Journal of Immunotherapy最新文献_第10页

Enhancing Efficacy of TCR-engineered CD4 + T Cells Via Coexpression of CD8α. 通过CD8α的共表达增强tcr工程CD4 + T细胞的疗效。

IF 3.9 4区医学

Journal of Immunotherapy Pub Date : 2023-05-01 DOI: 10.1097/CJI.0000000000000456

Victoria E Anderson, Sara S Brilha, Anika M Weber, Annette Pachnio, Guy E Wiedermann, Sumaya Dauleh, Tina Ahmed, George R Pope, Laura L Quinn, Roslin Y Docta, Adriano Quattrini, Siobhan Masters, Neil Cartwright, Preetha Viswanathan, Luca Melchiori, Louise V Rice, Alexandra Sevko, Claire Gueguen, Manoj Saini, Barbara Tavano, Rachel J M Abbott, Jonathan D Silk, Bruno Laugel, Joseph P Sanderson, Andrew B Gerry

{"title":"Enhancing Efficacy of TCR-engineered CD4 + T Cells Via Coexpression of CD8α.","authors":"Victoria E Anderson, Sara S Brilha, Anika M Weber, Annette Pachnio, Guy E Wiedermann, Sumaya Dauleh, Tina Ahmed, George R Pope, Laura L Quinn, Roslin Y Docta, Adriano Quattrini, Siobhan Masters, Neil Cartwright, Preetha Viswanathan, Luca Melchiori, Louise V Rice, Alexandra Sevko, Claire Gueguen, Manoj Saini, Barbara Tavano, Rachel J M Abbott, Jonathan D Silk, Bruno Laugel, Joseph P Sanderson, Andrew B Gerry","doi":"10.1097/CJI.0000000000000456","DOIUrl":"https://doi.org/10.1097/CJI.0000000000000456","url":null,"abstract":"Adoptive cell therapy with T cells expressing affinity-enhanced T-cell receptors (TCRs) is a promising treatment for solid tumors. Efforts are ongoing to further engineer these T cells to increase the depth and durability of clinical responses and broaden efficacy toward additional indications. In the present study, we investigated one such approach: T cells were transduced with a lentiviral vector to coexpress an affinity-enhanced HLA class I-restricted TCR directed against MAGE-A4 alongside a CD8α coreceptor. We hypothesized that this approach would enhance CD4 + T-cell helper and effector functions, possibly leading to a more potent antitumor response. Activation of transduced CD4 + T cells was measured by detecting CD40 ligand expression on the surface and cytokine and chemokine secretion from CD4 + T cells and dendritic cells cultured with melanoma-associated antigen A4 + tumor cells. In addition, T-cell cytotoxic activity against 3-dimensional tumor spheroids was measured. Our data demonstrated that CD4 + T cells coexpressing the TCR and CD8α coreceptor displayed enhanced responses, including CD40 ligand expression, interferon-gamma secretion, and cytotoxic activity, along with improved dendritic cell activation. Therefore, our study supports the addition of the CD8α coreceptor to HLA class I-restricted TCR-engineered T cells to enhance CD4 + T-cell functions, which may potentially improve the depth and durability of antitumor responses in patients.","PeriodicalId":15996,"journal":{"name":"Journal of Immunotherapy","volume":"46 4","pages":"132-144"},"PeriodicalIF":3.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/50/ca/cji-46-132.PMC10072215.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10124919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Immune Co-inhibitory Receptors CTLA-4, PD-1, TIGIT, LAG-3, and TIM-3 in Upper Tract Urothelial Carcinomas: A Large Cohort Study. 免疫共抑制受体CTLA-4、PD-1、TIGIT、LAG-3和TIM-3在上尿路上皮癌中的作用:一项大型队列研究

IF 3.9 4区医学

Journal of Immunotherapy Pub Date : 2023-05-01 DOI: 10.1097/CJI.0000000000000466

Shengming Jin, Zhi Shang, Wenwen Wang, Chengyuan Gu, Yu Wei, Yu Zhu, Chen Yang, Tiantian Zhang, Yao Zhu, Yiping Zhu, Junlong Wu, Dingwei Ye

