Neonatology, surgery and perinatal medicine最新文献

{"title":"А CLINICAL CASE OF TREATMENT OF BILIARY ATRESIA – SPLIT TRANSPLANTATION","authors":"O. Shchur, H. Kurylo, D. Grytsak, O. Terletskiy","doi":"10.24061/2413-4260.xiv.2.52.2024.26","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.2.52.2024.26","url":null,"abstract":"Transplantation is the only treatment for congenital and acquired liver malformations in the pediatric population. The most common are biliary atresia, A1 antitrypsin defi ciency, Wilson’s disease, metabolic diseases, acquired diseases complicated by cirrhosis and liver failure. In most cases, patients with biliary atresia require liver transplantation at an early age. In case of late diagnosis and inability to perform portoenterostomy (Kasai procedure), the only treatment option is transplantation at the age of ±1 year. The aim of study. Single- center case analysis of a child with biliary atresia demonstrates the current state of solving this problem in Ukraine with the absence of the possibility of family transplantation and shortage of donor organs. To study the potential development opportunities of SPLIT transplantation in this stage group. Analyze the possibilities of optimizing the process from diagnosis to transplantation with the aim of maximizing the preservation of the child’s physical and intellectual development and reducing the impact of the disease on other organs and systems. Results. In our work we analyzed the experience of treating a patient with uncorrected biliary atresia with late diagnosis. Patient P, blood group A(I) Rh(+) boy, 1st pregnancy, born with weight 2500g, height 50 cm at 39 weeks. Pregnancy: physiologic delivery, Apgar score 99. Liver biopsy confi rmed the diagnosis of biliary atresia with signifi cant cirrhosis. On esophagogastroscopy: signs of incipient portal hypertension. Considering these data and the child’s age (85 days), portoenterostomy as a method of treatment was not appropriate. A course of treatment was prescribed and liver transplantation was determined as the only method of treatment for the patient. Unfortunately, the examination of close relatives to determine the possibility of family donation did not give positive results. The donor was a 14-year-old boy, blood type I(O) Rh(+), with a congenital defect of the central nervous system. After prolonged treatment, the patient had a sudden hemorrhage. After brain death was declared, the parents gave their consent for organ transplantation to recipients on the waiting list. SPLIT transplantation was performed by dividing the donor organ for 2 recipients. The left lobe of the liver was transplanted to a patient with biliary atresia at the age of 1 year and 3 months. Three vascular anastomoses (caval, portal and arterial) were performed together with anastomoses between the bile duct and the intestinal tube of the child. The right hepatic lobe was similarly transplanted in an adult patient.The post-operative period was uneventful. Patients were successfully discharged and continue to receive immunosuppressive therapy on an outpatient basis. SPLIT transplantation is a successful way to solve the problem of donor organ shortage. Conclusions. 1. Liver transplantation is the main method of treatment for children with biliary atresia and other liver diseas","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141677811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VIDEO-ASSISTED THORACOSCOPIC SURGERY IN A 35-DAY-OLD INFANT WITH MULTILOCULATED THORACIC EMPYEMA: CASE REPORT","authors":"S. Babuci, V. Negru, I. Ambros, I. Revenco, D. Haidarlî","doi":"10.24061/2413-4260.xiv.2.52.2024.23","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.2.52.2024.23","url":null,"abstract":"The authors report a clinical case of a 35-day-old infant with multiloculated thoracic empyema who was successfully operated on by the surgical team. The infant was transferred from a regional medical facility with fever, low-productive cough, and dyspnea. The disease had started 7 days earlier, but despite 5 days of antibiotic treatment in the hospital of his place of residence, the child’s condition continued to deteriorate, so he was transferred to the pediatric intensive care unit of our institution. After admission, a CT scan revealed massive closed fl uid collections with subpleural localization in the right hemithorax and in the projection of the anterior mediastinum associated with subtotal atelectasis of the right lung, closed pleurisy without signs of lung tissue destruction, suspicion of intrathoracic cystic lymphangioma. The patient underwent video- assisted thoracoscopic surgery, during which several purulent localized collections were identifi ed, which were opened and drained with a volume of approximately 200 ml of viscous purulent fl uid. The postoperative period was diffi cult but favorable. 