Journal of Medical Case Reports最新文献

筛选
英文 中文
Heterotopic adrenal tissue in a specimen after unilateral salpingo-oophorectomy: a case report. 单侧输卵管卵巢切除术后标本中异位肾上腺组织:1例报告。
IF 0.9
Journal of Medical Case Reports Pub Date : 2025-05-14 DOI: 10.1186/s13256-025-05290-3
Dominika Trojnarska, Ewa Zabiegło, Robert Jach
{"title":"Heterotopic adrenal tissue in a specimen after unilateral salpingo-oophorectomy: a case report.","authors":"Dominika Trojnarska, Ewa Zabiegło, Robert Jach","doi":"10.1186/s13256-025-05290-3","DOIUrl":"https://doi.org/10.1186/s13256-025-05290-3","url":null,"abstract":"<p><strong>Background: </strong>Heterotopic adrenal tissue is an extremely rare finding. The most common site is the genitourinary tract and pelvis, more frequently in male than female children. In our report, we discuss an ectopic adrenal tissue detected incidentally in a perimenopausal woman, which is even more unusual.</p><p><strong>Case presentation: </strong>A 54-year-old Eastern European perimenopausal female patient was referred for surgical treatment due to a suspected 60 mm paratubal cyst. Her medical history was unremarkable and risk of ovarian malignancy algorithm score were normal. Laparoscopic left salpingo-oophorectomy was performed and the specimen was sent for histopathology. The examination revealed a normal ovary, a fallopian tube with a simple paratubal cyst, and a 2.5 mm nest of heterotopic adrenal tissue in the nearby fat tissue. The patient was discharged on the first postoperative day, reported no symptoms, and remained asymptomatic at 3-week follow-up.</p><p><strong>Conclusion: </strong>A review of the available English literature confirmed the rarity of heterotopic adrenal tissue in adult women. This case is presented due to its uniqueness, with the aim of raising awareness about the entity we encountered and presenting its possible implications.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"226"},"PeriodicalIF":0.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extrarenal Wilms tumor in the retroperitoneum of a 6-year-old girl: a case report and review of the literature. 6岁女童腹膜后肾外肾母细胞瘤1例报告及文献复习。
IF 0.9
Journal of Medical Case Reports Pub Date : 2025-05-13 DOI: 10.1186/s13256-025-05274-3
Neda Ashayeri, Elham Zarei, Nafiseh Mortazavi, Amirhesam Moosazadeh
{"title":"Extrarenal Wilms tumor in the retroperitoneum of a 6-year-old girl: a case report and review of the literature.","authors":"Neda Ashayeri, Elham Zarei, Nafiseh Mortazavi, Amirhesam Moosazadeh","doi":"10.1186/s13256-025-05274-3","DOIUrl":"10.1186/s13256-025-05274-3","url":null,"abstract":"<p><strong>Introduction: </strong>Extrarenal Wilms tumor is an extremely rare condition, typically documented only in isolated case reports. Unlike classical intrarenal Wilms tumors, extrarenal Wilms tumors arise outside the kidney, often presenting a diagnostic challenge owing to its unusual location and overlapping features with other retroperitoneal tumors. Its rarity necessitates further documentation to improve recognition and management. This report presents a case of extrarenal Wilms tumor located in the retroperitoneal space of a 6-year-old girl.</p><p><strong>Case presentation: </strong>A 6-year-old white Iranian girl presented with abdominal pain and swelling in the upper left abdomen. Physical examination revealed a firm, nontender, immobile mass. Ultrasound imaging identified a well-defined mass with significant necrotic and cystic areas. Abdominopelvic computed tomography scan showed a large mass on the left side of the abdomen, exerting pressure on the adjacent pancreas, spleen, and left kidney. The patient underwent laparotomy and received 19 weeks of chemotherapy, including actinomycin-D and vincristine. Post-treatment, she fully recovered and underwent monthly sonography follow-ups for 6 months after completing chemotherapy and has shown no signs of recurrence to date.</p><p><strong>Conclusions: </strong>Extrarenal Wilms tumor should be considered in the differential diagnosis of abdominal pain, especially in young children, owing to its rarity and the potential for misdiagnosis as other retroperitoneal tumors. A definitive diagnosis is made through surgical intervention followed by histopathological examination.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"222"},"PeriodicalIF":0.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-dose flecainide for symptomatic relief in paramyotonia congenita/severe neonatal episodic laryngospasm due to SCN4A G1306E: a case report. 大剂量氟卡因缓解SCN4A G1306E所致先天性肌张力副缩/新生儿严重发作性喉痉挛1例
IF 0.9
Journal of Medical Case Reports Pub Date : 2025-05-13 DOI: 10.1186/s13256-025-05164-8
Vanessa Ogueri, Jessica Chong, Melissa Fleming, Kara Simpson, Elizabeth Sherwin, Diana Bharucha-Goebel, Christopher Spurney
