Journal of Mathematical and Fundamental Sciences最新文献_第3页

Synthesis of Human Antibodies Against HBsAg in Newly Established Chinese Hamster Lung (CHL-YN) Cell Line 新建立的中国仓鼠肺(CHL-YN)细胞系人抗HBsAg抗体的合成

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Journal of Mathematical and Fundamental Sciences Pub Date : 2023-05-07 DOI: 10.5614/j.math.fund.sci.2022.54.3.1

Meutia Diva Hakim, Noriko Yamano- Adachi, T. Omasa, M. Tan, L. D. Juliawaty, E. Giri-Rachman

{"title":"Synthesis of Human Antibodies Against HBsAg in Newly Established Chinese Hamster Lung (CHL-YN) Cell Line","authors":"Meutia Diva Hakim, Noriko Yamano- Adachi, T. Omasa, M. Tan, L. D. Juliawaty, E. Giri-Rachman","doi":"10.5614/j.math.fund.sci.2022.54.3.1","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2022.54.3.1","url":null,"abstract":"Hepatitis B immunoglobulin (HBIG) is an effective treatment for hepatitis B, including postexposure prophylaxis of HBV infection, prevention of HBV reinfection in liver transplant patients, and reducing sexual transmission. This study investigated the synthesis of human IgG antibodies that specifically target HBsAg subtype adr in CHL-YN cells, a newly established cell line that grows faster than CHO-K1. To achieve the synthesis of human IgG antibodies, a plasmid vector encoding DNA sequences for human IgG antibodies against HBsAg was constructed and then transiently transfected into CHL-YN cells. The expression and antigen-binding capacity of the recombinant human IgG antibodies were analyzed using western blot and ELISA. The results showed successful expression and secretion of human IgG antibodies that recognize HBsAg subtype adr in CHL-YN cells. The ELISA test confirmed the specificity of the human IgG antibodies towards HBsAg subtype adr. Thus, this study concluded that human IgG antibodies that target HBsAg subtype adr were transiently expressed in CHL-YN cells.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78293281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of the Effect of Physical Parameters on Commercial Hydroponics Based on Internet of Things (IoT): A Case Study of Bok Coy Plants (Brassica rapa) and Water Spinach (Ipomoea Aquatica) 基于物联网的商业水培物理参数影响研究——以豆科植物(Brassica rapa)和水菠菜(Ipomoea Aquatica)为例

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Journal of Mathematical and Fundamental Sciences Pub Date : 2023-04-17 DOI: 10.5614/j.math.fund.sci.2022.54.2.5

M. Budiman, Efraim Partogi, A. Kristi, Prianka Anggara, N. Aminah

{"title":"Study of the Effect of Physical Parameters on Commercial Hydroponics Based on Internet of Things (IoT): A Case Study of Bok Coy Plants (Brassica rapa) and Water Spinach (Ipomoea Aquatica)","authors":"M. Budiman, Efraim Partogi, A. Kristi, Prianka Anggara, N. Aminah","doi":"10.5614/j.math.fund.sci.2022.54.2.5","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2022.54.2.5","url":null,"abstract":"Population growth causes the demand for food to increase. One solution that can be applied is agriculture with hydroponic technology. To increase production efficiency, one must know the physical parameters that most influence the production process. This research used an IoT system to gather accurate and precise measurement data of physical parameters to be used as a dataset for machine learning. The dataset consisted of light intensity, humidity, air temperature, and total dissolved solids (TDS). Plant growth was measured by leaf area of the plant, number of leaves, and plant stem length every 3 to 4 days. The models used in the machine learning process were linear regression, polynomial regression, and random forest regression. The machine learning results showed that the best model for predicting plant growth was random forest regression with an MAE of 8.3% and an R2 of 0.93, for both bok coy and water spinach. The variables that influence growth the most are TDS and light intensity. According to the relationship between TDS gradient and plant growth gradient, the most optimal growth can be achieved by raising the TDS gradient or by maintaining a high TDS, which can be achieved by adding nutrient solution to the tank regularly.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78856238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, Structure, Magnetic and Antibacterial Properties of polymeric [M(Quin)2(N(CN)2)2]∞ (M = Mn(II), Co(II); Quin = quinoline) 高分子[M(Quin)2(N(CN)2)2]∞(M = Mn(II)， Co(II))的合成、结构、磁性和抗菌性能喹啉)

