Journal of gynecology obstetrics and human reproduction最新文献

{"title":"Gestational weight management in women with class III obesity : associations with obstetric and perinatal outcomes","authors":"Hédia Karkar ,&nbsp;Sam Personne ,&nbsp;Mohamed Dakin ,&nbsp;Olivier Graesslin ,&nbsp;Delphine Rousseau ,&nbsp;Soukayna Badaoui ,&nbsp;René Gabriel ,&nbsp;Benjamin Birene","doi":"10.1016/j.jogoh.2025.103082","DOIUrl":"10.1016/j.jogoh.2025.103082","url":null,"abstract":"<div><h3>Background</h3><div>Class III obesity is associated with increased maternal and neonatal complications. Gestational weight gain (GWG) is a modifiable factor that may influence these outcomes, but evidence in women with severe obesity remains limited.</div></div><div><h3>Purpose</h3><div>To evaluate the impact of GWG adherence to the Institute of Medicine (IOM) and Journal of the American Medical Association (JAMA) recommendations on obstetric and neonatal outcomes in women with class III obesity, and to explore the role of nutritional follow-up.</div></div><div><h3>Methods</h3><div>Retrospective, single-center cohort study including women with class III obesity who delivered a singleton at the University Hospital of Reims, France. Women were classified according to whether they exceeded GWG recommendations from IOM (≤9 kg) and JAMA (&lt;6 kg), and by receipt of nutritional counseling. The primary outcome was mode of delivery. Secondary outcomes included maternal, obstetric, and neonatal morbidity.</div></div><div><h3>Main findings</h3><div>Among 300 women, exceeding GWG recommendations was not significantly associated with mode of delivery (IOM p=0.23; JAMA p=0.27). Non-excessive GWG was associated with shorter labor (IOM: 260 vs. 401.5 min, p&lt;0.001), reduced postpartum hemorrhage (IOM: ORa 0.44; 95% CI: 0.20–0.98; p=0.044), lower birthweight, and decreased risk of LGA neonates (IOM: ORa 0.31; 95% CI: 0.11–0.85; p=0.024). Nutritional follow-up was limited, with few women receiving structured guidance.</div></div><div><h3>Conclusions</h3><div>In women with class III obesity, non-excessive GWG according to recommendations does not appear to affect the mode of delivery. It seems to be associated with shorter labor and a lower risk of macrosomia.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 2","pages":"Article 103082"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No roads, no doctors, no missed screenings: The Mafate model in Reunion Island","authors":"Margaux Lebreton ,&nbsp;Martin Willemart ,&nbsp;Julie Marcadet ,&nbsp;Malik Boukerrou ,&nbsp;Capucine Benoit de coignac ,&nbsp;Phuong Lien Tran","doi":"10.1016/j.jogoh.2025.103085","DOIUrl":"10.1016/j.jogoh.2025.103085","url":null,"abstract":"","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 2","pages":"Article 103085"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of pelvic endometriosis on the chances of pregnancy in the context of oocyte donation","authors":"Julie Jourdaine ,&nbsp;Albane Vandecandelaere ,&nbsp;Dorian Bosquet ,&nbsp;Arthur Foulon ,&nbsp;Moncef Ben Khalifa ,&nbsp;Rosalie Cabry ,&nbsp;Florence Scheffler","doi":"10.1016/j.jogoh.2025.103079","DOIUrl":"10.1016/j.jogoh.2025.103079","url":null,"abstract":"<div><h3>Background</h3><div>Endometriosis is diagnosed in 25% to 40% of infertile patients. This disease can affect ovarian reserve and oocyte quality, as a result Assisted Reproductive Technology is often required. However, the influence of endometriosis on implantation rates remains debated. Here, we assessed its impact on the chances of pregnancy following oocyte donation.</div></div><div><h3>Material and methods</h3><div>A single-center retrospective study was conducted at the Picardie Center for the Study and Conservation of Oocytes and Sperm (CECOS de Picardie), Amiens CHU. Patients who received a fresh embryo transfer after from donated oocytes between January 2011 and December 2021 were included. Two groups were defined according to the presence or absence of endometriosis. All patients in the endometriosis group had stage III–IV disease, confirmed surgically or radiologically</div></div><div><h3>Results</h3><div>In total, 175 patients were included, 34 in the endometriosis group and 141 in the control group. Pregnancy rates were comparable between the two groups (29% vs. 37%, <em>p</em> = 0.43) and there were no significant differences in terms of pregnancy outcomes or obstetrical complications (20% vs. 27%, <em>p</em> = 1).