Journal of Intensive Care最新文献

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THE EFFECTIVENESS OF BRUNO MARS SONG IN DOO-WOPS & HOOLIGANS ALBUM ON STUDENTS' PRONUNCIATION MASTERY 布鲁诺·马尔斯的歌曲在DOO-WOPS中的效果流氓关于学生发音掌握的相册
2区 医学
Journal of Intensive Care Pub Date : 2023-10-31 DOI: 10.31602/intensive.v6i2.12851
Imas Kurnia Sari
{"title":"THE EFFECTIVENESS OF BRUNO MARS SONG IN DOO-WOPS &amp; HOOLIGANS ALBUM ON STUDENTS' PRONUNCIATION MASTERY","authors":"Imas Kurnia Sari","doi":"10.31602/intensive.v6i2.12851","DOIUrl":"https://doi.org/10.31602/intensive.v6i2.12851","url":null,"abstract":"The aim of this research is to find out the effect and significant difference of bruno mars song in doo-wops &amp; hooligans album for students' pronunciation mastery at Vocational High School Kartikatama Metro. Song is a media in the form of musical works that are suitable for teaching English, especially pronunciation. This research used quasi experimental design. The subjects of this research are the tenth grade students at Vocational High School Kartikatama Metro. The result of data analysis indicates that value of t obtained (to) is lower than value of t table (-16.482<2.074). Moreover, the second data indicates t obtained (to) is lower than value of t table (-13.657<2021). The conclusion are teaching English pronunciation using bruno mars song in doo-wops &amp; hooligans album is effective to increase students' pronunciation mastery and gives a significant differences. Researchers hope that this research can help future researchers to conduct similar research, especially when using English songs to teach pronunciation. Future researchers must use the latest songs in conducting further research.","PeriodicalId":16123,"journal":{"name":"Journal of Intensive Care","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135930050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THE EFFECTIVENESS OF WEB-BASED LEARNING ON THE STUDENTS’ MOTIVATION AND ABILITY IN WRITING NARRATIVE TEXT 网络学习对学生叙事语篇写作动机和能力的影响
2区 医学
Journal of Intensive Care Pub Date : 2023-10-31 DOI: 10.31602/intensive.v6i2.8617
Nur Rahmadani, Nurhaeni Nurhaeni
{"title":"THE EFFECTIVENESS OF WEB-BASED LEARNING ON THE STUDENTS’ MOTIVATION AND ABILITY IN WRITING NARRATIVE TEXT","authors":"Nur Rahmadani, Nurhaeni Nurhaeni","doi":"10.31602/intensive.v6i2.8617","DOIUrl":"https://doi.org/10.31602/intensive.v6i2.8617","url":null,"abstract":"In English, there are four skills which must be mastered, they are listening, speaking, reading, and writing. One of the language skills is writing that important for learners to practice their capability and their understanding, how to send ideas, and how to arrange words well. The objectives of this study were students’ motivation and ability to write narrative text who are taught through web-based learning, the writing motivation and ability of students who are not taught through web-based learning and to find out whether or not there is a significant effect of web-based learning to the students' motivation and ability to write narrative text for tenth-grade students of senior high school. The research was conducted at Muhammadiyah Boarding School in Prambanan Yogyakarta. This study used experimental research with nonrandomized-groups pre-test post-test control group design as the research design. The data were collected by using tests and questionnaires in the form of pre-test and post-test. The result of inferential analysis, showed by the result of the t-test, was found that the value of the ttable (2.001) was lower than the tobtained (3.532). Thus, H0 is rejected and H1 is accepted. It means that web-based learning had a significant effect on improving students’ writing motivation and ability.","PeriodicalId":16123,"journal":{"name":"Journal of Intensive Care","volume":"66 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135930053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IMPROVING THE STUDENTS’ VOCABULARY MASTERY BY USING WORD SQUARE MEDIA COMPARATIVE STUDY OF USING KWL AND QAR STRATEGIES ON STUDENTS’ READING COMPREHENSION 运用词方媒介提高学生的词汇掌握:KWL策略与qar策略在学生阅读理解中的比较研究
2区 医学
Journal of Intensive Care Pub Date : 2023-10-31 DOI: 10.31602/intensive.v6i2.12696
Sri - Lestari