{"title":"Immune Co-inhibitory Receptors CTLA-4, PD-1, TIGIT, LAG-3, and TIM-3 in Upper Tract Urothelial Carcinomas: A Large Cohort Study.","authors":"Shengming Jin, Zhi Shang, Wenwen Wang, Chengyuan Gu, Yu Wei, Yu Zhu, Chen Yang, Tiantian Zhang, Yao Zhu, Yiping Zhu, Junlong Wu, Dingwei Ye","doi":"10.1097/CJI.0000000000000466","DOIUrl":"https://doi.org/10.1097/CJI.0000000000000466","url":null,"abstract":"Programmed cell death 1 ligand 1), programmed cell death protein-1 (PD-1), cytotoxic T-lymphocyte antigen 4 (CTLA-4), T-cell immunoglobulin and mucin-domain containing-3, lymphocyte activation gene-3, and T-cell immunoglobulin and ITIM domain (TIGIT) are considered major immune co-inhibitory receptors (CIRs) and the most promising immunotherapeutic targets in cancer treatment, but they are largely unexplored in upper tract urothelial carcinoma (UTUC). The aim of this Cohort Study was to provide evidence concerning expression profiles and the clinical significance of CIRs among Chinese UTUC patients. A total of 175 UTUC patients who received radical surgery in our center were included. We used immunohistochemistry to evaluate CIR expressions in tissue microarrays (TMAs). Clinicopathological characteristics and prognostic correlations of CIR proteins were retrospectively analyzed. TIGIT, T-cell immunoglobulin and mucin-domain containing-3, PD-1, CTLA-4, Programmed cell death 1 ligand 1, and lymphocyte activation gene-3 high expression was examined in 136(77.7%), 86(49.1%), 57(32.6%), 18(10.3%), 28(16.0%), and 18(10.3%) patients, respectively. Log-rank tests and Multivariate Cox analysis both implied CTLA-4 and TIGIT expression was associated with worse relapse-free survival. In conclusion, this is the largest Chinese UTUC cohort study, and we analyzed the Co-inhibitory receptor expression profiles in UTUC. We identified CTLA-4 and TIGIT expression as promising biomarkers for tumor recurrence. Furthermore, a subset of advanced UTUCs are probably immunogenic, for which single or combined immunotherapy may be potential therapeutic approaches in the future.","PeriodicalId":15996,"journal":{"name":"Journal of Immunotherapy","volume":"46 4","pages":"154-159"},"PeriodicalIF":3.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/24/bd/cji-46-154.PMC10072209.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10135298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

COVID-19: Attacks Immune Cells and Interferences With Antigen Presentation Through MHC-Like Decoy System. COVID-19:通过mhc样诱饵系统攻击免疫细胞并干扰抗原呈递

IF 3.9 4区医学

Journal of Immunotherapy Pub Date : 2023-04-01 DOI: 10.1097/CJI.0000000000000455

Wenzhong Liu, Hualan Li

{"title":"COVID-19: Attacks Immune Cells and Interferences With Antigen Presentation Through MHC-Like Decoy System.","authors":"Wenzhong Liu, Hualan Li","doi":"10.1097/CJI.0000000000000455","DOIUrl":"https://doi.org/10.1097/CJI.0000000000000455","url":null,"abstract":"The high mortality of coronavirus disease 2019 is related to poor antigen presentation and lymphopenia. Cytomegalovirus and the herpes family encode a series of major histocompatibility complex (MHC)-like molecules required for targeted immune responses to achieve immune escape. In this present study, domain search results showed that many proteins of the severe acute respiratory syndrome coronavirus 2 virus had MHC-like domains, which were similar to decoys for the human immune system. MHC-like structures could bind to MHC receptors of immune cells (such as CD4 + T-cell, CD8 + T-cell, and natural killer-cell), interfering with antigen presentation. Then the oxygen free radicals generated by E protein destroyed immune cells after MHC-like of S protein could bind to them. Mutations in the MHC-like region of the viral proteins such as S promoted weaker immune resistance and more robust transmission. S 127-194 were the primary reason for the robust transmission of delta variants. The S 144-162 regulated the formation of S trimer. The mutations of RdRP: G671S and N: D63G of delta variant caused high viral load. S 62-80 of alpha, beta, lambda variants were the important factor for fast-spreading. S 616-676 and 1014-1114 were causes of high mortality for gamma variants infections. These sites were in the MHC-like structure regions.","PeriodicalId":15996,"journal":{"name":"Journal of Immunotherapy","volume":"46 3","pages":"75-88"},"PeriodicalIF":3.9,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9987643/pdf/cji-46-75.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10134802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Elevated PD-L1 Expression and Microsatellite Instability in Elderly Patients With Gastric Cancer. 老年胃癌患者PD-L1表达升高及微卫星不稳定性。

