Journal of long-term effects of medical implants最新文献

{"title":"Impact of Subgingival Lactobacillus reuteri Probiotic Therapy on Clinical Outcomes and Porphyromonas gingivalis Quantification in Peri-Implant Disease: A Prospective RT-PCR-Based Clinical Study.","authors":"Karthick Kamalakannan, Arvina Rajasekar","doi":"10.1615/JLongTermEffMedImplants.2025060737","DOIUrl":"10.1615/JLongTermEffMedImplants.2025060737","url":null,"abstract":"<p><p>Peri-implantitis is a biofilm-induced inflammatory disease that compromises peri-implant tissues, adversely affecting human health and implant survival. As an infectious disease, its management through mechanical debridement alone is often limited by persistent microbial burden. Adjunctive probiotic therapy, grounded in contemporary medicine, has therefore been proposed to improve peri-implant health and oral wellbeing, with potential relevance to broader public health outcomes. The aim of the study was to evaluate the clinical and microbiological effects of subgingival probiotic delivery as an adjunct to mechanical debridement in the non-surgical management of peri-implantitis. A prospective clinical study was conducted involving 52 systemically and periodontally healthy individuals aged 30-60 years with peri-implantitis. Participants were randomly divided into two groups (n = 26 each). Group 1 received mechanical debridement alone, while Group 2 received mechanical debridement combined with subgingival application of Lactobacillus reuteri probiotic. Clinical parameters (PI, GI, PPD, and CAL) and Porphyromonas gingivalis levels were assessed at baseline and three months. RT-PCR was used for microbiological evaluation. Data were analyzed using paired and independent t-tests, with P < 0.05 considered significant. Both groups showed significant intra-group improvements in clinical and microbiological parameters (P < 0.05). However, Group 2 exhibited significantly greater reductions in PI, GI, PPD, CAL, and P. gingivalis levels compared with Group 1 (P = 0.00), demonstrating the superior effectiveness of probiotic therapy. Adjunctive probiotic therapy significantly improves clinical outcomes and reduces microbial load in peri-implantitis patients, offering a beneficial addition to mechanical debridement.</p>","PeriodicalId":16125,"journal":{"name":"Journal of long-term effects of medical implants","volume":"36 1","pages":"85-90"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PLLA Screw-Related Foreign Body Reaction and Role in Pretibial Cyst Formation after ACL Reconstruction.","authors":"Orestis K Konstantas, Anastasios Roustemis, Dimitrios Koulalis, Dimitrios Mastrokalos","doi":"10.1615/JLongTermEffMedImplants.2025062524","DOIUrl":"https://doi.org/10.1615/JLongTermEffMedImplants.2025062524","url":null,"abstract":"<p><p>Pretibial cyst formation is an uncommon but clinically significant complication following anterior cruciate ligament (ACL) reconstruction using bioabsorbable poly-L-lactic acid (PLLA) interference screws. This study reviews six cases of pretibial cyst formation after ACL reconstruction to evaluate its etiology, clinical presentation, and treatment outcomes. A retrospective analysis was conducted on six patients from a cohort of 446 ACL reconstructions performed with PLLA screws. Patients presented 2-4 years postoperatively with pretibial swelling and tenderness without systemic infection or allergic manifestations. Radiographs and magnetic resonance imaging demonstrated multiloculated cystic lesions and tibial tunnel widening adjacent to degrading screws. All patients underwent cyst debridement and screw removal, and histopathological specimens were analyzed. Histological examination revealed granulomatous inflammation characterized by macrophages, foreign body giant cells, and focal necrosis, supporting a foreign body reaction to PLLA degradation. Clinical evaluation showed preserved knee stability, with stable Lysholm, IKDC, and Lachman scores, although Tegner activity scores demonstrated mild postoperative decline. No communication between the cyst and joint space was identified, supporting the hypothesis that cyst formation results from localized inflammatory reactions rather than synovial fluid leakage. These findings suggest that PLLA screw degradation may induce foreign body reactions leading to pretibial cyst formation after ACL reconstruction. Surgical excision of the cyst and removal of the bioabsorbable screw resulted in symptom resolution without recurrence. Further investigation into alternative bioabsorbable materials with improved biocompatibility and degradation profiles is warranted to reduce inflammatory complications following ACL reconstruction.