Neonatology, surgery and perinatal medicine最新文献

{"title":"CLINICAL DIAGNOSTIC ALGORITHMS OF ACTION IN THE PRACTICE OF A DOCTOR OF GENERAL PRACTICE – FAMILY MEDICINE DISEASES OF THE URINARY SYSTEM IN CHILDREN","authors":"V. Bezruk, D. Andriychuk, V. Velia, L. Rynzhuk, T. Bulyk","doi":"10.24061/2413-4260.xiv.1.51.2024.23","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.1.51.2024.23","url":null,"abstract":"Chronic kidney disease (CKD) is the presence of markers of pathological changes in the urinary system lasting more than 12 weeks, regardless of their cause. The number of cases in children with diseases of the urinary system has documented confi rmed chronic kidney disease according to the implemented regional registry of patients with CKD, but its signifi cant spread is observed. Early manifestations of CKD are often underestimated and not treated in time. CKD and chronic renal failure are not a narrowly defi ned nephrological problem. Nowadays, military aggression and the consequences of the 2019 coronavirus pandemic (COVID-19), which led to the destruction of standard ways (patient clinical routes) in the provision of medical care, the issue of providing medical care to children on the basis of evidence- based and personalized medicine is of particular relevance in Ukraine, which, according to the WHO strategy, should meet the needs and be safe,eff ective, timely and of appropriate quality. The introduction of innovations in pediatric practice in terms of standardization of medical care helps the physician to act eff ectively in specifi c clinical situations, avoiding ineff ective actions. Involvement of specialists of other specialties (general practitioners- family medicine, endocrinologists, urologists, cardiologists, pediatricians, ophthalmologists) in the management of CKD without coordination of cooperation to ensure the principle of continuity complicates the diagnostic and/or therapeutic support of the patient. Early diagnosis, proper management tactics of pediatric patients with diseases of the urinary system at the outpatient stage is an important component in the provision of integrated, patient- oriented medical care in the practice of a general practitioner- family medicine. The article highlights the clinical and diagnostic algorithms of action of a general practitioner- family medicine regarding the tactics ofmanagement of pediatric patients with the most common nephrological symptoms: leukocyturia (bacteriuria), proteinuria and erythrocyturia. The scientifi c research was carried out within the framework of the Department of Pediatrics, Neonatology and Perinatal Medicine of the Bukovinian State Medical University. The research topics included: Research project on «Chronobiological and adaptive aspects and features of autonomic regulation in pathological conditions in children of diff erent age groups» (State registration number: 0122U002245, duration: 01.01.2022-31.12.2026).","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":"4 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140729879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HYBRID VASCULAR APPROACH REDUCES THE INTENSIVE CARE UNIT STAY IN PATIENTS WITH CHRONICALLY THREATENING LIMB ISCHEMIA AND MULTILEVEL ATHEROSCLEROTIC LESIONS","authors":"Sorin Barat, Aurel Turcan, Stefan Manica, V. Maksimiuk, D. Dombrovskii, F. Grynchuk, R. Marchuk, T. Marchuk","doi":"10.24061/2413-4260.xiv.1.51.2024.15","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.1.51.2024.15","url":null,"abstract":"Chronic limb-threatening ischemia represents the fi nal stage of atherosclerosis and is often associated with signifi cantcardiovascular morbidity leading to high mortality. The hybrid approach combines surgical and endovascular techniques toachieve maximal revascularization of multilevel atherosclerotic lesions in the lower limb, with a shorter procedure time and less trauma compared to the classical method. It is also expected to reduce the length of hospital stay.The aim of the study is to analyze the relationship between the hybrid approach and the length of stay in the intensive careunit (ICU) compared to the classical vascular surgical approach in patients with chronic limb-threatening ischemia, multilevel atherosclerosis and high anesthesiological risk. Another endpoint is to compare the total ventilation time in the two groups.Material and methods. The study compares ICU length of stay and total mechanical ventilation time between two groups –a prospective group (n=48) of patients treated with hybrid revascularization and a control group (n=50) treated with classicalvascular revascularization. Patients included had multi- level atherosclerotic lesions (aorta- iliac, femur- popliteal and outfl ow) and chronic limb-threatening ischemia (Fontaine Grade III and IV). A database was created with subsequent statistical analysis using «SPSS» software. Tests used: Chi-square, p-value, frequencies. The chi-squared test was considered valid if the test statistic is chi-squared distributed under the null hypothesis, specifi cally Pearson’s chi-squared test. If