IF 3.9 4区医学

Journal of Immunotherapy Pub Date : 2023-04-01 DOI: 10.1097/CJI.0000000000000458

Tien-Hua Chen, Ming-Huang Chen, Yi-Ping Hung, Nai-Jung Chiang, Kuo-Hung Huang, Yi-Hsiang Lin, Ryan Weihsiang Lin, Yee Chao, Anna Fen-Yau Li, Hung-Yuan Yu, Hsuen-En Hwang, Yi-Chen Yeh, Yu-Chao Wang, Wen-Liang Fang

{"title":"Elevated PD-L1 Expression and Microsatellite Instability in Elderly Patients With Gastric Cancer.","authors":"Tien-Hua Chen, Ming-Huang Chen, Yi-Ping Hung, Nai-Jung Chiang, Kuo-Hung Huang, Yi-Hsiang Lin, Ryan Weihsiang Lin, Yee Chao, Anna Fen-Yau Li, Hung-Yuan Yu, Hsuen-En Hwang, Yi-Chen Yeh, Yu-Chao Wang, Wen-Liang Fang","doi":"10.1097/CJI.0000000000000458","DOIUrl":"https://doi.org/10.1097/CJI.0000000000000458","url":null,"abstract":"Immunotherapy in combination with chemotherapy is the current treatment of choice for frontline programmed cell death ligand 1 (PD-L1)-positive gastric cancer. However, the best treatment strategy remains an unmet medical need for elderly or fragile patients with gastric cancer. Previous studies have revealed that PD-L1 expression, Epstein-Barr virus association, and microsatellite instability-high (MSI-H) are the potential predictive biomarkers for immunotherapy use in gastric cancer. In this study, we showed that PD-L1 expression, tumor mutation burden, and the proportion of MSI-H were significantly elevated in elderly patients with gastric cancer who were older than 70 years compared with patients younger than 70 years from analysis of The Cancer Genome Atlas gastric adenocarcinoma cohort [≥70/<70: MSI-H: 26.8%/15.0%, P =0.003; tumor mutation burden: 6.7/5.1 Mut/Mb, P =0.0004; PD-L1 mRNA: 5.6/3.9 counts per million mapped reads, P =0.005]. In our real-world study, 416 gastric cancer patients were analyzed and showed similar results (≥70/<70: MSI-H: 12.5%/6.6%, P =0.041; combined positive score ≥1: 38.1%/21.5%, P <0.001). We also evaluated 16 elderly patients with gastric cancer treated with immunotherapy and revealed an objective response of 43.8%, a median overall survival of 14.8 months, and a median progression-free survival of 7.0 months. Our research showed that a durable clinical response could be expected when treating elderly patients with gastric cancer with immunotherapy, and this approach is worth further study.","PeriodicalId":15996,"journal":{"name":"Journal of Immunotherapy","volume":"46 3","pages":"111-119"},"PeriodicalIF":3.9,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10124912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Cell-based Luciferase Reporter Platform for the Development and Characterization of T-Cell Redirecting Therapies and Vaccine Development. 一种新的基于细胞的荧光素酶报告平台，用于开发和表征t细胞重定向疗法和疫苗开发。

