Neonatology, surgery and perinatal medicine最新文献

{"title":"QUALITY OF LIFE IN PREGNANT WOMEN WITH CHRONIC SLOW TRANSIT CONSTIPATION","authors":"I. Leschyshyn, L. Markulan, P. Byk, Y. Susak, N. Martyniuk, O. Okhotska","doi":"10.24061/2413-4260.xiv.2.52.2024.10","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.2.52.2024.10","url":null,"abstract":"A signifi cant number of pregnant women suff er from constipation, which tends to worsen as pregnancy progresses. Chronicconstipation worsens the course of pregnancy and may require emergency surgery with possible negative consequences for thefetus and the woman. The negative impact of constipation during pregnancy can be reduced by eliminating the manifestation ofsymptoms before it. The recommended surgical procedure is total colectomy. The aim of this study was to evaluate the quality of life (QoL) of pregnant women with chronic slow transit constipation (CSTC) after conservative versus surgical treatment. Method: Between 2017 and 2022, a comprehensive study was conducted on 46 women with CSTC that was resistant to conservative treatment. Among them, 22 patients underwent surgery (group M), while 24 patients received conservative treatment (group C). Quality of life was assessed using the SF-36 scale before treatment, 90 days after treatment initiation, and during each trimester of pregnancy.Rezalts: After treatment, physical QoL was comparable between groups (47.92±3.7 vs. 45.99±4.71), whereas mental QoL was signifi cantly higher in the surgical group (50.59±2.79 vs. 46.94±4.85, p=0.009). In the second trimester, the surgical group had signifi cantly higher physical QoL than the non-surgical group (43.9±2.4 vs. 40.5±2.6, p = 0.029). In the third trimester, both physical (39.3±3.6 vs. 29.7±5.1, p = 0.003) and mental (51.7±2.5 vs. 40.5±6.3, p = 0.003) QoL scores were signifi cantly higher in the surgical group.Conclusions: Compared with conservative therapy, colectomy improves the quality of life of pregnant women with CSTC, suggesting that it is a safe and eff ective treatment option before pregnancy.","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":" 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141679228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"QUALITY OF LIFE AND PLASMA LEVELS OF MELATONIN AND STEROID HORMONES IN WOMEN WITH UTERINE LEIOMYOMA","authors":"B. Sokolov, A. Berbets, O. Yuzko","doi":"10.24061/2413-4260.xiv.2.52.2024.12","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.2.52.2024.12","url":null,"abstract":"Uterine leiomyoma is the most common neoplasm of the female reproductive system, consisting of smooth muscle cells. This proliferative pathology accounts for up to 30 % of gynecological diseases, ranking second after pelvic infl ammatory processes. The appearance of clinical symptoms of uterine leiomyoma negatively aff ects the quality of life of such patients. It is also known that uterine leiomyoma is associated with changes in hormonal regulation in the female body; in particular, many researchers have noted an increase in blood levels of reproductive hormones, namely estradiol, in comparison with healthy women. However, the role of such an important hormone as melatonin, which has antioxidant properties and is capable of activating the processesof physiological apoptosis, in this disease is not fully understood. These processes require the most detailed study. The aim of the study was to estimate the quality of life and levels of melatonin and steroid hormones in women of reproductive age diagnosed with uterine leiomyoma. Materials and methods. 60 women of reproductive age diagnosed with uterine leiomyoma were studied. The control group consisted of 20 apparently healthy women of the same age. Quality of life was assessed using the UFS-QOL questionnaire. The level of melatonin in the women’s blood was determined once, on an empty stomach, at 8 o’clock in the morning, using the Human MT (melatonin) ELISA kit; also, the blood plasma concentrations of reproductive steroid hormones (estradiol andprogesterone) in the follicular phase (5th day of the menstrual cycle) were measured using the MAGLUMI diagnostic kits for immunochemoluminescence analysis. Statistical processing was performed using the MedCalc software package. The study was approved by the Commission on Biological and Medical Ethics of the Higher State Educational Institution of Ukraine «Bukovinian State Medical University» (Minutes № 4 of December 22, 2020) and was conducted in strict accordance with the Code of Ethics of the World Medical Association (Declaration of Helsinki) for experiments involving human subjects.All patients signed an appropriate informed consent. The publication is a fragment of the research work of the Department of Obstetrics and Gynecology of Bukovinian State Medical University «Preserving and restoring of the reproductive health of women and girls with obstetric and gynecologicalpathology». State registration number: 0121U110020. Period of conduction: 01.01.2021-12.2025. Results. It was found that patients of reproductive age with uterine leiomyoma have a probable decrease in overall self-assessment of quality of life (28.71 ± 14.65 points according to the UFS-QOL questionnaire, in the control group 98, 15 ± 3.45 points, p<0.01), sexual function (32.50 ± 16.63 points, control group 99.38 ± 2.80 points, p<0.01), and internal wellbeing(29.83 ± 17.76 points, control group 99.90 ± 0.45 points, p<0.001). We also found that the level of melatonin in the blood of w","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":" 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141678040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HISTOMORPHOLOGICAL PECULIARITIES OF THE PANCREATIC PARENCHYMA IN RATS WITH ALLOXAN-INDUCED DIABETES OF DIFFERENT DURATION","authors":"O. Olenovych, T. Boychuk, I. Davydenko, O. Davydenko","doi":"10.24061/2413-4260.xiv.2.52.2024.15","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.2.52.2024.15","url":null,"abstract":"The study of pathohistological and morphofunctional changes in the endocrine pancreas is an integral part of experimental diabetology, which allows obtaining a signifi cant amount of information on various aspects of the etiology and pathogenesis of diabetes and its complications using experimental animal models. Aim of the study was to conduct a comprehensive evaluation of histostructure peculiarities of the pancreas and the reparativepotential of the aff ected pancreatic islets of Langerhans in rats with alloxan- induced experimental diabetes mellitus (EDM) of diff erent duration.Materials and methods. The experiments were performed on 63 white non-linear adult male rats, experimental diabetes mellitus (EDМ) was induced in 53 of them (10 intact rats served as control group). At 10, 20, 25, 30, 40 and 45 days after the administration of the diabetogenic substance, the experimental animals were withdrawn from the experiment, the pancreas was removed and serial sections were made, stained with hematoxylin and eosin according to the standard technique, as well as with aldehyde fuchsin – for the identifi cation of β-cells of the islets of Langerhans. To quantify the endocrine part of the pancreas, the average diameter of the islets of Langerhans (μm), the average number of cells in the islets of Langerhans in the profi le of the histological section, as well as the specifi c volume of the islets of Langerhans in the pancreatic tissue (%) were studied in serial histological sections.Results. The course of alloxan- induced EDM was accompanied by signifi cant destructive- degenerative changes in the pancreatic islets during all observation periods. On the 11th day after alloxan administration, most of the cells of the islets of Langerhans were in a state of necrosis with signs of karyopyknosis and karyorrhexis. As a result of alterative processes, the number and size of islets of Langerhans, their specifi c volume in the pancreatic tissue, and the average number of cells in them were greatly reduced. No specific staining of β-cells with aldehyde fuchsin was detected. Moderate swelling of the pancreatic interstitium, focal dystrophic processes in the epitheliocytes of the exocrine pancreas, sometimes with pronounced microcystic formations, were found on the 11th day of the experiment. On the 21st and 26th day after alloxan administration, the specifi c volume, the size of the pancreatic islets of Langerhans and their cellularity parameters continued to decrease reliably. The majority of Langerhans islets were in a state of necrosis, but signs ofkaryolysis, observed mainly in the center of the islets, were added to the previously existing signs of karyopyknosis and karyorrhexis. The cells of the exocrine pancreas showed no visible signs of alteration, indicating their recovery after the 11th day of the experiment. In the 31-day EDM, all the main trends observed in the previous stages of the experiment were maintained, with the exception of necrotic chang","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":" 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141679616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INNOVATIVE METHODS IN TEACHING PEDIATRICS TO STUDENTS OF HIGHER MEDICAL EDUCATION IN V AND VI YEARS: DIALOGUE TEACHING","authors":"L. Vakulenko, L. Badogina, O. Obolonska, A. Riznyk, S. Samsonenko","doi":"10.24061/2413-4260.xiv.2.52.2024.4","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.2.52.2024.4","url":null,"abstract":"The article substantiates the need to fi nd and implement the latest learning technologies for students of higher medical education in the context