{"title":"[Death due to asphyxia after tracheotomy: Two case reports].","authors":"晓 亚 衣, 波 李, 欣 黄, 青 波 章","doi":"10.12116/j.issn.1004-5619.2022.420506","DOIUrl":"10.12116/j.issn.1004-5619.2022.420506","url":null,"abstract":"","PeriodicalId":15899,"journal":{"name":"Journal of Forensic Medicine","volume":"39 6","pages":"619-622"},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139478652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Sudden death due to cardiac tamponade caused by coronary artery perforation during coronary stent implanting: A case report].","authors":"国 庆 杜, 志 琴 刘, 帅 杰 刘, 永 华 史","doi":"10.12116/j.issn.1004-5619.2022.421111","DOIUrl":"10.12116/j.issn.1004-5619.2022.421111","url":null,"abstract":"","PeriodicalId":15899,"journal":{"name":"Journal of Forensic Medicine","volume":"39 6","pages":"614-616"},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139478663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xing Han, Xin Liu, Ming-Luo DU, Ruo-Lun Xu, Jia-Rong Li, Chao Liu, Wei-Guo Liu
{"title":"UPLC-MS/MS Method for Detection of Etomidate and Its Metabolite Etomidate Acid Quantity in Blood.","authors":"Xing Han, Xin Liu, Ming-Luo DU, Ruo-Lun Xu, Jia-Rong Li, Chao Liu, Wei-Guo Liu","doi":"10.12116/j.issn.1004-5619.2023.330901","DOIUrl":"10.12116/j.issn.1004-5619.2023.330901","url":null,"abstract":"<p><strong>Objectives: </strong>To establish a method for the simultaneous quantitative analysis of etomidate and its metabolite etomidate acid in blood, and to discuss its application value in actual cases.</p><p><strong>Methods: </strong>Acetonitrile precipitate protein method was used, and C<sub>18</sub> column was selected. Gradient elution was performed with acetonitrile and 5 mmol/L ammonium acetate within 6 min. Electrospray ionization source in positive ion mode was used. The internal standard etomidate acid-d<sub>5</sub> was obtained by etomidate-d<sub>5</sub> alkaline hydrolysis reaction. Ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was used for quantitative analysis. The methodological verification was conducted.</p><p><strong>Results: </strong>Etomidate and etomidate acid in blood showed good linear relationship in the quantitative linear range (<i>r</i>>0.999), with the lower limit of quantification was 2.5 ng/mL and 7.5 ng/mL, respectively. The accuracy, precision, recovery rate, and matrix effect of the method met the professional verification standards. The practical application results showed that etomidate and etomidate acid could be detected in the blood of the abusers, and their mass concentrations ranged from 17.24 to 379.93 ng/mL.</p><p><strong>Conclusions: </strong>The method established in this study can simultaneously quantify etomidate and etomidate acid in blood, which is simple and convenient to operate with accuracy. It can meet the detection needs of actual cases and provide technical support for law enforcement to crack down on etomidate abuse.</p>","PeriodicalId":15899,"journal":{"name":"Journal of Forensic Medicine","volume":"39 6","pages":"564-570"},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139478697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Identification of medical damage in endoscopic therapy of esophageal and gastric fundal varix: Three case reports].","authors":"同 博 焦, 娅 萍 朱, 孟 周 张","doi":"10.12116/j.issn.1004-5619.2022.220902","DOIUrl":"10.12116/j.issn.1004-5619.2022.220902","url":null,"abstract":"","PeriodicalId":15899,"journal":{"name":"Journal of Forensic Medicine","volume":"39 6","pages":"628-631"},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139478657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Forensic Analysis of Eighteen Tubal Pregnancy-Related Medical Damage.","authors":"Ying Li, Yong Yu, Xing-Hua Kou, Zhan-Long Han","doi":"10.12116/j.issn.1004-5619.2022.220707","DOIUrl":"10.12116/j.issn.1004-5619.2022.220707","url":null,"abstract":"<p><strong>Objectives: </strong>To analyze the cases of medical damage after misdiagnosis of tubal pregnancy, to explore the causes of medical damage, the causal relationship between medical malpractice and the damage consequences, as well as the causative potency, in order to provide evaluation ideas for forensic identification of such cases.</p><p><strong>Methods: </strong>Eighteen cases of forensic identification of tubal pregnancy related medical damage were collected and retrospectively analyzed from the aspects of age, maternity history, fertility requirements, risk factors, diagnosis and treatment, medical malpractice, damage consequences, and causative potency.</p><p><strong>Results: </strong>All 18 cases were tubal pregnancy, of which 17 cases had medical malpractice, resulting in 14 cases of affected tubal resection, 2 cases of hemorrhagic shock death, 1 case of intrauterine fetal death and affected tubal resection. The other case had the consequence of affected tubal resection, but there was no malpractice in the treatment.</p><p><strong>Conclusions: </strong>Correct diagnosis is helpful to make appropriate treatment plan, prevent disease progression and reduce serious adverse consequences and the occurrence of medical disputes. Scientific and reasonable analysis of the causal relationship between medical malpractice and damage consequences and the causative potency is of great significance to the successful settlement of medical disputes.</p>","PeriodicalId":15899,"journal":{"name":"Journal of Forensic Medicine","volume":"39 6","pages":"571-578"},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139478687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Modeling Methods and Influencing Factors for Age Estimation Based on DNA Methylation.","authors":"Yi-Hang Huang, Wei-Bo Liang, Hui Jian, Sheng-Qiu Qu","doi":"10.12116/j.issn.1004-5619.2023.530106","DOIUrl":"10.12116/j.issn.1004-5619.2023.530106","url":null,"abstract":"<p><p>Age estimation based on tissues or body fluids is an important task in forensic science. The changes of DNA methylation status with age have certain rules, which can be used to estimate the age of the individuals. Therefore, it is of great significance to discover specific DNA methylation sites and develop new age estimation models. At present, statistical models for age estimation have been developed based on the rule that DNA methylation status changes with age. The commonly used models include multiple linear regression model, multiple quantile regression model, support vector machine model, artificial neural network model, random forest model, etc. In addition, there are many factors that affect the level of DNA methylation, such as the tissue specificity of methylation. This paper reviews these modeling methods and influencing factors for age estimation based on DNA methylation, with a view to provide reference for the establishment of age estimation models.</p>","PeriodicalId":15899,"journal":{"name":"Journal of Forensic Medicine","volume":"39 6","pages":"601-607"},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139478690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}