{"title":"IMPROVING THE STUDENTS’ VOCABULARY MASTERY BY USING WORD SQUARE MEDIA COMPARATIVE STUDY OF USING KWL AND QAR STRATEGIES ON STUDENTS’ READING COMPREHENSION","authors":"Sri - Lestari","doi":"10.31602/intensive.v6i2.12696","DOIUrl":"https://doi.org/10.31602/intensive.v6i2.12696","url":null,"abstract":"Reading is a complex activity. Through reading activities, readers have responses like rejection, acceptance, and criticism of what they have read. Therefore, appropriate strategies are needed in reading learning activities for students to facilitate reading comprehension. This study aims to determine significant differences in using KWL and QAR strategies on students' reading comprehension abilities.This study used an experimental method with a post-test-only design. The population in this study were students of class VIII SMPN 5 Banjarmasin. The sampling technique used in this study was using a saturated sampling technique for as many as 261 students. The instrument used was multiple choice questions in the form of a post-test. The data analysis technique in this study was the t-test at a significance level of 5%.The results showed that the student's reading comprehension who were taught by using the KWL strategy was 52.09 lower than those of the students taught by using the QAR strategy of 57.09 with a tcount of 2.251 and a p of 0.025 (p < 0.05 ). The difference in the post-test mean of reading comprehension skills in the KWL strategy group and the QAR strategy group was 5.00. This shows that there is a significant difference in the use of KWL and QAR strategies on the reading comprehension skills of eight grade students at SMPN 5 Banjarmasin.","PeriodicalId":16123,"journal":{"name":"Journal of Intensive Care","volume":"19 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135930052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IMPROVING THE STUDENTS’ VOCABULARY MASTERY BY USING WORD SQUARE MEDIA 运用词方块媒介提高学生的词汇掌握能力
2区 医学
Journal of Intensive Care Pub Date : 2023-10-31 DOI: 10.31602/intensive.v6i2.12886
Ian Harum Prasasti, Yasmika Baihaqi, Bambang Eko Siagiyanto, Fitri Palupi Kusumawati, Winda Amilia
{"title":"IMPROVING THE STUDENTS’ VOCABULARY MASTERY BY USING WORD SQUARE MEDIA","authors":"Ian Harum Prasasti, Yasmika Baihaqi, Bambang Eko Siagiyanto, Fitri Palupi Kusumawati, Winda Amilia","doi":"10.31602/intensive.v6i2.12886","DOIUrl":"https://doi.org/10.31602/intensive.v6i2.12886","url":null,"abstract":"The purpose of this research is to find out whether using word square media can improve the vocabulary mastery of the eleventh grade students of SMK Negeri 3 Metro. In this study, researchers conducted classroom action research (CAR) which was carried out in three cycles. Each cycle consists of planning, acting, observing and reflecting. The subjects of this study were 32 students of eleventh grade at SMK Negeri 3 Metro. In collecting data, researchers used pre-test, post-test 1, post-test 2, post-test 3, observing, interview, and questionnaire. The results of the study show that using Word square media can improve stu-dents’ vocabulary mastery at eleventh grade of SMK Negeri 3 Metro, this can be seen in the progress of the pre-test and post-test cycle 1 to cycle 3. the average of pre-test score was 42.31% and the post-test in cycle 1 was 61.37%, the average value in post-test 2 was 75.40% and the average score in cycle 3 was 81.37%. pre-test and post-test cycle 1 to post-test cy-cle 3 there was an increase of 5.97%. it means that the results of the post test have reached indicators of success that can be achieved on the results of this post-test. Students responses in using word square media that have been done can be seen that 93.45% of students gave respones very positive in learning using word square learning media and word square media can be said to be practical and easy to use for students, this can be seen from the enthusiasm of students and their spirits at the first time in using word square media.","PeriodicalId":16123,"journal":{"name":"Journal of Intensive Care","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135929609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
INCORPORATING CEFR PRINCIPLES IN THE DEVELOPMENT OF A HYPERTEXT POETRY LEARNING PLATFORM FOR HIGH SCHOOL STUDENTS 结合cefr原则开发高中超文本诗歌学习平台
2区 医学
Journal of Intensive Care Pub Date : 2023-10-27 DOI: 10.31602/intensive.v6i2.12728
Sinta Indriyani, Lala Bumela Sudimantara
