Vigorous Osteoinductivity Observed in Crude Bone Morphogenetic Protein Stored for 25 Years after Extraction at Room Temperature

IF 0.3 4区 医学 Q4 ENGINEERING, BIOMEDICAL
K. Miyazawa, Takeo Sekiya, Misuzu Kawaguchi, Yuji Kojima, M. Tabuchi, Takuma Sato, T. Kawai, S. Goto
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引用次数: 0

Abstract

: Bone morphogenetic protein (BMP) is the only cytokine that induces heterotopic new bone. BMP has been classi-fied as a subfamily of the TGF superfamily. The most important and essential aspect for the clinical application of BMP is the replenishment and reinforcement of bone defects and fragile areas with new bone. However, it is difficult to ascertain long term clinical results. In this study, we examined the osteogenic potential in mouse femoral fascia of crude BMP ex-tracted from bovine bone that had been stored at room temperature for 25 years. The results showed vigorous osteogenesis. This study demonstrates the long-term stability of crude BMP. study, we examined the osteogenic potential of crude BMP (cBMP) ex-tracted from and the material exhibited vigorous This study reports the long-term stability of the cBMP osteogenic potential.
室温提取后保存25年的粗骨形态发生蛋白观察到强烈的骨诱导作用
骨形态发生蛋白(Bone morphogenetic protein, BMP)是唯一诱导异位新骨形成的细胞因子。BMP被归类为TGF超家族的一个亚家族。在临床上应用BMP的最重要和最基本的方面是用新骨补充和加固骨缺损和脆弱区域。然而,很难确定长期的临床结果。在这项研究中,我们检测了室温保存25年的牛骨中提取的粗BMP在小鼠股筋膜中的成骨潜能。结果显示骨生成旺盛。本研究证明了粗BMP的长期稳定性。在本研究中,我们检测了从中提取的粗BMP (cBMP)的成骨潜能,该材料表现出强劲的成骨潜能。本研究报告了cBMP成骨潜能的长期稳定性。
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来源期刊
Journal of Hard Tissue Biology
Journal of Hard Tissue Biology ENGINEERING, BIOMEDICAL-
CiteScore
0.90
自引率
0.00%
发文量
28
审稿时长
6-12 weeks
期刊介绍: Information not localized
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