Journal of geriatric oncology最新文献

{"title":"The care of older patients with cancer across the United Kingdom in 2024: A narrative review by the International Society of Geriatric Oncology UK Country Group","authors":"Fabio Gomes ,&nbsp;Naomi Farrington ,&nbsp;Jessica Pearce ,&nbsp;Daniel Swinson ,&nbsp;Jenny Welford ,&nbsp;Alastair Greystoke ,&nbsp;Mark Baxter ,&nbsp;Alana G. Brown-Kerr ,&nbsp;Lynda Wyld ,&nbsp;Jenna Morgan ,&nbsp;Nicolò Matteo Luca Battisti ,&nbsp;Anne Barrell ,&nbsp;David Cobben ,&nbsp;Anthea Cree ,&nbsp;Mark Johnston ,&nbsp;Kirsty Colquhoun ,&nbsp;Iain Phillips ,&nbsp;Jemima Smith ,&nbsp;Simon Stapley ,&nbsp;Lisa Lyons ,&nbsp;Kwok-Leung Cheung","doi":"10.1016/j.jgo.2024.102133","DOIUrl":"10.1016/j.jgo.2024.102133","url":null,"abstract":"<div><div>The worldwide population is ageing, alongside an increase in cancer incidence rates. Over the past 10 years, there has been huge progress in the field of oncology with earlier diagnosis and an expansion of treatment options, leading to a growing number of older people living with cancer. That has meant that caring for older patients with cancer is now part of day-to-day oncology practices. This cohort often has geriatric syndromes and a higher prevalence of frailty and complex needs and preparing our clinical services to optimise care for these patients is essential. Whilst it is widely accepted that comprehensive geriatric assessments are of benefit to patients, only a small proportion of patients can access these through specialised teams during their cancer care. In the past few years there has been significant progress in this field throughout the United Kingdom (UK). The goal of this review is to inform other health care systems how to learn from what has been done in the UK. This paper provides an update from our previous review in 2020, detailing the new services being implemented and made available to patients and an expansion in the number of new pilot teams and research projects/trials throughout the four nations of the UK.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 1","pages":"Article 102133"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotional impact of cancer from a patient's perspective","authors":"Ann Pennella","doi":"10.1016/j.jgo.2024.102155","DOIUrl":"10.1016/j.jgo.2024.102155","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 1","pages":"Article 102155"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geriatric assessment in older adults with metastatic breast cancer: A pilot study","authors":"Kaitlyn Kwok ,&nbsp;Bryn Rahusaar Routledge ,&nbsp;Kristen Haase ,&nbsp;Gregory Arbour ,&nbsp;Tracy Zhang ,&nbsp;Janet Kow ,&nbsp;Stephen Chia ,&nbsp;Caroline Mariano","doi":"10.1016/j.jgo.2024.102131","DOIUrl":"10.1016/j.jgo.2024.102131","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 1","pages":"Article 102131"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of lifestyle interventions on sarcopenia in advanced colorectal cancer: A systematic review","authors":"David Burke ,&nbsp;Malcolm Brown ,&nbsp;Conor O'Neill ,&nbsp;Helen G. Coleman ,&nbsp;Tilman Kuhn ,&nbsp;Sabrina Schlesinger ,&nbsp;Gillian Prue ,&nbsp;Vicky Coyle","doi":"10.1016/j.jgo.2024.102143","DOIUrl":"10.1016/j.jgo.2024.102143","url":null,"abstract":"<div><h3>Introduction</h3><div>Sarcopenia is a common syndrome in older patients with advanced colorectal cancer that is worsened during standard-of-care chemotherapy and is associated with increased chemotherapy toxicity, impaired quality of life, and poorer survival independent of cancer stage or chemotherapy response. Physical activity and nutrition interventions have been shown to support muscle mass in patients recovering from treatment for early-stage colorectal cancer. The aim of this present review was to evaluate the effect of physical activity and nutritional interventions on sarcopenia in patients with advanced colorectal cancer.</div></div><div><h3>Materials and Methods</h3><div>We performed a systematic literature review of studies investigating the impact of physical activity and nutritional interventions on muscle mass in patients with advanced colorectal cancer. Relevant key words were searched in appropriate databases through December 2022. Review procedures were performed in line with guidelines from the Cochrane Handbook for systematic reviews and Synthesis Without Meta-analysis (SWiM) guidelines.