the null hypothesis that there are no diff erences between classes in the population is true, the test statistic calculated from the observations follows a χ2 frequency distribution. If the p-value is greater than alpha, then we have not rejectedthe null hypothesis and assume that there is no signifi cant diff erence between the two samples. We set the signifi cance level at 0.05. The study protocol was approved by the Commission on Biomedical Ethics of the Bukovinian State Medical University (minutes of the Commission meeting No 4 from the 19.12.2023 year). The theme of the complex research work «Development, justifi cation and implementation of new approaches to the diagnosis and treatment of some acute surgical diseases, prediction of their course and prevention of complications (state registration number: 0121U110501, terms of execution: 01.2021-12.0225).Results. ICU length of stay and total ventilation time were analyzed in the two groups. Both ICU and total ventilation timeswere shorter with statistical signifi cance in the hybrid approach group. Therefore, the use of hybrid revascularization contributes to an accelerated stabilization of the patient’s condition. Therefore, the use of the hybrid vascular approach contributes to an accelerated stabilization of the patient’s condition. This reduces the duration of treatment, the cost of treatment. So, hybrid vascular approach is a promising","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":"70 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140729539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HISTOCHEMICAL AND IMMUNOHISTOCHEMICAL FEATURES OF DIFFERENTIATED TROPHOBLAST IN CHORIONIC VILLI OF THE PLACENTA IN PRETERM LABOR","authors":"P. Tokar","doi":"10.24061/2413-4260.xiv.1.51.2024.12","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.1.51.2024.12","url":null,"abstract":"The importance of studying the histochemical and immunohistochemical features of the diff erentiated trophoblast in chorionic villi of the placenta in preterm labor is determined by the threatening nature of this condition for both mother and fetus, as well as its high prevalence and serious consequences for the health of both. The understanding of the damage to the trophoblast of chorionic villi in the placenta can be expanded by histochemical and immunohistochemical methods, which allow the assessment of the concentration of specifi c marker molecules in one way or another.Objective. To determine certain histochemical and immunohistochemical characteristics of proteins in the trophoblast of theintermediate and terminal chorionic villi of the placenta in preterm labor.Material and Methods. The obtained material (30 placentas from preterm deliveries and 30 placentas from normalpregnancies) was fi xed for 20-24 hours in 10 % neutral formalin solution buff ered in Lilly’s phosphate buff er. After tissue removal, the placental tissue was dehydrated in an ascending ethanol series and embedded in paraffi n at a temperature of approximately 58 °C. Serial histologic sections were cut at 5.0 μm thickness using an MS-2 sliding microtome. After deparaffi nization, histological sections were stained with hematoxylin and eosin, histochemical methods for total protein with bromophenol blue according to Bonhéme, and immunohistochemical techniques according to the manufacturer’s protocols (Dako, Denmark). In particular, immunohistochemical reactions were performed with monoclonal antibodies against trophoblast hormone- placental lactogen and placental alkaline phosphatase. Visualization of primary antibodies was performed using the Dako polymer visualization system with diaminobenzidine as chromogen (resulting in brown staining of the sites of studied antigens). In addition to the descriptive method of histopathologic research, computer morphometry of digital microphotographs of histologic sections was performed using a Delta Optical Evolution 100 microscope and an Olympus SP550UZ digital camera. Digital copies of the images were processed using a legitimate copy of the ImageJ v1.52f computer program developed for histometric studies (National Institutes of Health, USA). Specifi cally, the evaluation of staining intensity (optical density) was performed on digital microphotographs using the method of computer microdensitometry. For this purpose, a microprobe method was used to obtain a computer brightness value in an 8-bit analysis system with 256 gray levels – from black (0) to white (255).The obtained values were then transformed into relative optical density values (r.OD) by logarithmic transformation (naturallogarithm method). The relative optical density value ranges from 0 (absolute transparency of the object) to 1 (absolute opacity of the object). The obtained digital data were processed using statistical analysis methods. A legitimate copy of the statis","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":"199 S588","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140730862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FEATURES FUNCTIONING OF THE DETOXIFICATION SYSTEM AT