{"title":"INCORPORATING CEFR PRINCIPLES IN THE DEVELOPMENT OF A HYPERTEXT POETRY LEARNING PLATFORM FOR HIGH SCHOOL STUDENTS","authors":"Sinta Indriyani, Lala Bumela Sudimantara","doi":"10.31602/intensive.v6i2.12728","DOIUrl":"https://doi.org/10.31602/intensive.v6i2.12728","url":null,"abstract":"This study examines the decline of English education in Indonesia and the need for innovative teaching methods to improve students' English proficiency. Despite Indonesia's low ranking on the English Proficiency Index, the traditional teaching approach remains prevalent, which focuses on grammar and vocabulary. The research by Sudimantara (2021) and highlight the benefits of non-traditional approaches such as incorporating nonverbal components. Lian A.-B (2017) also creates an innovative approach called reading for emotion to help students learn English better without worrying about grammar and vocabulary. The study also shows the importance of poetry and literature in English language learning, as proven by Zeman, A., Milton, F., Smith, A., &amp; Rylance, R. (2015) that poetry precedes prose and it is a knowledge management system in the world. The study employed a research and development design to demonstrate the collaboration of using pedagogy, technology, and CEFR to create innovative learning resources that shift students' mindsets and also build the students’ engagement in learning English. This study offers valuable insights into developing innovative learning resources for English language learning in Indonesia, and further research in this area could lead to more effective teaching methods and improve the English proficiency of Indonesian students.","PeriodicalId":16123,"journal":{"name":"Journal of Intensive Care","volume":"142 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136316776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THE IMPLEMENTATION OF TECHNOLOGY-BASED LEARNING EVALUATION TO INCREASE ENGLISH STUDENTS' LEARNING MOTIVATION: CASE STUDY OF E-PORTFOLIO USE 实施基于技术的学习评价提高英语学生的学习动机:电子档案袋使用案例研究
2区 医学
Journal of Intensive Care Pub Date : 2023-10-26 DOI: 10.31602/intensive.v6i2.12543
Noor Aida Aflahah, Miftah Al Farhan, Hafizhatu Nadia, Asyifa Asyifa
{"title":"THE IMPLEMENTATION OF TECHNOLOGY-BASED LEARNING EVALUATION TO INCREASE ENGLISH STUDENTS' LEARNING MOTIVATION: CASE STUDY OF E-PORTFOLIO USE","authors":"Noor Aida Aflahah, Miftah Al Farhan, Hafizhatu Nadia, Asyifa Asyifa","doi":"10.31602/intensive.v6i2.12543","DOIUrl":"https://doi.org/10.31602/intensive.v6i2.12543","url":null,"abstract":"This research aims to explore in depth the use of learning evaluation using technology, namely Google Site, which seeks to develop and increase student motivation and creativity in carrying out requested evaluations. This study is an intrinsic case study which was theoretically rooted in a unique case. The case raised in this research was the potential use of e-portfolios as an alternative option in evaluating technology-based learning. This study involved one lecturer and three students as research participants who were selected based on certain criteria or by purposive sampling technique. Lecturers were selected based on their experience in implementing e-portfolios to evaluate learning, and the students were participants in the learning. Research data were collected through semi-structured interviews with open questions, direct observation, and Focus Group Discussion (FGD). The results of this study confirmed the students gave similar opinions stating that e-portfolios could increase their extrinsic and intrinsic motivation. This research only focused on students' opinions regarding the implementation of e-portfolios in increasing their learning motivation. It is hoped that future research can further explore teachers' opinions for more comprehensive results.","PeriodicalId":16123,"journal":{"name":"Journal of Intensive Care","volume":"142 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134906733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THE EFFECT OF USING AUTHENTIC MATERIALS ON READING COMPREHENSION ACROSS SECONDARY STUDENT’ COGNITIVE LEARNING STYLE 使用真实材料对中学生认知学习风格阅读理解的影响
2区 医学
Journal of Intensive Care Pub Date : 2023-10-22 DOI: 10.31602/intensive.v6i2.8616
Noor Aisyah, Aulia Azmi
{"title":"THE EFFECT OF USING AUTHENTIC MATERIALS ON READING COMPREHENSION ACROSS SECONDARY STUDENT’ COGNITIVE LEARNING STYLE","authors":"Noor Aisyah, Aulia Azmi","doi":"10.31602/intensive.v6i2.8616","DOIUrl":"https://doi.org/10.31602/intensive.v6i2.8616","url":null,"abstract":"The teaching of reading nowadays is urged to empower students to cope with 21st century literacy challenges and to develop prevailing 21st century. Further, English teachers have to implement interesting and creative materials and strategies to motivate students in learning English. Compared to non-authentic materials, authentic materials seemed more promising to fulfill the demand. The aim of this study was to investigate whether or not the use of authentic materials in the classroom in teaching reading comprehension is effective toward students’ cognitive learning styles. The