</div></div><div><h3>Results</h3><div>Twelve studies were identified with 1461 participants of which 587 had advanced colorectal cancer. Eight studies were randomised controlled trials (RCTs). Only two studies exclusively reported on the population with advanced colorectal cancer. Physical activity and nutritional interventions explored were heterogenous. Studies reporting an improvement in muscle mass utilised protein supplementation (one study), moderate intensity aerobic exercise (one study), and assisted resistance training (two studies). However, only a small number of participants with advanced colorectal cancer were included in these studies. Risk of bias was moderate to high for most studies. Recruitment to physical activity interventions was often low although adherence to supervised interventions was high. Physical activity and nutritional interventions across studies were safe.</div></div><div><h3>Discussion</h3><div>A small number of studies with limited sample size and moderate-to-high risk of bias suggest that assisted resistance training and supported protein intake improve muscle mass in participants with cancer. However, there is currently sparse evidence for the effect of physical activity and nutritional interventions on sarcopenia in the setting of advanced and incurable colorectal cancer. Given the impact of sarcopenia in this population, further research in this area is warranted.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 1","pages":"Article 102143"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age disparities in clinical trials of poly (ADP-ribose) polymerase (PARP) inhibitors in patients with high grade serous ovarian cancer: A wake up call to improving outcomes in older patients","authors":"Omali Pitiyarachchi ,&nbsp;Michael Friedlander","doi":"10.1016/j.jgo.2024.102152","DOIUrl":"10.1016/j.jgo.2024.102152","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 1","pages":"Article 102152"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“I have a doctor that handles all the other stuff.” Perceptions of older adults with cancer about discussing aging-related conditions with their oncologists","authors":"Sindhuja Kadambi ,&nbsp;Lee Kehoe ,&nbsp;Megan Wells ,&nbsp;Amita Patil ,&nbsp;Lianlian Lei ,&nbsp;Marquita Wenonah Lewis-Thames ,&nbsp;Anna Job ,&nbsp;Yingzi Zhang PhD ,&nbsp;Marie Flannery ,&nbsp;Nikesha Gilmore ,&nbsp;Victor G. Vogel ,&nbsp;Tony Philip ,&nbsp;Judith O. Hopkins ,&nbsp;Mary Whitehead ,&nbsp;Allison Magnuson ,&nbsp;Supriya Mohile ,&nbsp;Sally A. Norton","doi":"10.1016/j.jgo.2024.102065","DOIUrl":"10.1016/j.jgo.2024.102065","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 1","pages":"Article 102065"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Falls in older adults during treatment for metastatic castration-resistant prostate cancer","authors":"Saul Cobbing ,&nbsp;Narhari Timilshina ,&nbsp;George Tomlinson ,&nbsp;Helen Yang ,&nbsp;Valerie S. Kim ,&nbsp;Urban Emmenegger ,&nbsp;Shabbir M.H. Alibhai","doi":"10.1016/j.jgo.2024.102047","DOIUrl":"10.1016/j.jgo.2024.102047","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 1","pages":"Article 102047"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review of nutrition interventions in older patients with cancer: A synthesis of evidence and a future research priority.","authors":"Brenton J Baguley, Hannah Arnold, Ashlee Bence, Emma Bryant, Eliza Martino, Kiara Stojanoski, Samantha Ackerly, Erin Laing, Jessica Jong, Nicole Kiss, Jenelle Loeliger","doi":"10.1016/j.jgo.2024.102181","DOIUrl":"https://doi.org/10.1016/j.jgo.2024.102181","url":null,"abstract":"<p><strong>Introduction: </strong>Older patients with cancer (65 years and older) are a growing population with unique nutrition-and treatment-related issues that accelerate aging. Nutrition interventions attenuate nutritional decline, muscle loss, and risk of malnutrition and sarcopenia in patients with cancer, however the evidence for older patients with cancer is limited. The aim of this systematic review was to evaluate the efficacy of nutrition interventions on nutritional status, body weight/composition and clinical outcomes in older patients with cancer and to identify future research priority areas.</p><p><strong>Materials and methods: </strong>Three databases were systematically searched from inception until January 2024. Eligible studies were randomised controlled trials (RCT) evaluating a nutrition intervention in older patients with cancer that reported nutrition-related and clinical outcomes. Studies including older patients were determined by the mean age ≥ 65 years with the error to the mean > 60 years. Between-group differences in nutritional and clinical outcomes were extracted.