Journal of Korean Medical Science最新文献

{"title":"Single-Dose Versus Multiple-Dose Prophylactic Antibiotics in Minimally Invasive Colorectal Surgery: A Propensity Score Matched Analysis.","authors":"Ga Yoon Ku, Beom-Jin Kim, Ji Won Park, Min Jung Kim, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park","doi":"10.3346/jkms.2024.39.e305","DOIUrl":"10.3346/jkms.2024.39.e305","url":null,"abstract":"<p><strong>Background: </strong>Recent guidelines about preventing surgical site infections (SSIs) recommend against the administration of prophylactic antibiotics after surgery. However, many colorectal surgeons still prefer prolonged use of prophylactic antibiotics. While minimally invasive surgery (MIS) has become the standard for colorectal cancer surgery, there were few studies about proper dose of prophylactic antibiotics in minimally invasive colorectal surgery.</p><p><strong>Methods: </strong>This is a retrospective study. All patients underwent elective colorectal cancer surgery using MIS. Intravenous cefotetan was administered as a prophylactic antibiotic. Two groups were classified according to the dose of prophylactic antibiotics: a group using a single dose preoperatively (single-dose group) and a group using a preoperative single dose plus additional doses within 24 hours after surgery (multiple-dose group). The SSI rates between the two groups were compared before and after propensity score matching (PSM). Risk factors of SSIs were assessed using univariate and multivariable analysis.</p><p><strong>Results: </strong>There were 902 patients in the single-dose group and 330 patients in the multiple-dose group. After PSM, 320 patients were included in each group. There were no differences in baseline characteristics and surgical outcomes except the length of hospital stay. SSI rates were not different between the two groups before and after PSM (before 2.0% vs. 2.1%, <i>P</i> = 0.890; after 0.9% vs. 1.9%, <i>P</i> = 0.505). In multivariable analysis, American Society of Anesthesiologists class 3, rectal surgery, intraoperative transfusion, and larger tumor size were identified as independent factors associated with SSI incidence.</p><p><strong>Conclusion: </strong>A single preoperative dose of prophylactic antibiotics may be sufficient to prevent SSIs in elective MIS for colorectal cancer.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"39 47","pages":"e305"},"PeriodicalIF":3.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11628240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Short- and Long-Term Dual-Antiplatelet Therapy After Transcatheter Aortic Valve Replacement: One-Year Outcomes.","authors":"Jun-Hyok Oh, Jinmi Kim, Jeong-Su Kim, Hye Won Lee, Sun Hack Lee, Jeong Cheon Choe, Min Sun Kim, Jinhee Ahn, Jung Hyun Choi, Han Cheol Lee, Kwang Soo Cha","doi":"10.3346/jkms.2024.39.e294","DOIUrl":"10.3346/jkms.2024.39.e294","url":null,"abstract":"<p><strong>Background: </strong>The optimal duration and net clinical benefit of dual antiplatelet therapy (DAPT) after transcatheter aortic valve replacement (TAVR) have not been elucidated in real-world situations.</p><p><strong>Methods: </strong>Using nationwide claims data from 2013 to 2021, we selected patients who underwent TAVR and categorized them into two groups: short- and long-term (≤ 3 and > 3 months, respectively) DAPT group. Propensity score matching was used to balance baseline characteristics. The primary endpoint was the occurrence of net adverse clinical events (NACEs), including all-cause death, myocardial infarction, stroke, any coronary and peripheral revascularization, systemic thromboembolism, and bleeding events, at 1 year. Survival analyses were conducted using Kaplan-Meier estimation and Cox proportional hazards regression.