</p>","PeriodicalId":16125,"journal":{"name":"Journal of long-term effects of medical implants","volume":"36 2","pages":"59-66"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Crown-to-Implant Ratio of Short Implants on Peri-Implant Stress: A Finite Element Analysis.","authors":"Naira Ghambaryan, Gagik Hakobyan","doi":"10.1615/JLongTermEffMedImplants.2025055634","DOIUrl":"10.1615/JLongTermEffMedImplants.2025055634","url":null,"abstract":"<p><p>Purpose of this study was to evaluate the distribution of bone tension around single implants with different С/I ratio (1.5:1, 1.75:1, 2:1) according to the von Mises criterion. Stress analysis was performed using Invesalius 3.0, Rhinoceros 3D 4.0 software. Three 3D models of the mandibular segment of the bone block were developed: model A, a short implant (6 mm) C/I -1.5:1; model B, a short implant (6 mm) C/I -1.75:1; model C, a short implant (6 mm) C/I -2:1. The results were evaluated: the cumulative frequency of implant engraftment, MBL changes around the implant, follow up for 5 years. Under axial load, the highest stresses were concentrated at the abutment/implant junctions, the highest stresses were 67.94 MPa C/I -1.5:1, 68.09 MPa C/I -1.75:1 and 68.24 MPa C/ I -2:1, respectively. The results of the current study, indicate the increase in crown height showed little difference in load at the crown/implant interface with crown/implant ratios of 1.5:1, 1.75:1 and 2:1. In vivo finite element analysis (FEA) study showed that short implantats are successful regardless the C/I ratio. Use of shorts implants for prosthetic rehabilitation can be considered favorable and well substantiated.</p>","PeriodicalId":16125,"journal":{"name":"Journal of long-term effects of medical implants","volume":"36 1","pages":"31-36"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flapless Graft-Free Sinus Floor Elevation Simultaneously with the Placement of a Dental Implant \"Aldary Technique\": A Case Report with 5 Years Follow-Up.","authors":"Haseeb H AlDary, Arwa AlSayed, Lina Droubi, Abdallah Alhassan, Rami S Al Fodeh","doi":"10.1615/JLongTermEffMedImplants.2025052914","DOIUrl":"10.1615/JLongTermEffMedImplants.2025052914","url":null,"abstract":"<p><p>Following the extraction of a tooth, the alveolar bone undergoes resorption, impacting the remaining bone volume. This phenomenon is particularly pronounced in the posterior upper jaw region, where the bone surrounding the extraction site undergoes physiological transformation, and potential pneumatization of the maxillary sinus. Consequently, there is a reduction in available bone volume and height. Various methods have been described in literature to address this issue. Two main scientifically based techniques for sinus lift are extensively studied and established today, each suitable for specific clinical scenario primarily determined by the residual bone height. The Tatum (direct) approach is recommended when there is less than 5 mm of remaining bone, while the Summer (indirect) technique is preferred when there is more than 5 mm of residual bone. This case report presents a novel technique that integrates the core principle of the above procedures, aiming to simplify indirect sinus lifts in situations that were previously considered challenging owing to inadequate bone volume. A patient with a 2 mm residual maxillary sinus floor height was selected for this case report. A flapless graft-free intracrestal approach was performed in two steps as follows: (1) a tissue-punch is used to harvest the soft tissue from the crest where the implant is to be placed, the graft is then relocated and placed buccal to the same site; (2) a circular knife is used at the exposed bone to cut an opening/bone window which allows performing the intra-crestal displacement of the Schneiderian membrane using curette and placing a dental implant through the same opening/implant bed. A six-month post-operative peri-apical radiograph and CBCT scan showed 4-5 mm extra height of newly formed bone around the implant in the lifted sinus. Also, CBCT scans after five years confirmed the stability, quality, and quantity of the newly formed bone. This novel approach of minimally invasive \"flapless\" intra-crestal sinus lifting, simultaneously with implant placement, may be effective in conducting bone formation in certain clinical conditions, where residual bone height is equal or less than 3 mm, even without utilizing bone substitute materials.