of modern circumstances in Ukraine, which have caused the situation that a certain part of teaching is conducted remotely. This reduces the possibility for students to acquire the competencies defi ned by the discipline program. The principles of teaching with the use of dialogue technology were analyzed according to the literature. The positive eff ects of dialogue training on the development of communicative skills, the ability to express one’s thoughts and ideas, and to listento others have been identifi ed. Meaningful dialogue contributes to a deeper understanding of the educational material and can be used as a basis for solving problem situations, working in groups, using the case method, in project technology. In addition, a dialogic approach to learning is an opportunity to support the development of critical thinking. Certain problems in the introduction of dialogic technology in higher medical education are also pointed out: the presence of diagnostic and treatment protocols in medicine somewhat limits discussions in the educational process. The implementation of the principles of dialogical learning in pediatrics teaching at the fi nal stages of higher medical education and in students’ research work is demonstrated.Conclusions. The search for alternative methods of education in higher medical education institutions is an urgent problem today. The dialogical method of learning, as a progressive method, should be included in the teaching process, as a method that promotes self-criticism, the development of students’ communicative skills, and has a positive infl uence on cognitive activity. Eff ective dialog among students and between students and teachers is possible in any variant of the educational process: in the classroom, at a distance and in a mixed format. The successful implementation of the dialogical teaching method in clinical teaching requires its thorough methodical development. Scientifi c activity of students can be considered as one of the options ofdialogical education.","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":" 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141679291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CASE HISTORY OF METACHROMATIC LEUKODYSTROPHY OF 5 YEAR OLD CHILD","authors":"L. Boiarska, I. Redko","doi":"10.24061/2413-4260.xiv.2.52.2024.25","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.2.52.2024.25","url":null,"abstract":"Leukodystrophy is a group of genetic neurodegenerative diseases affecting mainly the white matter of the brain. Spread ofleukodystrophies in the world is 1:40-100 thousand, however, these diseases have fatal consequences for life, serious predictions forhealth and social adaptation. Among all forms of leukodystrophies, metachromatic leukodystrophy attracts the attention of specialists.It is a rare hereditary disease from the group of lysosomal storage diseases with autosomal recessive inheritance mechanism of lipidmetabolism disorders. It is caused by a mutation in the ARSA gene, the absence or defi ciency of which leads to impaired degradationof lipids – sulfates, which results in accumulation of a metachromatic lipid substance in the nervous system (myelin, neurons, glia),leading to diff use demyelination.This article describes the case history of a 5-year-old child with metachromatic leukodystrophy. The boy was born at term. Pregnancyand delivery were without any abnormalities. The family heredity is not burdened. During the fi rst year of life the child’s physical andpsychomotor development corresponded to the age. The onset of the disease was noticed at the age of 1 year and 2 months during thefi rst visit to the neurologist, when the parents complained about gait disturbances when the child tried to walk, frequent falls, muscularhypotension with postural disturbances. In the second year of his life, the child was treated in the neurology department with the diagnosisof cerebral spastic paraparesis. Due to the ineff ective treatment, the child was referred to the National Specialized Children’s Hospitalof the Ministry of Health of Ukraine «OKHMATDYT» for examination, where he was diagnosed with metachromatic leukodystrophy,late infantile form МРТ on the basis of medical- genetic tests and MRI of the brain.In the past medical history, since the age of 2 years the child’s nutritional status has signifi cantly deteriorated – impairment of chewing and swallowing functions, and since the age of 4 years the child has been prescribed nutrition through a feeding tube. Taking into account the fact that at the age of 5 years the child suff ered from protein- energy defi ciency of the ІІІ stage (total weight was 9800 g), the doctor calculated the daily energy and protein intake with the use of therapeutic high-protein and high-energy mixture, due to which the child