Journal of Hard Tissue Biology最新文献_第5页

Investigation of Implant Stability Quotient Values of Dental Implants Placed in Vascularized Bone Grafts 血管化骨移植牙种植体稳定性商值的研究

IF 0.4 4区医学

Journal of Hard Tissue Biology Pub Date : 2022-01-01 DOI: 10.2485/jhtb.31.55

Keisuke Matsumoto, T. Mano, Kazuya Inoue, Kayoko Yamamoto, Naoko Imagawa, Ayaka Takahashi, T. Ueno

{"title":"Investigation of Implant Stability Quotient Values of Dental Implants Placed in Vascularized Bone Grafts","authors":"Keisuke Matsumoto, T. Mano, Kazuya Inoue, Kayoko Yamamoto, Naoko Imagawa, Ayaka Takahashi, T. Ueno","doi":"10.2485/jhtb.31.55","DOIUrl":"https://doi.org/10.2485/jhtb.31.55","url":null,"abstract":": Vascularized autologous bone grafts are widely used for mandibular reconstruction. There have also been numerous reports of occlusal reconstruction by placement of implants in the grafted bone following reconstruction of the mandible. However, the histological structure of the bone used for the graft is different from that of healthy mandibular bone, and the osseointegration process of implants placed in grafted bone is not clear. In this study, implants placed in reconstructions using grafted bone were assessed by measuring the implant stability quotient (ISQ), and their values were compared to those from implants in healthy mandibular bone. The subjects were 5 implants placed in the sites of mandibular reconstructions with vascularized fibula flaps. The controls were 54 implants placed in the molar region of healthy mandibles. All im plant placements were carried out by a two-stage procedure, and the ISQs were measured at first-stage surgery and at sec -ond-stage surgery. The ISQ values thus obtained and the change in ISQ from first-stage surgery to second-stage surgery were examined statistically. There was no significant difference in the ISQ between the two groups at first-stage surgery, but the values of the ISQ and the change in ISQ were significantly greater in the mandibular reconstruction at second-stage sur gery. This appears to be the result of histological differences between the reconstruction site and the healthy bone. The ISQ is an objective index of osseointegration of the implant. The present results suggest that observing changes in ISQ over time allows investigation of the usefulness of different types of bone grafts for implant therapy.","PeriodicalId":16040,"journal":{"name":"Journal of Hard Tissue Biology","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68966475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effect of Zoledronic Acid on Bone Structure of the Mandible in Ovariectomized Mice 唑来膦酸对去卵巢小鼠下颌骨骨结构的影响

IF 0.4 4区医学

Journal of Hard Tissue Biology Pub Date : 2022-01-01 DOI: 10.2485/jhtb.31.207

Yusuke Oomura, S. Matsunaga, M. Okamura, Taiki Suzuki, N. Kasahara, S. Abe, Takeshi Nomura

{"title":"Effect of Zoledronic Acid on Bone Structure of the Mandible in Ovariectomized Mice","authors":"Yusuke Oomura, S. Matsunaga, M. Okamura, Taiki Suzuki, N. Kasahara, S. Abe, Takeshi Nomura","doi":"10.2485/jhtb.31.207","DOIUrl":"https://doi.org/10.2485/jhtb.31.207","url":null,"abstract":": The objective of this study was to determine the effect of zoledronic acid on mandibular bone quality in osteo porotic model mice. Zoledronic acid was administered to ovariectomized mice, and mandibular bone was harvested. Pol ished specimens were prepared, and the biological apatite (BAp) crystal alignment and changes in collagen fiber bundles in the alveolar and basal regions of the mandible were analyzed. It was found that ovariectomy increased BAp crystal align -ment. The administration of zoledronic acid post-ovariectomy normalized BAp crystal alignment in the basal region of the mandible. However, BAp crystal alignment in the alveolar region decreased significantly. Ovariectomy decreased the diam eters of collagen fiber bundles in both the alveolar and basal regions and significantly increased their lengths. The adminis tration of zoledronic acid post-ovariectomy decreased both the diameters and lengths of collagen fiber bundles. These re sults showed that the microarchitecture of the mandibular bone changes to compensate for osteoporosis-induced loss of bone mass and adapts to the load environment resulting from mastication. Interestingly, they suggested that zoledronic acid severely reduces the bone quality of osteoporotic alveolar bone in a site-specific manner.","PeriodicalId":16040,"journal":{"name":"Journal of Hard Tissue Biology","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68966275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Withdrawal: Synthesis of a Novel bFGF/nHAP/COL Bone Tissue Engineering Scaffold for Mandibular Defect Regeneration in a Rabbit Model [Journal of Hard Tissue Biology 27(1) Vol.27, 2018, pp 85-94] 结论:一种新型bFGF/nHAP/COL骨组织工程支架的合成用于兔下颌骨缺损的再生[j] .硬组织生物学杂志27(1)Vol.27, 2018, pp 85-94。

