Journal of Korean Medical Science最新文献

{"title":"Sexual Risk Compensation and Retention in PrEP Care in Korea: An HIV PrEP Demonstration Study.","authors":"Yae Jee Baek, Yongseop Lee, Jung Ah Lee, Sangmin Ahn, Min Han, Jaeeun Seong, Sang-Guk Lee, Jung Ho Kim, Jin Young Ahn, Jun Yong Choi","doi":"10.3346/jkms.2025.40.e102","DOIUrl":"10.3346/jkms.2025.40.e102","url":null,"abstract":"<p><strong>Background: </strong>Pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate and emtricitabine (TDF-FTC) is effective in preventing human immunodeficiency virus (HIV), however, its feasibility has not been evaluated in the Republic of Korea (Korea). Therefore, this study aimed to assess the feasibility of PrEP in men who have sex with men (MSM) in Korea. This is the first demonstration study in Korea, in which PrEP medication, laboratory tests, and clinic visit fees were provided without charge to participants.</p><p><strong>Methods: </strong>HIV-negative MSM were prescribed daily TDF-FTC and followed up at an outpatient clinic. At each visit, adverse reactions, adherence, and sexual behavior were assessed using a questionnaire, and residual pills and blood and urine samples were collected. Tenofovir diphosphate (TFV) concentrations were measured in plasma and urine.</p><p><strong>Results: </strong>One hundred participants were enrolled and followed up for a median of 392 days. The retention-in-care was 77%. The incidence of HIV and other sexually transmitted infections (STIs) was 0.98 and 13.67 per 100 person-years, respectively. No serious adverse events were detected. Among the participants, 55.3% (47/85) and 41.7% (25/60) had plasma TFV concentrations > 40 ng/mL at weeks 28 and 52, respectively. Residual pill counts and self-reported adherence were not correlated with plasma TFV levels. Participants with positive STI test results were significantly more likely to have plasma TFV concentrations > 40 ng/mL (adjusted odds ratio, 3.67; <i>P</i> = 0.034). The reported proportion of episodes of non-condom receptive anal intercourse decreased during the study.</p><p><strong>Conclusion: </strong>Daily oral PrEP was safe and effective in MSM and not associated with increased sexual risk behavior. To our knowledge, this is the first analysis of risk compensation among PrEP users in East Asia.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 22","pages":"e102"},"PeriodicalIF":3.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12148550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk for Human Papillomavirus-Associated Gynecologic Cancers Among Women of Childbearing Age With Rheumatic Diseases: A Population-Based Cohort Study.","authors":"Jisoo Lee, In-Woon Baek, Hyunsun Lim, Min Kyung Chung, Pil Gyu Park, Chan Hee Lee, Jin-Su Park","doi":"10.3346/jkms.2025.40.e95","DOIUrl":"10.3346/jkms.2025.40.e95","url":null,"abstract":"<p><strong>Background: </strong>This study evaluated the risk of human papillomavirus (HPV)-associated gynecologic cancers in women with rheumatic diseases (RD) during their childbearing years.</p><p><strong>Methods: </strong>Using the Korean National Health Insurance Service-National Health Information Database (2011-2021), we conducted a cohort study of 40,514 women with RD and 199,366 women without RD aged 20-49 years. The RD cohort included 9,932 women with systemic lupus erythematosus (SLE), 23,731 with seropositive rheumatoid arthritis (SPRA), and 6,851 with ankylosing spondylitis (AS). Incidence rates and hazard ratios (HRs) for HPV-associated gynecologic cancers, including cervical intraepithelial neoplasia grade 3, and cervical, vaginal, and vulva cancers, were estimated using Cox regression.</p><p><strong>Results: </strong>Over the mean (standard deviation) follow-up period of 67.5 (37.7) months, the incidence rate of HPV-associated gynecologic cancers was 111.5/100,000 person-years in the RD cohort and 73.2/100,000 person-years in the non-RD cohort. The incidence rate/100,000 person-years of HPV-associated gynecologic cancers in the RD subcohorts was higher in SLE (223.6) and SPRA (83.1) and lower in AS (69.1) than in the non-RD cohort. The fully adjusted HR for HPV-associated gynecologic cancers was higher in the RD cohort (HR, 2.95; 95% confidence interval [CI], 2.44-3.57) and all the RD subcohorts (SLE: HR, 1.85; 95% CI, 1.33-2.57, SPRA: HR, 4.10; 95% CI, 3.03-5.55, and AS: HR, 1.91; 95% CI, 1.06-3.43). After adjusting for comorbidities and medication use, hazard ratios increased in SPRA and AS but decreased in SLE.