</p>","PeriodicalId":16125,"journal":{"name":"Journal of long-term effects of medical implants","volume":"36 1","pages":"45-54"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Three-Year Peri-Implant Maintenance Compliance on Clinical and Radiographic Outcomes: A Cross-Sectional Analysis of Peri-Implant Disease Prevalence.","authors":"Blessy Stella, Arvina Rajasekar","doi":"10.1615/JLongTermEffMedImplants.2025062354","DOIUrl":"https://doi.org/10.1615/JLongTermEffMedImplants.2025062354","url":null,"abstract":"<p><p>The long-term success of dental implants depends not only on osseointegration but also on maintaining peri-implant tissue health and overall human health and wellbeing. Despite predictable survival rates, peri-implant diseases such as mucositis and peri-implantitis remain prevalent due to poor plaque control, contributing to oral infectious disease and illness. Peri-implant maintenance therapy (PIMT) is essential for disease prevention through regular monitoring and intervention, supporting public health, preventive medicine, and long-term patient wellbeing. The aim of the study was to evaluate the effect of peri-implant maintenance compliance on clinical and radiographic parameters and its influence on peri-implant disease prevalence. A cross-sectional study was conducted on 736 implants in patients with single-unit implant-supported prostheses functioning for at least three years. Participants were classified as compliers (≥ 2 maintenance visits/year) and non-compliers (no visits). Clinical parameters including plaque index (PI), gingival index (GI), peri-implant probing depth (PPD), clinical attachment level (CAL), keratinized mucosa width (KMW), and radiographic crestal bone loss (CBL) were recorded. Peri-implant conditions were diagnosed based on the 2017 World Workshop criteria. Statistical analysis was performed using SPSS v23.0, with significance set at P < 0.05. Compliers showed significantly better peri-implant parameters than non-compliers: lower PI (P < 0.001), GI (P < 0.001), and PPD (P = 0.01), along with reduced CAL (P = 0.02) and CBL (P < 0.001) and higher KMW (P < 0.001). Peri-implantitis was more prevalent among non-compliers (17.8%) compared with compliers (6.7%) (P < 0.001). Regular compliance with PIMT significantly enhances peri-implant clinical and radiographic outcomes while reducing peri-implant disease prevalence.</p>","PeriodicalId":16125,"journal":{"name":"Journal of long-term effects of medical implants","volume":"36 2","pages":"37-42"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjunctive Role of Er,Cr:YSGG Laser in Non-Surgical Treatment of Peri-Implantitis Disease: A Six-Month Clinical, Radiographic, and Microbial Analysis.","authors":"Neha Jain, Arvina Rajasekar","doi":"10.1615/JLongTermEffMedImplants.2025062959","DOIUrl":"10.1615/JLongTermEffMedImplants.2025062959","url":null,"abstract":"<p><p>Peri-implantitis poses a significant challenge to implant success and overall human health and wellbeing, necessitating effective treatment strategies. As an infectious disease affecting peri-implant tissues, it contributes to oral illness and impacts public health. Lasers, such as Er,Cr:YSGG, have been explored as adjuncts to conventional therapy to enhance clinical and radiographic outcomes, supporting preventive medicine, disease control, and improved patient well-being. We sought to evaluate the clinical, radiographic, and microbiological efficacy of Er,Cr:YSGG laser as an adjunct to mechanical debridement in the management of peri-implantitis. This prospective clinical study included 52 systemically healthy patients diagnosed with peri-implantitis, randomly allocated into two groups: control group (mechanical debridement alone) and test group (mechanical debridement + Er,Cr:YSGG laser application). Clinical parameters, including Silness and Löe plaque index (PI), Löe and Silness gingival index (GI), probing depth (PD), radiographic crestal bone level (CBL), and microbiological counts (aerobic and anaerobic colony-forming units), were recorded at baseline and 6 months. Data were analyzed using independent and paired t-tests, with P < 0.05 considered significant. Both groups showed significant intragroup reductions in PI, GI, PD, and CBL at 6 months (P < 0.05). The test group demonstrated significantly greater improvements in PI (0.78 ± 0.14 vs. 1.32 ± 0.12), GI (0.86 ± 0.14 vs. 1.28 ± 0.13), PD (3.20 ± 0.15 mm vs. 3.71 ± 0.23 mm), and CBL (1.70 ± 0.18 mm vs. 1.85 ± 0.20 mm) compared with the control (P < 0.05). Microbial loads (aerobic and anaerobic) were markedly reduced in the test group (P < 0.05). Er,Cr:YSGG laser adjunctive to mechanical debridement significantly improved clinical, radiographic, and microbiological parameters in peri-implantitis management, supporting its role as an effective adjunctive therapy.</p>","PeriodicalId":16125,"journal":{"name":"Journal of long-term effects of medical implants","volume":"36 2","pages":"43-49"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Migrated Dental Implants into the Maxillary Sinus: Therapeutic Management. Scoping Review.","authors":"Hernan S Garzon, Heber Felipe Herrera, Laura Canizales, Oscar Tocarruncho","doi":"10.1615/JLongTermEffMedImplants.2025050135","DOIUrl":"10.1615/JLongTermEffMedImplants.2025050135","url":null,"abstract":"<p><strong>Introduction: </strong>The small amount of bone tissue can increase the risk of dental implant migration into the maxillary sinus. Treatment options include endoscopic or Caldwell-Luc techniques, as well as implant preservation in the sinus, with consideration given to patient symptoms, implant location, diameter, and length.