Journal of Experimental Pharmacology最新文献

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Response to Article "Antipyretic Potential of 80% Methanol Extract and Solvent Fractions of Bersama Abyssinica Fresen. (Melianthaceae) Leaves Against Yeast-Induced Pyrexia in Mice" [Letter]. 对“八成甲醇萃取物及溶剂馏分解热作用”一文的回应。(Melianthaceae)小鼠叶片抗酵母诱导的发热[Letter]。
Journal of Experimental Pharmacology Pub Date : 2023-01-01 DOI: 10.2147/JEP.S413591
Putri Reno Intan, Ariyani Noviantari, Sukmayati Alegantina
{"title":"Response to Article \"Antipyretic Potential of 80% Methanol Extract and Solvent Fractions of <i>Bersama Abyssinica</i> Fresen. (Melianthaceae) Leaves Against Yeast-Induced Pyrexia in Mice\" [Letter].","authors":"Putri Reno Intan,&nbsp;Ariyani Noviantari,&nbsp;Sukmayati Alegantina","doi":"10.2147/JEP.S413591","DOIUrl":"https://doi.org/10.2147/JEP.S413591","url":null,"abstract":"","PeriodicalId":15846,"journal":{"name":"Journal of Experimental Pharmacology","volume":"15 ","pages":"187-188"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/63/72/jep-15-187.PMC10075212.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9382624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-Diabetic Activities of Hydro-Methanolic Crude Extract and Solvent Fractions of Heteromorpha arborescens (Apiaceae) Leaves in Mice. 枫香水甲醇粗提物及溶剂组分对小鼠抗糖尿病活性的研究。
Journal of Experimental Pharmacology Pub Date : 2023-01-01 DOI: 10.2147/JEP.S392742
Yeshiwas Guadie Zeleke, Seyfe Asrade Atnafie, Tezera Jemere Aragaw
{"title":"Anti-Diabetic Activities of Hydro-Methanolic Crude Extract and Solvent Fractions of <i>Heteromorpha arborescens</i> (Apiaceae) Leaves in Mice.","authors":"Yeshiwas Guadie Zeleke,&nbsp;Seyfe Asrade Atnafie,&nbsp;Tezera Jemere Aragaw","doi":"10.2147/JEP.S392742","DOIUrl":"https://doi.org/10.2147/JEP.S392742","url":null,"abstract":"<p><strong>Background: </strong><i>Heteromorpha arborescens</i> has been used to treat diabetes traditionally. There was no in vivo study to support the claim. This study aimed to confirm anti-diabetic activity of 80% methanol in water extract and solvent fractions of <i>H. arborescens</i> leaves in mice.</p><p><strong>Methods: </strong><i>H. arborescens</i> leaves were macerated and extracted in 80% methanol in water. Hydro-methanol extract of <i>H. arborescens</i> leaves were tested in mice models. Overnight fasted mice were randomly divided into five groups for normoglycemic and glucose-loaded models as a negative control, positive control, and three tested groups, whereas, in streptozotocin-induced diabetic models, the mice were grouped into six groups each comprised six mice: diabetic negative control and normal negative control groups treated with 10 mL/kg distilled water, diabetic positive control group treated with Glibenclamide 5 mg/kg and three diabetic tested groups treated with extract at 100, 200, and 400 mg/kg doses. A one-way ANOVA was performed to analyze the data, and the post hoc Tukey's test was utilized for multiple comparisons. The P-value <0.05 was considered statistically significant.</p><p><strong>Results: </strong>Hydro-methanol extract of <i>H. arborescens</i> leaves at 400 mg/kg in normoglycemic mice significantly lowered blood glucose levels (BGLs) (P< 0.01). Mice with oral glucose-loaded test lowered BGLs at dosages of 200 mg/kg (P < 0.05) and 400 mg/kg (P < 0.01) respectively. Single-dose of ethyl acetate, n-hexane fractions and hydro-methanol extract at 100 mg/kg, 400 mg/kg and 200 mg/kg reduced BGLs (P < 0.05, P < 0.001, and P < 0.01) respectively. BGL drops in diabetic mice given daily repeated doses of 200 mg/kg of hydro-methanol extract and 400 mg/kg of ethyl acetate fraction (P < 0.001). Diabetic mice gained weight at a 400 mg/kg hydro-methanol extract and ethyl acetate fraction (P < 0.05 and P < 0.01) respectively. Hydro-methanol extract and ethyl acetate fraction and at 200 mg/kg decreased total cholesterol, triglycerides, and low-density lipoprotein and increased high-density lipoprotein (P < 0.001).</p><p><strong>Conclusion: </strong>80% methanol in water extract and solvent fractions of <i>H. arborescens</i> leaves showed anti-diabetic effects and significantly reduced hyperlipidemia in diabetics, this study supported the traditional usage of <i>H. arborescens</i> for treating diabetes; however, species variation could also limit such a straightforward extrapolation of the findings of this study in humans.</p>","PeriodicalId":15846,"journal":{"name":"Journal of Experimental Pharmacology","volume":"15 ","pages":"107-121"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c0/e7/jep-15-107.PMC10013569.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9131744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Contemporary Anti-Retroviral Drugs (ARVDs) Disrupt Follicular Development in Female Wistar Rats. 当代抗逆转录病毒药物(ARVDs)破坏雌性Wistar大鼠的卵泡发育。
