Annals of Medical Laboratory Science最新文献

{"title":"Cultural Barriers to Exclusive Breastfeeding Among Children Aged 0-6 Months in Tamale Metropolitan Area of Ghana","authors":"Habibu Issah","doi":"10.51374/annalsmls.2022.2.1.0053","DOIUrl":"https://doi.org/10.51374/annalsmls.2022.2.1.0053","url":null,"abstract":"Background: The World Health Organization recommends exclusively breastfeeding (EBF) for 6-months commencing at birth, with early breastfeeding commencing within 30 minutes of delivery. Cultural factors have been discovered to influence women's choice to EBF. The research was to determine the cultural influences on EBF and its implications on the nutritional status of infants 0-6 months. Methods: A descriptive cross-sectional study was conducted. The study included 300 women of reproductive age (18-45 years old) who had infants of 0-6 months and were accessing services at child welfare clinics in Tamale, Ghana. Data was collected using interviewer-administered questionnaire between mid-July to mid-August 2021. Results: Most of the mothers (54%) had poor knowledge of exclusive breastfeeding. More than half (72%) did not practice exclusive breastfeeding. Most mothers (57%) did not offer colostrum to their newborns. Mothers-in-law influenced their daughters-in-laws breastfeeding behaviours. Over 50% of those who did not practice EBF said it was taboo to indulge in sex while EBF, to EBF when pregnant, to EBF when there was insufficient breast milk for infants signified by their frequent crying, and to EBF when mothers are likely to face challenges introducing complementary foods after 6 months. Most of the newborns had indications of underweight (69%), stunting (68%), and wasting (66%). Conclusion: There are greater needs to develop health teaching, health education, and counselling strategies to change knowledge, attitude, and practices. Again, negative attitudes and behaviours of mothers and the community as whole regarding EBF could also be addressed using community-based social marketing approach.","PeriodicalId":160210,"journal":{"name":"Annals of Medical Laboratory Science","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125382740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Dyslipidemia and Sexual Dysfunction Among Type 2 Diabetics in Tema Metropolis of Ghana","authors":"Huseini Alidu","doi":"10.51374/annalsmls.2022.2.1.0054","DOIUrl":"https://doi.org/10.51374/annalsmls.2022.2.1.0054","url":null,"abstract":"Background: The prevalence of diabetes is high and still rising worldwide. This study sought to investigate the influence of dyslipidemia on the risk of sexual dysfunction among type 2 diabetics in Tema Metropolis of Ghana. Methods: An analytical cross-sectional study design was employed and involved 246 type 2 diabetics selected through consecutive sampling from Tema General Hospital. Sexual dysfunction was evaluated using the Golombok Rust Inventory of Sexual Satisfaction questionnaire. Lipid profile of subjects was determined and dyslipidemia diagnosed according to the National Cholesterol Education Program-Adult Treatment Panel III criteria. Regression analysis was performed to determine the association between dyslipidemia and sexual dysfunction. Results: About 64.9% and 66.4% of male and female diabetics had sexual dysfunction respectively. The prevalence of combined/Mixed dyslipidemia were 46.2% and 48.3% among male and female diabetics respectively. In male diabetics, hypercholesterolemia was significantly associated with sexual dysfunction. Male diabetics that had hypercholesterolemia were 3.2 times more likely to suffer from sexual dysfunction as compared to those without hypercholesterolemia (Adjusted Odds Ratio = 3.18; 95% Confidence Interval: 1.30-7.79; P=0.011). In female diabetics, dyslipidemia was not found to be associated with sexual dysfunction. Conclusion: Study concluded that dyslipidemia (Hypercholesterolemia) is an independent predictor of sexual dysfunction in male but not in female type 2 diabetics.","PeriodicalId":160210,"journal":{"name":"Annals of Medical Laboratory Science","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133835041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil gelatinase-associated lipocalin and Endothelin-1 as markers for the onset and severity of preeclampsia","authors":"Stephen Justice Adusu","doi":"10.51374/annalsmls.2022.2.1.0055","DOIUrl":"https://doi.org/10.51374/annalsmls.2022.2.1.0055","url":null,"abstract":"Background: The onset of preeclampsia (PE) may be early (EOPE), or late (LOPE). Preeclampsia may also be characterized by severe features (PS) or without severe features (PNS). This study aimed to predict the onset and severity of PE using biomarkers including neutrophil gelatinase-associated lipocalin (sNGAL) and endothelin-1 (ET-1). Method: This was a case-control study from January to June 2020. The study involved 270 pregnant women (control=135, PE=135), aged between 18-37 years. The cases and controls were matched by maternal and gestational age at sampling. Serum samples were assayed for sNGAL and ET-1 using the ELISA technique. Results: Serum NGAL and ET-1 were significantly increased in PE and also increased in PE characterized by severe features (P<0.010). Both sNGAL and ET-1 positively correlated with blood pressure in PE (P<0.050). In predicting PE, the