中性粒细胞明胶酶相关脂钙素和内皮素-1作为子痫前期发病和严重程度的标志物

Stephen Justice Adusu
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摘要

背景:先兆子痫(PE)的发病可能早(EOPE),也可能晚(LOPE)。子痫前期也可能表现为严重特征(PS)或无严重特征(PNS)。本研究旨在利用中性粒细胞明胶酶相关脂钙素(sNGAL)和内皮素-1 (ET-1)等生物标志物预测PE的发病和严重程度。方法:2020年1月至6月为病例对照研究。该研究涉及270名年龄在18-37岁之间的孕妇(对照组=135,对照组=135)。病例和对照组在抽样时与产妇和胎龄相匹配。采用ELISA技术检测血清中sNGAL和ET-1的含量。结果:PE组血清NGAL、ET-1明显升高,重度PE组血清NGAL、ET-1明显升高(P<0.010)。sNGAL和ET-1与PE患者血压呈正相关(P<0.050)。在预测PE方面,sNGAL的曲线下面积为0.76、46.2%、97.8%,ET-1的曲线下面积为0.82、66.8%、92.5%。ET-1鉴别PS和PNS的敏感性为85.7%,特异性为82.1%。结论:血清ET-1对PE的预测优于sNGAL。我们建议使用ET-1筛查孕妇,以便早期发现和处理PE。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neutrophil gelatinase-associated lipocalin and Endothelin-1 as markers for the onset and severity of preeclampsia
Background: The onset of preeclampsia (PE) may be early (EOPE), or late (LOPE). Preeclampsia may also be characterized by severe features (PS) or without severe features (PNS). This study aimed to predict the onset and severity of PE using biomarkers including neutrophil gelatinase-associated lipocalin (sNGAL) and endothelin-1 (ET-1). Method: This was a case-control study from January to June 2020. The study involved 270 pregnant women (control=135, PE=135), aged between 18-37 years. The cases and controls were matched by maternal and gestational age at sampling. Serum samples were assayed for sNGAL and ET-1 using the ELISA technique. Results: Serum NGAL and ET-1 were significantly increased in PE and also increased in PE characterized by severe features (P<0.010). Both sNGAL and ET-1 positively correlated with blood pressure in PE (P<0.050). In predicting PE, the area under the curve, sensitivity and specificity of sNGAL were 0.76, 46.2% and 97.8% while that of ET-1 were 0.82, 66.8%, and 92.5% respectively. Also, ET-1 could differentiate PS from PNS with a sensitivity of 85.7% and specificity of 82.1%. Conclusion: Serum ET-1 is better than sNGAL in the prediction of PE. We recommend screening pregnant women using ET-1 for the early detection and management of PE.
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