</p><p><strong>Conclusion: </strong>Korean women of childbearing age with RD have a threefold increased risk for HPV-associated gynecologic cancers compared with those without RD. Comorbidities and medication use in SLE may influence the risk. Improved screening strategies are needed for these women.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 21","pages":"e95"},"PeriodicalIF":3.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, Regional, and National Trends in Maternal Mortality Ratio Across 37 High Income Countries From 1990 to 2021, With Projections up to 2050: A Comprehensive Analysis From the WHO Mortality Database.","authors":"Sooji Lee, Soeun Kim, Hyeri Lee, Jaeyu Park, Yejun Son, Guillermo F López Sánchez, Damiano Pizzol, Jinseok Lee, Young Joo Lee, Hayeon Lee, Hyeon Jin Kim, Lee Smith, Selin Woo, Dong Keon Yon","doi":"10.3346/jkms.2025.40.e85","DOIUrl":"10.3346/jkms.2025.40.e85","url":null,"abstract":"<p><strong>Background: </strong>Understanding the global trends and future projections of maternal mortality ratio (MMR) is crucial as it can provide insights into improving policies and healthcare systems aimed at enhancing the quality of obstetric care and reducing preventable deaths. Given recent reports of increasing MMR trends in some high-income countries (HICs), we aimed to analyze the global trends of MMR from 1990 to 2021 and project future trends until 2050 across 37 countries.</p><p><strong>Methods: </strong>Age-standardized country-specific MMR for 37 countries from 1990 to 2021 were assessed through a locally weighted scatter plot smoother (LOESS) curve, with weighting based on individual country populations, utilizing the World Health Organization Mortality Database. The impact of premature mortality due to MMR was assessed by analyzing the years of life lost (YLLs). Furthermore, projections for MMR up to 2050 were derived using the Bayesian Age-Period-Cohort (BAPC) model. Decomposition analysis identified factors contributing to MMR variations such as population growth, aging and epidemiological changes.</p><p><strong>Results: </strong>The LOESS estimate of the global MMR decreased from 25.65 deaths per 100,000 live births (95% confidence interval [CI], 22.10, 29.20) in 1990 to 10.38 (6.41, 14.36) in 2021. While most continents showed a decreasing trend, young age groups in Asia-Pacific regions and all age groups in North America exhibited no significant changes from 1990 to 2021. MMR due to direct causes declined from 25.05 deaths per 100,000 live births (95% CI, 21.71, 28.38) in 1990 to 7.66 (3.90, 11.43) in 2021 across all age groups. Conversely, MMR due to indirect causes rose from 0.33 deaths per 100,000 live births (95% CI, -0.37, 1.03) in 1990 to 4.33 (3.43, 5.23) in 2021, with a more pronounced increase in advanced age groups. YLL due to MMR decreased from 866.00 (95% CI, 692.39, 1,039.60) in 1990 to 387.05 (182.82, 591.28) in 2021. Our analysis revealed negative correlations between MMR and the Human Development Index, Socio-demographic Index, and Universal Health Coverage Service Index. BAPC models predict a continued decrease in global MMR to 4.47 (4.07, 4.89) in 2030, 2.32 (1.82, 2.89) in 2040, and 1.25 (0.86, 1.81) in 2050. However, MMR due to indirect causes is projected to consistently increase. The global decrease in MMR from 1990 to 2021 can be primarily attributed to epidemiological changes.</p><p><strong>Conclusion: </strong>This study reveals a significant global decline in MMR since 1990, with projections indicating further decreases up to 2050, despite persistent increases in indirect causes and mortality among older age groups. These findings highlight the critical need for targeted strategies to address indirect causes and protect vulnerable populations.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 21","pages":"e85"},"PeriodicalIF":3.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rosacea and Its Potential Role in the Development of Irritable Bowel Syndrome: Insights From the Korean National Health Insurance Service-National Sample Cohort.","authors":"Young Woo Jo, Joon-Hong Min, Jae Woo Kwon, Young Her","doi":"10.3346/jkms.2025.40.e97","DOIUrl":"10.3346/jkms.2025.40.e97","url":null,"abstract":"<p><strong>Background: </strong>Rosacea is a chronic inflammatory skin disease. Recent studies have indicated its impacts on systemic health beyond dermatological symptoms. The gut-skin axis theory, which explores the interaction between gastrointestinal and skin health, may explain the influence of rosacea on gastrointestinal disorders. This study investigates the potential link between rosacea and the risk of developing irritable bowel syndrome (IBS) using the Korean National Health Insurance Service-National Sample Cohort (NHIS-NSC).