IF 0.4 4区医学

Journal of Hard Tissue Biology Pub Date : 2022-01-01 DOI: 10.2485/jhtb.31.61

Yue Cai, Xue-xin Tan, Li Zhao, Ran Zhang, Tong Zhu, Yang Du, Xukai Wang

引用次数: 0

Inhibitory Effects of Resveratrol on Inflammatory Response in Rat Dental Pulp 白藜芦醇对大鼠牙髓炎症反应的抑制作用

IF 0.4 4区医学

Journal of Hard Tissue Biology Pub Date : 2022-01-01 DOI: 10.2485/jhtb.31.135

L. Hu, Hao Shen, Shiliang Guo

引用次数: 1

Association of Peroxisome Proliferator-Activated Receptor Gamma 2 Gene Polymorphism with Susceptibility to Diabetic Periodontitis: Experience of a Tertiary Hospital in Fujian Province, China 过氧化物酶体增殖物激活受体γ 2基因多态性与糖尿病牙周炎易感性的关系:福建省某三级医院的经验

IF 0.4 4区医学

Journal of Hard Tissue Biology Pub Date : 2022-01-01 DOI: 10.2485/jhtb.31.127

Xiaohua Zeng, Cheng Chen

引用次数: 0

Studies on Change in Solubility over Time of the Bioactive Material Amorphous Calcium Phosphate and Precipitation of Hydroxyapatite 生物活性物质无定形磷酸钙溶解度随时间变化及羟基磷灰石沉淀的研究

IF 0.4 4区医学

Journal of Hard Tissue Biology Pub Date : 2022-01-01 DOI: 10.2485/jhtb.31.1

Fumitaka Yoshino, Rina Sasaki, Yuka Asada, K. Shiozaki, S. Shimoda, Takatsugu Yamamoto

{"title":"Studies on Change in Solubility over Time of the Bioactive Material Amorphous Calcium Phosphate and Precipitation of Hydroxyapatite","authors":"Fumitaka Yoshino, Rina Sasaki, Yuka Asada, K. Shiozaki, S. Shimoda, Takatsugu Yamamoto","doi":"10.2485/jhtb.31.1","DOIUrl":"https://doi.org/10.2485/jhtb.31.1","url":null,"abstract":"In this study, we immersed amorphous calcium phosphate (ACP) powder in biochemical buffer solutions and performed analysis of its solubility and phase transformation of the precipitate. After preparing ACP powder that contains no impurities, we used 4-(2-hydroxyethyl)-1-piperazinetethanesulfonic acid (HEPES) buffer, one of the good buffers, as a buffer solution and measured the amount of calcium ions eluted from ACP and other calcium phosphate crystals. ACP was immersed in the buffer solution at 5°C, 20°C, and 37°C, and the amount of eluted calcium ions was measured from 15 min to 24 h thereafter. The precipitated solid phase was analyzed using X-ray diffraction and its morphology was observed using transmission electron microscopy. The precipitation of hydroxyapatite (HAp) was observed after 15 min in HEPES buffer solution. Furthermore, in this experimental group, the precipitates of the sample incubated in HEPES buffer solution at 37°C for 24 h produced the largest HAp crystals. From these results we concluded that ACP immersed in HEPES buffer solution easily releases calcium ions and phosphate ions, and a rapid phase transformation to HAp occurs. Moreover, we assume that, in addition to the thermodynamic effect, the crystal growth of HAp is enhanced by the buffer solution.","PeriodicalId":16040,"journal":{"name":"Journal of Hard Tissue Biology","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68965873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Comparison of Mesenchymal Stem Cells from Human Adipose Tissues by Resection and by Liposuction 人脂肪组织间充质干细胞切除与吸脂的比较

IF 0.4 4区医学

Journal of Hard Tissue Biology Pub Date : 2022-01-01 DOI: 10.2485/jhtb.31.15

Le Wang, Xingqiang Wang, Rui Liang, Shusen Wang, Jinglin Cao

引用次数: 0

Gene Expression in Early Stages of Low-Intensity Pulsed Ultrasound Exposure on Bone Marrow Cells 低强度脉冲超声暴露早期对骨髓细胞的基因表达

IF 0.4 4区医学

Journal of Hard Tissue Biology Pub Date : 2022-01-01 DOI: 10.2485/jhtb.31.23

Daisuke Yamaguchi, Kazuo Takeuchi, Atsuko Ueno, Masataka Yamaguchi, H. Murakami, Suguru Kimoto