</p><p><strong>Results: </strong>Patients who met the inclusion criteria (1,695) were selected. Propensity score matching yielded 1,215 pairs of patients: 416 and 799 in the short- and long-term DAPT groups, respectively. In the unmatched cohort, the mean ages were 79.8 ± 6.1 and 79.7 ± 5.8 years for the short- and long-term DAPT groups, respectively. In the matched cohort, the mean ages were 80.6 ± 5.9 and 79.9 ± 5.9 years for the short- and long-term DAPT groups, respectively. Over one year in the unmatched cohort, the NACE incidence was 11.9% and 11.5% in the short- and long-term DAPT groups, respectively (<i>P</i> = 0.893). The all-cause mortality rates were 7.4% and 4.7% (<i>P</i> = 0.042), composite ischemic event rates were 2.5% and 4.7% (<i>P</i> = 0.056), and bleeding event rates were 2.7% and 4.7% (<i>P</i> = 0.056) in the short- and long-term groups, respectively. In the matched cohort, the incidence of NACE was 9.6% in the short-term DAPT group and 11.6% in the long-term DAPT group, respectively (<i>P</i> = 0.329). The all-cause mortality rates were 6.5% and 4.9% (<i>P</i> = 0.298), composite ischemic event rates were 1.4% and 4.5% (<i>P</i> = 0.009), and bleeding event rates were 2.2% and 4.4% (<i>P</i> = 0.072) in the short- and long-term groups, respectively.</p><p><strong>Conclusion: </strong>In patients who successfully underwent transfemoral TAVR, the short- and long-term DAPT groups exhibited similar one-year NACE rates. However, patients in the long-term DAPT group experienced more bleeding and ischemic events.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"39 47","pages":"e294"},"PeriodicalIF":3.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11628237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of Death From Various Causes According to Prevalent Atrial Fibrillation: A Nationwide Population-Based Study.","authors":"Young-Kwan Kim, So-Ryoung Lee, Eue-Keun Choi, Hyun Jin Ahn, Nan Young Bae, Kyung-Yeon Lee, JungMin Choi, Hyo-Jeong Ahn, Soonil Kwon, Kyungdo Han, Seil Oh, Gregory Y H Lip","doi":"10.3346/jkms.2024.39.e306","DOIUrl":"10.3346/jkms.2024.39.e306","url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation (AF) is associated with increased risks of adverse events including stroke and all-cause death. Understanding the pattern of causes of death (COD) with the relative risks in patients with AF compared to the non-AF population is essential in planning optimal care for patients with AF. We aimed to analyze the COD and its relative risks in patients with AF, using a nationwide population-based cohort.</p><p><strong>Methods: </strong>Using the Korean nationwide claims database, people aged 40 or older who received health examinations in 2009 were included if they had no missing values (n = 6,877,929). In total the study included 40,585 people with AF and 6,837,344 without AF. COD was defined by International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) diagnostic codes. Comparison between the AF and non-AF groups was performed with Multivariate Cox proportional regression model.</p><p><strong>Results: </strong>In the AF group, cardiovascular diseases were the most common COD, causing 39.8% of all deaths, compared with 19.0% for non-AF subjects. The AF group was associated with a higher risk of death from cardiovascular and cerebrovascular diseases by almost 3-fold than the matched non-AF group (hazard ratios [HR], 3.082; 95% confidence intervals [CIs], 2.963-3.205 for cardiovascular diseases; HR, 2.981; 95% CI, 2.799-3.175 for cerebrovascular diseases, all <i>P</i> < 0.001). Among patients with AF, the risks of all-cause, cardiovascular, and cerebrovascular death were well-stratified by CHA₂DS₂-VASc scores. The risk of cerebrovascular death was 11 times higher among patients with a CHA₂DS₂-VASc score ≥ 7.</p><p><strong>Conclusion: </strong>Compared to non-AF individuals, patients with AF had a higher risk of death from cardiovascular and cerebrovascular diseases, and the mortality risks were well-stratified by the CHA₂DS₂-VASc score. Integrated care management of cardiovascular and cerebrovascular diseases for patients with AF might help mitigate mortality.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"39 47","pages":"e306"},"PeriodicalIF":3.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11628238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In This Issue on 02-December-2024.","authors":"Jin-Hong Yoo","doi":"10.3346/jkms.2024.39.e330","DOIUrl":"10.3346/jkms.2024.39.e330","url":null,"abstract":"","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"39 46","pages":"e330"},"PeriodicalIF":3.