</div></div><div><h3>Conclusion</h3><div>In recipients of donated oocytes, advanced-stage endometriosis does not appear to negatively affect implantation or pregnancy outcomes. These findings support the hypothesis that reduced fertility in endometriosis is primarily related to oocyte quality rather than impaired endometrial receptivity.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 2","pages":"Article 103079"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145634444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A smartphone coaching program (“Bouge Grossesse”) improves daily physical activity in pregnant women","authors":"Matthieu Muller ,&nbsp;Pandora James ,&nbsp;Philippe Merviel ,&nbsp;Alain Saraux ,&nbsp;Yannick Guillodo ,&nbsp;Véronique Kerlan ,&nbsp;Sarah Bouee ,&nbsp;Emmanuel Nowak ,&nbsp;Romain Morgant ,&nbsp;Emmanuelle Communier-Courtois","doi":"10.1016/j.jogoh.2024.102847","DOIUrl":"10.1016/j.jogoh.2024.102847","url":null,"abstract":"<div><h3>Background</h3><div>Physical activity has been shown to reduce obstetrical risks however pregnant women reduce their physical activity and sedentary behaviors increase.</div></div><div><h3>Objective</h3><div>Our aim was to evaluate the impact of a smartphone application developed to increase daily physical activity in pregnant women.</div></div><div><h3>Methods</h3><div>We enrolled 250 pregnant women in a prospective randomized controlled study. These women were instructed to download either an intervention application called «Bouge Grossesse» (coaching program and a pedometer; <em>n</em> = 125) or a Placebo application (pedometer only; <em>n</em> = 125). Primary outcome was defined as a daily increase of 2000 steps/day between day 1 and day 90 or 10 000 steps/week between week 1 and week 12. Data was analyzed with intention to treat. Secondary outcomes were the number of steps at week 12 and the evolution of quality of life measured by WHO score, EIFEL score and SPIEGEL scale, and on maternal and fetal outcomes.</div></div><div><h3>Results</h3><div>Patients were enrolled between August 2017 and February 2019. They were retrospectively registered after September 2018. We found a significant difference in the primary outcome between the two groups in favor of the intervention group (22.4 % success vs 3.2 % in the control group, <em>P</em> &lt; .001) but only 43 women in the intervention group (34.4 %) and 16 women in the placebo group (12.8 %) completed the 12-week coaching program. There were no significant differences in the SPIEGEL, EIFEL and WHO scores. The mean number of daily steps at week 12 was significantly higher in the intervention group (6900.0 vs 4371.9, <em>P</em> &lt; .001).</div></div><div><h3>Conclusion</h3><div>The mobile health intervention « Bouge Grossesse » significantly increased physical activity in pregnant women but we observed a high percentage of withdrawals from the 12-week program.</div></div><div><h3>Trial registration</h3><div>This clinical trial was registered under the number NCT03688087 ClinicalTrials.gov.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 2","pages":"Article 102847"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of body fat percentage on hormonal profiles, metabolism and adipokine-related indicators in PCOS patients with a normal body mass index: A cross-sectional study","authors":"Yangyang Zhang ,&nbsp;Pan Dou ,&nbsp;Nuo Huang ,&nbsp;Jiao Yu ,&nbsp;Xi Wang ,&nbsp;Fei Chen ,&nbsp;Haiyu Li ,&nbsp;Yang Xu","doi":"10.1016/j.jogoh.2025.103099","DOIUrl":"10.1016/j.jogoh.2025.103099","url":null,"abstract":"<div><h3>Background</h3><div>To date, research on polycystic ovary syndrome (PCOS) has focused on patients who are overweight/obese, with less attention given to PCOS patients who have a normal body mass index (BMI). The latter may also exhibit an increased body fat percentage (BFP). Studies have shown that BFP can affect hormonal profiles, metabolism and adipokine-related indicators. Therefore, the aim of this study was to investigate the effects of BFP on the aforementioned indicators in PCOS patients with a normal BMI.</div></div><div><h3>Methods</h3><div>In total, 115 PCOS patients with and without a normal BMI were included in this cross-sectional cohort study. The women were divided into two groups: the high-BFP group (BFP≥30 %) and the normal-BFP group (BFP&lt;30 %). Body composition indicators such as BFP were assessed with an Inbody770 body composition measuring instrument made by Biospace Co., Ltd. Serum hormonal profiles and glucose and lipid metabolism-related indicators were determined via biochemical assessments. Among the 115 PCOS patients with a normal BMI, 56 were tested for inflammation and adipokine-related indicators by ELISA. These indicators were analysed with a two-sided t test.