Journal of evaluation in clinical practice最新文献

{"title":"Effect of a Contamination Prevention Activity Against Contamination of Blood Culture","authors":"Jun Ohnishi,&nbsp;Naoto Ishimaru,&nbsp;Toshio Shimokawa,&nbsp;Saori Kinami,&nbsp;Takahiro Nakajima,&nbsp;Yohei Kanzawa,&nbsp;Shimpei Mizuki","doi":"10.1111/jep.70024","DOIUrl":"https://doi.org/10.1111/jep.70024","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Blood culture is important in the diagnosis of blood infections and the identification of treatment strategies. Increased contamination in blood culture is a reduction in quality of care. This retrospective observational study, set in an emergency department in Japan, aims to elucidate the contamination rate before and after the introduction of contamination prevention activities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We compared the contamination rates before and one year after contamination prevention activities. Specifically, these activities included a novel and specific use of a blood culture cart and adherence to a checklist. The checklist included noting the actual site of collection, the method of disinfection, and whether gloves were worn.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There were 1184 and 1129 blood culture samples before and after the preventive activities, respectively. The rates of contamination were 2.03% (95% Cl = 1.30% to 3.00%) and 1.24% (95% Cl = 0.68% to 2.07%), respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Prevention activities including specific use of a blood culture cart and careful adherence to a checklist were not associated with a significant decrease in contamination rate in our hospital. Further studies based in hospitals with greater rates of contamination may see higher rates of reduction.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15997,"journal":{"name":"Journal of evaluation in clinical practice","volume":"31 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143380304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Convocation Address at McMaster: Evidence-Based Medicine, Predictability and Unpredictability","authors":"John P. A. Ioannidis","doi":"10.1111/jep.70026","DOIUrl":"https://doi.org/10.1111/jep.70026","url":null,"abstract":"&lt;p&gt;Madam Chancellor, President Farrar, Honored Guests, Graduands, Family, and Friends:&lt;/p&gt;&lt;p&gt;It is a great honor and unique pleasure to receive this doctorate from McMaster University and to give this Convocation Address. McMaster is a leading world-class institution. This is the place where evidence-based medicine was born, where its principles matured and where its impressive applications keep growing. The advent of evidence-based medicine represents a momentous turning point in the history of health sciences and health care. I come today as a pilgrim to your institution thankful for everything I have learned from you over the years. I hope to continue to learn from your brilliant achievements for years to come.&lt;/p&gt;&lt;p&gt;I congratulate all of you who graduated today. I am delighted to share your joy and applaud your accomplishments. You and your family and friends must be very proud. May your paths in the future provide abundant opportunities for more celebration and joy, for exciting stimulation and a sense of fulfilment.&lt;/p&gt;&lt;p&gt;While I wish you success in all your endeavors, this is not enough. My valediction needs to be coupled with a second wish: May you have wisdom, resilience, and ingenuity to benefit also from whatever disappointments, obstacles, and frustrations you may encounter. Setbacks and failures can be wonderful. I admire people who can become grand masters at the art of failing. Personally, I am grateful for my numerous failures and defeats, for all the calamities I have encountered. I consider myself fortunate whenever I realize even more deeply how little I know, how uninformed or misinformed I have been, how miserably I have failed. Then I have a reason to wake up the next day and do better. Well, perhaps one day I may wake up and think that everything is perfect. If that perfection ever happens, I suspect I will be hallucinating, lobotomized, or clinically dead.&lt;/p&gt;&lt;p&gt;None of us knows for sure what the next day will be like. I do like to plan, even meticulously so. I try to think in advance, using the best available evidence. I indulge in making far-reaching plans and outlines for research, for projects or for my life. As a meta-researcher focused on research methodology, I am sort of a maniac about fleshing out protocols and methods sections in painful detail. But I am always fascinated by my recurrent inability to predict and by how often these over-ambitious plans require revisions or simply fall apart. Science, medicine, health and life at large can be so stunningly surprising.&lt;/p&gt;&lt;p&gt;We live in an era of tremendous predictive power, or so we are told by experts, decision makers, artificial intelligence gurus, and many other pundits. Both experts and non-experts proclaim predictions all the time. While it is precarious to extrapolate any regression beyond the already observed values, we do this routinely, nonetheless. The voices that are heard the loudest are not necessarily the ones that use the best predictive methods. W.B.","PeriodicalId":15997,"journal":{"name":"Journal of evaluation in clinical practice","volume":"31 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jep.70026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143380148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccine Hesitancy Among Family Doctors and Family Health Workers: Prevalence and Associated Factors","authors":"Mehtap Yucel,&nbsp;Merve Aydin Keser","doi":"10.1111/jep.70012","DOIUrl":"https://doi.org/10.1111/jep.70012","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>The