Journal of immunopharmacology最新文献_第2页

Cytosine arabinoside induced changes in natural killer and antibody dependent cellular cytotoxicity functions in multiple sclerosis patients. 阿拉伯糖胞嘧啶诱导多发性硬化症患者自然杀伤和抗体依赖性细胞毒性功能的改变。

Journal of immunopharmacology Pub Date : 1986-01-01 DOI: 10.3109/08923978609028618

D J Moody, J L Fahey, D Durkos-Smith, G W Ellison, L W Myers

{"title":"Cytosine arabinoside induced changes in natural killer and antibody dependent cellular cytotoxicity functions in multiple sclerosis patients.","authors":"D J Moody, J L Fahey, D Durkos-Smith, G W Ellison, L W Myers","doi":"10.3109/08923978609028618","DOIUrl":"https://doi.org/10.3109/08923978609028618","url":null,"abstract":"Five multiple sclerosis patients were treated weekly with cytosine arabinoside (araC) on an escalating dose schedule. The dose was initiated at 50 mg/M2 and then increased once each week by 50 mg/M2 (unless toxicity caused delay). Dosage decisions were based on whether or not the antibody-dependent cellular-cytotoxicity (ADCC) or natural killer (NK) cytotoxicity levels had been reduced to a level more than 2 standard deviations below the control range. Cytosine arabinoside treatment was discontinued in 2 of 5 subjects at doses of 500 mg/M2 due to toxicity. The 3 remaining patients demonstrated sustained reductions in the percentage of FcR+ cells in their peripheral blood. The maximum percentage reductions from the baseline values ranged from 50% to 76%. Concomitant reductions in the NK activity at the same doses ranged from 65% to 83%. ADCC activity in all 3 patients, however, was relatively resistant to suppression. The nadirs for the ADCC activity were only 16% to 44% below the baseline minimum. AraC was shown to reduce the proportion of FcR+ cells and NK cytotoxic activity in preference to ADCC activity.","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"8 2","pages":"259-69"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08923978609028618","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14077608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of benzodiazepine derivatives: I. Augmentation of T cell-dependent antibody response by diazepam in mouse spleen cells. 苯二氮卓衍生物的作用:1 .地西泮增强小鼠脾细胞T细胞依赖性抗体反应。

Journal of immunopharmacology Pub Date : 1986-01-01 DOI: 10.3109/08923978609026493

T Okimura, I Nagata

{"title":"Effect of benzodiazepine derivatives: I. Augmentation of T cell-dependent antibody response by diazepam in mouse spleen cells.","authors":"T Okimura, I Nagata","doi":"10.3109/08923978609026493","DOIUrl":"https://doi.org/10.3109/08923978609026493","url":null,"abstract":"Oral administration of diazepam at doses of 5-10 mg/kg to restraint-stressed mice resulted in almost complete recovery in the stress-induced suppression of the antibody response to sheep red blood cell (SRBC). Moreover, this compound restored the suppression of antibody response to SRBC in cyclophosphamide-treated mice. Diazepam treatment also enhanced the antibody response against SRBC in normal mice only when the animals were immunized with the reduced amount of antigen. It was demonstrated that antigen specific helper T cell activity was promoted by diazepam administration in mice. Addition of diazepam augmented the in vitro anti-SRBC hemolytic plaque-forming cell (PFC) response in mouse splenocytes without altering kinetics of the response. However, the enhancing effect was observed only when the drug was added to the medium at the culture initiation. On the other hand, antibody response to T cell-independent antigens such as trinitrophenylated (TNP)-Ficoll and TNP-lipopolysaccharide were not enhanced by diazepam. Concanavalin A or LPS-induced 3H-thymidine uptake into splenocytes were not stimulated by diazepam. These results suggest that diazepam promotes the antibody response through stimulating helper T cell functions.","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"8 3","pages":"327-46"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08923978609026493","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14080447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Pharmacokinetics of murine tumor necrosis factor. 小鼠肿瘤坏死因子的药动学。

Journal of immunopharmacology Pub Date : 1986-01-01 DOI: 10.3109/08923978609031087