</div></div><div><h3>Results</h3><div>The prevalence of high BFP in PCOS patients with a normal BMI was 60 %. With a waist‒to‒hip ratio ≥0.85 set as the threshold, the incidence of central obesity was 65.22 % in the high-BFP group and 19.57 % in the normal-BFP group. The LH/FSH ratio, free androgen index (FAI), and DHEAS and androstenedione levels were greater in the high-BFP group than in the normal-BFP group. On the basis of a HOMA-IR &gt;2.69 as the diagnostic criterion for insulin resistance, no significant difference in the prevalence of insulin resistance was observed between the two groups. The blood glucose and insulin levels at 2 hours after sugar intake were greater in the high-BFP group than in the normal-BFP group. Among the lipid metabolism indicators, the triglyceride level was significantly greater and the HDL level was significantly lower in the high-BFP group than in the normal-BFP group. There were no significant differences in inflammation-related indicators between the two groups. With respect to adipokines, the leptin level was significantly higher in the high-BFP group than in the normal-BFP group. The levels of other indicators, such as adiponectin and resistin, did not differ significantly between the two groups.</div></div><div><h3>Conclusions</h3><div>More attention should be given to PCOS patients with a normal BMI. Our study revealed that approximately 60 % of these patients have elevated BFP. A high BFP can lead to disruptions in sex hormone levels, metabolism and adipokine levels, which may further affect pregnancy outcomes. These findings suggest that a more intense focus on body composition analysis and BFP control is needed in the diagnosis and treatment of PCOS.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 2","pages":"Article 103099"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145843806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structured approach to one-step cesarean hysterectomy for placenta accreta spectrum: A video-based technical note","authors":"Pierre Carvelli ,&nbsp;Mona Massoud ,&nbsp;Océane Lablanche ,&nbsp;Fabienne Allias ,&nbsp;Edouard Ruaux ,&nbsp;Pascal Rousset ,&nbsp;François Golfier ,&nbsp;Pierre-Adrien Bolze","doi":"10.1016/j.jogoh.2025.103096","DOIUrl":"10.1016/j.jogoh.2025.103096","url":null,"abstract":"<div><div>Placenta accreta spectrum (PAS) disorders are increasingly encountered due to the rise in cesarean deliveries and uterine surgeries. In patients with no future fertility desire, planned cesarean hysterectomy may be the most appropriate approach. We report the case of a 37-year-old woman with anterior placenta previa and suspected PAS, managed through a scheduled cesarean hysterectomy following multidisciplinary assessment. Key surgical steps are demonstrated through five didactic video sequences. The procedure was completed without complications, and histology confirmed placenta increta. The patient recovered uneventfully and was discharged on postoperative day seven. This video-enhanced technical note illustrates a structured surgical strategy and highlights important pre-, intra-, and postoperative considerations in PAS cases.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 2","pages":"Article 103096"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145827899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endometriosis phenotypes and staging in relation to lipid biomarkers: Findings from the ENDO Cohort Study","authors":"Karen C. Schliep ,&nbsp;May Shaaban ,&nbsp;Emmanuel Adediran ,&nbsp;Anna Z. Pollack ,&nbsp;Kathryn M. Rexrode ,&nbsp;Rachael Hemmert ,&nbsp;Madeline Paulsen ,&nbsp;Jessica Treidl ,&nbsp;Hediyeh Baradaran ,&nbsp;Jennifer J. Majersik ,&nbsp;Michael W. Varner ,&nbsp;C. Matthew Peterson ,&nbsp;Joseph B. Stanford ,&nbsp;Jenna R. Krall ,&nbsp;Jessica M. Page ,&nbsp;Leslie V. Farland","doi":"10.1016/j.jogoh.2025.103087","DOIUrl":"10.1016/j.jogoh.2025.103087","url":null,"abstract":"<div><h3>Background</h3><div>Endometriosis has been linked to cardiometabolic alterations, but whether these associations vary by disease severity or phenotype is unclear. We examined lipid profiles across endometriosis diagnosis, stage, and typology.