effect of authentic materials was compared to the non-authentic ones. This study employed a quasi-factorial 2 x 2 design and involved 68 tenth graders SMKN 3 Banjarmasin, South Kalimantan Province. The instruments used were reading comprehension posttest and GEFT. Statistical analysis was performed using SPSS 23.0 to test hypotheses at .05 level of significance. The results showed that authentic materials improved students’ reading comprehension compared to the non-authentic ones. It conforms to the theory of authentic materials and the previous studies indicating authentic material is effective in improving students’ reading comprehension. It was further found that there was no significant difference in the reading comprehension between field independent and field dependent students. Based on the results, it can be concluded that using authentic materials is promising alternative materials to help students increase students’ reading comprehension with different cognitive learning styles.","PeriodicalId":16123,"journal":{"name":"Journal of Intensive Care","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135462454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A CONTENT ANALYSIS OF THE READING COMPREHENSION QUESTIONS IN THE TEXTBOOK ENDORSED BY THE GOVERNMENT 政府认可的教科书中阅读理解问题的内容分析
2区 医学
Journal of Intensive Care Pub Date : 2023-10-20 DOI: 10.31602/intensive.v6i2.8350
Aulia Azmi, Noor Aisyah
{"title":"A CONTENT ANALYSIS OF THE READING COMPREHENSION QUESTIONS IN THE TEXTBOOK ENDORSED BY THE GOVERNMENT","authors":"Aulia Azmi, Noor Aisyah","doi":"10.31602/intensive.v6i2.8350","DOIUrl":"https://doi.org/10.31602/intensive.v6i2.8350","url":null,"abstract":"Material is a component of teaching to create a successful teaching and learning process. The purpose of this study is to describe the content of reading material in “Bahasa Inggris” textbook which endorsed by the government, especially the cognitive levels of the questions that follow the reading texts. This study used the qualitative research design. Meanwhile, the qualitative data of the research were cognitive level of questions that followed the reading texts. The researcher also used content analysis which was as one of the techniques used in qualitative research to collect and analyze the data of the textbook. Moreover, the instruments for analyzing cognitive level of questions that followed the reading texts were a checklist proposed by Igbaria (2013) and a guide for deciding the level of the questions based on the cognitive domain of Bloom’s taxonomy. The result showed that cognitive levels of questions that followed the reading texts found that 125 questions (89.9%) which were categorized as lower order thinking skills. Meanwhile, there were 14 (10.07%) questions which were categorized as higher order thinking skills. Thus, the questions which were categorized as Lower-order Thinking Skills (LOTS) were more dominant in the textbook.","PeriodicalId":16123,"journal":{"name":"Journal of Intensive Care","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135665223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends in massive transfusion practice for trauma in Japan from 2011 to 2020: a nationwide inpatient database study. 2011年至2020年日本大规模创伤输血实践的趋势:一项全国住院患者数据库研究。
IF 7.1 2区 医学
Journal of Intensive Care Pub Date : 2023-10-18 DOI: 10.1186/s40560-023-00685-0
Hiroyuki Ohbe, Takashi Tagami, Akira Endo, Shigeki Miyata, Hiroki Matsui, Kiyohide Fushimi, Shigeki Kushimoto, Hideo Yasunaga
{"title":"Trends in massive transfusion practice for trauma in Japan from 2011 to 2020: a nationwide inpatient database study.","authors":"Hiroyuki Ohbe, Takashi Tagami, Akira Endo, Shigeki Miyata, Hiroki Matsui, Kiyohide Fushimi, Shigeki Kushimoto, Hideo Yasunaga","doi":"10.1186/s40560-023-00685-0","DOIUrl":"10.1186/s40560-023-00685-0","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have reported conflicting results regarding fresh frozen plasma (FFP)-to-red blood cell (RBC) ratio and platelet-to-RBC ratio on outcomes for massive transfusion for trauma. Moreover, nationwide data on massive transfusion practices for trauma in the real-world clinical setting are scarce. This study aimed to examine the nationwide practice patterns and trends in massive transfusion for trauma in Japan using a national administrative, inpatient database.