</p><p><strong>Results: </strong>Eleven studies describing nine RCTs were included in this review. Three trials specifically included patients 65 years and older. Most interventions intended to reduce malnutrition risk across a mix of cancer types and treatments, and one trial was designed to reduce comorbidities after treatment. Changes in dietary intake (n = 4), nutrition status (n = 1), weight (n = 5), and muscle mass (n = 3) were inconsistently reported, but preliminary evidence showed dietary counselling with oral nutrition supplements (ONS) resulted in improved weight maintenance in patients with pancreatic cancer. There was limited evidence of a benefit from nutrition interventions on treatment tolerance or quality of life. The heterogeneous findings in methodological design, including dietary prescription and frequency of consultations and reporting of outcomes, inhibits evidence-based recommendations for older adults with cancer.</p><p><strong>Discussion: </strong>Nutrition interventions designed specifically to address nutrition-related issues unique to older patients with cancer is a clear research priority. Research specifically targeting older patients post treatment, a period during which treatment-related side effects still occur, is limited. To support the growing population of older patients with cancer, future research must consistently report the dietary prescription, adherence to nutritional requirements, and clearly-defined nutrition-related parameters and clinical outcomes that are specific to older patients.</p>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":" ","pages":"102181"},"PeriodicalIF":3.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Daily life mobility detects frailty, falls, and functioning in older prostate cancer survivors treated with androgen deprivation therapy","authors":"Deanne C. Tibbitts ,&nbsp;Martina Mancini ,&nbsp;Sydnee Stoyles ,&nbsp;Nathan F. Dieckmann ,&nbsp;Julie N. Graff ,&nbsp;Mahmoud El-Gohary ,&nbsp;Fay B. Horak ,&nbsp;Kerri M. Winters-Stone","doi":"10.1016/j.jgo.2024.102180","DOIUrl":"10.1016/j.jgo.2024.102180","url":null,"abstract":"<div><h3>Introduction</h3><div>Androgen deprivation therapy (ADT) increases the risk of frailty, falls, and poor physical functioning in older adults with prostate cancer. Detection of frailty is limited to self-report instruments and performance measures, so unbiased tools are needed. We investigated relationships between an unbiased measure – daily life mobility – and ADT history, frailty, fall history, and functioning in older prostate cancer survivors treated with ADT.</div></div><div><h3>Materials and Methods</h3><div>This cross-sectional study recruited prostate cancer survivors with a history of ADT from an exercise clinical trial, an academic medical center, and the community. Participants completed performance measures and surveys to assess frailty, fall history, and physical functioning, then wore instrumented socks for up to seven days to continuously monitor daily life mobility. We performed a principal component analysis on daily life mobility metrics and used regression analyses to investigate relationships between domains of daily life mobility and frailty, fall history, and physical functioning.</div></div><div><h3>Results</h3><div>Participants (<em>N</em> = 99) were aged 73.0 +/− 7.3 years, most were pre-frail or frail (75 %), and 35 % had fallen at least once in the last year. Daily life mobility metrics clustered into four domains: Gait Pace, Rhythm, Activity, and Balance. Worse scores on Rhythm and Activity were associated with increased odds of frailty (odds ratio [OR] 1.59, 95 % confidence interval [CI]: 1.04, 2.49 and OR 1.81, 95 % CI: 1.19, 2.83, respectively). A worse score on Rhythm was associated with increased odds of ≥1 falls in the previous year (OR 1.60, 95 % CI: 1.05, 2.47). Worse scores on Gait Pace, Rhythm, and Activity were associated with worse physical functioning. Mobility metrics were similar between current and past users of ADT.</div></div><div><h3>Discussion</h3><div>Continuous passive monitoring of daily life mobility may identify prostate cancer survivors who have developed frailty, falls, and declines in physical functioning.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 2","pages":"Article 102180"},"PeriodicalIF":3.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of p16(INK4a), a biomarker of cellular senescence, with receipt of therapy and frailty status among adults with plasma cell disorders.","authors":"Christopher E Jensen, Allison M Deal, Shweta Srikanth, Kirsten A Nyrop, Natalia Mitin, Matthew R LeBlanc, Hyman B Muss, Samuel M Rubinstein, Sascha A Tuchman, Eben I Lichtman","doi":"10.1016/j.jgo.2024.102174","DOIUrl":"https://doi.org/10.1016/j.jgo.2024.102174","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":" ","pages":"102174"},"PeriodicalIF":3.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}