gained weight (he gained 7 kg in 6 months). In the course of time, at the age of 5 years, epilepsy with generalized seizures was diagnosed for the fi rst time and anticonvulsant therapy was prescribed and showed positive dynamics. The doctors discussed the need for palliative care for children with this pathology and psychological support for families, involving an interdisciplinary team of specialists (neurologists, psychologists, rehabilitation therapists).","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":" 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141679547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FETAL ANATOMICAL VARIABILITY OF THE ULNAR AND RADIAL ARTERY SYSTEM","authors":"O. Koval, T. Khmara, I. Zamorskii, M. Kryvchanska, O. Garvasiuk","doi":"10.24061/2413-4260.xiv.2.52.2024.14","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.2.52.2024.14","url":null,"abstract":"Variability in the topography of the arteries of the upper extremity is associated with fetal development. Determination of individual anatomical variants of the upper extremity blood supply at diff erent stages of ontogeny, especially in human fetuses, is of great practical importance in vascular surgery.Aim of the study. To study the individual anatomical variability of the ulnar and radial arteries in human fetuses of diff erent ages. Material and methods. The study of variants of the topography of the branches of the radial and ulnar arteries, the peculiarities of the formation of the superfi cial palmar arterial arch was carried out on 46 preparations of the upper extremities of 23 human fetuses 81. 0-375, 0 mm parieto- coccygeal length using macromicroscopic dissection, vascular injection and morphometry without external signs of anatomical abnormalities or congenital malformations of skeletal, fascial- muscular and vascular- nerve structures of the upper extremities.Results and discussion. Our study demonstrated fetal anatomical variability and bilateral asymmetry of the right and left upper extremity arteries in human fetuses. Thus, in a fetus with a PCL of 210.0 mm, the right brachiocephalic artery was found to originate from the right axillary artery. It should be noted that the initial portion of the right brachiocephalic artery passed anteriorly, not posteriorly, to the median nerve, and at the level of the middle third of the anterior shoulder region, the artery occupied a superfi cial position relative to the median nerve, which is located in the lateral bicuspid groove of the shoulder. The brachiocephalic artery was then directed in an oblique lateral direction to the lateral surface of the forearm. In this fetus, a high origin of the right ulnar artery was found, which originated from the trunk of the brachiocephalic artery in the upper third of the right anterior shoulder region. At the border of the middle and lower thirds of the anterior shoulder region, the ulnar artery crossed the ulnar nerve anteriorly and passed with it in the median biceps groove of the shoulder. 3.0 mm below the beginning of the ulnar artery, the superior circumfl ex ulnar artery bifurcated from the brachiocephalic artery, and in the lower third of the anterior shoulder region, a common trunk bifurcated from the brachiocephalic artery and bifurcated into the middle and inferior circumfl ex ulnar arteries. We found arterial anastomoses between the latter and branches of the ulnar artery. The immediate continuation of the right brachiocephalic artery in the palm was the brachiocephalic artery of the thumb. At the level of the base of the proximal phalanx of the thumb, the brachiocephalic artery branched into three palmar fi nger arteries, which were directed to both edges of the palmar surface of the fi rst fi nger and the radial edge of the palmar surface of the second fi nger. The superfi cial palmar arch was formed by the superfi cial palmar branch of th","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":" 33","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141678951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FEATURES OF MICROBIAL COLONIZATION IN THE INTESTINES IN COLIC IN INFANTS WITH A HISTORY OF ANTIBIOTIC THERAPY","authors":"O. Moshtuk, M. Kiselyova","doi":"10.24061/2413-4260.xiv.2.52.2024.6","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.2.52.2024.6","url":null,"abstract":"Research on the problem of colic in infants shows inconsistencies in conclusions regarding its etiology, pathogenesis, diagnosis, and management. They suggest that colic remains a hot topic for further research. Experimental evidence does not support the claim that colic is a self-limiting and safe process. On the contrary, the described possible consequences of the eff ects of colic on the behavior and quality of the disturbed digestion indicate that this is an