Journal of Lipid and Atherosclerosis最新文献_第9页

Comparison of the Effects of High-intensity Statin Therapy with Moderate-Intensity Statin and Ezetimibe Combination Therapy on Major Adverse Cardiovascular Events in Patients with Acute Myocardial Infarction: a Nationwide Cohort Study. 高强度他汀类药物与中强度他汀与依折替米联合治疗急性心肌梗死患者主要不良心血管事件的比较:一项全国性队列研究。

Journal of Lipid and Atherosclerosis Pub Date : 2021-09-01 Epub Date: 2021-05-25 DOI: 10.12997/jla.2021.10.3.291

Kihyun Kim, Woo-Dae Bang, Kyungdo Han, Bongseong Kim, Jung Myung Lee, Hyemoon Chung

{"title":"Comparison of the Effects of High-intensity Statin Therapy with Moderate-Intensity Statin and Ezetimibe Combination Therapy on Major Adverse Cardiovascular Events in Patients with Acute Myocardial Infarction: a Nationwide Cohort Study.","authors":"Kihyun Kim, Woo-Dae Bang, Kyungdo Han, Bongseong Kim, Jung Myung Lee, Hyemoon Chung","doi":"10.12997/jla.2021.10.3.291","DOIUrl":"https://doi.org/10.12997/jla.2021.10.3.291","url":null,"abstract":"Objective: We compared the effects of high-intensity statin monotherapy versus moderate-intensity statin and ezetimibe combination therapy on major adverse cardiovascular events (MACE) in patients with acute myocardial infarction (AMI).Methods: Using the Korean National Health Insurance Service database, we screened 82,941 patients with AMI who underwent percutaneous coronary intervention (PCI) between 2013 and 2016. Among them, we identified 9,908 patients treated with atorvastatin 40 mg (A40, n=4,041), atorvastatin 20 mg + ezetimibe 10 mg (A20+E10, n=233), rosuvastatin 20 mg (R20, n=5,251), or rosuvastatin 10 mg + ezetimibe 10 mg (R10+E10, n=383). The primary outcome was MACE, a composite of all-cause death, non-fatal myocardial infarction undergoing PCI, repeat revascularization, and ischemic stroke. Multivariable analyses were performed using the inverse probability of treatment weighting method.Results: The incidence rate of MACE in the overall population was 42.97 cases per 1,000 person-years. There was no significant difference in the risk of composite outcomes of MACE between the groups. However, the R10+E10 group showed a higher risk of all-cause death (hazard ratio, 2.07; 95% confidence interval, 1.08-3.94) than the A40 group (reference group) in the weighted multivariable model.Conclusions: In this study, there was no significant difference in the composite outcome of MACE between high-intensity statin monotherapy and moderate-intensity statin and ezetimibe combination therapy.","PeriodicalId":16284,"journal":{"name":"Journal of Lipid and Atherosclerosis","volume":"10 3","pages":"291-302"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0b/91/jla-10-291.PMC8473958.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39496160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Intravital Two-photon Imaging of Dynamic Alteration of Hepatic Lipid Droplets in Fasted and Refed State. 空腹和进食状态下肝脂滴动态变化的活体双光子成像。

Journal of Lipid and Atherosclerosis Pub Date : 2021-09-01 Epub Date: 2021-06-28 DOI: 10.12997/jla.2021.10.3.313

Jieun Moon, Pilhan Kim

{"title":"Intravital Two-photon Imaging of Dynamic Alteration of Hepatic Lipid Droplets in Fasted and Refed State.","authors":"Jieun Moon, Pilhan Kim","doi":"10.12997/jla.2021.10.3.313","DOIUrl":"https://doi.org/10.12997/jla.2021.10.3.313","url":null,"abstract":"Objective: The liver plays a central role in lipid metabolism. During fasting and feeding, the fatty acid trafficking between adipose tissue and liver induces accumulation and dissociation of dynamic hepatic lipid droplets (LDs). Herein, we established an intravital 2-photon imaging technique to longitudinally visualize the dynamic in vivo alteration of hepatic LD deposition during fasting and refeeding in the liver of live mouse.Methods: Intravital 2-photon imaging of liver was performed to observe hepatic LD alteration induced by fasting for different periods of time, 12, 24, and 48 hours followed by refeeding. Hepatic LDs were fluorescently labelled in vivo by intravenous injection of Seoul-Flour 44 and visualized by custom-built intravital 2-photon microscope.Results: Significant increases of the number and size of hepatic LDs were observed by intravital 2-photon imaging of the liver after 12 hours of fasting. The degree of hepatic LD accumulation continuously increased with fasting up to 48 hours. Remarkably, with refeeding for 24 hours, the hepatic LDs accumulated by fasting were fully dissociated and the LD occupancy in the liver was recovered to the normal state.Conclusion: Utilizing intravital 2-photon microscope with in vivo systemic fluorescent labeling of LD in live mice, dynamic alterations of hepatic LDs such as accumulation and dissociation by fasting and refeeding were successfully visualized at a subcellular level in vivo. The established method enabling the in vivo visualization of LDs will be a useful tool to investigate the pathophysiology of various diseases associated with dysregulated lipid metabolism.","PeriodicalId":16284,"journal":{"name":"Journal of Lipid and Atherosclerosis","volume":"10 3","pages":"313-321"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/45/d4/jla-10-313.PMC8473963.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39496162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Zebrafish Vascular Development: General and Tissue-Specific Regulation. 斑马鱼血管发育:一般和组织特异性调节。