</p><p><strong>Methods: </strong>Data for this retrospective cohort study were sourced from 746,060 individuals in the NHIS-NSC database, classified according to the Korean Standard Classification of Diseases (KCD) version 6, based on the International Classification of Diseases, 10th Revision. The drugs were also identified by their GNL code in Korea. We focused on individuals diagnosed with rosacea and their subsequent development of IBS. This study was conducted with 1,087 patients diagnosed with Rosacea between 2002 and 2013 in NHIS-NSC. A total of 4,348 controls were matched at 1:4 based on sex, age, and index data. Adjustments were made for potential confounders such as age, sex, and comorbidities through multivariate Cox proportional hazard models, to assess the risk of IBS among patients with rosacea compared to those without it.</p><p><strong>Results: </strong>Our findings show that individuals with rosacea have a significantly higher incidence of IBS than those without rosacea. After adjusting for multiple potential confounders, the association remained significant, with rosacea patients showing a 21% increased risk of developing IBS compared to controls. The study also noted that the incidence of IBS increased as rosacea became chronic.</p><p><strong>Conclusion: </strong>The findings support the hypothesis that rosacea may be associated with an increased risk of IBS, potentially mediated by systemic inflammatory pathways and neurological interactions as suggested by the gut-skin axis. This indicates that gastrointestinal symptoms and diseases should be considered when managing rosacea patients. Further studies are needed to explore the underlying mechanisms of this association and to confirm these findings in other populations.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 21","pages":"e97"},"PeriodicalIF":3.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"User Experiences and Effects of Expert-Led YouTube Mind-Body Interventions on Insomniacs: A Survey Study.","authors":"Jung-Won Shin, Jaesung Yoo, Hyeyun Kim","doi":"10.3346/jkms.2025.40.e91","DOIUrl":"10.3346/jkms.2025.40.e91","url":null,"abstract":"<p><strong>Background: </strong>Behavioral and psychological therapies have been shown to be beneficial in insomnia treatment. YouTube, a video-based social media platform, has become the most widely used platform and is easily accessible to everyone. Therefore, this study investigated the effects of expert-led YouTube-delivered mind-body interventions (MBIs), including mindfulness, breathwork, and mental imagery, on sleep disturbance and user satisfaction.</p><p><strong>Methods: </strong>We retrospectively analyzed data from 411 users of expert-led YouTube-delivered MBIs who completed a questionnaire from November 20 to 27, 2021. The content of the videos had multicomponent approaches, including education on sleep hygiene and MBIs.</p><p><strong>Results: </strong>Participants were mostly females (86.6%) and individuals in their 20s (59.1%). Most of the participants complained of difficulty falling asleep (91%), and 55.2% reported experiencing non-restorative sleep. After YouTube-delivered MBIs, significant improvements in sleep-onset latency, sleep maintenance, sleep quality, daytime dysfunction, and difficulty waking up in the morning (<i>P</i> < 0.001) were observed. Participants who had improved sleep quality complained of more severe insomnia with psychological stress. The 77% of users reported overall convenience and satisfaction with the platform.</p><p><strong>Conclusion: </strong>This survey showed the effectiveness of YouTube-delivered MBIs developed by experts. The accessibility advantage of YouTube as a social media platform was effectively used, highlighting the need for future research to explore its practical applications in clinical settings.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 21","pages":"e91"},"PeriodicalIF":3.