{"title":"High-dose flecainide for symptomatic relief in paramyotonia congenita/severe neonatal episodic laryngospasm due to SCN4A G1306E: a case report.","authors":"Vanessa Ogueri, Jessica Chong, Melissa Fleming, Kara Simpson, Elizabeth Sherwin, Diana Bharucha-Goebel, Christopher Spurney","doi":"10.1186/s13256-025-05164-8","DOIUrl":"10.1186/s13256-025-05164-8","url":null,"abstract":"<p><strong>Background: </strong>Severe neonatal episodic laryngospasm has been previously reported in multiple patients with the heterozygous pathogenic variant G1306E in SCN4A. Treatment can be difficult due to side effects from therapies utilized conventionally for the management of myotonia and paramyotonia congenita.</p><p><strong>Case presentation: </strong>We report on two female siblings of Irish, Scandinavian, and German ethnicity aged 7 and 3 years with severe neonatal episodic laryngospasm and paramyotonia congenita due to a paternally inherited heterozygous pathogenic variant of the SCN4A gene and the use of high-dose flecainide therapy for symptomatic management. Interestingly, one of the two siblings has a coexisting separate maternally inherited and pathogenic CLCN1 variant that may further impact phenotype. High-dose flecainide 220-250 mg/m<sup>2</sup>/day was not associated with any cardiac side effects.</p><p><strong>Conclusion: </strong>This report supports the use of high-dose flecainide in combination with standard therapies in pediatric patients with SCN4A mutations to modulate acute symptoms and provides suggested dosing with an acute and long-term monitoring protocol.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"224"},"PeriodicalIF":0.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An approach to reconstructing a segmental defect of the mandible involving the condyle secondary to nodular fasciitis in a pediatric patient: a case report. 一个方法重建下颌骨节段缺损累及髁继发结节性筋膜炎在儿科患者:一个病例报告。
IF 0.9
Journal of Medical Case Reports Pub Date : 2025-05-13 DOI: 10.1186/s13256-025-05269-0
Nitin Bhola, Shreya Pawar
{"title":"An approach to reconstructing a segmental defect of the mandible involving the condyle secondary to nodular fasciitis in a pediatric patient: a case report.","authors":"Nitin Bhola, Shreya Pawar","doi":"10.1186/s13256-025-05269-0","DOIUrl":"10.1186/s13256-025-05269-0","url":null,"abstract":"<p><strong>Background: </strong>Nodular fasciitis is a rare, benign, and rapidly growing soft tissue lesion that predominantly affects the fascia and is typically observed in the extremities. However, its occurrence in the head and neck region is uncommon, making it a challenging entity to diagnose and treat. In the head and neck, the lesion can involve various structures including the soft tissue, muscles, and even the parotid gland. Clinically, patients may present with swelling, pain, or a rapidly enlarging mass often leading to misdiagnosis with more malignant conditions such as sarcomas or fibromatosis.</p><p><strong>Case presentation: </strong>We present a case of a 12-year-old boy of Indian ethnicity with a progressively growing swelling over the face, which was initially thought to be a malignant tumor owing to its rapid growth. Biopsy confirmed the diagnosis of nodular fasciitis. Imaging revealed a large expansile lytic lesion involving the left hemimandible. The lesion was surgically excised and reconstruction and total joint replacement were done using patient-specific implants.</p><p><strong>Conclusion: </strong>This report highlights the importance of considering nodular fasciitis in the differential diagnosis of rapidly growing soft tissue masses in the head and neck region. Prompt recognition and surgical intervention can lead to favorable results, restoring both function and esthetics for patients affected by this benign yet challenging condition.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"225"},"PeriodicalIF":0.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment approach with clinical follow-up in monostotic fibrous dysplasia: a case series. 单性纤维结构不良的临床随访治疗方法:一个病例系列。
IF 0.9
Journal of Medical Case Reports Pub Date : 2025-05-13 DOI: 10.1186/s13256-025-05261-8
Man-Hua Liu, Hong-Xia Zhu, Lei Fu, Lun-Li Xie