area under the curve, sensitivity and specificity of sNGAL were 0.76, 46.2% and 97.8% while that of ET-1 were 0.82, 66.8%, and 92.5% respectively. Also, ET-1 could differentiate PS from PNS with a sensitivity of 85.7% and specificity of 82.1%. Conclusion: Serum ET-1 is better than sNGAL in the prediction of PE. We recommend screening pregnant women using ET-1 for the early detection and management of PE.","PeriodicalId":160210,"journal":{"name":"Annals of Medical Laboratory Science","volume":"604 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116371941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Hepatitis B, C and HIV infections among haemodialysis patients at the Cape Coast Teaching Hospital, Ghana; A retrospective study","authors":"R. D. Ephraim","doi":"10.51374/annalsmls.2022.2.1.0057","DOIUrl":"https://doi.org/10.51374/annalsmls.2022.2.1.0057","url":null,"abstract":"Background: End stage renal disease (ESRD) patients undergoing hemodialysis could be at a higher risk of acquiring viral infections such as hepatitis B, C (HBV, HCV) and human immunodeficiency virus (HIV). The study investigated the prevalence of HBV, HCV, HIV and identified the determinants of these viral infections among end stage renal disease (ESRD) patients undergoing hemodialysis at the Cape Coast Teaching Hospital (CCTH). Methods: This retrospective hospital-based record review was conducted at the CCTH among 89 patients who underwent hemodialysis in at the renal unit of the hospital. The viral infection histories of all the recruited patients were collected as well as clinical and demographic data to identify the determinants of viral infections. Results: Of the 89 patients comprising of 59 (66.3%) males and 30 (33.7%) females, 11(12.4%) were found to be positive for HbsAg, and 6 (6.7%) were found to be positive for HCV infection. Five (5.6%) patients were positive for HIV and 5 (5.6%) participants had co-infection of HBV and HCV. No co-infection of the three viral infections was reported among the participants. Of the various parameters assessed, only average monthly dialysis sessions varied significantly by gender. Univariate logistics regression analysis indicated that HCV [OR=64.17; 95% CI (6.42-641.41) p<0.001] and HBV [OR=35.45; 95% CI (3.78-332.35) p=0.002] infection was a significant independent risk factor of acquiring HBV and HCV infection respectively. The commonest causes of ESRD among participants were hypertension (54.5%) and chronic glomerulonephritis (27.3%). Conclusion: Prevalence rates of the three viral infections studied were high. The likelihood of getting infected with one viral agent as a result of an already existing viral agent was significant. There is therefore an urgent need for the intensification of health education on the occurrence so as to help curb a possible escalation of the viral infection in the general population.","PeriodicalId":160210,"journal":{"name":"Annals of Medical Laboratory Science","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121566868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of automated malaria parasite diagnostic machines based on first principle: A pre-requisite for acceptable results and treatment monitoring in resource limited settings","authors":"Iseimokumo Christopher Peletiri","doi":"10.51374/annalsmls.2022.2.1.0056","DOIUrl":"https://doi.org/10.51374/annalsmls.2022.2.1.0056","url":null,"abstract":"Background: Following the very recent introduction of automated malaria parasite diagnostic machines; the need to validate these high technology machines based on the first principle protocol in malaria parasite density determination for acceptable results and treatment monitoring cannot be over-emphasized. The aim of this review is to update Medical Laboratory Scientists, Medical Laboratory Technicians, and researchers alike on the first principle in the diagnosis of malaria using Giemsa stained thick and thin blood films and to build their capacity on how to validate any automated malaria parasite diagnostic machine. Methods: The first principle protocol in malaria parasite density determination was used. With 8 µL of blood spread within 18 mm diameter of circle (thick film), the volume of blood in one thick film field (0.002 µL) is obtained; which when multiplied by a factor (500) gives 1 µL. The number of parasites seen per 100 thick film fields or average number per each thick film field multiplied by 500 gives the number of parasites / µL of blood. Results: Malaria parasites counts of 5 – 50 parasites (1+), 50 – 500 parasites (2+), 500 – 5000 parasites (3+), and (4+) > 5000 parasites / µL of blood, and with the results obtained from the automated machine which when entered into a 2 x 2 table reveal the performance evaluation of automated machine. Conclusion: With several results obtained, any automated malaria diagnostic machine can be validated for its ability to detect disease (sensitivity, specificity, positive and negative predictive values). Commencement of the use of automated malaria parasites diagnostic machines in parasitology laboratory should not lead to discontinuity in the use of thick and thin blood films in malaria diagnosis as it remains the gold standard in resource limited settings.","PeriodicalId":160210,"journal":{"name":"Annals of Medical Laboratory