</p><p><strong>Objective: </strong>To compare the clinical outcomes of various techniques for retrieving implants that have migrated to the maxillary sinus, based on current literature.</p><p><strong>Methodology: </strong>A systematic search was conducted using MESH and non-MESH terms for the endoscopic technique (\"dental implant, migration, maxillary sinus, endoscopic\") and the Caldwell-Luc technique using words such as \"dental implants, foreign-body, migration, maxillary sinus\" and non-MESH terms such as \"technique Caldwell-Luc, removal\" with the operators AND/OR. Only case reports published between 2000 and 2022 were included in the analysis.</p><p><strong>Results: </strong>A total of 70 initial articles were obtained. Duplicate articles were eliminated, leaving 56 articles. Titles and abstracts of these articles were reviewed, and 37 studies were excluded. A total of 19 articles were included in the study, of which four were eliminated due to eligibility criteria. The study included five case reports on the Caldwell-Luc technique and 10 on the endoscopic procedure. In a total of 19 patients, 23 implants migrated into the sinus. Fifteen patients reported late implant migration (occurring after one month) and four experienced immediate migration (within 0-15 days), with a range of 2 days to 15 years. Of the 19 cases, 12 presented symptoms such as unilateral nasal obstruction, purulent secretions, unilateral facial pain, pain on percussion, and foul odor, while the remaining seven patients were asymptomatic. Only one case was reported to have presented with an absence of reossification of the lateral access window and thickening of Schneider's membrane after implant removal using the Caldwell-Luc technique.</p><p><strong>Conclusions: </strong>The endoscopic approach resulted in no complications during or after removal of the migrated implant from the maxillary sinus. Despite having more significant morbidity, the Caldwell-Luc technique provides better access and visibility for implants in areas the endoscopic technique cannot reach. Asymptomatic patients can preserve the implant in the maxillary sinus with rigorous follow-up and the possibility of later complications.</p>","PeriodicalId":16125,"journal":{"name":"Journal of long-term effects of medical implants","volume":"36 1","pages":"9-21"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Ceramic Veneering on the Metallurgical Properties of Cobalt-Chromium Alloys Fabricated Using Different Techniques.","authors":"Elie E Daou","doi":"10.1615/JLongTermEffMedImplants.2026061463","DOIUrl":"https://doi.org/10.1615/JLongTermEffMedImplants.2026061463","url":null,"abstract":"<p><p>This study was designed to assess the interface between ceramic and cobalt-chromium (Co-Cr) and to detect changes in the alloys microstructure after ceramic layering. Thirty disks (n = 36) were fabricated from cobalt-chromium (Co-Cr) alloys, cast, milled, and selective laser melting (SLM) (n = 12 in each group). Half of each group (n = 5) were observed as initially fabricated. The remaining disks were ceramic veneered. Scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS) were used to observe the morphology and chemical-analysis of the materials. Non-veneered disks were submitted to ceramic firing protocol without ceramic. X-ray diffraction (XRD) and atomic force microscope (AFM) were used to study the crystalline structure and surface roughness of the specimens. The alloys' microstructure was observed before and after ceramic veneering in each group. The General Linear Model was used to assess the means differences among groups, mainly grain size and surface roughness. The mean difference is significant at the 0.05 level. Intimate bonding interface between Co-Cr and ceramic was observed on SEM images. In milled Co-Cr, the ceramic veneering led to a significant reduction in grain sizes (P = 0.017), but to an increase in the cast and SLM groups (P = 0.012). A significant increase in the surface roughness of cast Co-Cr (P = 0.031) and SLM (P = 0.005) resulted from ceramic veneering. XRD analysis showed differences in the crystalline structure after porcelain veneering in cast and SLM Co-Cr. Co-Cr showed an intimate interface with ceramic. Unlike Co-Cr cast and SLM, milled Co-Cr attained a stable and final crystal arrangement upon sintering. Presintered materials showed fine homogenous surface.