understudied phenomenon.The aim of the study: to evaluate the comparative relationship between qualitative microbial colonization and the state of digestive processes in the intestine and the development of colic in infants aged 2 weeks to 6 months who were treated with antibiotics from birth to 5 months of age, taking into account the clinical severity of colic manifestations, by studying the comparative characteristics of clinical and demographic indicators and qualitative results of bacteriological examination of feces. Research materials and methods. The study included 103 infants with colic diagnosed according to Rome IV criteria, aged 2 weeks to 6 months, mean age 2 months, with a history of antibiotic treatment. The main group consisted of infants with severe colic (n=43), and the comparison group consisted of infants with mild clinical manifestations of colic (n=34). The peculiarities of the microbial colonization of the intestine and the functional state of digestion were determined on the basis of the results of the study of the colic coprogram. To achieve this goal, we performed macroscopic and microscopic examination of feces, assessment of clinical and anamnestic indicators: obstetric history, gestational age, sex, anthropometric data, history of diseases, nosologiccharacteristics of diseases and treatment received by infants.The materials of the publication concerning examination, laboratory and scientifi c research and treatment of patients comply with the norms of bioethics, as confi rmed by the conclusion of the Bioethics Commission of the Lviv National Medical University named after Danylo Halytskyi (Protocol No. 1 dated January 25, 2021). The materials of the publication regarding the observance of ethical, moral and legal principles while performing the work correspond to the norms of bioethics, as evidenced by the conclusion of the Bioethics Commission of the Lviv National Medical University named after Danylo Halytskyi (Protocol No. 3 dated 18.03.2024).Informed written consent was obtained from the parents of the patients before the start of the study, explaining the purpose, tasks, and methods of the laboratory research. Statistical analysis was performed using descriptive and analytical statistics. In connection with the non- Gaussian distribution of the obtained data (testing with the Shapiro- Wilks test), the mean values were presented as median with 1 and 3 quartiles (Me [25 %; 75 %]). Their comparison between the studied groups was performed using the Mann- Whi","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141677457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PREREQUISITES FOR EARLY PREGNANCY LOSS IN WOMEN WITH CHRONIC ENDOMETRITIS","authors":"V. Likhachov, O. Taranovska, I. Zhabchenko, V. Oksyuta, V. Palapa, E. Krutikova","doi":"10.24061/2413-4260.xiv.2.52.2024.9","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.2.52.2024.9","url":null,"abstract":"The incidence of chronic endometritis is particularly high in women with spontaneous abortions, especially habitual ones. There are insuffi cient data on the mechanisms of miscarriage in women whose pregnancy occurred along with this pathology. Aim: to assess the level of synthesis of cytokines and endometrial proteins in women with CE in the preconceptional stage and in the early stages of pregnancy; to identify pathogenetic aspects of the impact of imbalance of these substances on the processes of pregnancy loss; to assess the possibility of correcting the identifi ed changes in the preconceptional stage. Materials and methods. The study was conducted in 2 phases. In the fi rst phase, 426 women with CE were studied (168 patients (group I) were treated for CE in the preconception period, and the rest, 258 patients (group II), did not receive treatment). The control group consisted of 30 healthy women. The levels of cytokines TNF-a, INF-γ, and IL-10 in cervical mucus and glycodelin in menstrual blood were determined by enzyme- linked immunosorbent assay. In the second phase of the study, women who became pregnant were followed: 135 women from group I who received preconceptional treatment for CE; 168 women from group II who became pregnant along with untreated CE; and 20 healthy women from the control group who became pregnant and subsequently had no complications. At 5-6 weeks of gestation, serum glycodelin concentration and cervical content levelsof TNF-a, INF-γ and IL-10 were determined. The data were processed using mathematical statistical methods, Student’s t-test, Pearson’s correlation coeffi cient (r) and odds ratio were evaluated using the STATISTICA program of StatSoft Inc. (USA). The study adhered to the tenets of the Declaration of Helsinki. The study protocol was approved by the local ethics committee of PSMU for all women enrolled in this study. The article