{"title":"Gene Expression in Early Stages of Low-Intensity Pulsed Ultrasound Exposure on Bone Marrow Cells","authors":"Daisuke Yamaguchi, Kazuo Takeuchi, Atsuko Ueno, Masataka Yamaguchi, H. Murakami, Suguru Kimoto","doi":"10.2485/jhtb.31.23","DOIUrl":"https://doi.org/10.2485/jhtb.31.23","url":null,"abstract":": The aim of this study was to identify genes that are prominently expressed in rat bone marrow cell-derived osteoblasts during the initial phase of low-intensity pulsed ultrasound (LIPUS) exposure. Bone marrow cells were obtained from three Sprague-Dawley rats (8-week-old, male), and cell cultures were prepared by suspension in osteogenic medium. After cultures were established, test cultures were exposed to LIPUS from the bottom of the cell culture plate for 15 min/d on days 1–4 (LIPUS group). LIPUS signals were transmitted at a frequency of 3 MHz and a spatial average intensity of 40 mW/cm 2 . The control group was not exposed to LIPUS. On day 14, alizarin red S staining was performed to detect calcifi -cation. On day 4, total RNA was extracted from both cultures, hybridized to microarray slides, and the resulting data set was analyzed. Genes exhibiting a fold-change ≥2 and a p-value <0.05 (LIPUS vs. control) were identified as differentially expressed genes. Pathway analysis was performed on genes whose expression increased in the LIPUS group. The cellular areas stained with alizarin red S were significantly larger in the LIPUS group than in the control group on day 14. LIPUS exposure increased the expression of genes related to type II interferon signaling, and endochondral ossification was ob served after 4 d of culture. The results demonstrated that LIPUS exposure activated the immune response and promoted osteoblast differentiation.","PeriodicalId":16040,"journal":{"name":"Journal of Hard Tissue Biology","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68966392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognosis of Medication-Related Osteonecrosis of the Jaw with Surgical Treatment 药物相关性颌骨骨坏死手术治疗的预后

IF 0.4 4区医学

Journal of Hard Tissue Biology Pub Date : 2022-01-01 DOI: 10.2485/jhtb.31.39

E. Kobayashi, Haruka Takahashi, Kensuke Igarashi, Hiroki Katagiri, M. Haga-Tsujimura, I. Ogura, K. Nakahara, A. Tanaka

{"title":"Prognosis of Medication-Related Osteonecrosis of the Jaw with Surgical Treatment","authors":"E. Kobayashi, Haruka Takahashi, Kensuke Igarashi, Hiroki Katagiri, M. Haga-Tsujimura, I. Ogura, K. Nakahara, A. Tanaka","doi":"10.2485/jhtb.31.39","DOIUrl":"https://doi.org/10.2485/jhtb.31.39","url":null,"abstract":": In 2014, the American Association of Oral and Maxillofacial Surgery (AAOMS) recommended surgical treatment for medication-related osteonecrosis of the jaw (MRONJ) patients classified as Stage 3. In 2016, the Japanese position pa per recommended surgical treatment classified as Stage 2. Some systematic review reported effectiveness of surgical treat ment for MRONJ. However there is no concerted consciousness on the treatment methods of MRONJ patients in the pres-ent. This study aimed to retrospectively elucidate clinical outcomes of the surgical treatment of MRONJ patients under the same criteria. This study included 86 patients in 40 osteoporosis patients (5 men and 35 women, average age: 78.8 years) and 46 cancer patients (18 men and 28 women, average age: 67.7 years). The outcome was classified into two categories: Healing or No healing in each stage. Among 86 patients, MRONJ was found in 91 jaws, of which 69 jaws (75.8%) were surgically operated. Total healing rate of surgical treatment was 85.5%, and total healing rate of conservative treatment was 4.5%. It was suggested that surgical treatment for MRONJ had a high clinical response rate in all stages.","PeriodicalId":16040,"journal":{"name":"Journal of Hard Tissue Biology","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68966464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vigorous Osteoinductivity Observed in Crude Bone Morphogenetic Protein Stored for 25 Years after Extraction at Room Temperature 室温提取后保存25年的粗骨形态发生蛋白观察到强烈的骨诱导作用

IF 0.4 4区医学

Journal of Hard Tissue Biology Pub Date : 2022-01-01 DOI: 10.2485/jhtb.31.253

K. Miyazawa, Takeo Sekiya, Misuzu Kawaguchi, Yuji Kojima, M. Tabuchi, Takuma Sato, T. Kawai, S. Goto

引用次数: 0