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Journal of Mathematical and Fundamental Sciences Pub Date : 2023-03-19 DOI: 10.5614/j.math.fund.sci.2022.54.2.4

Wayan Dasna, Ubed Sonai, Fahruddin Arrozi, H. W. Wijaya, Sutandyo Dwija Laksmana, S. Golhen

引用次数: 0

Antibacterial Activity of Gyrinops versteegii Fruit Extracts against Staphylococcus aureus and Escherichia coli and GC-MS Analysis 黄花楸果实提取物对金黄色葡萄球菌和大肠杆菌的抑菌活性及GC-MS分析

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Journal of Mathematical and Fundamental Sciences Pub Date : 2023-03-04 DOI: 10.5614/j.math.fund.sci.2022.54.2.3

E. Hidayati, Yulifa Handayani, I. Sudarma

{"title":"Antibacterial Activity of Gyrinops versteegii Fruit Extracts against Staphylococcus aureus and Escherichia coli and GC-MS Analysis","authors":"E. Hidayati, Yulifa Handayani, I. Sudarma","doi":"10.5614/j.math.fund.sci.2022.54.2.3","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2022.54.2.3","url":null,"abstract":"Gyrinops versteegii is widely used in the perfume, incense, and cosmetic industries as a raw material. Other potential uses of the plant are being explored, including in food and medicine. Therefore, this study carried out antibacterial assay and gas chromatography-mass spectroscopy of G. versteegii fruit extracts in three solvents with different polarities, i.e., n-hexane, dichloromethane, and methanol. The agar well diffusion method was then used to test the extracts against Staphylococcus aureus and Escherichia coli. The dichloromethane extract showed the most effective antibacterial activity against S. aureus at a concentration of 40%, with a zone of inhibition of 13.17 mm compared to E. coli, for which it was 7 mm. Furthermore, the bacterial species showed different responses to the extracts. Total and partial inhibition was shown by the G. versteegii fruit extracts and E. coli, respectively, against S. aureus. Furthermore, GC-MS identified the following compounds in G. versteegii fruit extract: palmitic, oleic, and stearic acid, as well as bis-(2-ethylhexyl) phthalate, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one, methyl octadec-9-enoate, squalene, and 2-monopalmitin derivates. The results showed antibacterial potency of G. versteegii fruit extract against pathogenic bacteria. Additionally, the antibacterial activity of the extract was stronger against S. aureus compared to E. coli.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88864739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mathematical Analysis of Two Strains Covid-19 Disease Using SEIR Model 用SEIR模型对两株Covid-19疾病进行数学分析

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Journal of Mathematical and Fundamental Sciences Pub Date : 2022-12-28 DOI: 10.5614/j.math.fund.sci.2022.54.2.1

A. S. Eegunjobi, O. Makinde

引用次数: 2

Metagenomic Analysis of Bacterial Community in the Gut of Blister Beetle Mylabris pustulata Thunberg 水疱甲虫肠道细菌群落的宏基因组分析

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Journal of Mathematical and Fundamental Sciences Pub Date : 2022-10-18 DOI: 10.5614/j.math.fund.sci.2022.54.1.10