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, Regional, and National Trends in Liver Disease-Related Mortality Across 112 Countries From 1990 to 2021, With Projections to 2050: Comprehensive Analysis of the WHO Mortality Database.","authors":"Jong Woo Hahn, Selin Woo, Jaeyu Park, Hyeri Lee, Hyeon Jin Kim, Jae Sung Ko, Jin Soo Moon, Masoud Rahmati, Lee Smith, Jiseung Kang, Damiano Pizzol, Mark A Tully, Elena Dragioti, Guillermo F López Sánchez, Kwanjoo Lee, Yeonjung Ha, Jinseok Lee, Hayeon Lee, Sang Youl Rhee, Yejun Son, Soeun Kim, Dong Keon Yon","doi":"10.3346/jkms.2024.39.e292","DOIUrl":"10.3346/jkms.2024.39.e292","url":null,"abstract":"<p><strong>Background: </strong>Liver disease causes over two million deaths annually worldwide, comprising approximately 4% of all global fatalities. We aimed to analyze liver disease-related mortality trends from 1990 to 2021 using the World Health Organization (WHO) Mortality Database and forecast global liver disease-related mortality rates up to 2050.</p><p><strong>Methods: </strong>This study examined age-standardized liver disease-related death rates from 1990 to 2021, employing data from the WHO Mortality Database across 112 countries across five continents. The rates over time were calculated using a locally weighted scatter plot smoother curve, with weights assigned based on the population of each country. Furthermore, this study projected liver disease-related mortality rates up to 2050 using a Bayesian age-period-cohort (BAPC) model. Additionally, a decomposition analysis was conducted to discern influencing factors such as population growth, aging, and epidemiological changes.</p><p><strong>Results: </strong>The estimated global age-standardized liver disease-related mortality rates surged significantly from 1990 to 2021 across 112 countries, rising from 103.4 deaths per 1,000,000 people (95% confidence interval [CI], 88.16, 118.74) in 1990 to 173.0 deaths per 1,000,000 people (95% CI, 155.15, 190.95) in 2021. This upward trend was particularly pronounced in low- and middle-income countries, in Africa, and in populations aged 65 years and older. Moreover, age-standardized liver disease-related mortality rates were correlated with a lower Human Development Index (<i>P</i> < 0.001) and sociodemographic index (<i>P</i> = 0.001). According to the BAPC model, the projected trend indicated a sustained and substantial decline in liver disease-related mortality rates, with an estimated decrease from 185.08 deaths per 1,000,000 people (95% CI, 179.79, 190.63) in 2021 to 156.29 (112.32, 214.77) in 2050. From 1990 to 2021, age-standardized liver disease-related deaths surged primarily due to epidemiological changes, whereas from 1990 to 2050, the impact of population aging and growth became the primary contributing factors to the overall increase.</p><p><strong>Conclusion: </strong>Global age-standardized liver disease-related mortality has increased significantly and continues to emerge as a crucial global public health issue. Further investigation into liver disease-related mortality rates in Africa is needed, and updating policies is necessary to effectively manage the global burden of liver disease.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"39 46","pages":"e292"},"PeriodicalIF":3.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Multiple Suicide Attempts in Adolescents From 10 Years Suicide Repository.","authors":"Sunghwan Kim, Eun-Young Yang, Kyoung Ho Choi, Hae Kook Lee, Yong-Sil Kweon, Kyoung-Uk Lee","doi":"10.3346/jkms.2024.39.e289","DOIUrl":"10.3346/jkms.2024.39.e289","url":null,"abstract":"<p><strong>Background: </strong>While there are many studies on adolescents' suicide attempts in the western countries, studies on adolescent suicide in South Korea are relatively scarce. We compared demographical and clinical variables between the first and multiple suicide attempters and examined potential risk factors predicting multiple suicide attempts.