Journal of Lipid and Atherosclerosis Pub Date : 2021-05-01 Epub Date: 2021-03-02 DOI: 10.12997/jla.2021.10.2.145

Hiroyuki Nakajima, Ayano Chiba, Moe Fukumoto, Nanami Morooka, Naoki Mochizuki

引用次数: 6

Iron Reshapes the Gut Microbiome and Host Metabolism. 铁重塑肠道微生物群和宿主代谢。

Journal of Lipid and Atherosclerosis Pub Date : 2021-05-01 Epub Date: 2021-03-10 DOI: 10.12997/jla.2021.10.2.160

Amy Botta, Nicole G Barra, Nhat Hung Lam, Samantha Chow, Kostas Pantopoulos, Jonathan D Schertzer, Gary Sweeney

{"title":"Iron Reshapes the Gut Microbiome and Host Metabolism.","authors":"Amy Botta, Nicole G Barra, Nhat Hung Lam, Samantha Chow, Kostas Pantopoulos, Jonathan D Schertzer, Gary Sweeney","doi":"10.12997/jla.2021.10.2.160","DOIUrl":"10.12997/jla.2021.10.2.160","url":null,"abstract":"Compelling studies have established that the gut microbiome is a modifier of metabolic health. Changes in the composition of the gut microbiome are influenced by genetics and the environment, including diet. Iron is a potential node of crosstalk between the host-microbe relationship and metabolic disease. Although iron is well characterized as a frequent traveling companion of metabolic disease, the role of iron is underappreciated because the mechanisms of iron's influence on host metabolism are poorly characterized. Both iron deficiency and excessive amounts leading to iron overload can have detrimental effects on cardiometabolic health. Optimal iron homeostasis is critical for regulation of host immunity and metabolism in addition to regulation of commensal and pathogenic enteric bacteria. In this article we review evidence to support the notion that altering composition of the gut microbiome may be an important route via which iron impacts cardiometabolic health. We discuss reshaping of the microbiome by iron, the physiological significance and the potential for therapeutic interventions.","PeriodicalId":16284,"journal":{"name":"Journal of Lipid and Atherosclerosis","volume":"10 2","pages":"160-183"},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/80/7b/jla-10-160.PMC8159756.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39068541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

The Role of Vitamin D in Adipose Tissue Biology: Adipocyte Differentiation, Energy Metabolism, and Inflammation. 维生素D在脂肪组织生物学中的作用:脂肪细胞分化、能量代谢和炎症。

Journal of Lipid and Atherosclerosis Pub Date : 2021-05-01 Epub Date: 2021-03-16 DOI: 10.12997/jla.2021.10.2.130

Chan Yoon Park, Sung Nim Han

{"title":"The Role of Vitamin D in Adipose Tissue Biology: Adipocyte Differentiation, Energy Metabolism, and Inflammation.","authors":"Chan Yoon Park, Sung Nim Han","doi":"10.12997/jla.2021.10.2.130","DOIUrl":"https://doi.org/10.12997/jla.2021.10.2.130","url":null,"abstract":"Adipose tissue is composed of diverse cell types and plays a major role in energy homeostasis and inflammation at the local and systemic levels. Adipose tissue serves as the main site for vitamin D storage and is among the most important extraskeletal targets of vitamin D which can modulate multiple aspects of adipose tissue biology. Vitamin D may exert inhibitory or stimulatory effects on adipocyte differentiation depending on cell type, stage of differentiation, and the treatment time point. Moreover, vitamin D controls energy metabolism in adipose tissue by affecting fatty acid oxidation, expression of uncoupling proteins, insulin resistance, and adipokine production. Adipose tissue inflammation can have a significant impact on the metabolic disorders often associated with obesity, and vitamin D can modulate the inflammatory response of immune cells and adipocytes within the adipose tissue. This review discusses the role of adipose tissue in vitamin D metabolism, as well as the regulatory role of vitamin D in adipocyte differentiation, adipose tissue energy metabolism, and inflammation, thereby providing insights into the importance of vitamin D in adipose tissue biology.","PeriodicalId":16284,"journal":{"name":"Journal of Lipid and Atherosclerosis","volume":"10 2","pages":"130-144"},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/de/d9/jla-10-130.PMC8159757.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38999837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Bacterial Postbiotics as Promising Tools to Mitigate Cardiometabolic Diseases. 细菌后生制剂作为减轻心脏代谢疾病的有希望的工具。