6 months later, CT and scintigraphy showed some insignifi cant residual lung changes and diff use perfusion changes, confi rming the slow regression of the septic infl ammatory process of the pleural cavity after resolution. The authors conclude that the presented case highlights the diffi culties of imaging diff erential diagnosis and suggests that VATS is an eff ective and safe treatment option for infants with pleural empyema, especially in multiloculated fi brinopurulent forms, allowing a favorable outcome with a short duration of thoracostomy with tube and comparatively short recovery and hospitalization periods.","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":" 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141680245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MARKERS FOR PREDICTING THE MANIFESTATION OF GLOMERULONEPHRITIS IN PATIENTS AFTER COVID","authors":"B. Horban, L. Zub","doi":"10.24061/2413-4260.xiv.2.52.2024.17","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.2.52.2024.17","url":null,"abstract":"Recently, there have been reports in the scientifi c- medical literature about the occurrence of renal pathology after COVID-19 of moderate severity, detected 1 year after this viral infection. Often such changes are detected for the fi rst time. It is now known that after a severe course of COVID-19, interstitial lesions are found in the kidneys, and glomerular changes are added over time. Today, there is no clear answer as to which changes predominate in patients with moderate COVID-19. Of great interest is the probability of glomerulonephritis manifestation 1 year after moderate COVID-19.  The aim of the study was to identify a possible relationship between moderate COVID-19 and the manifestation of glomerulonephritis. Materials and methods. We studied 25 patients with stage I-II chronic glomerulonephritis (GN) who had moderate COVID-19 1 year ago, 27 patients who had moderate COVID 1 year ago without the onset of glomerulonephritis, and 20 healthy people with no history of COVID-19. Cluster and classifi cation methods of data mining, enzyme- linked immunosorbent assay were used to study the levels of IL-1 β, IL-6, IL-10 in blood and urine. We investigated possible relationships between moderate- severe COVID-19 and the manifestation of glomerulonephritis. For this purpose, three diff erent clustering methods were used, which are based on completely diff erent mathematical theories: the classical method of k-means, Kohonen maps (neural networks), fuzzy k-means (fuzzy logic). The research was carried out within the framework of the National Research Council of the Department of Internal Medicine of Bukovyna State Medical University «Clinical- pathogenetic justifi cation of diff erentiated treatment of patients with combined pathology of internal organs» (0122U002209 02.2022-12.2026).Results. A signifi cant increase in the content of IL-1β (p<0.05), IL-6 (p<0.05) and a decrease in the content of IL-10 in blood and urine (p<0.05) were found in patients with chronic glomerulonephritis who were sick with COVID-19 of moderate severity 1 year ago (p<0. 05), and a decrease in the level of IL-10 only in blood in patients who had COVID-19 of moderate severity 1 year ago without further development of glomerulonephritis (p<0.05). The clustering technique confi rmed the association between moderate COVID-19 and glomerulonephritis. Signifi cant indicators were found: IL-1β in urine, IL-6 in urine, IL-6 in blood. The main factor that characterizes the patient’s belonging to the healthy cluster is urine IL-1β with the same threshold –4.953≤ urine IL-1β ≤ 9.431, but the factor that determines the belonging to the disease type is urine IL-6 factor (urine IL-6> 0.994). Such an analysis gives reason to believe thatCOVID-19 of moderate severity may have signs of a factor causing the manifestation of glomerulonephritis. Conclusion. In clinical practice, the method of clustering and classifi cation analysis can be used to determine the main factors for diagnosis an","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":" 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141680467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANALYSIS OF THE DETECTION OF ABNORMAL HYSTEROSCOPIC FINDINGS IN WOMEN WITH INFERTILITY","authors":"N. Kotsabyn, A. Boychuk, L. Nykolyn, Y. Yakymchuk","doi":"10.24061/2413-4260.xiv.2.52.2024.13","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.2.52.2024.13","url":null,"abstract":"The state of health of the mother’s body and directly of the uterine cavity, which is the place of the fi rst meeting of the embryo and the pregravid endometrium, are extremely important for the normal development of the fertile egg. Abnormalities of the uterine cavity can be the cause of infertility in 10-15 % of women. Pathology of the uterine cavity is considered one of the leading causes of unsuccessful attempts at additional reproductive technologies (ART), causes of early pregnancy loss. The aim of this study was to analyze hysteroscopic fi ndings in women with infertility based on the results of offi ce hysteroscopy and compare them with uterine pathology detected by ultrasound (US).Material and methods. A retrospective analysis of the medical records of 208 women with infertility who underwent office hysteroscopy and endometrial biopsy was performed. 