THE THREAT TERMINATION OF PREGNANCY AS A CONSEQUENCE OF ACCUMULATION OF 137CS","authors":"A. Zhyvetska- Denysova, I. Vorobiova, L. Lozova, V. Tkachenko, O. Voloshyn, C. Tolkach, O. Shamaieva, S. Stryzhak","doi":"10.24061/2413-4260.xiv.1.51.2024.11","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.1.51.2024.11","url":null,"abstract":"To date, there is no consensus on the pathogenesis of miscarriage. In modern life, human health is signifi cantly infl uenced by environmental factors. In this regard, 37 years after the accident at the Chornobyl nuclear power plant, the question of remote cytogenetic and hereditary eff ects in the off spring of parents aff ected by radiation remains relevant. Ecosystems contaminated with radioactive substances are a source of exposure for humans. Internal irradiation is the cause of reproductive losses. Radiation stress aff ects the course of redox processes in the body. Biochemical indicators are markers of the infl uence of environmental factors on a person. The study is dedicated to determining the state of peroxide hemostasis in the case of miscarriage. Aim: to determine the peculiarities of the functioning of the detoxification system in case of miscarriage due to the accumulation of 137Cs.Material and methods. The fi rst (research) group included women with reproductive losses in anamnesis and signs oftermination of the current pregnancy; the second (control) group included women with an uncomplicated history and course of pregnancy. Additionally, the fi rst group was divided into subgroups according to pregnancy outcomes: А – 38 women who gave birth at 37-40 weeks, despite the complicated course of the current pregnancy, В – 13 women who gave birth at 28-36 weeks + 6 days, С – 9 women who birth at 22-27 weeks + 6 days. The state of peroxide hemostasis in women was studied using biochemical studies. Accumulation of 137Cs with diff erent activity was detected in the placentas of the examined women of both groups using β-spectrometry. Morphological examination of placentas was performed according to the protocol. The severity of placental damage was studied by Olympus BX51 and Axioskop 40 microscopes. Analyzing the results revealed a relationship between biochemical indicators, the activity of 137Cs, and pregnancy scenarios. Statistical data analysis was performed using Microsoft Excel (2016) and Fisher angular transformation. The diff erence between comparative values was considered signifi cant at p < 0.05 (probability index greater than 95 %). Permission to conduct research was obtained from the Medical Ethics Committee of the SI «Institute of Pediatrics, Obstetrics, and Gynecology named academic Elena M. Lukyanova of the National Аcademy of Мedical Sciences of Ukraine» (protocol No 3 of 07.06.2017).Scientifi c research work is to «Develop the latest and improve existing technologies for diagnosis, prevention, and treatmentof premature termination of pregnancy in women with miscarriage taking into account the passport of the placenta» (2018-2020). Code VN.20.00.02.18, state registration number 0118U000039, KPKV 6561040.Results. It has been confi rmed that the state of the environment plays a decisive role in the pathogenesis of miscarriage. Ithas been proven that placental dysfunction caused by abnormal oxidative stress due to the action ","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140730186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSESSMENT OF THE CLINICAL AND NOSOLOGICAL CHARACTERISTICS OF TRAFFIC INJURIES IN CHILDREN AS A MEDICAL AND SANITARY CONSEQUENCE OF A MAN MADE EMERGENCY SITUATION","authors":"S. Guryev, V. Kushnir, V. Grebeniuk","doi":"10.24061/2413-4260.xiv.1.51.2024.16","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.1.51.2024.16","url":null,"abstract":"All over the world, children’s injuries receive considerable attention. Road traffi c injury is the main cause of child death.The aim of the research. To study and evaluate the clinical and nosological characteristics of traffi c injuries in children asa medical and sanitary consequence of an emergency situation.Research materials and methods. This work is a continuation of the previous research [2], and is based on the study andretrospective analysis of 259 cases of children injured as a result of a traffi c accident in the Kyiv and Chernivtsi regions in2018-2019. The array of this study was formed by the method of irreversible randomization from the total array of 1,671 cases of traffi c injuries that occurred in urban and rural areas of these regions. This work was carried out within the framework of the Doctoral Thesis «Traffi c accidents (clinical- epidemiological, clinical- nosological characteristics, clinical features of the course of the traumatic process, principles of medical care)», approved by the Academic Council of the «Ukrainian Scientifi c and Practical Center of Emergency Medical Aid and Disaster Medicine» of the Ministry of Health of Ukraine (Minutes of the meeting of the Scientifi c Council No. 6, December 15, 2020), in accordance with the provisions of the Declaration of