aim of the study was to determine the prevalence of vaccine hesitancy among family doctors and family health workers regarding vaccines included in the childhood vaccination calendar and to identify factors that may be associated with vaccine hesitancy among participants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 131 people, 76 family doctors and 55 family health workers in Bilecik province and its districts, representing 89.7% of the population, were included in the cross-sectional study. The study data collection period was 01−31 March 2024. Data were collected online. All participants were asked to complete a socio-demographic data form, their intention to vaccinate their children for each of the 14 vaccines included in the vaccination calendar in Turkey, and a data collection form asking about variables that may be associated with vaccine hesitancy. Participants were categorised according to their intention to vaccinate their children and grouped into vaccine hesitancy and vaccine acceptance, and statistical analyses were performed between the groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>It was found that 19.1% of participants had at least one vaccine hesitancy. The age and years of experience of family doctors and family health workers with vaccine hesitancy were higher than those with vaccine acceptance. In addition, the rate of vaccine ambivalence was significantly higher among these participants who had children (<i>p</i> &lt; 0.05).</p>\u0000 \u0000 <p>The belief that children should only be vaccinated against serious diseases is significantly higher among vaccine ambivalent than vaccine accepting respondents (<i>p</i> &lt; 0.05). The belief that vaccines are not one of the safest ways to protect against infectious agents, the belief that vaccines have not become better and more effective through scientific research, and the belief that vaccines do not strengthen the immune system were significantly higher among vaccine ambivalents than among vaccine acceptors (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In conclusion, the results of this study indicate that vaccine hesitancy is common among healthcare workers, that vaccine hesitancy is associated with factors such as age, working years, and having children, and that individuals with vaccine hesitancy hold various misconceptions about vaccines.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15997,"journal":{"name":"Journal of evaluation in clinical practice","volume":"31 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143380149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a Volunteer-Staffed Outreach Call Initiative on Video Usage and Attendance for Telehealth Visits in an Urban Primary Care Safety-Net Setting","authors":"Kevin Chen,&nbsp;Khera Bailey,&nbsp;Simon Nemytov,&nbsp;Mackenzie Morrison,&nbsp;Christine Zhang,&nbsp;Kenan Katranji,&nbsp;Hannah B. Jackson","doi":"10.1111/jep.70019","DOIUrl":"https://doi.org/10.1111/jep.70019","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Rationale</h3>\u0000 \u0000 <p>Telehealth navigation programmes have shown potential to improve video visit usage and attendance. However, their effectiveness in safety-net healthcare settings remains uncertain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims and Objectives</h3>\u0000 \u0000 <p>This project assessed the impact of a volunteer-staffed telehealth navigation programme on video visit usage and attendance at an urban safety-net primary care clinic.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Volunteers conducted outreach calls to patients with upcoming telehealth appointments to help them prepare for their visits. Outcomes, including video usage (video vs. audio-only visits) and no-show rates, were compared between patients who received outreach and those who did not.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Analysis revealed no significant differences in video usage (14.1% for outreach vs. 14.0% for non-outreach) or no-show rates (22.5% for outreach vs. 22.0% for non-outreach). The study included 881 patients who received outreach and 2728 patients who did not.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Patients unresponsive to outreach had lower portal activation rates and higher non-attendance, suggesting the presence of distinct engagement subgroups within the population. While volunteer-staffed programmes may provide a practical method to reach patients, telephone outreach alone was insufficient to improve video visit usage or attendance rates. Further research is needed to explore alternative or complementary strategies to enhance telehealth engagement in safety-net settings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15997,"journal":{"name":"Journal of evaluation in clinical practice","volume":"31 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143379951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the Relationship Between Perceived Social Support and Immunosuppressive Medication Adherence After Kidney Transplantation: A Descriptive Correlational Study","authors":"Ebru Karazeybek","doi":"10.1111/jep.70021","DOIUrl":"https://doi.org/10.1111/jep.70021","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>What is known about how the level of social support, which is among the factors affecting medication adherence, affects medication adherence is limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study investigated the relationship between perceived social support and immunosuppressive medication adherence among kidney recipients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>This study was conducted using a descriptive correlational research method.