1993 IEEE Annual Northeast Bioengineering Conference最新文献_第10页

A simulation study of the LETI TTV03 TOF PET scanner LETI TTV03型TOF PET扫描仪的仿真研究

1993 IEEE Annual Northeast Bioengineering Conference Pub Date : 1993-03-18 DOI: 10.1109/NEBC.1993.404364

G. Tzanakos, S. Pavlopoulos

引用次数: 1

Follow-up computerized study of Clozaril therapy 氯萨瑞治疗的随访计算机化研究

1993 IEEE Annual Northeast Bioengineering Conference Pub Date : 1993-03-18 DOI: 10.1109/NEBC.1993.404357

M. T. Ortiz, K. Kozma

引用次数: 0

Facilitatory effect of thinking about movement on motor evoked potentials to transcranial magnetic stimulation of the brain 运动思维对经颅磁刺激下运动诱发电位的促进作用

1993 IEEE Annual Northeast Bioengineering Conference Pub Date : 1993-03-18 DOI: 10.1109/NEBC.1993.404429

Shin-lchi lzumi, T. Findley, T. Ikai, J. Andrews, M. Daum, N. Chino

引用次数: 54

A computer assisted receptor mapping approach to the design of anti-AIDS agents directed at HIV reverse transcriptase 针对HIV逆转录酶的抗艾滋病药物设计的计算机辅助受体定位方法

1993 IEEE Annual Northeast Bioengineering Conference Pub Date : 1993-03-18 DOI: 10.1109/NEBC.1993.404373

M. A. Fisher, P. Yadav, J. Yadav, S. Laxminarayan, D. Kristol, M. Modak

{"title":"A computer assisted receptor mapping approach to the design of anti-AIDS agents directed at HIV reverse transcriptase","authors":"M. A. Fisher, P. Yadav, J. Yadav, S. Laxminarayan, D. Kristol, M. Modak","doi":"10.1109/NEBC.1993.404373","DOIUrl":"https://doi.org/10.1109/NEBC.1993.404373","url":null,"abstract":"The authors take a pharmacophoric approach to the identification of a substrate/inhibitor binding site on HIV-1 RT. A pharmacophore is defined as the spatial arrangement of a set of atoms or groups in a ligand molecule while bound to a given receptor. The pharmacophore's usefulness is in the assumption that a single one exists for a series of compounds binding at the same receptor site. The superposition of a series of substrate and/or inhibitors along a pharmacophoric pattern provides an enzyme excluded volume, which represents a minimum volume requirement for substrate/inhibitors at the receptor binding site. The structure of HIV-1 RT complexed with dsDNA template-primer has been recently described at 7 /spl Aring/ resolution and is currently being extended to 3 /spl Aring/. The combination of crystallographic, pharmacophoric, and existing biochemical and genetic data regarding the substrate binding residues will help to generate an accurate structure of the substrate binding domain of HIV-1 RT and aid in the evaluation of new and specific RT inhibitors.<<ETX>>","PeriodicalId":159783,"journal":{"name":"1993 IEEE Annual Northeast Bioengineering Conference","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1993-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134462110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calculation of mechanical energy cost in a simple model of human walking 人类行走简单模型中机械能消耗的计算

1993 IEEE Annual Northeast Bioengineering Conference Pub Date : 1993-03-18 DOI: 10.1109/NEBC.1993.404392

H. Lacker, H. Chaudhry, T. Choi, W. Boda, W. Tapp, S. Reisman, T. Findley, P. Engler

引用次数: 4

Integration of hypertext and object-oriented databases for information retrieval 超文本和面向对象数据库的信息检索集成

1993 IEEE Annual Northeast Bioengineering Conference Pub Date : 1993-03-18 DOI: 10.1109/NEBC.1993.404355

G. Rao, V. Balasubramanian, B. A. Suresh

引用次数: 5

Real-time in vitro observation of cavitation on prosthetic heart valves 人工心脏瓣膜空化的实时体外观察

1993 IEEE Annual Northeast Bioengineering Conference Pub Date : 1991-07-01 DOI: 10.1109/NEBC.1993.404378

C. Zapanta, E. Liszka, D. Stinebring, S. Deutsch, D. Geselowitz, J. Tarbell

引用次数: 29