{"title":"Treatment approach with clinical follow-up in monostotic fibrous dysplasia: a case series.","authors":"Man-Hua Liu, Hong-Xia Zhu, Lei Fu, Lun-Li Xie","doi":"10.1186/s13256-025-05261-8","DOIUrl":"10.1186/s13256-025-05261-8","url":null,"abstract":"<p><strong>Background: </strong>Long bones are one of the most common sites involved in fibrous dysplasia. In some cases, there is no deformity, but patients suffer sustained or intermittent dull pain.</p><p><strong>Case presentation: </strong>Since 2021, a retrospective case series of seven East Asian patients with fibrous dysplasia of a long bone without severe deformity were reviewed. These patients include three male and four female patients, with an average age of 32.7 years (range 4-70 years). Fibrous dysplasia was diagnosed at a total of three different sites in these seven cases including five femurs (71.4%), one humerus (14.3%), and one fibular bone (14.3%). All patients received treatment with allogenic bone grafting or cortical strut grafting with or without compression locking and screw fixation. The radiological and clinicopathologic presentation was analyzed by the surgeon. There were no cases with polyostotic forms or fibrous dysplasia in combination with extraskeletal disease. The presenting complaint was pain in all cases and localized swelling in 1 (14.3%) of the cases.</p><p><strong>Conclusions: </strong>Autogenous fibular cortical strut grafting and compression hip screw fixation achieved good postoperative function and provided an early return to work for adult patients with fibrous dysplasia of the femoral neck with mild but prolonged symptoms. However, total hip replacement may be a suitable method for fibrous dysplasia of the femoral neck accompanied by pathological fracture.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"223"},"PeriodicalIF":0.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute infectious purpura fulminant due to Enterococcus faecium infection: a case report. 粪肠球菌感染致急性感染性暴发性紫癜1例。
IF 0.9
Journal of Medical Case Reports Pub Date : 2025-05-12 DOI: 10.1186/s13256-025-05160-y
Raghad G Tanbour, Riad Amer, Abdelrahman N Matar, Banan M Aiesh
{"title":"Acute infectious purpura fulminant due to Enterococcus faecium infection: a case report.","authors":"Raghad G Tanbour, Riad Amer, Abdelrahman N Matar, Banan M Aiesh","doi":"10.1186/s13256-025-05160-y","DOIUrl":"https://doi.org/10.1186/s13256-025-05160-y","url":null,"abstract":"<p><strong>Background: </strong>Purpura fulminant is a rare life-threatening disorder characterized by a dysregulated response that is often associated with poor prognosis and lethal outcomes. It is often associated with disseminated intravascular coagulation, skin necrosis, and protein C deficiency leading to thrombotic occlusion of skin arterioles, causing palpable purpuric lesions, spreading ecchymosis, and gangrene, along with hypotension and fever. Purpura fulminant is classified into three distinct categories according to the trigger mechanisms, including neonatal, idiopathic, and acute infectious. Acute infectious purpura fulminant is the most common manifestation, which occurs after bacterial infections caused by acquired protein C deficiency. Although traditionally occurring in Neisseria meningitidis infection and Streptococcus infection, acquired protein C deficiency causing purpura fulminant due to Enterococcus faecium has not been described in the literature. This case report highlights the fact that purpura fulminans can also be a rare presentation of Entercoccus faecium infection.</p><p><strong>Case presentation: </strong>A 61-year-old Arab man who is immunocompetent presented with sepsis, which later escalated into septic shock due to Enterococcus faecium bacteremia. The patient's hospitalization rapidly developed into multiorgan dysfunction, disseminated intravascular coagulation, and purpura fulminans. Aggressive interventions were initiated, involving the administration of broad-spectrum antibiotics, multiple vasopressors, and mechanical ventilation. Despite these intensive measures, the patient ultimately succumbed to the complications of multiorgan failure and death.</p><p><strong>Conclusion: </strong>This case illustrates the devastating outcomes that can present from purpura fulminant. However, physicians should consider purpura fulminant caused by Enterococcus faecium infection in the workup of patients presenting with purpuric rash and fever.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"216"},"PeriodicalIF":0.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12067727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Infestation of eyelashes by Pediculus humanus capitis (family: pediculidae): a case report. 人头虱(科:头虱科)侵染睫毛1例。
IF 0.9
Journal of Medical Case Reports Pub Date : 2025-05-12 DOI: 10.1186/s13256-025-05272-5
Madineh Abbasi, Saideh Yousefi