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Participants</h3>\u0000 \u0000 <p>The study conducted research with 168 kidney transplant recipients who agreed to participate between April and June 2021. Participants completed the Immunosuppressive Medication Adherence Scale (IMAS) and the Multidimensional Scale of Perceived Social Support (MSPSS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Measurements and Results</h3>\u0000 \u0000 <p>Participants had a mean IMAS and MSPSS score of 50.24 ± 3.71 and 57.21 ± 13.96, respectively. Participants' MSPSS total (<i>r</i> = 0.209, <i>p</i> = 0.006) and ‘family’ (<i>r</i> = 0.248, <i>p</i> = 0.001) and ‘friends’ (<i>r</i> = 0.226, <i>p</i> = 0.003) subscale scores were weakly and positively correlated with their IMAS total score.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Understanding the effect of perceived social support on immunosuppressive medication adherence is important for designing future interventions to increase immunosuppressive medication adherence.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15997,"journal":{"name":"Journal of evaluation in clinical practice","volume":"31 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jep.70021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143380303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dentists' Awareness of Antibiotic Stewardship and Their Willingness to Support Its Implementation: A Cross-Sectional Survey in a Dental School","authors":"Arwa A. Banjar","doi":"10.1111/jep.70023","DOIUrl":"https://doi.org/10.1111/jep.70023","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Antibiotic overuse is highly reported among dentists worldwide. An antibiotic stewardship programme has been shown to be effective for decreasing the number of unappropriated antibiotic prescriptions. The goal of this survey was to assess dentists' awareness of antibiotic stewardship and their willingness to implement changes accordingly.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A structured questionnaire was developed and distributed to dentists at a university hospital with different levels of experience. It included questions regarding antibiotic prescription habits, antibiotic stewardship knowledge and willingness to implement changes in such a programme.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, 256 dentists participated in the survey. Among them, 16.4% (95% confidence interval: 12.1%–21.5%) reported awareness regarding antibiotic stewardship. Awareness levels were higher among specialists (28.3%) and increased with experience. Most dentists in this study reported willingness to improve their antibiotic prescribing practices. The mean willingness score was 8.78 (standard deviation: 1.81).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Awareness of antibiotic stewardship was low among dentists with different levels of experience. However, dentists were willing to change their antibiotic prescription habits if policies were implemented as part of a stewardship programme at the school.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15997,"journal":{"name":"Journal of evaluation in clinical practice","volume":"31 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jep.70023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143380877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers and Facilitators of Implementing Arabic-Validated Standardised Outcome Measures for Chronic Stroke Rehabilitation Among Physical Therapists","authors":"Maha Almarwani,&nbsp;Reham Alhamyani","doi":"10.1111/jep.70018","DOIUrl":"https://doi.org/10.1111/jep.70018","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Implementing standardised outcome measures (SOMs) in stroke rehabilitation practices enhances patient care, communication, and overall clinical effectiveness. However, the implementation of Arabic-validated SOMs in stroke rehabilitation practices among Arabic-speaking patients has not been fully explored.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To examine the use, facilitators, and barriers of implementing Arabic-validated SOMs for chronic stroke rehabilitation among physical therapists.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional survey was conducted among 262 physical therapists managing patients with chronic stroke. The survey evaluated the use, facilitators, and barriers to implementing Arabic-validated SOMs. Descriptive statistics summarised demographic and professional characteristics, while multivariate logistic regression identified independent predictors of SOM use, with adjusted odds ratios and 95% confidence intervals calculated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The use of Arabic-validated SOMs in chronic stroke rehabilitation was reported by 54% of therapists within the first week of physical therapy services and 64% at discharge. The Berg Balance Scale and the Timed Up and Go test were the two most commonly employed scales. Facilitators for implementing SOMs included facilitating adherence to clinical practice guidelines, providing valuable patient insights, and supporting balanced assessments. Barriers included time constraints, financial limitations, and time demands on both patients and therapists. Familiarity with clinical practice guidelines was significantly associated with increased use of Arabic-validated SOMs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Implementing Arabic-validated SOMs is essential to ensure culturally appropriate and linguistically accurate evaluations that support evidence-based decision-making and enhance patient management in stroke rehabilitation among Arabic-speaking patients. Enhancing familiarity with clinical practice guidelines and addressing barriers such as time constraints and financial challenges can further promote the implementation