</p><p><strong>Methods: </strong>Two hundred forty-eight suicide attempters aged from 11 to 19 years old who visited emergency department of Uijeongbu St. Mary's Hospital, South Korea were recruited and divided into two groups: first attempter (n = 139, 56%) and multiple attempter (n = 109, 44%). A psychiatric interview with the Brief Emergency Room Suicide Risk Assessment were administered to all participants, and univariate analyses to compare characteristics of the two group and a multivariable logistic regression analysis to predict multiple suicidal attempts were performed.</p><p><strong>Results: </strong>Our results showed multiple suicide attempters were mostly female (78%), more severe in psychopathology (e.g., higher rate of psychiatric family history, diagnosis of axis I history, history of major depressive disorder, higher feeling of hopelessness/helplessness) and suicidality (e.g., repetitive/severe/continuous suicide ideation, lower regret for suicide attempt). Moreover, multiple suicide attempters were lower in psychiatric resources, such as lower personal achievement, lower ability to control emotion, and less insight. Multivariate logistic regression analysis showed that suicide ideation severity (odds ratio [OR], 2.30; <i>P</i> = 0.004), past history of axis I diagnosis (especially major depressive disorder; OR, 2.55; <i>P</i> = 0.002), and the use of \"cutting\" (OR, 2.85; <i>P</i> = 0.001) predicted multiple suicide attempts.</p><p><strong>Conclusion: </strong>The present study suggests that multiple suicide attempters tend to have more severe clinical profiles than the first suicide attempters. Intervention for depression and self-mutilation behavior of suicide attempters may be important in preventing multiple suicide attempts of adolescents.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"39 46","pages":"e289"},"PeriodicalIF":3.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Clarification of Evidence and Consensus on Strengthening Pharmacovigilance for Vaccine Safety.","authors":"Hye Young Kim","doi":"10.3346/jkms.2024.39.e333","DOIUrl":"10.3346/jkms.2024.39.e333","url":null,"abstract":"","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"39 46","pages":"e333"},"PeriodicalIF":3.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Large Language Models to Extract Core Injury Information From Emergency Department Notes.","authors":"Dong Hyun Choi, Yoonjic Kim, Sae Won Choi, Ki Hong Kim, Yeongho Choi, Sang Do Shin","doi":"10.3346/jkms.2024.39.e291","DOIUrl":"10.3346/jkms.2024.39.e291","url":null,"abstract":"<p><strong>Background: </strong>Injuries pose a significant global health challenge due to their high incidence and mortality rates. Although injury surveillance is essential for prevention, it is resource-intensive. This study aimed to develop and validate locally deployable large language models (LLMs) to extract core injury-related information from Emergency Department (ED) clinical notes.</p><p><strong>Methods: </strong>We conducted a diagnostic study using retrospectively collected data from January 2014 to December 2020 from two urban academic tertiary hospitals. One served as the derivation cohort and the other as the external test cohort. Adult patients presenting to the ED with injury-related complaints were included. Primary outcomes included classification accuracies for information extraction tasks related to injury mechanism, place of occurrence, activity, intent, and severity. We fine-tuned a single generalizable Llama-2 model and five distinct Bidirectional Encoder Representations from Transformers (BERT) models for each task to extract information from initial ED physician notes. The Llama-2 model was able to perform different tasks by modifying the instruction prompt. Data recorded in injury registries provided the gold standard labels. Model performance was assessed using accuracy and macro-average F1 scores.</p><p><strong>Results: </strong>The derivation and external test cohorts comprised 36,346 and 32,232 patients, respectively. In the derivation cohort's test set, the Llama-2 model achieved accuracies (95% confidence intervals) of 0.899 (0.889-0.909) for injury mechanism, 0.774 (0.760-0.789) for place of occurrence, 0.679 (0.665-0.694) for activity, 0.972 (0.967-0.977) for intent, and 0.935 (0.926-0.943) for severity. The Llama-2 model outperformed the BERT models in accuracy and macro-average F1 scores across all tasks in both cohorts. Imposing constraints on the Llama-2 model to avoid uncertain predictions further improved its accuracy.