Journal of Korean Medical Science最新文献

{"title":"Effects of Genetic Risk and Lifestyle Habits on Gout: A Korean Cohort Study.","authors":"Hyunjung Kim, Hyunsue Do, Chang-Nam Son, Jae-Won Jang, Sun Shim Choi, Ki Won Moon","doi":"10.3346/jkms.2025.40.e1","DOIUrl":"10.3346/jkms.2025.40.e1","url":null,"abstract":"<p><strong>Background: </strong>Gout is a type of inflammatory arthritis caused by monosodium urate crystal deposits, and the prevalence of this condition has been increasing. This study aimed to determine the combined effects of genetic risk factors and lifestyle habits on gout, using data from a Korean cohort study. Identifying high-risk individuals in advance can help prevent gout and its associated disorders.</p><p><strong>Methods: </strong>We analyzed data from the Korean Genome and Epidemiology Study-Urban Health Examinees cohort (KoGES-HEXA). Genetic information of the participants was collected at baseline, and gout cases were identified based on patient statements. The polygenic risk score (PRS) was calculated using nine independent genome-wide association study datasets, and lifestyle factors and metabolic syndrome status were measured for each participant using the KoGES. Logistic regression models were used to estimate the odds ratios (ORs) for gout in relation to genetic risk, lifestyle habits, and metabolic health status, after adjusting for age and sex.</p><p><strong>Results: </strong>Among 44,605 participants, 617 were diagnosed with gout. Gout was associated with older age, higher body mass index, and higher prevalence of hypertension, diabetes, and hypertriglyceridemia. High PRS, unfavorable lifestyle habits, and poor metabolic profiles were significantly associated with an increased risk of gout. Compared with that in the low-genetic-risk and healthy lifestyle group or ideal metabolic profile group, the risk of gout was increased in the high-genetic-risk plus unfavorable lifestyle (OR, 3.64; 95% confidence interval [CI], 2.32-6.03) or poor metabolic profile (OR, 7.78; 95% CI, 4.61-13.40) group. Conversely, adherence to favorable lifestyle habits significantly reduced gout risk, especially in high-genetic-risk groups.</p><p><strong>Conclusion: </strong>Genetic predisposition and unhealthy lifestyle habits significantly increase the risk of gout. Promoting healthy lifestyle habits is crucial to prevent the development of gout, particularly in individuals with high genetic susceptibility.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 2","pages":"e1"},"PeriodicalIF":3.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights Into <i>JKMS</i> Submissions and Medical Journal Publications in Korea.","authors":"Jaehun Jung, Yumi Jang, Munkhzul Radnaabaatar, Dae Sun Jo, Jong-Min Kim, Jin-Hong Yoo","doi":"10.3346/jkms.2025.40.e76","DOIUrl":"https://doi.org/10.3346/jkms.2025.40.e76","url":null,"abstract":"<p><p>We analyzed the publication and submission statuses of Korean medical journals from 2010 to 2024, amidst challenges impacting researchers. Data from 58 domestic journals identified through the 2023 JCR database were used to assess publication status, while data from the <i>Journal of Korean Medical Science</i> (<i>JKMS</i>) were utilized to examine submission status. The proportion of published original articles by domestic authors decreased by 3% in 2024 compared to 2023. Submissions to <i>JKMS</i> also decreased overall, except for slight increases in May and October 2024. In contrast, international submissions to <i>JKMS</i> showed consistent growth, surpassing the 15-year average, reflecting growing global interest. Addressing issues, including medical school admission policies and the lingering effects of coronavirus disease 2019, is vital to ensure a sustainable and thriving medical research environment in Korea.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 1","pages":"e76"},"PeriodicalIF":3.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Needs Assessment for Public Health Competency in Infection Prevention and Control: Importance and Performance Analysis (IPA) of Infectious Disease Response Practitioners.","authors":"Youngjon Kim, Jin Gwack, Yunhyung Kwon, Moon Joo Cheong, Ju-Hyung Lee","doi":"10.3346/jkms.2025.40.e23","DOIUrl":"https://doi.org/10.3346/jkms.2025.40.e23","url":null,"abstract":"<p><strong>Background: </strong>The Field Epidemiology Training Program Frontline, initiated by the Korea Disease Control and Prevention Agency in 2019, aims to enhance the competencies of infectious disease practitioners across 17 regions in South Korea. With the September 2024 amendment to the Infectious Disease Prevention Act mandating infectious disease prevention and crisis response training for government employees who are associated with infectious diseases responses, there is an urgent need to assess and optimize the effectiveness and cost-efficiency of such competency-based education programs amidst constraints of budget and manpower.