IF 3.9 4区医学

Journal of Immunotherapy Pub Date : 2023-04-01 DOI: 10.1097/CJI.0000000000000453

Jamison Grailer, Zhijie Jey Cheng, Jim Hartnett, Michael Slater, Frank Fan, Mei Cong

{"title":"A Novel Cell-based Luciferase Reporter Platform for the Development and Characterization of T-Cell Redirecting Therapies and Vaccine Development.","authors":"Jamison Grailer, Zhijie Jey Cheng, Jim Hartnett, Michael Slater, Frank Fan, Mei Cong","doi":"10.1097/CJI.0000000000000453","DOIUrl":"https://doi.org/10.1097/CJI.0000000000000453","url":null,"abstract":"T-cell immunotherapies are promising strategies to generate T-cell responses towards tumor-derived or pathogen-derived antigens. Adoptive transfer of T cells genetically modified to express antigen receptor transgenes has shown promise for the treatment of cancer. However, the development of T-cell redirecting therapies relies on the use of primary immune cells and is hampered by the lack of easy-to-use model systems and sensitive readouts to facilitate candidate screening and development. Particularly, testing T-cell receptor (TCR)-specific responses in primary T cells and immortalized T cells is confounded by the presence of endogenous TCR expression which results in mixed alpha/beta TCR pairings and compresses assay readouts. Herein, we describe the development of a novel cell-based TCR knockout (TCR-KO) reporter assay platform for the development and characterization of T-cell redirecting therapies. CRISPR/Cas9 was used to knockout the endogenous TCR chains in Jurkat cells stably expressing a human interleukin-2 promoter-driven luciferase reporter gene to measure TCR signaling. Reintroduction of a transgenic TCR into the TCR-KO reporter cells results in robust antigen-specific reporter activation compared with parental reporter cells. The further development of CD4/CD8 double-positive and double-negative versions enabled low-avidity and high-avidity TCR screening with or without major histocompatibility complex bias. Furthermore, stable TCR-expressing reporter cells generated from TCR-KO reporter cells exhibit sufficient sensitivity to probe in vitro T-cell immunogenicity of protein and nucleic acid-based vaccines. Therefore, our data demonstrated that TCR-KO reporter cells can be a useful tool for the discovery, characterization, and deployment of T-cell immunotherapy.","PeriodicalId":15996,"journal":{"name":"Journal of Immunotherapy","volume":"46 3","pages":"96-106"},"PeriodicalIF":3.9,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7a/28/cji-46-96.PMC9988225.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10131959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk Factors for Refractory Immune Checkpoint Inhibitor-related Pneumonitis in Patients With Lung Cancer: Erratum. 肺癌患者发生难治性免疫检查点抑制剂相关肺炎的风险因素：勘误。

IF 3.2 4区医学

Journal of Immunotherapy Pub Date : 2023-04-01 Epub Date: 2023-03-08 DOI: 10.1097/CJI.0000000000000462