Helsinki and approved by the Bioethics Commission of the «Ukrainian Scientifi c and Practical Center of Emergency Medical Aid and Disaster Medicine» of the Ministry of Health of Ukraine (Protocol No. 10, December 8, 2020).Research results. As a result of the research it was established that in the total number of children with road traffi c injuries,the largest specifi c weight have children with the extent of damage to two anatomical and functional areas (AFA) – 47.67 %, and the smallest specifi c weight – four AFA (13.95 %). In 84.88 % of traffi c injuries in children, they are polysystemic, i. e. two or more AFA are damaged, in the mass of the dead, the specifi c weight of such an injury is 90.91 %. The highest mortality rate was observed in children with damage to three AFAs (15.00 %), with damage to one AFA the mortality rate was 7.69 %, with damage to two AFAs – 14.63 %, with damage to four AFAs – 8.33 %. In the total number of injured children, the most frequent injury is to the head (82.56 %), and the least frequent is damage to the abdomen and pelvis with a specifi c gravity of 13.95 %. Limb injuries (56.98 %), chest injuries (41.86 %) and spine injuries (16.28 %) are also quite common in children. The combination factor in the general fi eld is 2.26, in the fi eld of the dead – 2.46 and in the fi eld of the survivors – 2.23. The highest mortality is observed in victims with abdominal and pelvic trauma (25.0 % each), which is almost twice as high as the mortality in the general population (12.79 %). In second place is the mortality rate of children with chest trauma – 19.44 %, with head trauma – 16.90 %, with spinal trauma – 7.14 %. The lowest mortal","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":"182 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140731030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PRE- AND POST-NATAL METHODS FOR PREVENTING EARLY CHILDHOOD CARIES","authors":"O. Godovanets, D. Romanuyk, L. Hrynkevych, O. Khomyshyn","doi":"10.24061/2413-4260.xiv.1.51.2024.21","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.1.51.2024.21","url":null,"abstract":"In general, the world recognizes the lack of preventive measures against dental caries in children, as evidenced by itsprevalence and intensity with a signifi cant range of fl uctuations.The aim of the study. To describe modern approaches to the prevention of early childhood dental caries in children basedon the analysis of foreign and domestic literature.Materials and methods. The study used the bibliosemantic method and structural and logical analysis. The electronicdatabases PubMed, MEDLINE, Scopus, Web of Science and EMBASE were used to search modern scientifi c literature using the key words «early childhood caries», «macro and trace elements», «probiotics», «prenatal prevention», «postnatal prevention», «oral cavity microfl ora».Results and discussion. At this stage of caries development, the most eff ective prevention programs are those developedon the basis of methods to minimize the impact of risk factors for the development of the disease, such as microbial plaque,low resistance of dental tissues to demineralization, frequent consumption of carbohydrates. The practical implementation of comprehensive prevention programs is very diffi cult, as it should be carried out before the birth of a child and continue throughout life. Often the role of the dentist is to organize and monitor the program, while specifi c preventive measures can and should be implemented by health and education authorities, medical personnel, parents and educators. The greatest impact will be achieved through collaboration among specialists in various medical and non-medical fi elds.Conclusions. Based on the analysis of the literature, there is a great interest of the world’s leading scientists in the prevention of early childhood caries. However, the problems of developing adapted preventive measures taking into account etiologic factors remain relevant.","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":"20 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140727873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MENKES DISEASE: A LITERATURE REVIEW AND CLINICAL CASE","authors":"N. Tokarchuk, T. Chekotun, L. Starynets, V. Antonets, L. Stanislavchuk","doi":"10.24061/2413-4260.xiv.1.51.2024.20","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.1.51.2024.20","url":null,"abstract":"Menkes Kinky Hair Disease (MKHD) is characterized by an abnormality in copper metabolism caused by a mutation in the ATP7A gene, which is located on Xq13.3 and has 23 exons. In addition, this gene encodes 1500 amino acids and is expressed in large quantities in various organs. It’s worth mentioning that about 357 diff erent mutations have been identifi ed in the ATP7A gene. It is a relatively rare disease with an incidence of 1 case per 100,000 to 250,000 live births. MKHD is an X-linked recessive trait that almost exclusively aff ects boys.The diagnosis of this rare disease is based on the genetic- molecular study of a metabolic disease panel, including the ATP7A gene and the biochemical phenotype (a decrease in serum copper and ceruloplasmin levels).In developing therapeutic strategies for individuals with Menkes disease, three fundamental problems are being addressed: 1) unlocking the absorption of copper in the intestine; 2) making copper available to enzymes in cells that require it as a cofactor; and 3) identifying infants with Menkes disease and initiating treatment at a very early stage of life, before irreversible neurodegeneration occurs. This article presents a clinical case of Menkes disease in a 7-month-old boy. The diagnosis was confi rmed by molecular genetic testing (NGS) of the Neurometabolic Disorders Panel, which included the ATP7A gene and biochemical phenotype.  