</p><p><strong>Methods: </strong>This study examined the educational needs and priorities of public health competencies among infectious disease practitioners. The competency framework for Infectious Disease Response Practitioners (IDRP) in South Korea was used to evaluate the validity, importance, and performance level of competencies for infectious disease response personnel. For the training needs analysis, differences in performance by group were analyzed, and an importance performance analysis (IPA) was conducted using the Borich Needs Assessment based on the IPA matrix to derive training priorities.</p><p><strong>Results: </strong>The analysis revealed a significant gap between perceived importance and self-reported performance levels in most competencies, especially epidemiologic methods. Competencies related to safety and ethics, fieldwork, and crisis management have high importance and performance ratings, indicating a need for ongoing training. Of the 27 competencies, the IPA identified specific training needs and priorities, suggesting eight competencies for focused intervention to strengthen the capacity of IDRPs.</p><p><strong>Conclusion: </strong>The IDRP competency framework in South Korea plays a pivotal role in establishing a standardized, competency-based approach to training IDRP. The identified gaps and training priorities highlight the need for continued curriculum development and the integration of real-world, field-based scenarios into training programs.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 1","pages":"e23"},"PeriodicalIF":3.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artemisinin-Quinidine Combination for Suppressing Ventricular Tachyarrhythmia in an Ex Vivo Model of Brugada Syndrome.","authors":"Hyung Ki Jeong, Namsik Yoon, Yoo Ri Kim, Ki Hong Lee, Hyung Wook Park","doi":"10.3346/jkms.2025.40.e2","DOIUrl":"https://doi.org/10.3346/jkms.2025.40.e2","url":null,"abstract":"<p><strong>Background: </strong>The ionic mechanism underlying Brugada syndrome (BrS) arises from an imbalance in transient outward current flow between the epicardium and endocardium. Previous studies report that artemisinin, originally derived from a Chinese herb for antimalarial use, inhibits the Ito current in canines. In a prior study, we showed the antiarrhythmic effects of artemisinin in BrS wedge preparation models. However, quinidine remains a well-established antiarrhythmic agent for treating BrS. Therefore, this study aims to investigate the efficacy of combining artemisinin with low-dose quinidine in suppressing ventricular tachyarrhythmia (VTA) in experimental canine BrS models.</p><p><strong>Methods: </strong>Transmural pseudo-electrocardiogram and epicardial/endocardial action potential (AP) were recorded from coronary-perfused canine right ventricular wedge preparation. To mimic the BrS model, acetylcholine (3 μM), calcium channel blocker verapamil (1 μM), and Ito agonist NS5806 (6-10 μM) were administered until VTA was induced. Subsequently, low-dose quinidine (1-2 μM) combined with artemisinin (100 μM) was perfused to mitigate VTA. Key parameters, including AP duration, J wave area, notch index, and T wave dispersion, were measured.</p><p><strong>Results: </strong>After administering the provocation agents, all sample models exhibited prominent J waves and VTA. Artemisinin alone (100-150 μM) suppressed VTA and restored the AP dome in all three preparations. Its infusion resulted in reductions in the J wave area and epicardial notch index. Consequently, low-dose quinidine (1-2 μM) did not fully restore the AP dome in all six sample models. However, when combined with additional artemisinin (100 μM), low-dose quinidine effectively suppressed VTA in all six models and restored the AP dome while also decreasing the J wave area and epicardial notch index.</p><p><strong>Conclusion: </strong>Low-dose quinidine alone fails to fully alleviate VTA in the BrS wedge model. However, its combination with artemisinin effectively suppresses VTA. Artemisinin may reduce the therapeutic dose of quinidine, potentially minimizing its associated adverse effects.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 1","pages":"e2"},"PeriodicalIF":3.