is extracted from the initiative scientifi c research project of the Obstetrics and Gynecology Department No 2 of the Poltava State Medical University «Optimization of approaches to pregnancy management in women at high risk of obstetric and perinatal pathology» (term: 2022-2027; state registration number 0122U201228).Results and Discussion. At the preconceptional stage, patients with CE showed a signifi cant decrease in glycodelin levels by 2.9 times (p<0.05), an increase in proinfl ammatory cytokines (INF-γ by 2.8 times (p<0.001), TNF-α by half (p<0.001)), and a decrease in IL-10 by 2 times (p<0.001) compared to the levels in healthy non-pregnant women. A decrease in the level of glycodelin in menstrual blood of women with CE is inversely correlated with an increase in the level of proinfl ammatory cytokines in cervical mucus (both INF-γ; r= –0.77; p<0.05, and TNF-α; r= –0.69; p<0.05). At 5-6 weeks of gestation, the level of serumglycodelin was 14.5 % lower (р˂0.05) in patients with pregestational untreated CE and 58.6 % lower (p<0.001) in women with early pregnancy loss. The l","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":" 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141679877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SOME POTENTIAL PREREQUISITES FOR THE FORMATION OF THE GUT MICROBIOTA IN PREMATURE BABIES: PART II","authors":"T. Znamenska, O. Vorobiova","doi":"10.24061/2413-4260.xiv.2.52.2024.27","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.2.52.2024.27","url":null,"abstract":"Abnormal microbial colonization of the gut from birth in newborns aff ects growth, development, and health, leading to short- and long-term adverse eff ects. The microbiota of preterm infants diff ers from that of term infants. This is because preterm infants and their mothers have more complicated prenatal and postnatal health conditions and anatomically- functional immaturity of organs and systems depending on gestational age. Maternal conditions, antibiotics, type of feeding, and use of probiotics can signifi cantly aff ect the gut microbiota of preterm infants in the early neonatal period; however, these eff ects decrease with age. Although some factors and processes are diffi cult to intervene or avoid, understanding the potential factors and determinants will help to develop timely strategies to promote a healthy gut microbiota in preterm infants. This review discusses potential determinants of gut microbial colonization in preterm infants, the underlying mechanisms, and recommendations for addressing adverse eff ects.","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":" 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141680466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DAILY HOLTER ECG MONITORING IN THE DIAGNOSTIC ALGORITHM OF HEART RHYTHM AND CONDUCTION DISORDERS IN CHILDREN AND ADOLESCENTS","authors":"T. Kryuchko, S. Tanyanska, Y. Ruban, M. Oliinichenko, S. Litus","doi":"10.24061/2413-4260.xiv.2.52.2024.22","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.2.52.2024.22","url":null,"abstract":"Recent years have seen an increase in the prevalence of cardiac arrhythmias and conduction disorders in children, which are not always diagnosed in time. In order to verify the nature of arrhythmias in pediatrics as well as in therapy, an accessible and informative method of daily Holter ECG monitoring (DHECGM) is widely used. Aim of the study was to assess the practical value of DHECGM in the algorithm for diagnosing heart rhythm and conductiondisorders in pediatric patients. Materials and Methods: Analysis of DHECGM was performed in 48 children who were hospitalized in the pediatricdepartment of the Specialized Pediatric Care Center (SPCC) of the Poltava Regional Clinical Hospital (PRCH) in 2022-2023.Research results. Sinus tachyarrhythmia or bradyarrhythmia, wandering atrial pacemaker was detected in half of the patients studied. Supraventricular and/or ventricular extrasystoles were detected in 87.5 % of children. Bi-, tri- and quadrigeminy were observed in 14 (27.1 %) of the patients. First or second degree sinoatrial block was observed in 25 % of patients. Atrioventricular block of 1st or 2nd degree (Mobitz type) with Wenkenbach- Samoilov periods was observed in 8 patients (16.6 %). Combined rhythm and conduction disturbances were observed in 82.3 % of the children studied. The article is illustrated by clinical cases of cardiac rhythm and conduction disorders in children of diff erent ages.Conclusions: DHECGM has broad capabilities for diagnosing cardiac rhythm and conduction abnormalities, allowing early detection of arrhythmias in pediatric patients and providing personalized recommendations.","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141677238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}