Science","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126455833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Placental Oxidative Stress in the pathogenesis of Hypertensive Disorders of Pregnancy","authors":"M. A. Akilla","doi":"10.51374/annalsmls.2021.1.2.0041","DOIUrl":"https://doi.org/10.51374/annalsmls.2021.1.2.0041","url":null,"abstract":"Background: Hypertensive disorders of pregnancy are a major complication of pregnancies and can lead to fetal growth retardation, premature delivery and maternal morbidity and mortality. The study aimed at assessing the potential role of the placenta in the pathogenesis of hypertensive disorders of pregnancy. Methods: This study was a case-control study conducted at the Upper East Regional Hospital, Ghana from September, 2016 to March 2017. Twenty (20) pregnant women with hypertensive disorders of pregnancy (i.e., Pregnancy induced hypertension, preeclampsia and eclampsia) as cases and 30 normotensive pregnancies as controls, were included in the study. The placenta was excised after delivery, homogenized and assayed for malondialdehyde, catalase, total peroxide, oxidative stress index, total antioxidant capacity and placental lipid profile. Results: The ages of the two groups were similar, with malondialdehyde (p = 0.001) and Oxidative Stress Index (p < 0.001) being significantly higher in the hypertensive group compared to the control group whereas Total Antioxidant Capacity (p < 0.001) and Catalase (p = 0.011) were significantly higher in the control group compared to the hypertensive group. The proportion of normal, term and livebirth deliveries were significantly higher among controls compared to the hypertensive disorders of pregnancy group. Among the estimated oxidative stress markers, total antioxidant capacity turned out to be the best predictor of the hypertensive disorders of pregnancy. Conclusion: Our findings suggest oxidative stress in women with hypertensive disorders of pregnancy and that placental oxidative stress could be the driving factor for the pathogenesis and severity of these hypertensive disorders of pregnancy.","PeriodicalId":160210,"journal":{"name":"Annals of Medical Laboratory Science","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115910470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperglycaemia in newly diagnosed pulmonary tuberculosis patients: a cross-sectional study of the Agona District Hospital","authors":"R. D. Ephraim","doi":"10.51374/annalsmls.2021.1.2.0042","DOIUrl":"https://doi.org/10.51374/annalsmls.2021.1.2.0042","url":null,"abstract":"Background: Diabetes mellitus is an important risk factor associated with tuberculosis (TB). This study investigated the prevalence and determinants of hyperglycemia among newly diagnosed pulmonary tuberculosis patients in the Agona Swedru Municipality. Method: A hospital-based cross-sectional study was conducted from December 2015 to April 2016. One hundred (100) newly diagnosed pulmonary tuberculosis patients at the Agona Swedru Municipal Hospital (ASMH) were enrolled for the study. Socio-demographic, clinical and anthropometric measurements were collected and fasting blood glucose (FBG) measured using standard protocols. Data was analyzed using Statistical Package for Social Sciences (SPSS) software version 20.0. Result: Of the 100 participants, 26% had hyperglycemia. The significant factors associated with increased risk of hyperglycemia among participants were history of diabetes mellitus (OR = 8.17, p= 0.004), severity of infection (OR = 23.64, p < 0.001) and duration of symptoms (OR= 2.63, p= 0.042). Conclusion: Hyperglycemia was common among newly diagnosed pulmonary tuberculosis patients. History of diabetes mellitus, severity of infection, and duration of symptoms were the determinants of hyperglycemia in pulmonary tuberculosis. Regular screening of hyperglycemia is essential in the management of tuberculosis. Finally, further studies should be conducted on glucose levels among pulmonary tuberculosis patients using higher sample size to increase the understanding of the subject.","PeriodicalId":160210,"journal":{"name":"Annals of Medical Laboratory Science","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125563277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Types of Sexual Dysfunction Among Female Medical Students","authors":"A. Salifu","doi":"10.51374/annalsmls.2021.1.2.0039","DOIUrl":"https://doi.org/10.51374/annalsmls.2021.1.2.0039","url":null,"abstract":"Background: Sexuality is a complex phenomenon that is being influenced by psychological, nutritional as well as physiological factors. Its dysfunction includes desire, arousal, orgasmic and sex pain disorders. The present study aimed to assess the prevalence of sexual dysfunction (SD) and risk factors in a cohort of both married and unmarried female students in UDS-Tamale. Methods: The Golombok Rust Inventory of Sexual Satisfaction (GRISS) was administered to 150 female students independent of age (mean±SD: single (24.1 ± 2.0) and married (29.6 ± 5.2)) domiciled in UDS-Tamale campus. Results: Out of a total of 150 questionnaires administered. 