of Arabic-validated SOMs into routine practice, ultimately improving patient outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15997,"journal":{"name":"Journal of evaluation in clinical practice","volume":"31 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143380147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a Trial of Computerised Cognitive Behavioural Therapy Programme Within Local Child and Adolescent Mental Health Services","authors":"Deborah Bell","doi":"10.1111/jep.70022","DOIUrl":"https://doi.org/10.1111/jep.70022","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Rationale</h3>\u0000 \u0000 <p>NICE guidelines recommend offering computerised Cognitive Behavioural Therapy (cCBT) to young people with mild mental health issues to ensure early treatment access and reduce service demand. Emerging evidence suggests cCBT reduces symptoms, but further evaluation is needed. SilverCloud is a recommended digital CBT programme.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Evaluate a pilot trial of SilverCloud in CAMHS at a local NHS Foundation Trust.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>(1) Symptomology: Is there a change in depression or anxiety symptoms after using the intervention? (measured by outcome scores); (2) Adoption: What was young people's engagement with SilverCloud? (measured by time spent on the platform and uptake); (3) Satisfaction: How satisfied were young people with SilverCloud? (measured by module feedback ratings and a questionnaire).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The SilverCloud intervention for young people was evaluated over 9 months. Reductions in symptoms of generalised anxiety disorder (GAD) and low mood were measured using the Revised Children's Anxiety and Depression Scale (RCADS), GAD, and Major Depressive Disorder (MDD) subscales. Adoption was measured by time spent on SilverCloud and intervention uptake. Satisfaction was measured by module feedback ratings and a questionnaire.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Ninety-one people were offered SilverCloud, 77% started, 46% completed it and 27% disengaged. Thirty-two participants completed SilverCloud during the evaluation (12 CYP and 20 parents). No statistically significant reduction was found in any subscale. Satisfaction was varied; 94% rated the intervention favourably, but no participants reported behaviour changes due to the intervention.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This evaluation suggests tentative pessimism regarding SilverCloud's benefits. However, due to significant challenges and limitations, further analysis is recommended. Recommendations were given for local services.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15997,"journal":{"name":"Journal of evaluation in clinical practice","volume":"31 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jep.70022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143380150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"We Certainly Need Real Life Research—But What Is Real Life?","authors":"John P. A. Ioannidis","doi":"10.1111/jep.70027","DOIUrl":"https://doi.org/10.1111/jep.70027","url":null,"abstract":"","PeriodicalId":15997,"journal":{"name":"Journal of evaluation in clinical practice","volume":"31 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143379952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between COVID-19 Vaccination Status and Persistent Symptoms: A Prospective Study of Reproductive-Age Women","authors":"Ilkin Seda Can Caglayan,&nbsp;Gulbahtiyar Demirel,&nbsp;Ceren Eda Can","doi":"10.1111/jep.70005","DOIUrl":"https://doi.org/10.1111/jep.70005","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The present study was conducted to determine the relationship between prolonged complaints of women who had COVID-19 infection and whose symptoms persisted and their vaccination status against COVID-19.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective observational study consisted of three groups [The Unvaccinated Group (Control Group: 89), the BioNTech Vaccine Group (114 people), and the Sinovac Vaccine Group (84 people)]. In this study, which included 287 women, prolonged COVID-19 symptoms in their spouses were also questioned. Information was obtained from the participants in the form of questions and answers under outpatient clinical conditions 2 months after their recovery. Women between the ages of 18–45 who had regular menstrual periods in the last 6 months before the pandemic, those whose COVID-19 test was negative and those who received a single dose of vaccine in the vaccinated group were included in the study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The rates of loss of taste and prolonged symptoms of high fever in Sinovac-vaccinated participants were lower than in the other groups in the present study (<i>p</i> &lt; 0.05). A total of 40.5% of those who were vaccinated with Sinovac after COVID-19 had a menstrual cycle length of every 28–40 days, which was higher than the percentage of participants in other groups, and 40.5% of those in this group did not have menstrual pain. Additionally, the menstrual period length of 62.3% of the participants who received the BioNTech vaccine increased (<i>p</i> &lt; 0.05). This increase is higher than the participants in the other group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The study indicated that certain prolonged symptoms of COVID-19 infection were less common among participants vaccinated with Sinovac. In this group, the menstrual cycle length increased, while menstrual pain decreased.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15997,"journal":{"name":"Journal of evaluation in clinical practice","volume":"31 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}