Journal of Lipid and Atherosclerosis Pub Date : 2021-05-01 Epub Date: 2021-02-09 DOI: 10.12997/jla.2021.10.2.123

Fernando F Anhê, Benjamin A H Jensen, Lais Rossi Perazza, André Tchernof, Jonathan D Schertzer, André Marette

引用次数: 8

Dyslipidemia Fact Sheets in Korea 2020: an Analysis of Nationwide Population-based Data. 2020年韩国血脂异常情况表:全国人口数据分析

Journal of Lipid and Atherosclerosis Pub Date : 2021-05-01 Epub Date: 2021-04-02 DOI: 10.12997/jla.2021.10.2.202

So Mi Jemma Cho, Hokyou Lee, Hyeok-Hee Lee, Jongmin Baek, Ji Eun Heo, Hyung Joon Joo, Soon Jun Hong, Hyeon Chang Kim

{"title":"Dyslipidemia Fact Sheets in Korea 2020: an Analysis of Nationwide Population-based Data.","authors":"So Mi Jemma Cho, Hokyou Lee, Hyeok-Hee Lee, Jongmin Baek, Ji Eun Heo, Hyung Joon Joo, Soon Jun Hong, Hyeon Chang Kim","doi":"10.12997/jla.2021.10.2.202","DOIUrl":"https://doi.org/10.12997/jla.2021.10.2.202","url":null,"abstract":"Objective: The Korean Society of Lipid and Atherosclerosis (KSoLA) has published the Dyslipidemia Fact Sheets in Korea 2020 to provide an overview of magnitude and management status of dyslipidemia and their recent trends therein.Methods: The Fact Sheets were based on the analyses of Korean adults aged 20 years or older of the 2007-2018 Korea National Health and Nutrition Examination Survey (KNHANES) and the 2002-2018 National Health Insurance Big Data (NHI-BD).Results: Between 2007 and 2018, the crude prevalence of hypercholesterolemia increased from 9.0% to 20.7%. During the same period, its management rate also improved yet remained unsatisfactory. In 2018, the prevalence of dyslipidemia was 45.6% in men and 31.3% in women, which increased with older age and presence of metabolic abnormalities. Indeed, the number of people diagnosed with dyslipidemia has increased nearly 8-fold from 1.5 million in 2002 to 11.6 million in 2018; alongside, the number of people receiving pharmacological treatment for dyslipidemia has also risen. Of the 7.7 million people treated for dyslipidemia in 2018, statin accounted for the majority (91.8%) of lipid-lowering drug prescriptions, followed by ezetimibe (14.6%), fibrate (8.5%), and omega-3 acid (5.9%). The most frequently used combination therapy was statin plus ezetimibe, accounting for 72% of dual therapy prescriptions.Conclusion: Dyslipidemia continues to impose a substantial disease burden in Korea. Both healthcare practitioners and patients need to actively adopt guideline-recommended lifestyle modification and pharmacological treatment for comprehensive, timely, and sustained management.","PeriodicalId":16284,"journal":{"name":"Journal of Lipid and Atherosclerosis","volume":"10 2","pages":"202-209"},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/33/65/jla-10-202.PMC8159761.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39068542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 52

Cardiovascular Outcomes Comparison of Dipeptidyl Peptidase-4 Inhibitors versus Sulfonylurea as Add-on Therapy for Type 2 Diabetes Mellitus: a Meta-Analysis. 二肽基肽酶-4抑制剂与磺脲类药物作为2型糖尿病附加治疗的心血管结局比较:一项荟萃分析

Journal of Lipid and Atherosclerosis Pub Date : 2021-05-01 Epub Date: 2021-01-25 DOI: 10.12997/jla.2021.10.2.210