A. Dinoto, Z. Noviana, O. Efendy, H. Julistiono

{"title":"Metagenomic Analysis of Bacterial Community in the Gut of Blister Beetle Mylabris pustulata Thunberg","authors":"A. Dinoto, Z. Noviana, O. Efendy, H. Julistiono","doi":"10.5614/j.math.fund.sci.2022.54.1.10","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2022.54.1.10","url":null,"abstract":"Blister beetles are an important object of study in the field of agriculture and health. Despite being known to be important for the host animal, the gut bacteria of blister beetles have not been investigated deeply. This study aimed to provide the first initial description of the gut bacterial community of Mylabris pustulata as one species of blister beetles, based on a culture-independent technique. Adult blister beetles of the same colony were sampled and confirmed as Mylabris pustulata Thunberg. The gut content was used in high throughput sequencing, targeting the V3-V4 regions of 16S rRNA gene, and in the cultivation of resident bacteria. The results showed that higher bacterial richness was present in the gut communities when compared to the grown bacterial culture. Proteobacteria was confirmed as the most abundant phylum in the gut of M. pustulata, whereby most reads belonged to the class of Gammaproteobacteria. The dominant bacterial genera were determined as Enterobacter, Acinetobacter, Enterococcus, Klebsiella, and Pseudomonas. In addition, our cultivation attempts led to successful isolation of members of Klebsiella and Enterococcus. The subject of this study could be explored further to find the potential roles of these microbiota in the gut of the specific beetles and their bioprospects.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81780192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Backward Bifurcation Emerging from a Mathematical Model of African Animal Trypanosomiasis Disease in White Rhino Populations 非洲动物锥虫病在白犀牛种群中的数学模型的后向分叉

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Journal of Mathematical and Fundamental Sciences Pub Date : 2022-09-12 DOI: 10.5614/j.math.fund.sci.2022.54.1.9

D. Aldila, Tama Windyhani

{"title":"Backward Bifurcation Emerging from a Mathematical Model of African Animal Trypanosomiasis Disease in White Rhino Populations","authors":"D. Aldila, Tama Windyhani","doi":"10.5614/j.math.fund.sci.2022.54.1.9","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2022.54.1.9","url":null,"abstract":"This paper introduces a mathematical model for African animal trypanosomiasis (AAT) in white rhino and tsetse fly populations. The model accommodates two types of interventions, namely infection detection and ground spraying. The dynamical system properties were thoroughly investigated to show the existence of equilibrium points, backward bifurcation, and how they are related to the basic reproduction number. We found that there is a chance that AAT may die out from the population if the basic reproduction number is smaller than one. However, the possible existence of backward bifurcation implies a condition where we may have a stable endemic equilibrium, even when the basic reproduction number is smaller than one. Hence, the basic reproduction number is no longer sufficient to guarantee the disappearance of AAT from the population. Our sensitivity analysis on the basic reproduction number showed that the interventions of infection detection and ground spraying have good potential to eradicate AAT from the population. To analyze the most effective intervention as time-dependent variable, we reconstructed our model as an optimal control problem. Numerical simulations on various scenarios were conducted for the optimal control problem. Cost-effectiveness analysis using the Average Cost-Effectiveness Ratio (ACER) and the Incremental Cost-Effectiveness Ratio (ICER) methods was performed. From the cost-effectiveness analysis, we found that ground spraying is the most cost-effective intervention to combat the spread of AAT in white rhino populations.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84540019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Basin Study in Atambua, West Timor, Indonesia from Gravity Data 印度尼西亚西帝汶Atambua盆地重力数据研究

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Journal of Mathematical and Fundamental Sciences Pub Date : 2022-09-02 DOI: 10.5614/j.math.fund.sci.2022.54.1.8