</p><p><strong>Method: </strong>We identified patients who underwent emergency hospitalization for trauma and received massive transfusion, defined as administration of at least 20 units of RBC within the first 2 days of admission, using the nationwide inpatient database, which covers approximately 90% of all tertiary emergency hospitals in Japan, between 2011 and 2020. Trends in the incidence and practice patterns of massive transfusion were described by calendar year. The association of practice patterns with mortality or adverse events was tested.</p><p><strong>Results: </strong>A total of 3,530,846 trauma hospitalizations were identified, of which 5247 (0.15%) received massive transfusion. A significant declining trend was observed in the incidence of massive transfusion in trauma hospitalizations from 0.24% in 2011 to 0.10% in 2020 (P for trend < 0.001). The FFP-to-RBC ratio rose significantly from 0.77 in 2011 to 1.08 in 2020 (P for trend < 0.001), while the platelet-to-RBC ratio remained virtually unchanged from 0.71 in 2011 to 0.78 in 2020 (P for trend 0.060). Massive transfusion with lower FFP-to-RBC (< 0.75) and platelets-to-RBC ratio (< 1.00) were associated with increased in-hospital mortality compared with those ≥ 1.00, while there were linear increases in adverse events with increasing FFP and platelets ratios.</p><p><strong>Conclusions: </strong>This study demonstrated a declining trend in the incidence and a rise in higher FFP-to-RBC ratios in massive transfusion in association with patient outcomes for trauma from 2011 to 2020 in Japan.</p>","PeriodicalId":16123,"journal":{"name":"Journal of Intensive Care","volume":"11 1","pages":"46"},"PeriodicalIF":7.1,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10585788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49678364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polymyxin B-immobilised fibre column treatment for acute exacerbation of idiopathic pulmonary fibrosis patients with mechanical ventilation: a nationwide observational study. 多粘菌素B固定纤维柱治疗机械通气下特发性肺纤维化患者急性加重期:一项全国性观察性研究。
IF 7.1 2区 医学
Journal of Intensive Care Pub Date : 2023-10-11 DOI: 10.1186/s40560-023-00693-0
Nobuyasu Awano, Taisuke Jo, Takehiro Izumo, Minoru Inomata, Yu Ito, Kojiro Morita, Hiroki Matsui, Kiyohide Fushimi, Hirokazu Urushiyama, Takahide Nagase, Hideo Yasunaga
{"title":"Polymyxin B-immobilised fibre column treatment for acute exacerbation of idiopathic pulmonary fibrosis patients with mechanical ventilation: a nationwide observational study.","authors":"Nobuyasu Awano, Taisuke Jo, Takehiro Izumo, Minoru Inomata, Yu Ito, Kojiro Morita, Hiroki Matsui, Kiyohide Fushimi, Hirokazu Urushiyama, Takahide Nagase, Hideo Yasunaga","doi":"10.1186/s40560-023-00693-0","DOIUrl":"10.1186/s40560-023-00693-0","url":null,"abstract":"<p><strong>Background: </strong>The prognosis for acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is poor, and there is no established treatment. Hence, we aimed to investigate the effectiveness of a polymyxin B-immobilised fibre column (PMX) for the treatment of AE-IPF.</p><p><strong>Methods: </strong>Data were retrospectively collected from the Japanese Diagnosis Procedure Combination database from 1 July 2010 to 31 March 2018. We identified adult patients with idiopathic pulmonary fibrosis who received high-dose methylprednisolone (mPSL) therapy and mechanical ventilation upon admission. Eligible patients (n = 5616) were divided into those receiving PMX treatment combined with high-dose mPSL (PMX group, n = 199) and high-dose mPSL alone (mPSL alone group, n = 5417). To compare outcomes between the two groups, we applied a stabilised inverse probability of treatment weighting (IPTW) using propensity scores. The primary outcome was in-hospital mortality, and the secondary outcomes were 14- and 28-day mortality and length of hospital stay.</p><p><strong>Results: </strong>The in-hospital mortality rates of the PMX and mPSL alone groups were 79.9% and 76.4%, respectively. The results did not significantly differ between the two groups after performing a stabilised IPTW. The odds ratio of the PMX group compared with the mPSL alone group was 1.56 (95% confidence interval 0.80-3.06; p = 0.19). The 14- and 28-day mortality and length of hospital stay (secondary outcomes) also did not significantly differ between the two groups.</p><p><strong>Conclusions: </strong>In AE-IPF patients using mechanical ventilation, the treatment outcome was not significantly better for PMX combined with high-dose mPSL than for high-dose mPSL alone.</p>","PeriodicalId":16123,"journal":{"name":"Journal of Intensive Care","volume":"11 1","pages":"45"},"PeriodicalIF":7.1,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41203218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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