D A Flick, G E Gifford

引用次数: 55

Stimulation of hematopoiesis in untreated and cyclophosphamide treated mice by the inhibition of prostaglandin synthesis. 通过抑制前列腺素合成刺激未治疗和环磷酰胺治疗小鼠的造血功能。

Journal of immunopharmacology Pub Date : 1986-01-01 DOI: 10.3109/08923978609026491

D A Nikcevich, M R Young, N K Ellis, M Newby, H T Wepsic

{"title":"Stimulation of hematopoiesis in untreated and cyclophosphamide treated mice by the inhibition of prostaglandin synthesis.","authors":"D A Nikcevich, M R Young, N K Ellis, M Newby, H T Wepsic","doi":"10.3109/08923978609026491","DOIUrl":"https://doi.org/10.3109/08923978609026491","url":null,"abstract":"Indomethacin (IN) was administered to untreated or to cyclophosphamide (CY) treated C57B1/6 mice to study the roles of prostaglandins in regulating hematopoiesis. The following hematopoietic parameters were quantitated: peripheral blood leukocyte (PBL) count; total nucleated cells per spleen; total nucleated cells per femur; and spleen weight. Assays were performed in vitro to measure the number of colony forming units (CFU) present in the bone marrow and spleen. Untreated mice administered IN had a transient rise in their PBL count. These animals also developed splenomegaly and had an increased number of nucleated cells in their spleen. All CY treated mice had a marked decrease in PBL count, spleen cellularity, bone marrow cellularity, and spleen size during the first 5 days after CY treatment. These observations were followed by hematopoietic recovery over the next 10 days. Cyclophosphamide treated mice exhibited a more rapid hematopoietic recovery when treated with IN than without IN treatment. Analysis of the CFU capacity of bone marrow and spleen cells in soft agar showed a larger number of CFU in the bone marrow and spleen of IN treated mice or of CY/IN treated mice than in animals not receiving IN. These results indicate that prostaglandins are involved in the regulation of hematopoiesis in untreated mice and that prostaglandins may limit the hematopoietic recovery of CY treated mice.","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"8 3","pages":"299-313"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08923978609026491","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14878339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Antiviral activity of Bordetella pertussis vaccine-elicited peritoneal exudate cells. 百日咳疫苗诱导的腹膜渗出细胞的抗病毒活性。

Journal of immunopharmacology Pub Date : 1986-01-01 DOI: 10.3109/08923978609026507

D. Baggett, P. A. Leblanc, F. S. Allison, M. J. Thomley, A. Winters

引用次数: 2

Target ricin by coupling to an anti-macrophage monoclonal antibody. 通过偶联抗巨噬细胞单克隆抗体靶向蓖麻毒素。

Journal of immunopharmacology Pub Date : 1986-01-01 DOI: 10.3109/08923978609031083

N E Kaminski, J F Roberts, F E Guthrie

{"title":"Target ricin by coupling to an anti-macrophage monoclonal antibody.","authors":"N E Kaminski, J F Roberts, F E Guthrie","doi":"10.3109/08923978609031083","DOIUrl":"https://doi.org/10.3109/08923978609031083","url":null,"abstract":"By altering the receptor binding specificity of the highly potent natural toxin ricin, a macrophage specific immunotoxin was developed. Ricin ordinarily does not demonstrate cell type specificity and is capable of binding and entering cells through galactose containing receptors resulting in rapid cell death. A murine anti-rat peritoneal macrophage IgGl monoclonal antibody, B-6, was developed to serve as a target specific carrier for ricin. By covalently binding monoclonal antibody B-6 and reversibly binding lactose to ricin, a new biologically active hybrid toxin possessing macrophage specificity was developed. When P3X63-Ag8.653 myeloma cells, which served as an nonspecific target cell type, and macrophages were treated with the ricin conjugate over a broad range of concentrations and various time periods, the conjugate demonstrated substantially greater toxicity toward macrophages than myeloma cells even though both cell types responded similarly to treatments with unconjugated ricin. It was also observed that ricin was considerably more toxic to macrophages when conjugated to monoclonal antibody B-6 than unconjugated ricin. Through ricin-antibody conjugation a high degree of specificity and toxicity can be attained potentially suitable for anti-tumor reagents and immuno-modulators.","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"8 1","pages":"15-37"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08923978609031083","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14218376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Suppression of humoral and cell-mediated immune responses in vitro by benzo(a)pyrene. 苯并(a)芘体外抑制体液和细胞介导的免疫反应。