引用次数: 0

Pembrolizumab-Induced Acral Vasculitis. 派姆单抗诱导的肢端血管炎。

IF 3.9 4区医学

Journal of Immunotherapy Pub Date : 2023-04-01 DOI: 10.1097/CJI.0000000000000457

Binoy Yohannan, Tate Truly, Jaya Kala, Syed Hasan Jafri

{"title":"Pembrolizumab-Induced Acral Vasculitis.","authors":"Binoy Yohannan, Tate Truly, Jaya Kala, Syed Hasan Jafri","doi":"10.1097/CJI.0000000000000457","DOIUrl":"https://doi.org/10.1097/CJI.0000000000000457","url":null,"abstract":"Immune checkpoint inhibitors (ICIs) have emerged as groundbreaking new therapies for a variety of solid tumors. ICIs stimulate the host immune system to attack cancer cells. However, this nonspecific immune activation can cause autoimmunity across multiple organ systems-this is referred to as an immune-related adverse event. Vasculitis secondary to ICI administration is an extremely rare event seen in <1% of cases. We identified 2 cases of pembrolizumab-induced acral vasculitis at our institution. The first patient, with stage IV adenocarcinoma of the lung, developed antinuclear antibody-positive vasculitis 4 months after initiation of treatment with pembrolizumab. The second patient had stage IV oropharyngeal cancer and presented with acral vasculitis 7 months after starting pembrolizumab. Unfortunately, both cases resulted in dry gangrene and poor outcomes. Here, we discuss the incidence, pathophysiology, clinical features, treatment, and prognosis of patients with ICI-induced vasculitis with the intention of raising awareness about this rare and potentially fatal immune-related adverse event. Early diagnosis and discontinuation of ICIs are critical for improving clinical outcomes in this situation.","PeriodicalId":15996,"journal":{"name":"Journal of Immunotherapy","volume":"46 3","pages":"107-110"},"PeriodicalIF":3.9,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10131963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Engineered CAR T Cells Targeting Tumor-Associated Glycoforms of MUC1 for the Treatment of Intrahepatic Cholangiocarcinoma. 靶向MUC1肿瘤相关糖型的工程化CAR - T细胞治疗肝内胆管癌

IF 3.9 4区医学

Journal of Immunotherapy Pub Date : 2023-04-01 DOI: 10.1097/CJI.0000000000000460

Li Mao, Sheng Su, Jia Li, Songyang Yu, Yu Gong, Changzhou Chen, Zhiqiang Hu, Xiaowu Huang

{"title":"Development of Engineered CAR T Cells Targeting Tumor-Associated Glycoforms of MUC1 for the Treatment of Intrahepatic Cholangiocarcinoma.","authors":"Li Mao, Sheng Su, Jia Li, Songyang Yu, Yu Gong, Changzhou Chen, Zhiqiang Hu, Xiaowu Huang","doi":"10.1097/CJI.0000000000000460","DOIUrl":"https://doi.org/10.1097/CJI.0000000000000460","url":null,"abstract":"Intrahepatic cholangiocarcinoma (ICC) is a common malignancy arising from the liver with limited 5-year survival. Thus, there is an urgency to explore new treatment methods. Chimeric antigen receptor T (CAR T) cell therapy is a very promising cancer treatment. Though, several groups have investigated CAR T cells targeting MUC1 in solid cancer models, Tn-MUC1-targeted CAR T cells have not yet to be reported in ICC. In this study, we confirmed Tn-MUC1 as a potential therapeutic target for ICC and demonstrated that its expression level was positively correlated with the poor prognosis of ICC patients. More importantly, we successfully developed effective CAR T cells to target Tn-MUC1-positive ICC tumors and explored their antitumor activities. Our results suggest the CAR T cells could specifically eliminate Tn-MUC1-positive ICC cells, but not Tn-MUC1-negative ICC cells, in vitro and in vivo. Therefore, our study is expected to provide new therapeutic strategies and ideas for the treatment of ICC.","PeriodicalId":15996,"journal":{"name":"Journal of Immunotherapy","volume":"46 3","pages":"89-95"},"PeriodicalIF":3.9,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8b/05/cji-46-89.PMC9988215.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10507219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Pustular Lichenoid Eruptions Induced by Immune Checkpoint Inhibitors: Two Case Reports and a Review of the Literature. 免疫检查点抑制剂引起的脓疱性地衣样疹:两例报告和文献综述。

IF 3.9 4区医学

Journal of Immunotherapy Pub Date : 2023-02-01 DOI: 10.1097/CJI.0000000000000449

Charlotte Emonet, Florence Tétart, Olivia Bauvin, Lucie Cellier, Philippe Courville, Claire Mignard, Raphaël Janela-Lapert, Alexis Lefebvre, Samy Lachkar, Diane Lechevalier, Laurence Lagarce, Priscille Carvalho, Billal Tedbirt