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Linear Relationship Between Alcohol Consumption and Neurological Outcomes in Patients With Out-of-Hospital Cardiac Arrest Presenting to the Emergency Department.","authors":"Arom Choi, Incheol Park, Je Sung You, Sung Phil Chung, Yoo Seok Park","doi":"10.3346/jkms.2025.40.e96","DOIUrl":"10.3346/jkms.2025.40.e96","url":null,"abstract":"<p><strong>Background: </strong>Out-of-hospital cardiac arrest (OHCA) is a major public health issue associated with low survival rates and poor neurological outcomes. Comorbidities and various triggers are associated with OHCA incidence and outcomes. However, the association between alcohol consumption and the neurological prognosis in patients with OHCA remains unknown. Therefore, this study aimed to examine the potential association between the frequency of alcohol consumption and neurological outcomes in patients with OHCA.</p><p><strong>Methods: </strong>This retrospective observational study used data from the Korean Cardiac Arrest Research Consortium registry, encompassing 62 hospitals in Korea. Patients aged > 18 years who experienced OHCA and were transported by the public emergency medical service system were included. Alcohol consumption was categorized into four groups: never drinkers, light drinkers, moderate drinkers, and heavy drinkers. The primary outcome measured was a favorable neurological outcome at hospital discharge (cerebral performance category score 1 or 2).</p><p><strong>Results: </strong>Among the 6,671 enrolled patients, 14.7% had favorable neurological outcomes. The odd ratio of achieving a good neurologic outcome was reduced by 0.597 (95% confidence interval [CI], 0.444-0.802; <i>P</i> < 0.001), 0.650 (95% CI, 0.431-0.983; <i>P</i> = 0.041), and 0.666-fold (95% CI, 0.448-0.989; <i>P</i> = 0.044) for never, light, and heavy drinkers, respectively, compared to moderate drinkers.</p><p><strong>Conclusion: </strong>This study revealed a nonlinear association between the frequency of alcohol consumption and neurological prognosis in patients with OHCA. Therefore, future studies should focus on investigating the mechanism underlying the potential brain-protective effects of alcohol to further understand its impact on neurological recovery following OHCA.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT03222999.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 21","pages":"e96"},"PeriodicalIF":3.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing the Current Status of the Telemedicine Pilot Project Using Korean National Health Insurance Service Data.","authors":"Jeong-Yeon Kim, Jeonghoon Ha, Yeryeon Jung, Seongwoo Seo, Youseok Kim, Min Jung Ko, Hun-Sung Kim","doi":"10.3346/jkms.2025.40.e166","DOIUrl":"10.3346/jkms.2025.40.e166","url":null,"abstract":"<p><p>This study evaluated the performance and status of a telemedicine pilot project implemented in 2023. The analysis used National Health Insurance Service (NHIS) claim data from June 1 to December 14, 2023, focusing on patients who received telemedicine at least once during this period. The findings indicate that 8.5% of healthcare institutions participated in telemedicine, accounting for 0.16% of total health insurance cases. Telemedicine-related costs constituted 0.06% of total health insurance expenditures. Among the diseases where telemedicine was utilized, acute bronchitis was the most common in individuals under 40, while hypertension and type 2 diabetes mellitus increased significantly after age 30. This study is the first study to analyze the possibility and status of current telemedicine in Korea using NHIS data. The findings underscore its potential as an effective tool for managing chronic and acute diseases in Korea's healthcare system while identifying opportunities for further improvement.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 21","pages":"e166"},"PeriodicalIF":3.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspectives of Artificial Intelligence Use for In-House Ethics Checks of Journal Submissions.","authors":"Fatima Alnaimat, Abdel Rahman Feras AlSamhori, Omar Hamdan, Birzhan Seiil, Ainur B Qumar","doi":"10.3346/jkms.2025.40.e170","DOIUrl":"10.3346/jkms.2025.40.e170","url":null,"abstract":"<p><p>Artificial intelligence (AI) has shown its ability to transform academic writing and publishing. It offers significant benefits, including enhancing efficiency, consistency, and integrity, However, these advancements are accompanied by ethical concerns (particularly around authorship, originality, and transparency) and the need for human oversight in peer review and editorial processes. In this study we explore AI for ethics checks in journal submissions. Specific AI platforms-such as YesChat for bias detection, Turnitin's iThenticate for plagiarism, Proofig for image integrity, and GPTZero for AI-generated content-can identify ethical breaches through tailored prompts and queries. Additionally, AI is increasingly used to detect missing or vague ethics statements, conflicts of interest, and citation manipulation by analyzing structured text and databases. AI-enhanced tools like Elsevier's Editorial Manager and Enago Read assist in ensuring compliance with journal-specific ethical guidelines and streamline peer review. Moreover, emerging algorithms, such as CIDRE, have shown promise in identifying abnormal citation behaviors. As AI accuracy improves, these platforms are expected to be integrated directly into submission systems, enhancing research integrity, transparency, and accountability.