93 (62.0%) females returned the questionnaires, and 79 were complete and evaluable questionnaires. This represents 52.7% response rate. From this study, the age ranges as well as the mean (SD) of the age of the participants are 20 to 42 and 27.0 ± 4.8 years respectively. The mean duration of marriage is 4.6 ± 3.4 years. Majority of the studied participants are non-smokers (97.5%), do not consumed alcoholic beverages (67.1%), do not have any chronic disease (69.6%) and do not also have any family history of any chronic disease condition (55.7%). The mean income level, BMI as well as WHR are Ghc 590.1 ±406.9, 25.6 ± 3.5 kg m-2 and 0.8 ± 0.1 respectively. The prevalence of sexual dysfunction among the single respondent was 67.6%. The most prevalent areas of difficulties were: infrequency 81.1%, Avoidance 64.9%, non-communication 64.9%, dissatisfaction 64.9%, anorgasmia 62.2%, non-sensuality 56.8% and vaginismus 56.8%. The prevalence of sexual dysfunction among the married respondent was 54.8%. Sexual dysfunction is high in both single female (67.9%) and married female (54.8%) medical students in the study. Conclusion: Married females in the study were more obese than single females, and the married-obese group was associated with high sexual dysfunction. Notwithstanding this however, the single-normal females had more sexual dysfunction compared to the married-normal females. The SD in the females appear to be contributed mostly by infrequency and avoidance in the single female group, whereas by dissatisfaction and infrequency in the married female group.","PeriodicalId":160210,"journal":{"name":"Annals of Medical Laboratory Science","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132280453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echinococcus granulosus Antibodies in Dogs and Breeder practices promoting spread of infection in Plateau State, Nigeria","authors":"R. Weka","doi":"10.51374/annalsmls.2021.1.2.0038","DOIUrl":"https://doi.org/10.51374/annalsmls.2021.1.2.0038","url":null,"abstract":"Background: Echinococcosis caused by Echinococcus granulosus is a zoonotic disease of public health significance, but there have been few studies of the infection in dogs in Nigeria. This study aimed to establish the seroprevalence of E. granulosus in dogs in four Local Government Area of Plateau State, Nigeria. Methods: A total of 179 dog sera were examined for the presence of E. granulosus antibody using an ELISA kit between May to October 2017. Results; Eleven of the sera (6.1%) were seropositive with a prevalence of 7.4% and 2.3% for dogs less than 2 years and those above 2 years of age respectively. More male dogs (7.5%) than females (4.1%) were seropositive. Seroprevalence was associated with <2years than > 2 years dogs (OR=3.33, p=0.46) and male than female dogs (OR=1.90, p=0.53) but association were not significant. Dogs from Bassa had the highest seroprevalence (15.2%), followed by Mangu (5.9%), Kanke (4.8%) and Jos South (2.0%). Odds ratio showed an association which was not significant between Bassa (OR=3.3), Kanke (OR=2.50). Conclusion: This study shows that E. granulosus infection is present in dogs in some parts of Plateau State. More studies should be done to ascertain echinococcus infection in dogs in Nigeria to aid the formulation of control programmes to forestall its public health impacts.","PeriodicalId":160210,"journal":{"name":"Annals of Medical Laboratory Science","volume":"492 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114586889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study of glycaemic variability using four different Point-of-Care Testing (POCT) devices","authors":"P. Dapare","doi":"10.51374/annalsmls.2021.1.2.0037","DOIUrl":"https://doi.org/10.51374/annalsmls.2021.1.2.0037","url":null,"abstract":"Background: Blood glucose measurement is a way of monitoring changes in glycaemia. Different point-of-care testing (POCT) glucose meters are on the market and hence there is an increase in variability of the results given by these meters. This study sought to measure the glycaemic variability using four different point-of-care glucose meters Methods: Four point of care glucometers namely; Accu-chek performer nano, OneTouch select plus flex, OneTouch Ultra 2 and Easy Check were used test blood samples from a total of 100 patients visiting the collection point of the Tamale Teaching Hospital Laboratory. A chemistry analyzer (Mindray BS 240 fully automated) was used as the reference method. Results: The median (interquartile range), Bland Altman Plot and Regression Equation were used to assess the agreement between the various meters and the reference method. The OneTouch Select plus had the least bias (-0.85) and the the OneTouch Ultra 2 had the highest bias (1.49). The OneTouch select had the best limits of agreement (-2.51 – 0.82) and the OneTouch Ultra 2 had the widest limits of agreement (-1.91 – 4.89) when compared to the reference method. Conclusion: OneTouch Select plus had the best agreement with the reference method and the OneTouch Ultra 2 had the least agreement with the reference method. Blood glucose meters should be used for the monitoring of blood glucose however, it should not be used as a diagnostic tool. Annals of Medical Laboratory Science (2021) 1(2), 1 - 8 Keywords: glucometer, point-of-care, blood glucose, glycaemia","PeriodicalId":160210,"journal":{"name":"Annals of Medical Laboratory Science","volume":"52 13","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120817027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}