{"title":"Pustular Lichenoid Eruptions Induced by Immune Checkpoint Inhibitors: Two Case Reports and a Review of the Literature.","authors":"Charlotte Emonet, Florence Tétart, Olivia Bauvin, Lucie Cellier, Philippe Courville, Claire Mignard, Raphaël Janela-Lapert, Alexis Lefebvre, Samy Lachkar, Diane Lechevalier, Laurence Lagarce, Priscille Carvalho, Billal Tedbirt","doi":"10.1097/CJI.0000000000000449","DOIUrl":"https://doi.org/10.1097/CJI.0000000000000449","url":null,"abstract":"Immune checkpoint inhibitors (ICIs) have become the standard treatment for many types of cancer. After several years of using these therapies, many adverse events related to ICIs have been observed. Dermatologic toxicities such as nonspecific morbilliform rash, vitiligo, Stevens-Johnson syndrome/toxic epidermal necrolysis, and more rarely, lichenoid eruptions have been described in the literature. We report 2 cases of pustular lichenoid eruptions, 1 in a patient with nonsmall cell lung carcinoma and 1 in a patient with metastatic melanoma, induced by pembrolizumab and nivolumab, respectively. The 2 patients were treated with topical corticosteroids, and complete healing of lesions was slowly obtained. Due to the severity of the cutaneous eruptions, pembrolizumab and nivolumab were discontinued. We identified 6 cases of pustular lichenoid eruptions induced by ICIs in the published literature and in the French Pharmacovigilance Database and reviewed their main clinical features and courses.","PeriodicalId":15996,"journal":{"name":"Journal of Immunotherapy","volume":"46 2","pages":"59-63"},"PeriodicalIF":3.9,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10786769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Haploidentical γδ T Cells Induce Complete Remission in Chemorefractory B-cell Non-Hodgkin Lymphoma. 单倍体γδ T细胞诱导化疗难治性b细胞非霍奇金淋巴瘤完全缓解

IF 3.9 4区医学

Journal of Immunotherapy Pub Date : 2023-02-01 DOI: 10.1097/CJI.0000000000000450

Anna Bold, Johannes Gaertner, Alexander Bott, Volker Mordstein, Kerstin Schaefer-Eckart, Martin Wilhelm

{"title":"Haploidentical γδ T Cells Induce Complete Remission in Chemorefractory B-cell Non-Hodgkin Lymphoma.","authors":"Anna Bold, Johannes Gaertner, Alexander Bott, Volker Mordstein, Kerstin Schaefer-Eckart, Martin Wilhelm","doi":"10.1097/CJI.0000000000000450","DOIUrl":"https://doi.org/10.1097/CJI.0000000000000450","url":null,"abstract":"The transformation of chronic lymphocytic leukemia to an aggressive lymphoma, called Richter transformation, is often accompanied by resistance to chemotherapy and high mortality. Thus, novel therapeutic strategies are required for the successful treatment of these patients. One possibility is cellular immunotherapy with chimeric antigen receptor T cells. However, the time delay until cells are available and the limited number of effector cells due to the impaired immune system of these patients potentially compromises the efficacy of this approach. Another promising attempt might be the therapy with γδ T cells. Once activated, they exhibit various antitumor effects against several types of malignancies. Furthermore, they can be safely used in an allogeneic setting and can be multiplied in vivo as already demonstrated in clinical studies. In vitro data, in addition, show that the cytotoxicity of γδ T cells can be significantly enhanced by monoclonal antibodies. Here we present a patient, who suffered from Richter transformation and did not respond to several lines of immunochemotherapy. Due to the lack of further therapy options, we conducted an individual therapy with adoptive transfer of haploidentical γδ T cells combined with the application of the monoclonal antibody obinutuzumab. A histologically confirmed complete remission was achieved through this therapy approach, whereby relevant side effects were not seen. This case highlights the potential of γδ T cells and the feasibility of this therapeutic approach for further clinical trials.","PeriodicalId":15996,"journal":{"name":"Journal of Immunotherapy","volume":"46 2","pages":"56-58"},"PeriodicalIF":3.9,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4a/2c/cji-46-56.PMC9889192.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10736706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2