years, 130 (62.2%) were male, and 80 (38.3%) received ECMO sopport due to failure to wean from cardiopulmonary bypass. The 28-day mortality was 54.1%. Across increasing 24h-mean PaO2 categories, 28-day survival declined from 64.1% in the <150 mm Hg group to 17.9% in the ≥300 mm Hg group (<i>P</i> < .001). Each 10 mm Hg increase in 24h-mean PaO<sub>2</sub> was associated with a 2.8% increased mortality risk (adjusted HR 1.028, 95% CI: 1.011-1.046, <i>P</i> = .002). Severe hyperoxia (≥300 mm Hg) was independently associated with higher mortality (adjusted HR 2.392, 95% CI: 1.359-4.210). A nonlinear dose-response curve showed increased mortality beyond ∼200 mm Hg. Associations were more pronounced in elderly and male subgroups.ConclusionsEarly hyperoxia is independently associated with increased 28-day mortality in PC-ECMO patients in a dose-dependent manner, highlighting the need for conservative oxygen management.</p>","PeriodicalId":16307,"journal":{"name":"Journal of Intensive Care Medicine","volume":" ","pages":"8850666261477389"},"PeriodicalIF":2.3,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early Mobilization in Critically Ill Patients with Cancer: A Scoping Review. 危重癌症患者早期动员:范围综述。
IF 2.3 3区 医学
Journal of Intensive Care Medicine Pub Date : 2026-09-08 DOI: 10.1177/08850666261484866
Amanda Wheeler, Michaela Avallone, Christina A Watkins, Steven H Hsu
{"title":"Early Mobilization in Critically Ill Patients with Cancer: A Scoping Review.","authors":"Amanda Wheeler, Michaela Avallone, Christina A Watkins, Steven H Hsu","doi":"10.1177/08850666261484866","DOIUrl":"https://doi.org/10.1177/08850666261484866","url":null,"abstract":"<p><p>BackgroundCritically ill patients with active malignancy increasingly survive intensive care unit admissions but remain at risk of profound deconditioning and functional decline. Early mobilization has demonstrated benefits in general intensive care unit populations; however, oncology-specific evidence remains limited.ObjectiveTo map and synthesize the available evidence on early mobilization interventions in adult and pediatric oncology ICU patients, focusing on feasibility, safety, functional outcomes, quality of life, length of stay, and mortality.MethodFollowing PRISMA-ScR guidelines, a scoping review was conducted using PubMed, CINAHL Ultimate, OTseeker, and ProQuest Dissertations & Theses. Studies published between 2010 and 2025 were eligible if they included adult or pediatric intensive care patients with active malignancy who received early mobilization interventions during ICU admission.ResultsEight studies met inclusion criteria. Early mobilization was consistently reported as feasible and safe, with no serious mobilization related adverse events. Most studies described improvements in functional participation or mobility, although outcome measures were heterogeneous and frequently descriptive. Evidence regarding length of stay, quality of life, and mortality was limited and inconsistent. The literature was derived predominantly from adult oncology intensive care unit populations, with limited pediatric data, which focused primarily on feasibility and process-related outcomes.ConclusionEarly mobilization appears to be a feasible and safe practice in oncology ICU settings and is commonly reported alongside improvements in functional participation. However, evidence supporting benefits in length of stay, quality of life, or survival remains limited, highlighting the need for higher-quality comparative studies.</p>","PeriodicalId":16307,"journal":{"name":"Journal of Intensive Care Medicine","volume":" ","pages":"8850666261484866"},"PeriodicalIF":2.3,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Etiology Matters: A Systematic Review and Meta-Analysis of Incidence and Outcomes in Abdominal Compartment Syndrome. 病因学问题:腹隔室综合征发病率和结局的系统回顾和荟萃分析。
IF 2.3 3区 医学
Journal of Intensive Care Medicine Pub Date : 2026-09-08 DOI: 10.1177/08850666261479996
Nicholas J Larson, John Kosmach, Claire Attarian, Frederick B Rogers, Kelsey Berndt, Benoit Blondeau, Kwok M Ho