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gaps and Similarities in Research Use LOINC Codes Utilized in Korean University Hospitals: Towards Semantic Interoperability for Patient Care.","authors":"Kuenyoul Park, Min-Sun Kim, YeJin Oh, John Hoon Rim, Shinae Yu, Hyejin Ryu, Eun-Jung Cho, Kyunghoon Lee, Ha Nui Kim, Inha Chun, AeKyung Kwon, Sollip Kim, Jae-Woo Chung, Hyojin Chae, Ji Seon Oh, Hyung-Doo Park, Mira Kang, Yeo-Min Yun, Jong-Baeck Lim, Young Kyung Lee, Sail Chun","doi":"10.3346/jkms.2025.40.e4","DOIUrl":"https://doi.org/10.3346/jkms.2025.40.e4","url":null,"abstract":"<p><strong>Background: </strong>The accuracy of Logical Observation Identifiers Names and Codes (LOINC) mappings is reportedly low, and the LOINC codes used for research purposes in Korea have not been validated for accuracy or usability. Our study aimed to evaluate the discrepancies and similarities in interoperability using existing LOINC mappings in actual patient care settings.</p><p><strong>Methods: </strong>We collected data on local test codes and their corresponding LOINC mappings from seven university hospitals. Our analysis focused on laboratory tests that are frequently requested, excluding clinical microbiology and molecular tests. Codes from nationwide proficiency tests served as intermediary benchmarks for comparison. A research team, comprising clinical pathologists and terminology experts, utilized the LOINC manual to reach a consensus on determining the most suitable LOINC codes.</p><p><strong>Results: </strong>A total of 235 LOINC codes were designated as optimal codes for 162 frequent tests. Among these, 51 test items, including 34 urine tests, required multiple optimal LOINC codes, primarily due to unnoted properties such as whether the test was quantitative or qualitative, or differences in measurement units. We analyzed 962 LOINC codes linked to 162 tests across seven institutions, discovering that 792 (82.3%) of these codes were consistent. Inconsistencies were most common in the analyte component (38 inconsistencies, 33.3%), followed by the method (33 inconsistencies, 28.9%), and properties (13 inconsistencies, 11.4%).</p><p><strong>Conclusion: </strong>This study reveals a significant inconsistency rate of over 15% in LOINC mappings utilized for research purposes in university hospitals, underlining the necessity for expert verification to enhance interoperability in real patient care.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 1","pages":"e4"},"PeriodicalIF":3.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Entering the New Year of 2025 With Concerns About the Decline of Medical Academics in Korea.","authors":"Jin-Hong Yoo","doi":"10.3346/jkms.2025.40.e64","DOIUrl":"https://doi.org/10.3346/jkms.2025.40.e64","url":null,"abstract":"","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 1","pages":"e64"},"PeriodicalIF":3.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expert Consensus on Developing Information and Communication Technology-Based Patient Education Guidelines for Rheumatic Diseases in the Korea.","authors":"Junghee Yoon, Soo-Kyung Cho, Se Rim Choi, Soo-Bin Lee, Juhee Cho, Chan Hong Jeon, Geun-Tae Kim, Jisoo Lee, Yoon-Kyoung Sung","doi":"10.3346/jkms.2025.40.e67","DOIUrl":"https://doi.org/10.3346/jkms.2025.40.e67","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to identify key priorities for the development of guidelines for information and communication technology (ICT)-based patient education tailored to the needs of patients with rheumatic diseases (RDs) in the Republic of Korea, based on expert consensus.</p><p><strong>Methods: </strong>A two-round modified Delphi study was conducted with 20 rheumatology, patient education, and digital health literacy experts. A total of 35 items covering 7 domains and 18 subdomains were evaluated. Each item was evaluated for its level of importance, and the responses were rated on a 4-point Likert scale. Consensus levels were defined as \"high\" (interquartile range [IQR] ≤ 1, agreement ≥ 80%, content validity ratio [CVR] ≥ 0.7), \"Moderate\" (IQR ≥ 1, agreement 50-79%, CVR 0.5-0.7), and \"Low\" (IQR > 1, agreement < 50%, CVR < 0.5).</p><p><strong>Results: </strong>Strong consensus was reached for key priorities for developing guidelines in areas such as health literacy, digital health literacy, medical terminology, user interface, and user experience design for mobile apps. Chatbot use and video (e.g., YouTube) also achieved high consensus, whereas AI-powered platforms such as ChatGPT showed moderate-to-high agreement. Telemedicine was excluded because of insufficient consensus.</p><p><strong>Conclusion: </strong>The key priorities identified in this study provide a foundation for the development of ICT-based patient education guidelines for RDs in the Republic of Korea. Future efforts should focus on integrating digital tools into clinical practice to enhance patient engagement and improve clinical outcomes.