</p><p><strong>Conclusion: </strong>Locally deployable LLMs, trained to extract core injury-related information from free-text ED clinical notes, demonstrated good performance. Generative LLMs can serve as versatile solutions for various injury-related information extraction tasks.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"39 46","pages":"e291"},"PeriodicalIF":3.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sites of Metastasis and Survival in Metastatic Renal Cell Carcinoma: Results From the Korean Renal Cancer Study Group Database.","authors":"Chan Ho Lee, Minyong Kang, Cheol Kwak, Young Hwii Ko, Jung Kwon Kim, Jae Young Park, Seokhwan Bang, Seong Il Seo, Jungyo Suh, Wan Song, Cheryn Song, Hyung Ho Lee, Jinsoo Chung, Chang Wook Jeong, Jung Ki Jo, Seock Hwan Choi, Joongwon Choi, Changil Choi, Seol Ho Choo, Jang Hee Han, Sung-Hoo Hong, Eu Chang Hwang","doi":"10.3346/jkms.2024.39.e293","DOIUrl":"10.3346/jkms.2024.39.e293","url":null,"abstract":"<p><strong>Background: </strong>In patients with metastatic renal cell carcinoma (mRCC), sites of metastatic involvement have been reported to be associated with a difference in survival. However, the frequency and survival according to different sites of metastases in Korean patients with mRCC remain unclear. Therefore, this study aimed to assess the frequency of metastatic site involvement and the association between sites of metastatic involvement and survival in Korean patients with mRCC.</p><p><strong>Methods: </strong>This retrospective study used the multicenter cohort of the Korean Renal Cancer Study Group mRCC database to identify patients who started targeted therapy between December 2005 and March 2018. Data on the frequency of metastatic organ involvement at the time of mRCC diagnosis and oncologic outcomes according to different sites of metastasis were analyzed.</p><p><strong>Results: </strong>A total of 1,761 patients were eligible for analysis. Of the 1,761 patients, 1,564 (88.8%) had clear cell RCC, and 1,040 (59.1%) had synchronous metastasis. The median number of metastasis sites was 2 (interquartile range [IQR], 1-6). The median age at the initiation of systemic therapy was 60 years (IQR, 29-88), 1,380 (78.4%) were men, and 1,341 (76.1%) underwent nephrectomy. Based on the International Metastatic Renal Cell Carcinoma Database Consortium model, patients were stratified into favorable-, intermediate-, and poor-risk groups with 359 (20.4%), 1,092 (62.0%), and 310 (17.6%) patients, respectively. The lung (70.9%), lymph nodes (37.9%), bone (30.7%), liver (12.7%), adrenal gland (9.8%), and brain (8.2%) were the most common sites of metastasis, followed by the pancreas, pleura, peritoneum, spleen, thyroid, and bowel. Among the most common sites of metastasis (> 5%), the median cancer-specific survival (CSS) ranged from 13.9 (liver) to 29.1 months (lung). An association was observed between liver, bone, and pleural metastases and the shortest median CSS (< 19 months).</p><p><strong>Conclusion: </strong>In Korean patients with mRCC, metastases to the lung, lymph nodes, bone, liver, adrenal gland, and brain were more frequent than those to other organs. Metastases to the liver, bone, and pleura were associated with poor CSS. The findings of this study may be valuable for patient counseling and guiding future study designs.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"39 45","pages":"e293"},"PeriodicalIF":3.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11596476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In This Issue on 25-November-2024.","authors":"Jin-Hong Yoo","doi":"10.3346/jkms.2024.39.e327","DOIUrl":"10.3346/jkms.2024.39.e327","url":null,"abstract":"","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"39 45","pages":"e327"},"PeriodicalIF":3.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11596474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}