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 21","pages":"e170"},"PeriodicalIF":3.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging Hospital Information Data for Effective Antibiotic Stewardship.","authors":"Se Yoon Park","doi":"10.3346/jkms.2025.40.e163","DOIUrl":"10.3346/jkms.2025.40.e163","url":null,"abstract":"<p><p>Clinical informatics has emerged as a valuable approach to enhance antimicrobial stewardship programs in healthcare settings. By integrating information technology with healthcare services, hospitals can systematically collect, store, and utilize medical data to improve antibiotic management. Studies have demonstrated that information technology interventions improve antibiotic prescription appropriateness and patient outcomes. The implementation of effective antimicrobial stewardship employs a multifaceted approach that incorporates diagnostic tools, laboratory findings, and clinical situations through advanced dashboard systems and rule-based feedback mechanisms. Recent advances in artificial intelligence have shown promising results in predicting antibiotic resistance, and the integration of hospital information systems with clinical informatics offers sustainable solutions for enhancing antimicrobial stewardship programs in clinical practice.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 20","pages":"e163"},"PeriodicalIF":3.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National Trends of Vascular Risk Factor Control Among Stroke Survivors in Korea: From the National Health and Nutrition Examination Survey 2010 to 2021.","authors":"Eung-Joon Lee, Han-Yeong Jeong, Keun-Hwa Jung","doi":"10.3346/jkms.2025.40.e74","DOIUrl":"10.3346/jkms.2025.40.e74","url":null,"abstract":"<p><strong>Background: </strong>To prevent stroke recurrence in stroke survivors, effective management of vascular risk factors (VRFs), including hypertension, diabetes, hyperlipidemia, and smoking, is essential. This study aimed to assess the VRF control status and trends among stroke survivors in Korea.</p><p><strong>Methods: </strong>This cross-sectional study analyzed data from 1,261 stroke survivors aged ≥ 19 years (mean age: 65.2 years; 43.1% female) who were part of the Korea National Health and Nutrition Examination Survey from 2010 to 2021. The control status of VRFs was evaluated using standardized criteria: hypertension (blood pressure < 140/90 mmHg), diabetes (hemoglobin A1c < 7%), hyperlipidemia (low-density lipoprotein cholesterol [LDL-C] < 70 mg/dL), and smoking status. Multivariate logistic regression analysis was conducted to identify factors associated with uncontrolled VRFs.</p><p><strong>Results: </strong>The rates of age-adjusted hypertension, diabetes, and smoking control remained consistent throughout the observation period. However, overall LDL-C control improved from 30.1% in 2010-2012 to 40.4% in 2019-2021 (<i>P</i> = 0.015), particularly in those aged ≥ 65 years. However, in the 19-49 age group, the control rate decreased from 47.0% to 15.8% (<i>P</i> = 0.048). Smoking rates showed no significant improvement (70.2% in 2019-2021 compared to 69.6% in 2010-2012), particularly among men. Living alone (adjusted odds ratio [aOR], 1.85; 95% confidence interval [CI], 1.03-3.32) was significantly associated with uncontrolled hypertension, whereas living in urban areas was linked to uncontrolled diabetes (aOR, 2.75; 95% CI, 1.06-7.17). Non-health screening was significantly associated with uncontrolled hyperlipidemia (aOR, 2.28; 95% CI, 1.25-4.14), and men were more likely to continue smoking (aOR, 4.47; 95% CI, 3.12-6.72).</p><p><strong>Conclusion: </strong>These findings highlight the need for targeted health strategies to enhance risk-factor management and reduce stroke recurrence.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 20","pages":"e74"},"PeriodicalIF":3.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}