Won Kyeong Jeon, Jeehoon Kang, Hyo-Soo Kim, Kyung Woo Park

{"title":"Cardiovascular Outcomes Comparison of Dipeptidyl Peptidase-4 Inhibitors versus Sulfonylurea as Add-on Therapy for Type 2 Diabetes Mellitus: a Meta-Analysis.","authors":"Won Kyeong Jeon, Jeehoon Kang, Hyo-Soo Kim, Kyung Woo Park","doi":"10.12997/jla.2021.10.2.210","DOIUrl":"https://doi.org/10.12997/jla.2021.10.2.210","url":null,"abstract":"Objective: Recent studies have raised concern about the cardiovascular safety of dipeptidyl peptidase-4 (DPP4) inhibitors. We performed a systematic review through meta-analysis to compare cardiovascular outcomes of sulfonylurea (SU) versus DPP4 inhibitors when used in combination with metformin.Methods: After searching for trials using combination therapy of metformin with DPP4 inhibitor or SU in PubMed, Cochrane Library, and Embase, one prospective observation study and 15 randomized controlled studies were selected.Results: Regarding the primary analysis endpoint, there were no significant differences in the risk of all-cause mortality between SU and DPP4 inhibitors as an add-on therapy to metformin (random-effect relative risk [RR], 1.14; 95% confidence interval [CI], 0.98-1.33; p=0.811; I2=0%). Cardiovascular death was also similar between the two drug classes in the five studies which reported outcomes (random-effect RR, 1.03; 95% CI, 0.83-1.27; p=0.517; I2=0%). Furthermore, there were no significant differences in major adverse cardiac events (MACE), coronary heart disease, myocardial infarction, ischemic stroke and heart failure. However, there were less hypoglycemic events and weight gain in the DPP4 inhibitor group as compared with the SU group (random-effect RR, 3.79; 95% CI, 1.53-9.39; p<0.001; I2=98.2 and weighted mean difference, 1.68; 95% CI, 1.07-2.29; p<0.001; I2=94.7, respectively).Conclusion: As add-on therapy to metformin, there were no significant differences in all-cause mortality and cardiovascular mortality between DPP4 inhibitors and SUs.","PeriodicalId":16284,"journal":{"name":"Journal of Lipid and Atherosclerosis","volume":"10 2","pages":"210-222"},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39068543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Differential Angiogenic Responses of Human Endothelial Colony-Forming Cells to Different Molecular Subtypes of Breast Cancer Cells. 人内皮集落形成细胞对不同分子亚型乳腺癌细胞的差异血管生成反应

Journal of Lipid and Atherosclerosis Pub Date : 2021-01-01 Epub Date: 2021-01-18 DOI: 10.12997/jla.2021.10.1.111

Hyunsook Lee, Kyu-Tae Kang

{"title":"Differential Angiogenic Responses of Human Endothelial Colony-Forming Cells to Different Molecular Subtypes of Breast Cancer Cells.","authors":"Hyunsook Lee, Kyu-Tae Kang","doi":"10.12997/jla.2021.10.1.111","DOIUrl":"https://doi.org/10.12997/jla.2021.10.1.111","url":null,"abstract":"Objective: Triple negative breast cancer (TNBC) is one subtype of breast cancer. It is characterized by lack of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. Compared with non-TNBC, TNBC is more aggressive, of higher grade, and frequently metastatic with poor prognosis, which is correlated with upregulated microvascular density. Endothelial colony-forming cells (ECFCs) mediate neovascularization, which is the crucial contributor to cancer growth and metastasis. The present study aimed to determine whether angiogenic responses of ECFCs are regulated differently by TNBC compared with non-TNBC.Methods: MDA-MB-231 and MCF7 cells were utilized for TNBC and non-TNBC, respectively. Bone-marrow-derived human ECFCs were treated with a conditioned medium (CM) of cancer cells to investigate the paracrine effect on angiogenesis. Also, ECFCs were co-cultured with cancer cells to evaluate the angiogenic effect of direct cell-to-cell interaction. Angiogenic responses of ECFCs were evaluated by proliferation, migration, and tube formation. Gene expression profiles of pro-angiogenic factors were also analyzed.Results: Migration and tube formation of ECFCs were increased by treatment with CM of MDA-MB-231, which correlated with a higher gene expression profile of pro-angiogenic factors in MDA-MB-231 compared to MCF7. Interestingly, ECFCs co-cultured with MDA-MB-231 showed further increase of tube formation, suggesting synergic mechanisms between the paracrine effect and direct interaction between the cells.Conclusion: The angiogenic potential of ECFCs was enhanced by TNBC through both direct and indirect mechanisms. Therefore, the investigation of signaling pathways to regulate ECFC-mediated angiogenesis will be important to the discovery of anti-angiogenic therapies to treat TNBC patients.","PeriodicalId":16284,"journal":{"name":"Journal of Lipid and Atherosclerosis","volume":"10 1","pages":"111-122"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e5/2e/jla-10-111.PMC7838508.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25329008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Inborn Errors of Mitochondrial Fatty Acid Oxidation: Overview from a Clinical Perspective. 线粒体脂肪酸氧化的先天性错误:从临床角度综述。

Journal of Lipid and Atherosclerosis Pub Date : 2021-01-01 Epub Date: 2020-12-01 DOI: 10.12997/jla.2021.10.1.1

Han-Wook Yoo

引用次数: 2