</div></div><div><h3>Material and methods</h3><div>Data came from 476 women in the NICHD ENDO cohort. Endometriosis was confirmed laparoscopically and staged using the rASRM criteria (<em>I</em>−IV). Typology was categorized as superficial endometriosis (SE), ovarian endometrioma (OE), deep infiltrating endometriosis (DE), and OE+DE. We compared endometriosis status, stage (I/II vs III/IV), and typology to no endometriosis using adverse lipid thresholds (total cholesterol ≥200 mg/dL, HDL &lt;50 mg/dL, LDL ≥100 mg/dL, triglycerides ≥175 mg/dL, non-HDL ≥130 mg/dL, VLDL ≥30 mg/dL, ApoA1 &lt;125 mg/dL, and ApoB ≥120 mg/dL). Adjusted prevalence ratios (aPR) and 95 % CIs were estimated via generalized linear models, controlling for age, race/ethnicity, BMI, income, marital status, and serum cotinine.</div></div><div><h3>Results</h3><div>Endometriosis diagnosis alone was not associated with adverse lipid profiles. In contrast, moderate/severe disease showed higher prevalence of elevated triglycerides (aPR= 2.27; 95 % CI: 1.18,4.35) and VLDL (aPR= 2.41; 95 % CI: 1.50, 3.85). Typology revealed stronger patterns: OE and OE+DE were associated with adverse profiles across multiple markers (aPRs 1.59–4.09), particularly ApoB and triglycerides. Minimal/mild disease and SE were not associated.</div></div><div><h3>Conclusions</h3><div>The metabolic signal was phenotype-driven rather than diagnosis-driven, with severe stage and OE/OE+DE showing clear associations with adverse lipid profiles. These findings suggest lipid profiles may serve as markers of phenotype severity or shared biological milieu. Replication in larger cohorts is needed.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 2","pages":"Article 103087"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145774884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New ACR/EULAR 2023 classification criteria for antiphospholipid syndrome, what should a gynaecologist know in 2025","authors":"Anne Murarasu ,&nbsp;Grégoire Martin de Frémont ,&nbsp;Gaelle Guettrot-Imbert ,&nbsp;Nathalie Morel ,&nbsp;Emmanuelle Pannier ,&nbsp;Adriana Costin-Mihai ,&nbsp;Nathalie Costedoat Chalumeau ,&nbsp;Véronique Le Guern","doi":"10.1016/j.jogoh.2025.103095","DOIUrl":"10.1016/j.jogoh.2025.103095","url":null,"abstract":"<div><div>Antiphospholipid syndrome (APS) is characterised by thrombotic, obstetric and/or systemic manifestations associated with antiphospholipid antibodies (aPL). The definition of APS manifestations has been imprecise, resulting in heterogeneous study populations and in limited and inconsistent data, particularly for obstetric APS. In 2023, the American College of Rheumatology and the European League Against Rheumatism introduced new classification criteria that prioritize specificity over sensitivity.</div><div>Obstetric APS manifestations are mainly the consequence of preeclampsia and placental insufficiency, often early and severe, leading to fetal growth restriction, fetal death, induced prematurity or maternal morbidity. Accordingly, in the new classification criteria, isolated fetal death without preeclampsia and/or placental insufficiency has little significance. The biological definition remains unchanged, requiring persistent aPL. Isolated anticardiolipin or anti-β2-glycoprotein-I antibodies of the IgM isotype or anticardiolipin or anti-β2-glycoprotein-I antibodies of the IgG isotype &lt;40 GPL are no longer sufficient for the classification of APS due to their weak association with clinical manifestations. Lupus anticoagulant is the strongest risk factor for thromboses and adverse obstetric outcomes.</div><div>Despite adequate treatment, pregnancies in these patients still carry a significant risk of preeclampsia, placental insufficiency, thrombosis and haemorrhagic events, those events being frequently associated and occurring mainly in the peripartum period, and in women with lupus anticoagulant. In the future, inclusion of individuals using these new classification criteria should ensure more homogeneity in APS trials, especially for obstetric APS. Importantly, these criteria were not designed for diagnosis, thus, in clinical practice, the risks and benefits of modifying the treatment of patients falling out of the 2023 criteria should be weighed by the clinicians (e.g. using aPL profile) and carefully explained to the patient.