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 1","pages":"e67"},"PeriodicalIF":3.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender Difference of Moderated Mediating Effect of Grit Between Occupational Stress and Suicidal Ideation in Korean Workers.","authors":"Sra Jung, Hyejeong Jeon, Mi Yeon Lee, Eunsoo Kim, Dong-Won Shin, Young-Chul Shin, Kang-Seob Oh, Min-Kyoung Kim, Sang-Won Jeon, Sung Joon Cho","doi":"10.3346/jkms.2024.39.e308","DOIUrl":"10.3346/jkms.2024.39.e308","url":null,"abstract":"<p><strong>Background: </strong>This study examined gender differences in occupational stress, depressive symptoms, and suicidal ideation by considering the potential moderating effect of grit on Korean employees.</p><p><strong>Methods: </strong>A total of 11,369 participants (7,735 men and 3,634 women) aged 19-65 years, employed across 18 private companies and local government organizations in Korea, completed questionnaires including the Short Grit Scale, Korean Occupational Stress Scale, and Center for Epidemiologic Studies Depression Scale between April 2020 and March 2022. Suicidal ideation was assessed based on its presence or absence. Mediation and moderation analyses were performed using the Statistical Package for the Social Sciences PROCESS macro.</p><p><strong>Results: </strong>Depressive symptoms partially mediated the relationship between occupational stress and suicidal ideation in male employees, whereas depressive symptoms fully mediated the relationship in female employees. Grit moderated the relationship between depressive symptoms and suicidal ideation in male employees but not in female employees. Furthermore, the moderated mediating effect of grit in male employees on the relationship between occupational stress and suicidal ideation provided less protection in cases of severe depression. The cross-sectional design does not allow for causal inferences.</p><p><strong>Conclusion: </strong>These findings contribute to understanding of the gender differences in the impact of depressive symptoms on the relationship between occupational stress and suicidal ideation, as well as the protective effect of grit. These findings highlight the need for gender-specific approaches to prevent suicidal ideation among employees.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"39 50","pages":"e308"},"PeriodicalIF":3.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11685280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concise Recommendations for EDitorials: Enhancing Narratives and Composition Effectively (CREDENCE).","authors":"Ilke Coskun Benlidayi, Latika Gupta","doi":"10.3346/jkms.2024.39.e338","DOIUrl":"10.3346/jkms.2024.39.e338","url":null,"abstract":"<p><p>An editorial article is a type of scholarly communication providing expert views and critical analysis of issues. It may reflect the view of the author(s) or of the organization/journal on a certain topic. An editorial may also comment on a published paper. Editorials are expected to be objective, evidence-based, and informative focusing attention on recent developments and matters of current societal/disciplinary concern. This format allows for timely dissemination of expert insight and facilitates ongoing scholarly discourse. The structure of editorials varies: critical, explanatory, and commendatory types serve varied purposes. Authors of editorials should follow certain principles of academic writing. The aim should be provided in an introductory paragraph. Thereafter, a constructive and balanced critique of the index article and/or a detailed yet concise analyze of the subject of matter should be provided. The conclusion paragraph should include brief take-home messages. Critical arguing should be supported by relevant references. A declaration of any potential conflicts of interests is essential to maintain objectivity and fairness. The current article aims to provide a primer, along with a checklist, on writing editorials.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"39 50","pages":"e338"},"PeriodicalIF":3.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11685276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In This Issue on 30-December-2024.","authors":"Jin-Hong Yoo","doi":"10.3346/jkms.2024.39.e337","DOIUrl":"10.3346/jkms.2024.39.e337","url":null,"abstract":"","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"39 50","pages":"e337"},"PeriodicalIF":3.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11685278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}