Edy Wijanarko, I. Arisbaya, P. Sumintadireja, W. Warsa, H. Grandis

{"title":"Basin Study in Atambua, West Timor, Indonesia from Gravity Data","authors":"Edy Wijanarko, I. Arisbaya, P. Sumintadireja, W. Warsa, H. Grandis","doi":"10.5614/j.math.fund.sci.2022.54.1.8","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2022.54.1.8","url":null,"abstract":"Timor Island, Indonesia has complex geological structures related to its tectonic history. There is an existing subsurface geological model that is based on geophysical data. It is limited to the regional crustal scale and has a relatively low spatial resolution. The objective of our study was to delineate the sedimentary basin configuration of the area, both laterally and vertically, based on gravity data. Spectral analysis of the Bouguer anomaly allowed for anomaly enhancement by wavenumber domain filtering. Two main basins were identified from elongated low gravity anomalies that follow a SW-NE trend, i.e., the Central Basin and the Atambua Basin. The 2½D gravity modeling of selected profiles perpendicular to the regional structural direction revealed the sedimentary fills of the basins and the basement based on their densities. The Bobonaro mélanges and Viqueque sequences dominate and overlay the syn-rift (Kekneno sequences) and post-rift (Kolbano sequences) with varying lithology. These para-autochthon sediments are dominated by shale and carbonaceous rocks. Their respective thicknesses and depths of burial imply the possibility of hydrocarbon generation. The underlying basement may be associated with the Australian crust protruding from the south.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86341345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Flower Pollination and Elitism Algorithms for Inversion of TDEM Data TDEM数据反演中的花授粉和精英算法

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Journal of Mathematical and Fundamental Sciences Pub Date : 2022-08-30 DOI: 10.5614/j.math.fund.sci.2022.54.1.7

Widodo Widodo, Farkhan Raflesia, Susanti Awaliyah, Setianingsih Setianingsih, D. Santoso, W. Parnadi, F. Fatkhan

引用次数: 2

Piper crocatum Ameliorates APAP-Induced Hepatotoxicity through Antioxidant and Anti-Inflammatory Mechanisms 番椒通过抗氧化和抗炎机制改善apap诱导的肝毒性

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Journal of Mathematical and Fundamental Sciences Pub Date : 2022-06-21 DOI: 10.5614/j.math.fund.sci.2022.54.1.6

I. Lister, C. Ginting, Ermi Girsang, A. Amansyah, L. Chiuman, N. L. W. E. Yanti, W. Widodo, D. T. Yusepany, R. Rizal, W. Widowati

{"title":"Piper crocatum Ameliorates APAP-Induced Hepatotoxicity through Antioxidant and Anti-Inflammatory Mechanisms","authors":"I. Lister, C. Ginting, Ermi Girsang, A. Amansyah, L. Chiuman, N. L. W. E. Yanti, W. Widodo, D. T. Yusepany, R. Rizal, W. Widowati","doi":"10.5614/j.math.fund.sci.2022.54.1.6","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2022.54.1.6","url":null,"abstract":"Cirrhosis is a serious hepatic disease that occurs worldwide and is caused by progressive fibrosis in the liver. Free radicals are the major cause of reactive oxygen species (ROS) generation, which affects the balance of the liver metabolism. Piper crocatum, commonly called red betel, is widely used in ethnomedicine because it has biological capabilities, including antioxidant and anti-inflammatory properties. The present study was undertaken to examine the possibility of hepaprotective activity of red betel extract on acetaminophen (APAP)-induced HepG2 cells as the cirrhosis in vitro model. Assessment of red betel extract (RBE) was performed using the colorimetric method for the quantification of LDH, AST, and ALT. As preliminary study, a cytotoxicity assay was performed at various RBE concentrations (100.00; 50.00; 25.00; 12.50; 6.25; 3.13 μg/ml) using an MTS assay to decide the safe concentration based on cell viability. The RBE treatment did not affect cell viability, even at a high concentration (100 µg/ml, p > 0.05). RBE at concentrations 25 and 100 µg/ml successfully reduced LDH, AST, and ALT activities in the hepatotoxic model in a dose-dependent manner. In the APAP-induced hepatotoxicity model, RBE positively indicated a hepatoprotective effect and cell amelioration by a decrease in hepatotoxic markers.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84859565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0