94 (45.2 %) patients had primary infertility and 114 (54.8 %) had secondary infertility. All women underwent preoperative transvaginal US on a Voluson S8 unit. A 5 mm Bettocchi hysteroscope with a surgical channel was used during the proliferative phase of the menstrual cycle. Examination of the uterine cavity, a bubble test to determine tubal patency, targeted endometrial biopsy with histologic and immunohistochemical studies, and treatment of any pathology detected were performed. A statistical analysis package based on Microsoft Excel and the «Statistica 12.0» program (StatSoft Inc., USA) was used. Patients’ rights were respected in accordance with the Declaration of Helsinki «Ethical Principles of Medical Research InvolvingHuman Subjects» developed by the World Medical Association, «Universal Declaration of Bioethics and Human Rights (UNESCO)». All pregnant women issued «Informed consent to participate in the study.» The study was carried out within the framework of the National Development Program «Improvement of diagnosis and treatment of pregnant women with a burdened somatic history» of the Department of Obstetrics and Gynecology, Faculty of Postgraduate Education, Ternopil National Medical University named after I. Ya. Gorbachevsky, state registration number N 0121U100153, implementationperiod 2021-2023) Results and conclusions. 164 (78.8 %) patients had a normal hysteroscopic picture, 44 (21.2 %) had pathological hysteroscopicfi ndings, among which endometrial polyps predominated in women with primary infertility, and synechiae of the cervical canal and uterine cavity were most frequently found in secondary infertility. The tubal patency test showed a higher frequency of cases of obstruction of both fallopian tubes in primary infertility, while in secondary infertility the tubes were patent in most people. The normal state of the uterus according to US was determined in 174 women, of whom 87.9 % were confi rmed to have no pathological formations, and 12.1 % of them had abnormal hysteroscopic fi ndings. Pathological conditions of the uterus were diagnosed by ultrasound in 34 patients","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":" 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141679975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PERINATAL ASPHYXIA AND ITS CONSEQUENCES: TODAY’S CHALLENGES IN UKRAINE","authors":"O. Kovalova, S. Dudnyk, V. Pokhylko, Y. Cherniavska, S. Tsvirenko, A. Davydenko","doi":"10.24061/2413-4260.xiv.2.52.2024.2","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.2.52.2024.2","url":null,"abstract":"Despite recent advances in perinatal medicine, neonatal hypoxic- ischemic encephalopathy, approximately 4 million babies worldwide are born asphyxiated each year. According to the World Health Organization (WHO), perinatal asphyxia is the third leading cause of neonatal death (23 %) and accounts for 8 % of all deaths in children under 5 years of age. Modern studies have identifi ed a number of risk factors for birth asphyxia, which may vary according to the level of development of the health care system. Despite the diffi culties in predicting and diagnosing neonatal asphyxia in settings with limited resources, there are potential opportunities to reduce neonatal mortality. Successful resuscitation, including early and eff ective positive pressure ventilation and/or tracheal intubation, and maintenance of normal body temperature are strategies that have the potential to reduce mortality.The aim of the study was to determine the number of hypoxic/asphyxial states of the fetus/child in 2023 according to the data of EHCS (Electronic Health Care System), as well as to identify problematic issues of clinical and organizational nature facing the obstetric and neonatal service of Ukraine. To achieve the goal, the following tasks were defi ned: to analyze the frequency of hypoxic states of the fetus during pregnancy, the number of infants with a diagnosis of severe asphyxia, severe hypoxic- ischemic encephalopathy and diagnoses related to brain damage coded in the EMR (electronic medical records), and also to analyze the number of deaths among infants with severe asphyxia.Materials and methods. The information base of the study became all the EMRs created by doctors according to the following packages «Medical assistance during childbirth»; «Medical care for newborns in complex neonatal cases» with the basis «born in a hospital» and «transferred from another institution» (hereinafter, the neonatal package); «Inpatient care for adults and children without surgical operations» with the basis «born in a hospital» (hereinafter, the therapeutic package) and «sectional examination». If two or more EMRs were created for a child, the information from these EMRs was combined into one treated case.The results of the study showed that a total of 9,938 (5.7 %) women were coded with a diagnosis of «labor and delivery complicated by fetal distress,» while 72 women were coded with two diagnoses of the same rubric. This diagnosis is also reported in