{"title":"Infestation of eyelashes by Pediculus humanus capitis (family: pediculidae): a case report.","authors":"Madineh Abbasi, Saideh Yousefi","doi":"10.1186/s13256-025-05272-5","DOIUrl":"10.1186/s13256-025-05272-5","url":null,"abstract":"<p><strong>Background: </strong>This case report describes a rare instance of Pediculus humanus capitis infestation affecting the eyelashes of a 10-year-old boy, notable for its ocular implications and unique diagnostic challenges.</p><p><strong>Case presentation: </strong>In November 2023, a 10-year-old Iranian boy from East Azerbaijan Province, northwest Iran, presented to the ophthalmologist with symptoms that included itching, eyelash adhesions, redness, and swelling around the eyes, along with small yellow spots on the eyelashes. The ophthalmological examination revealed no visual defects. An eyelash sample collected for analysis confirmed the presence of lice eggs and nymphs; lice were also found on the scalp. The treatment included tetracycline ointment. By the third day, the nymphs had been eradicated, but lice eggs remained. The remaining lice eggs were subsequently removed using forceps.</p><p><strong>Conclusions: </strong>This case underscores the importance of considering parasitic infestations in patients with ocular symptoms and highlights the associated public health and hygiene implications.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"220"},"PeriodicalIF":0.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simultaneous development of Guillain-Barre syndrome and bacterial meningitis as complications of pneumonia caused by Staphylococcus aureus: a case report. 格林-巴利综合征和细菌性脑膜炎同时发展为金黄色葡萄球菌引起的肺炎并发症:1例报告。
IF 0.9
Journal of Medical Case Reports Pub Date : 2025-05-12 DOI: 10.1186/s13256-025-05176-4
Yuliia Solodovnikova, Anastasiia Revurko, Svitlana Oliinyk, Anatoliy Son
{"title":"Simultaneous development of Guillain-Barre syndrome and bacterial meningitis as complications of pneumonia caused by Staphylococcus aureus: a case report.","authors":"Yuliia Solodovnikova, Anastasiia Revurko, Svitlana Oliinyk, Anatoliy Son","doi":"10.1186/s13256-025-05176-4","DOIUrl":"https://doi.org/10.1186/s13256-025-05176-4","url":null,"abstract":"<p><strong>Background: </strong>Guillain-Barre syndrome is an acquired inflammatory polyradiculoneuropathy that often follows gastrointestinal infection. A review of available literature revealed only few cases where Guillain-Barre syndrome developed after different types of meningitis. Furthermore, there are isolated cases of Guillain-Barre syndrome combined with meningeal irritation. This is the first reported case of Guillain-Barre syndrome and bacterial meningitis occurring simultaneously as complications of community-acquired pneumonia.</p><p><strong>Case presentation: </strong>We report the case of a 77-year-old Ukrainian male patient who presented to the hospital with clinical symptoms of pneumonia. Over the next day, he developed clinical symptoms of acute symmetric ascending flaccid tetraparesis. A few days later, synkinesis-like movements appeared in the paralyzed lower limbs. Microbiological studies of the cerebrospinal fluid identified antibiotic-sensitive Staphylococcus aureus. The patient received treatment with intravenous immunoglobulin and combination antibacterial therapy. The patient was discharged with improvement.</p><p><strong>Conclusion: </strong>In this case, a potentially life-threatening condition, such as bacterial meningitis, was asymptomatic and clinically unrecognized. It is important to recognize atypical cases of Guillain-Barre syndrome to achieve early diagnosis and treatment.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"217"},"PeriodicalIF":0.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12067702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urrets-Zavalia syndrome following implantable collamer lens (ICL) implantation: a case report and review of the literature. 植入式晶体(ICL)植入术后的urretts - zavalia综合征1例报告及文献复习。
IF 0.9
Journal of Medical Case Reports Pub Date : 2025-05-12 DOI: 10.1186/s13256-025-05255-6
Ke Li, Ting Huang, Juan Yuan, Siyi Bao
{"title":"Urrets-Zavalia syndrome following implantable collamer lens (ICL) implantation: a case report and review of the literature.","authors":"Ke Li, Ting Huang, Juan Yuan, Siyi Bao","doi":"10.1186/s13256-025-05255-6","DOIUrl":"10.1186/s13256-025-05255-6","url":null,"abstract":"<p><strong>Background: </strong>Urrets-Zavalia syndrome is a condition that arises after eye surgery, often linked to increased intraocular pressure following the procedure. We present a case of a progressively dilated and fixed pupil in one eye following the implantation of a toric implantable collamer lens. There are no documented cases in the literature regarding this condition in China. The patient gradually and completely recovered after our intervention. This case differs from all previous implantable collamer lens implantation cases, and the treatment method used is unprecedented.