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 2","pages":"Article 103095"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145804639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference values for biochemical tests during pregnancy: Analysis of the PRECAREbio Cohort and correlation with precarious status","authors":"Juliette Phelippeau ,&nbsp;Elie Azria ,&nbsp;Pierre-François Ceccaldi ,&nbsp;Carine Khater ,&nbsp;Martin Koskas ,&nbsp;Laurent Mandelbrot ,&nbsp;Candice Estellat ,&nbsp;Françoise Muller ,&nbsp;Thomas Schmitz ,&nbsp;Dominique Luton ,&nbsp;PreCARE study group","doi":"10.1016/j.jogoh.2024.102825","DOIUrl":"10.1016/j.jogoh.2024.102825","url":null,"abstract":"<div><h3>Objective</h3><div>To establish normal current values of various biochemical parameters during pregnancy in the northern area of Paris (France) in a subgroup from the PreCARE cohort and to study their changes according to the term of pregnancy, and to determine the influence of maternal precarity.</div></div><div><h3>Design</h3><div>The PreCAREbio cohort of pregnant women was defined in the PreCARE study, a multicenter cohort study.</div></div><div><h3>Setting</h3><div>Participants completed detailed questionnaires at enrolment and immediately postpartum. Data were collected prospectively. 26 biochemical parameters were longitudinally assessed.</div></div><div><h3>Population</h3><div>All women registered to deliver or who delivered at one of the four participating university hospitals in Paris between October 2010 and November 2011 were eligible for study inclusion (<em>n</em> = 10,419).</div></div><div><h3>Methods</h3><div>We studied 26 biochemical markers during pregnancy and the influence of maternal social deprivation.</div></div><div><h3>Main outcome measures</h3><div>Baseline values for 26 biochemical markers and their changes according to the term of pregnancy, and the influence of maternal social deprivation on these biochemical markers.</div></div><div><h3>Results</h3><div>386 patients with 1733 blood samples recruited in one of the four centers in the PreCARE cohort were included. Baseline concentrations (median, 2.5th and 97.5th percentile) for each marker and did not differ at the different time points. Mean concentrations of each biochemical marker did not differ between socially deprived women and non-socially deprived women.</div></div><div><h3>Conclusions</h3><div>We have established normal values for 26 biochemical parameters during pregnancy. We have also shown no difference in these values between socially deprived and non- socially deprived women.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 2","pages":"Article 102825"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141748387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calculation of specific risk of trisomy 13: probably still a utopia","authors":"Corinne Sault ,&nbsp;Sophie Dreux ,&nbsp;Estelle Roland ,&nbsp;Gilles Renom","doi":"10.1016/j.jogoh.2025.103081","DOIUrl":"10.1016/j.jogoh.2025.103081","url":null,"abstract":"<div><h3>Background</h3><div>In France, legislation regarding pregnancy monitoring considers screening solely for Down syndrom or trisomy 21 (T21). However, health authorities are exploring the possibility of calculating the risks of trisomy 13 (T13) and trisomy 18 (T18), Patau and Edwards syndromes respectively, for patients with indicative serum marker profiles (MSM), to make wider use of the potential of non-invasive prenatal testing (NIPT). Currently, only LifeCycle (revvity®), a software distributed worlwide, offers a specific risk calculation for T13, but its performance has never been assessed.</div></div><div><h3>Methods</h3><div>We retrospectively studied 88 cases of T13 from a cohort of over 800,000 patients who underwent first-trimester MSM testing. In each case, in addition to the T21 risk, we calculated the specific risks of T18 and T13 using the LifeCycle software, both with and without the measurement of nuchal translucency for these two aneuploidies.</div></div><div><h3>Results</h3><div>None of the patients with a foetus affected by T13 showed an increased risk for this aneuploidy without simultaneously presenting a high risk for T21 or T18.</div></div><div><h3>Conclusion</h3><div>The specific risk calculation for T13 using LifeCycle does not improve the screening for this aneuploidy.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 2","pages":"Article 103081"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145696042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}