the EMR for women who gave birth prematurely. The main cause of fetal distress was a violation of the fetal heart rate in 77.9 % of cases, the presence of meconium and other fetal distress in 21.7 % of cases.The next step in our research was to determine the number of children whose medical records indicated a diagnosis of asphyxia or a condition related to asphyxia. A total of 587 diagnoses with code P21.0 (severe asphyxia) were identifi ed in the primary or secondary diagnoses of the EMR, or 1.04 %. It should be noted that","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":" 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141677082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL CHARACTERISTICS AND POSSIBILITIES OF LABORATORY DIAGNOSTICS OF GASTROINTESTINAL DISEASES IN PERINATAL PATHOLOGY OF PREMATURE INFANTS","authors":"O. Godovanets, Y. Nechytaylo","doi":"10.24061/2413-4260.xiv.2.52.2024.5","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.2.52.2024.5","url":null,"abstract":"The neonatal period is crucial for the development of postnatal adaptation and the formation of health and quality of life. Premature birth of a child in conditions of hypoxia and morphological and functional immaturity implies a high risk of adaptation disorders in the postnatal period, causing the formation of functional and chronic diseases in the later years of life. The course of the neonatal period can be characterized both by transient states due to the formation of physiological adaptation and the development of dysfunction of organ systems, in particular the digestive system, which is a consequence of pathological labor stress in the implementation of adverse factors during pregnancy and childbirth in the mother. Timely detection and correction of early manifestations of gastrointestinal dysfunction in perinatal pathology will improve approaches to the provision of medical care to newborns, especially premature infants, should be aimed at both stabilizing the child’s condition and preventing the development of its long-term consequences.Aim of the study. To study the peculiarities of clinical and laboratory indicators of intestinal dysfunction in perinatal pathology in premature infants.Materials and methods. A comprehensive clinical and laboratory examination of premature infants of gestational age 34-36 weeks who had signs of disorders of the functional state of the gastrointestinal system in perinatal pathology in the early neonatal period was carried out. Group I consisted of 55 children with clinical signs of severe perinatal pathology; group II (control) consisted of 50 conditionally healthy children of the same gestational age. Exclusion criteria were newborns with diagnosed congenital malformations.The list of laboratory indicators of the functional state of the intestine included: the level of α1-antitrypsin (A1AT), secretory IgA (sIgA), fecal elastase 1 (FE-1), PMN elastase and albumin in the coprofi ltrate of newborns in the fi rst week of life. Methods of indicators determination: using enzyme- linked immunosorbent assay (ELISA) on the basis of Ukrainian- German laboratory «BUKINTERMED» (Chernivtsi, Ukraine). The scientifi c research was conducted in accordance with the provisions of GCP (1996), the Convention of the Council of Europe on Human Rights and Biomedicine (April 4, 1997), the Declaration of Helsinki of the World Medical Association for the Ethical Principles of Research Involving Human Subjects (1964-2008), the Order of the Ministry of Health of Ukraine No. 690 of September 23, 2009 (as amended by the Order of the Ministry of Health of Ukraine No. 523 of July 12, 2012). Protocol of the researchstudy of the Biomedical Ethics Committee of BSMU dated 12.09.2015. Informed written consent was obtained from the parents of the patients before the study with an explanation of the purpose, objectives and methods of laboratory research.Statistical processing of the results was performed using STATISTICA software (StatSoft In","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":" 41","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141679009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MANAGEMENT OF BREASTFEEDING SUPPORT IN THE CONDITIONS OF WAR","authors":"V. Bezruk, I. Seman- Minko, I. Shkrobanets, T. Bulyk, L. Rynzhuk, M. Hresko, N. Vasylieva, M. Velia","doi":"10.24061/2413-4260.xiv.2.52.2024.20","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.2.52.2024.20","url":null,"abstract":"Breastfeeding is the only natural way to provide a baby with the nutrients essential for healthy growth and development. Virtually all mothers can breastfeed their babies if they receive support from their families, the health care system, and society. In international and domestic law, armed aggression against a sovereign country is associated with the term «war». Wars are always equated with physical threat and psycho- emotional stress. A state of stress occurs even in babies, the main factor of which is the psychoemotional state of their mothers. The article analyzes both the positive eff ects of