Journal of immunopharmacology Pub Date : 1986-01-01 DOI: 10.3109/08923978609028616

P Urso, N Gengozian, R M Rossi, R A Johnson

引用次数: 26

Protective effect(s) of rIL-2 modulation. I. The effects of chemotherapeutic/cytotoxic agents on human natural killer cells and lymphokine-activated killer cells. il -2调节的保护作用。1 .化疗/细胞毒性药物对人自然杀伤细胞和淋巴因子活化杀伤细胞的影响。

Journal of immunopharmacology Pub Date : 1986-01-01 DOI: 10.3109/08923978609026501

E. Ades, A. Hinson

引用次数: 4

Macrophage involvement in the antitumor activity of a synthetic acyltripeptide (FK-565) against experimental lung carcinoma metastases. 巨噬细胞参与合成酰基三肽(FK-565)对实验性肺癌转移的抗肿瘤活性。

Journal of immunopharmacology Pub Date : 1986-01-01 DOI: 10.3109/08923978609026503

R M Schultz, M G Altom

引用次数: 10

Immunomodulating activity of Wy-41,770 (5H-dibenzo[A,D]cyclohepten-5-ylidene) acetic acid. Wy-41,770 (5h -二苯并[A,D]环庚烯-5-酰基)乙酸的免疫调节活性。

Journal of immunopharmacology Pub Date : 1986-01-01 DOI: 10.3109/08923978609028615

R P Carlson, L J Datko, L O'Neill-Davis, A J Lewis

{"title":"Immunomodulating activity of Wy-41,770 (5H-dibenzo[A,D]cyclohepten-5-ylidene) acetic acid.","authors":"R P Carlson, L J Datko, L O'Neill-Davis, A J Lewis","doi":"10.3109/08923978609028615","DOIUrl":"https://doi.org/10.3109/08923978609028615","url":null,"abstract":"The immunomodulatory effects of Wy-41,770 (5H-dibenzo[a,d]cyclohepten-5-ylidene) acetic acid, were compared to levamisole and indomethacin in several in vivo models. In the Jerne plaque assay, Wy-41,770 (1 and 100 mg/kg, p.o.) administered on day 1 after sensitization suppressed IgM plaque forming cells (PFC) while levamisole was active when given on days 1 and 2 after sensitization. In contrast, indomethacin administered on days 2 and 3 after sensitization increased PFC. In the rat experimental allergic encephalomyelitis (EAE) model, Wy-41,770 reduced limb paralysis at 10 and 100 mg/kg, p.o. when dosed before sensitization. Indomethacin was active too when predosed in the rat EAE model. In the methylated bovine serum albumin model (MBSA) delayed hypersensitivity (DH) model in mouse, Wy-41,770 (10 mg/kg, p.o.) given on day 1 prior to sensitization and day 2 after sensitization in subliminally sensitized animals augmented the DH response while inhibiting the subliminal DH response when administered at 6 hr after challenge. Levamisole showed similar activity in this subliminal model while indomethacin given 6 hr post challenge was inhibitory. All three drugs were inactive in mice normally sensitized to MBSA at the same drug regimens. In guinea pigs, subliminally sensitized to tuberculin, Wy-41,770 (10 and 100 mg/kg, p.o.) and levamisole augmented the DH response. No changes in DH response were observed for both drugs in normally sensitized guinea pigs. In the rat adjuvant arthritic model, Wy-41,770 (5 and 15 mg/kg, p.o.) inhibited day 16 uninjected paw edema and restored significantly the depressed proliferative responses to mitogen by spleen cells taken from the same arthritic rats at day 16. The moderate immunomodulatory activity of Wy-41,770 may contribute along with its antiinflammatory activity, towards the treatment of arthritic diseases.","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"8 2","pages":"205-21"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08923978609028615","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14611485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3