The described case illustrates the complexity of diagnosing Menkes disease in the neonatal period due to the non-specifi city of disease symptoms (lethargy, weak sucking, weight loss, etc.) and the importance of biochemical and molecular genetic methods of fetal investigation in subsequent pregnancies or in a newborn sibling for early diagnosis and treatment. This case will be published with the consent of the mother in accordance with bioethical principles.","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":"124 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140731389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ROLE OF MATERNAL SERUM FIBROBLAST GROWTH FACTOR 21 LEVEL IN PREDICTION OF PREECLAMPSIA","authors":"Alaa Mohamed Atef Karim El-din, Magdy Hassan Kolib, Gehad Sayed Abdel-Rahman Bakhat, Amr Helmy Yehia","doi":"10.24061/2413-4260.xiv.1.51.2024.13","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.1.51.2024.13","url":null,"abstract":"Pregnancy complications resulting from hypertensive disorders are a serious problem that impact 2-10 % of all pregnanciesglobally. Preeclampsia is defi ned as new onset hypertension and proteinuria after 20 weeks of gestation which may be associated with other maternal organ dysfunction, such as liver or renal insuffi ciency, hematological or neurological complications, uteroplacental dysfunction and fetal growth restriction.Aim of the Work: Primary outcome is to determine the correlation between fi broblast growth factor 21 level and preeclampsia & signifi cance of serum fi broblast growth factor 21 levels as a predictive tool for preeclampsia. Secondary outcome is to establish the relationship between maternal serum fi broblast growth factor 21 level and Maternal complictions: - Eclampsia (tonic clonic fi ts after 20 weeks with elevated blood pressure and proteinuria)- HELLP syndrome (hemolysis, elevated liver enzymes and low platelet occur as a complication of severe preeclampsia)- placental abruption (bleeding after 20 weeks gestation due to premature separation of a normally situated placenta)Patients and Methods: This was a Nested case-control study that was conducted on 90 primigravidas at Ain Shams University maternity hospital from April 2021 to April 2022. Ethical approval was obtained from the ethical committee at Ain- Shams university maternity hospital. Data was recruited from patient attending obstetric clinic at Ain Shams University Maternity Hospital. Blood samples were collected after 20 weeks to 28 weeks gestation. Patients was followed up until delivery and grouped according to development of preeclampsia.Random samples from 45 patients (group who develop PE) and 45 random samples from control group were assessed forfi broblast growth factor 21. Serum fi broblast growth factor 21 levels were measured by a commercially available enzyme- linked immunosorbent assay kit.Results: our study showed that there was a significant difference in FGF21 levels between the groups, patients withpreeclampsia having higher levels than controls, 15.9 % of patients with preeclampsia experienced maternal complicationscompared to none in the control group. Meanwhile, 18.2 % of patients with preeclampsia experienced fetal complicationscompared to 0 % in the control group.Conclusion: Serum FGF-21 levels are signifi cantly higher in preeclamptic pregnant women compared to healthy normotensive pregnant women. So, it can be used as a predictor for preclampsia and maternal complicationsFunding information: The article was written and published without any fi nancial support.Confl ict of interest disclosure: The authors of the article have noconfl ict of interest related to the publication of the article","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":"108 S122","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140731598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A CASE OF TREATMENT OF CONGENITAL ICHTHYOSIS IN A NEWBORN CHILD","authors":"O. Obolonskyi, O. Kapustina, O. Obolonska, N. Kuznetsova","doi":"10.24061/2413-4260.xiv.1.51.2024.24","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.1.51.2024.24","url":null,"abstract":"Congenital ichthyoses (CI) are a group of rare inherited disorders that cause keratinization defects. This group includes hereditary ichthyosis and hereditary syndromes with ichthyosiform lesions. Offi cial statistics