breastfeeding on the infant’s organism and the mechanisms of psycho- emotional stress associated with military events in the interaction of the «mother- child» pair. The objective of the research is to develop existing guidelines, recommendations and the algorithm of actions aimed at supporting breastfeeding in emergencies for the family, health system and society, followed by generalization and presentation of the management methodology involving institutions in the areas of cooperation considering the support of breastfeeding in conditions of war. Conducting further studies with the development of eff ectivestrategies to support the «mother- child» pair in the context of ensuring existence, in conditions of military aggression, is an urgent issue for the health care system in Ukraine. The scientifi c researches were carried out within the framework of the Department of Pediatrics, Neonatology and Perinatal Medicine of the Bukovinian State Medical University. The research topics included: Research project on «Chronobiological and adaptive aspects and features of autonomic regulation in pathological conditions in children of diff erent age groups». State registration number: 0122U002245, duration: 01.01.2022-31.12.2026.","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":" 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141678902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ERYPTOSIS AS A LINK BETWEEN BACTERIAL REPRODUCTIVE TRACT INFECTION AND ANEMIA IN PREGNANT WOMEN","authors":"I. Kudin, V. Lazurenko, V. Prokopiuk, O. Zhelezniakov, M. Panasovskyi","doi":"10.24061/2413-4260.xiv.2.52.2024.11","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.2.52.2024.11","url":null,"abstract":"Genital tract infections of various etiologies and anemia remain common in pregnant women. At present, there is a paucity of data on the impact of reproductive tract infections on the development of anemia in pregnant women, with particular emphasis on the contribution of eryptosis. The aim of the current study was to assess the ability of bacterial, viral and fungal reproductive tract infections to trigger eryptosis of circulating erythrocytes in pregnant women.Methods. The study included 47 pregnant women. According to the pathology of the infection, the patients were divided into three groups: 14 women with bacterial, 12 women with viral, 11 women with fungal infections of the reproductive tract and 10 pregnant women without extragenital and obstetric pathology (control subjects). The following methods were used to determine infection: bacteriologic, microscopic, polymerase chain reaction, immunoenzymatic, etc. Flow cytometry- based detection of eryptosis parameters (cell morphology, membrane phospholipid scrambling, and oxidative stress) was performed in pregnant women with reproductive tract infections of bacterial, viral, or fungal origin and in healthy individuals. Annexin V-FITC staining and 2’,7’-dichlorodihydrofl uorescein diacetate (H2DCFDA) staining were used to quantify phosphatidylserine exposure and reactive oxygen species (ROS) generation, respectively. Fluorescence was acquired using a BD FACSCanto™ II fl ow cytometer. ANOVA test was used to compare numerical data of eryptosis assays. Post-hoc Bonferroni test was applied afterwards. Data were processed by Graph Pad Prism 5.0 software (USA). The diff erence was considered statistically signifi cant at p < 0.05. The research was conducted in accordance with the fundamental principles of Good Clinical Practice (GCP, 1996), the Council of Europe Convention on Human Rights and Biomedicine (April 4, 1997), the Helsinki Declaration of the World Medical Association on Ethical Principles for Medical Research Involving Human Subjects (1964-2008), as well as the Ministry of Health of Ukraine Order No. 690 dated September 23, 2009 (amended by the Ministry of Health of Ukraine Order No. 523 dated July 12, 2012). The research design was discussed and approved at the meeting of the Medical and Ethical Committee of the Kharkiv National Medical University (Protocol No. 19 dated May 19, 2024). The paper is an excerpt from the scientifi c research project of the Department of Obstetrics and Gynecology No. 2 at Kharkiv National Medical University, entitled «Optimisation of diagnostics, treatment of diseases of the reproductive system and pregnancy complications in women with extragenital pathology» (state registration number 0121U110923).)Results. Erythropoiesis parameters were evaluated in pregnant women with bacterial, viral and fungal reproductive tract infections. Pregnancy- associated bacterial reproductive tract infections were associated with increased phosphatidylserine externalization in ci","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":" 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141678183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REGIONAL FEATURES OF THE TERMS OF PERMANENT TEETH ERUPTION IN EARLY MIXED DENTITIONAMONG CHILDREN OF ODESA","authors":"V. Horokhovskyi, O. Dienha, S. Skulska, V. Pochtar","doi":"10.24061/2413-4260.xiv.2.52.2024.8","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.2.52.2024.8","url":null,"abstract":"The