</p><p><strong>Case presentation: </strong>A 33-year-old Han Chinese woman successfully had a toric implantable collamer lens implanted in both eyes. The left eye surgery was performed on the first day. Within 10 days post-operation, the pupil of the left eye continued to dilate. We considered the cause of pupil dilation in this case to be pupillary sphincter paralysis caused by elevated intraocular pressure and the excessive size of the toric implantable collamer lens. Therefore, the toric implantable collamer lens needed to be replaced with a smaller one. However, it would take 3-4 months to prepare the new toric implantable collamer lens. After discussing the situation with the patient and obtaining her consent, we repositioned the toric implantable collamer lens to the new target location. The alternative toric implantable collamer lens was ultimately available more than 2 months later. After the replacement operation, the pupil gradually returned to normal.</p><p><strong>Conclusion: </strong>The vault is not the only criterion for determining whether the size of an implantable collamer lens is appropriate. In this case, it can be concluded that the potential reason for pupil dilation was that the size of the toric implantable collamer lens was too large, and it reversed after changing to a smaller size. The dilated pupil would not return to normal if the toric implantable collamer lens were not replaced. When persistent mydriasis (Urrets-Zavalia syndrome) occurs after implantable collamer lens implantation, it is essential to determine whether the implantable collamer lens size is appropriate besides controlling the intraocular pressure. In addition, alternative toric implantable collamer lenses often need to be customized. During long waiting times, provisional implantable collamer lens realignment will predictive simulation for planned exchange.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"219"},"PeriodicalIF":0.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Induction hepatic arterial infusion chemotherapy followed by surgery for hepatocellular carcinoma with massive portal vein tumor thrombosis: a case series of 20 patients. 诱导肝动脉输注化疗后手术治疗肝癌合并门静脉肿瘤血栓形成20例
IF 0.9
Journal of Medical Case Reports Pub Date : 2025-05-12 DOI: 10.1186/s13256-025-05253-8
Yuta Kimura, Yukio Tokumitsu, Yoshitaro Shindo, Hiroto Matsui, Satoshi Matsukuma, Issei Saeki, Taro Takami, Takahiro Yamasaki, Tatsuya Ioka, Hiroaki Nagano
{"title":"Induction hepatic arterial infusion chemotherapy followed by surgery for hepatocellular carcinoma with massive portal vein tumor thrombosis: a case series of 20 patients.","authors":"Yuta Kimura, Yukio Tokumitsu, Yoshitaro Shindo, Hiroto Matsui, Satoshi Matsukuma, Issei Saeki, Taro Takami, Takahiro Yamasaki, Tatsuya Ioka, Hiroaki Nagano","doi":"10.1186/s13256-025-05253-8","DOIUrl":"https://doi.org/10.1186/s13256-025-05253-8","url":null,"abstract":"<p><strong>Background: </strong>The prognosis of hepatocellular carcinoma with portal vein tumor thrombosis is very poor, and the optimal treatment remains controversial. The aim of this study is to examine the safety and feasibility of our multimodal treatment.</p><p><strong>Methods: </strong>This was a single-institution, retrospective case series. From 2013 to 2018, induction hepatic arterial infusion chemotherapy was given to 20 consecutive Japanese patients with hepatocellular carcinoma harboring portal vein tumor thrombosis in the main portal trunk or first branch, even with intrahepatic and extrahepatic metastasis. When the cancers including thrombus and metastatic disease were well controlled, surgical resection was considered. When macroscopic complete resection was achieved, two courses of hepatic arterial infusion chemotherapy were added as adjuvant therapy, whereas patients who had remnant disease after surgery were provided treatment according to the type of lesion.</p><p><strong>Results: </strong>No treatment-related deaths were noted. The objective response rate and disease control rate were 35.0% and 65.0%, respectively. After induction treatment, 10 of 20 patients underwent surgery. Postoperative complications (Clavien-Dindo grade III or more) were observed in three cases, and median postoperative hospital stay was 15.5 days. Median survival time of all 20 patients was 14.5 months and that in patients who underwent surgery was significantly longer than that in patients with unresectable hepatocellular carcinoma (19.5 months versus 9.0 months, p = 0.0018).</p><p><strong>Conclusion: </strong>Induction treatment followed by surgery was safe and feasible for hepatocellular carcinoma with massive portal vein tumor thrombosis. Surgical resection might be oncologically appropriate for selected patients after induction treatment even with advanced stage hepatocellular carcinoma.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"218"},"PeriodicalIF":0.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12067759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信