are not yet available in Ukraine. The most common clinical manifestation is nonbullous hyperkeratosis characterized by thick hyperkeratotic scales, skin thickening, severe skin dryness and erythema. In more severe forms – ectropion, eclabion. Skin permeability is increased in CI patients, resulting in increased fl uid and calorie loss, diffi culty in thermoregulation, and reduced elasticity, which limits mobility. Symptoms can vary in severity, but severe manifestations at birth are not always indicative of a more severe course later in life. Challenges in defi nitive diagnosis are due to the need for karyotyping, which is quite expensive. Currently available treatment modalities include continuous moisturization, reduction of transepidermal water loss, control of hyperkeratotic layer thickness (reducing it to a minimum) with local keratolytics, emollients, and systemic retinoids in severe cases. The article presents a clinical case of successful local treatment of CI with a pronounced eff ect without the use of systemic retinoids. The publication of the materials has been approved by the Bioethics Commission of the CI «Regional Medical Center for Family Health» DRC». All anamnestic data, examination results and photographs are provided with prior written consent of the parents. Conclusion. Congenital ichthyoses require careful monitoring. The initial clinical manifestations can not be a marker for the severity of the disease course.","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":"40 31","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140728018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CORRELATION RATIO OF CHRONIC ENDOMETRITIS WITH ANAMNESTIC FACTORS AND ULTRASOUND CHARACTERISTICS OF THE ENDOMETRIUM IN WOMEN OF REPRODUCTIVE AGE","authors":"V. Likhachov, O. Taranovska, O. Akimov, L. Dobrovolska, O. Makarov","doi":"10.24061/2413-4260.xiv.1.51.2024.10","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.1.51.2024.10","url":null,"abstract":"The diagnosis of chronic endometritis is problematic because of its asymptomatic course and the need for invasive uterineprocedures to confi rm the diagnosis histologically. Therefore, it is important to identify factors that indicate a high risk of this condition. Aim: The aim of this study is to identify factors that have a statistically signifi cant correlation with the presence of CE in women of reproductive age and to validate them by histologic examination of the endometrium.Material and Methods. A retrospective analysis of 400 histories of women of reproductive age who underwent hysteroscopyand endometrial biopsy for histologic examination was performed. Histologically, 154 women (38.5 %) were found to havechronic endometritis (the group of women with chronic endometritis), while 246 women (61.5 %) were found to have otherconditions unrelated to chronic endometritis (the group of women without chronic endometritis). Analysis of anamnestic factors and ultrasound criteria associated with an increased likelihood of chronic endometritis was performed when comparing data from women in these groups. The strength of the relationship between these factors on the one hand and the development of chronic endometritis on the other hand was assessed by calculating the Kendall’s τ (tau) rank correlation coeffi cient. The strength of the relationship between the mentioned factor and CE was considered strong (+++) with a τ coeffi cient of 0.5 or higher, moderate (++) with a τ coeffi cient in the range of 0.2 to 0.499, weak (+) with a τ coeffi cient in the range of 0.1 to 0.199. A τ-coeffi cient value between 0 and 0.099 indicated no correlation between the factor and chronic endometritis.The study was conducted in accordance with the principles of patient- centered care, the requirements of the Tokyo Declaration of the World Medical Association, the international recommendations of the Helsinki Declaration of Human Rights, the Convention of the Council of Europe on Human Rights and Biomedicine, the laws of Ukraine, and the Code of Ethics of the Ukrainian Physician.The paper is an excerpt from the initiative scientifi c research project of the Department of Obstetrics and Gynecology No.2 at Poltava State Medical University, entitled «Optimization of approaches to the management of pregnancy in women at high risk of obstetric and perinatal pathology» (State registration number 0122U201228, duration: 10.2022-09.2027) in collaboration with the Department of Pathological Physiology at Poltava State Medical University.Results and Discussion. The determination of the correlation coeffi cient allowed us to identify the factors with the strongestassociation with chronic endometritis. Among them are 5 infectious factors: cervicitis in the past medical history (τ coeffi cient 0.625245229; p<0.0000000001); chronic infl ammation of the uterine appendages (τ coeffi cient 0.522536031; p<0.0000000001); sexually transmitted diseases in the past medical history (τ coeffi c","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140729474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}