eruption of permanent teeth in children is a complex physiological process that is important for the development of the dentoalveolar system. The timing of eruption is a key indicator of biological age and prenosological diagnosis of children’s health. The need to update research on this topic is due both to changes in society and the importance of modern data for pediatric dentistry and public health. The aim of the study was to determine the regional characteristics of the terms of eruption of permanent teeth in early mixed dentition among children of Odesa. Material and methods. Dental examination was performed on children aged 4 to 8 years of both sexes. The examination was performed according to the generally accepted methodology, using standard dental instruments included in the examination kit. The children were divided into groups according to age and sex. Patients were examined on the basis of age and period of teeth eruption.Results. The results of the study of the eruption of the permanent teeth of the upper and lower jaws in children aged 4.5-8.5 years in Odesa indicate an earlier eruption of the permanent teeth in girls. Thus, in girls the eruption of the first permanent molars began at the age of 4.5 years and ended at the age of 6 years. In boys, the age of onset of fi rst molar eruption was 5 years and the age of completion was 6.5 years. It was found that the timing of the beginning and the end of the eruption of the central permanent incisors of the upper jaw was the same in boys and girls (6 years), but the average duration of eruption was different. The timing of the beginning and end of eruption of the upper lateral incisors was identical in boys and girls. However,diff erences in the average terms of eruption of permanent upper lateral incisors were obtained. The analysis of the results of the terms of eruption of the central permanent incisors of the lower jaw in boys and girls shows the same terms of beginning of eruption and average terms of eruption of these teeth. However, there were diff erences in the time of the end of eruption. The beginning of the eruption of the permanent central incisors of the upper jaw was noted earlier (at the age of 6 years) than the data given in the modern dental manuals of Ukraine and was completed at the age of 8 years. The age of the beginning and the end of eruption was one year earlier than the generally accepted data. The data on the time of eruption of the fi rst permanent molarsand incisors obtained as a result of the study are necessary for planning programs for prevention of dental caries in children in the period of early replacement dentition. The data obtained as a result of the study indicate the need for further epidemiological studies in other regions of Ukraine in order to establish the current national norms for the eruption of permanent teeth in children. \u0000Conclusion. The discrepancy between the dates of eruption of permanent incisors and molars in Odesa children and ","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":" 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141679892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A CLINICAL CASE OF ACUTE DIFFUSE LUNG INJURY IN A TEENAGE VAPER","authors":"S. Ilchenko, A. Fialkovska, O. Obolonska, O. Zabudska","doi":"10.24061/2413-4260.xiv.2.52.2024.24","DOIUrl":"https://doi.org/10.24061/2413-4260.xiv.2.52.2024.24","url":null,"abstract":"Recently, there have been increasing reports of acute diff use lung injury in adolescents and young adults caused by the use of electronic cigarettes or vapes (EVALI), requiring a complex diff erential diagnosis between infectious (acute bilateral pneumonia), systemic, and interstitial lung diseases. The article presents a rare clinical case of development of sarcoidosis in a teenage vaper, which was established on the basis of clinical and anamnestic data (acute onset of the disease with fever, dry cough, dyspnea, chest pain, hypoxemia, papular rash on the extremities at the beginning of the disease); inconsistencies of the meager auscultatory picture of the lungs during the physical examination of a diff use lung lesion with an increase in intrathoracic lymph nodes and signs of calcinosis according to the x-ray and CT scan of the thoracic cavity; ineff ectiveness of antibacterial therapy with the exclusion of pulmonary tuberculosis and the disappearance of radiological pathological signs without treatment within 2 weeks, but with the girl’s refusal to smoke. Given the rapidly increasing popularity of vaping among adolescents, family physicians and pulmonologists should be particularly vigilant for severe and potentially fatal respiratory pathology. The clinical case is published with the consent of the parents in accordance with the principles of bioethics.","PeriodicalId":162458,"journal":{"name":"Neonatology, surgery and perinatal medicine","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141677526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}