</p>","PeriodicalId":16125,"journal":{"name":"Journal of long-term effects of medical implants","volume":"36 2","pages":"85-94"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing the Therapeutic Potential of Locally Delivered 1% Metformin Gel for Modulation of Clinical and Inflammatory Parameters in Peri-Implantitis Disease: A Prospective Clinical Evaluation.","authors":"Karthick Kamalakannan, Arvina Rajasekar","doi":"10.1615/JLongTermEffMedImplants.2025062172","DOIUrl":"10.1615/JLongTermEffMedImplants.2025062172","url":null,"abstract":"<p><p>Peri-implantitis is a chronic inflammatory disease that poses a significant challenge to human health due to persistent microbial biofilm accumulation and limited peri-implant tissue regeneration, adversely affecting oral wellbeing and implant survival. Adjunctive pharmacological interventions in implant medicine, such as locally delivered metformin, may enhance therapeutic outcomes by attenuating inflammation and promoting peri-implant tissue repair, with potential relevance to public health. This study aimed to evaluate the clinical and biochemical effects of 1% metformin gel as an adjunct to mechanical debridement in peri-implantitis management. In this prospective clinical study, 54 systemically healthy participants (25-60 years) with peri-implantitis were randomly assigned to control (mechanical debridement alone, n = 27) or test (mechanical debridement + 1% metformin gel, n = 27) groups. Plaque Index (PI), Gingival Index (GI), Probing Pocket Depth (PPD), Clinical Attachment Level (CAL), and interleukin-6 (IL-6) levels in peri-implant crevicular fluid were assessed at baseline and 6 months. Data were analyzed using paired and independent t-tests. Baseline values were comparable between groups (P > 0.05). At 6 months, the test group showed significantly lower PI (0.49 vs. 1.37, P < 0.001), GI (0.51 vs. 1.40, P < 0.001), PPD (3.02 mm vs. 4.17 mm, P < 0.001), CAL (3.22 mm vs. 4.34 mm, P < 0.001), and IL-6 levels (8.13 pg/mL vs. 19.23 pg/mL, P < 0.001) compared with the control. Both groups improved from baseline (P < 0.001), with markedly greater reductions in the test group. Local application of 1% metformin gel adjunctive to mechanical debridement significantly enhances clinical and anti-inflammatory outcomes in peri-implantitis, highlighting its potential as a safe, cost-effective, and bioactive therapeutic strategy.</p>","PeriodicalId":16125,"journal":{"name":"Journal of long-term effects of medical implants","volume":"36 2","pages":"3-9"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hormonal Transition and Osseointegration: Evaluating the Nexus between Vitamin D Status and Peri-Implant Health and Disease in Women.","authors":"Blessy Stella, Arvina Rajasekar","doi":"10.1615/JLongTermEffMedImplants.2025060266","DOIUrl":"10.1615/JLongTermEffMedImplants.2025060266","url":null,"abstract":"<p><strong>Background: </strong>Vitamin D plays a pivotal role in bone metabolism and immune regulation, both of which are fundamental to peri-implant health and overall human wellbeing. Postmenopausal women are particularly susceptible to vitamin D deficiency due to hormonal alterations, a condition that may predispose them to peri-implant disease and compromise implant success. Addressing this deficiency through evidence-based medicine has important implications for maintaining oral health and mitigating broader public health concerns related to implant failure.</p><p><strong>Aim: </strong>To evaluate and compare the correlation between serum 25-hydroxyvitamin D [25(OH)D] levels and peri-implant clinical and radiographic parameters among premenopausal and postmenopausal women.</p><p><strong>Methods: </strong>This cross-sectional study included 180 female patients with functional dental implants placed at least 12 months prior to recruitment. Group I consisted of 90 premenopausal women, while Group II included 90 postmenopausal women. Peri-implant probing depth (PPD) and crestal bone level (CBL) were assessed clinically and radiographically. Serum 25(OH)D levels were measured using electrochemiluminescence immunoassay. Data were analyzed using unpaired t-tests and Pearson correlation.</p><p><strong>Results: </strong>Postmenopausal women exhibited significantly lower serum 25(OH)D levels (18.0 ± 0.6 ng/mL) compared to premenopausal women (34.5 ± 0.8 ng/mL), along with greater PPD and CBL (p < 0.05). A significant moderate negative correlation was found between serum 25(OH)D and both PPD and CBL in both groups, stronger in postmenopausal women (r = -0.64 for PPD, -0.47 for CBL).</p><p><strong>Conclusion: </strong>Vitamin D deficiency is associated with increased peri-implant probing depth and crestal bone loss, particularly in postmenopausal women. Screening and correcting vitamin D levels may enhance implant outcomes in this population.</p>","PeriodicalId":16125,"journal":{"name":"Journal of long-term effects of medical implants","volume":"36 1","pages":"73-78"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}