{"title":"Etiology Matters: A Systematic Review and Meta-Analysis of Incidence and Outcomes in Abdominal Compartment Syndrome.","authors":"Nicholas J Larson, John Kosmach, Claire Attarian, Frederick B Rogers, Kelsey Berndt, Benoit Blondeau, Kwok M Ho","doi":"10.1177/08850666261479996","DOIUrl":"https://doi.org/10.1177/08850666261479996","url":null,"abstract":"<p><p>ObjectiveTo determine if abdominal compartment syndrome (ACS) is a homogenous clinical entity, or if incidence and outcomes after ACS differ by precipitating cause.Data SourcesMEDLINE, Cochrane Reviews, Science Direct, and relevant articles identified through citation matching from January 2018 to January 2026.Study SelectionAdult patients (≥18 years old) diagnosed with ACS. For the metaanalysis, outcomes were compared between those with ACS (experimental group) and those without ACS (controls).Data ExtractionThis study was conducted in accordance with PRISMA guidelines. Dual independent review was conducted to screen studies at the abstract, full text, then outcome extraction level. After completion, all data was validated by a senior reviewer to ensure alignment with criteria.Data SynthesisA total of 100 manuscripts met inclusion criteria for data extraction, 33 reporting mortality, 90 reporting incidence of ACS, and a total of 21 studies included for meta-analysis of mortality. Total incidence of ACS was 0.05% across 1,176,638 unique patients, ranging from 15.16% in patients with moderate/severe pancreatitis to 0.22% in trauma patients.The unadjusted association between ACS and mortality varied by pathology, ranging from no observed association in ECMO patients to a moderate association in trauma patients (odds ratio [OR] 3.15; 95% CI 2.24, 4.43) and large association in nontrauma patients (OR 8.60; 95% CI 4.60, 16.07).ConclusionsCurrent literature related to ACS suggests that despite a similar underlying pathophysiology, ACS is a unique entity varying by precipitating cause. Future research should identify if treatment algorithms should consider the underlying disease state when managing ACS.</p>","PeriodicalId":16307,"journal":{"name":"Journal of Intensive Care Medicine","volume":" ","pages":"8850666261479996"},"PeriodicalIF":2.3,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Infections in ECMO: A Comprehensive Review of the Epidemiology, Diagnosis, Management and Prevention. ECMO感染:流行病学、诊断、管理和预防的综合综述。
IF 2.3 3区 医学
Journal of Intensive Care Medicine Pub Date : 2026-09-08 DOI: 10.1177/08850666261487150
Erika R O'Neil, Joseph Marcus, Aditya Shah, Graeme MacLaren, Ryan P Barbaro
{"title":"Infections in ECMO: A Comprehensive Review of the Epidemiology, Diagnosis, Management and Prevention.","authors":"Erika R O'Neil, Joseph Marcus, Aditya Shah, Graeme MacLaren, Ryan P Barbaro","doi":"10.1177/08850666261487150","DOIUrl":"https://doi.org/10.1177/08850666261487150","url":null,"abstract":"<p><p>Extracorporeal membrane oxygenation (ECMO) provides life support for severe respiratory and cardiac failure, including failure from severe infection such as sepsis and acute respiratory distress syndrome. Additionally, ECMO-acquired infections are frequent and associated with prolonged hospitalization, increased healthcare utilization, and higher mortality. This review summarizes current evidence regarding the epidemiology, pathophysiology, diagnosis, prevention, and management of infectious adverse events during ECMO. Future work should aim to refine ECMO-related infectious adverse event definitions, improve harmonized multicenter data collection, and to invest in high-quality, well-designed studies.</p>","PeriodicalId":16307,"journal":{"name":"Journal of Intensive Care Medicine","volume":" ","pages":"8850666261487150"},"PeriodicalIF":2.3,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal Sepsis for the Intensivist: Recognition, ICU Triage, and Pregnancy-Adapted Management. 重症监护员的产妇败血症:识别,ICU分诊和妊娠适应管理。
IF 2.3 3区 医学
Journal of Intensive Care Medicine Pub Date : 2026-09-03 DOI: 10.1177/08850666261480633
Felicia Chen
{"title":"Maternal Sepsis for the Intensivist: Recognition, ICU Triage, and Pregnancy-Adapted Management.","authors":"Felicia Chen","doi":"10.1177/08850666261480633","DOIUrl":"https://doi.org/10.1177/08850666261480633","url":null,"abstract":"<p><p>Sepsis in pregnancy and the puerperium is a leading, and often preventable, cause of maternal critical illness. This narrative review summarizes pregnancy-adapted physiology, epidemiology, clinical recognition, intensive care unit triage, and management, with particular emphasis on decision-making around ICU admission and the practical delivery of organ support for intensivists who do not routinely manage obstetric patients.</p>","PeriodicalId":16307,"journal":{"name":"Journal of Intensive Care Medicine","volume":" ","pages":"8850666261480633"},"PeriodicalIF":2.3,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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