Journal of Experimental Pharmacology Pub Date : 2023-01-01 DOI: 10.2147/JEP.S398343
Aigbe Gregory Ohihoin, Esther Ngozi Ohihoin, Ifeoma Ujomu, Airat Bakare, Oladeji Olanrewaju, Arinze Okafor, Mercy Ojetunde, Joy Boluwatife Ayoola, Oluwagbemiga Aina, Olusola Ajibaye, Simon D Taylor-Robinson
{"title":"Contemporary Anti-Retroviral Drugs (ARVDs) Disrupt Follicular Development in Female Wistar Rats.","authors":"Aigbe Gregory Ohihoin,&nbsp;Esther Ngozi Ohihoin,&nbsp;Ifeoma Ujomu,&nbsp;Airat Bakare,&nbsp;Oladeji Olanrewaju,&nbsp;Arinze Okafor,&nbsp;Mercy Ojetunde,&nbsp;Joy Boluwatife Ayoola,&nbsp;Oluwagbemiga Aina,&nbsp;Olusola Ajibaye,&nbsp;Simon D Taylor-Robinson","doi":"10.2147/JEP.S398343","DOIUrl":"https://doi.org/10.2147/JEP.S398343","url":null,"abstract":"<p><strong>Introduction: </strong>There are genuine concerns that long-term use of anti-retroviral drugs may be associated with reproductive complications in females. This study aimed to ascertain the effect of highly active anti-retroviral drugs on the ovarian reserve and reproductive potential of female Wistar rats and by extension to HIV-positive human females.</p><p><strong>Methods: </strong>A total of 25 female Wistar rats, weighing between 140g and 162g, were randomly allotted into non-intervention and intervention groups, receiving the anti-retroviral drugs, Efavirenz (EFV), Tenofovir Disoproxil Fumarate (TDF), Lamivudine (3TC), and a fixed-dose combination (FDC). The dosage was administered orally at 8 am daily for 4 weeks. Serum concentrations of anti-Mullerian hormone (AMH), follicle-stimulating hormone (FSH), luteinising hormone (LH), and estradiol were measured using standard biochemical techniques (ELISA). Follicular counts were made on fixed ovarian tissue from the sacrificed rats.</p><p><strong>Results: </strong>The mean AMH level for the control group and the EFV, TDF, 3TC, and FDC groups were 11.20, 6.75, 7.30, 8.27, and 6.60 pmol/L, respectively. The EFV and FDC groups had the lowest AMH, compared to the other groups, but there was no statistically significant difference in AMH across the groups. The mean count of antral follicles was significantly lower in the group that received EFV when compared to the other groups. The corpus luteal count was significantly higher in the control group than in the intervention groups.</p><p><strong>Conclusion: </strong>The study demonstrated a disruption in the reproductive hormones of female Wistar rats receiving anti-retroviral regimens containing EFV. Clinical studies are required to determine if these changes are seen in women receiving EFV-based treatment, as this may compromise reproductive function and predispose them to early menopause.</p>","PeriodicalId":15846,"journal":{"name":"Journal of Experimental Pharmacology","volume":"15 ","pages":"267-278"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10167673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacological Activities of Fingerroot Extract and Its Phytoconstituents Against SARS-CoV-2 Infection in Golden Syrian Hamsters. 指根提取物及其植物成分抗叙利亚金仓鼠SARS-CoV-2感染的药理活性
Journal of Experimental Pharmacology Pub Date : 2023-01-01 DOI: 10.2147/JEP.S382895
Teetat Kongratanapasert, Supasek Kongsomros, Nlin Arya, Kripitch Sutummaporn, Witthawat Wiriyarat, Yada Akkhawattanangkul, Tussapon Boonyarattanasoonthorn, Nithi Asavapanumas, Phongthon Kanjanasirirat, Ampa Suksatu, Khanit Sa-Ngiamsuntorn, Suparerk Borwornpinyo, Pornpun Vivithanaporn, Somchai Chutipongtanate, Suradej Hongeng, Boonsong Ongphiphadhanakul, Arunee Thitithanyanont, Phisit Khemawoot, Piyamitr Sritara
{"title":"Pharmacological Activities of Fingerroot Extract and Its Phytoconstituents Against SARS-CoV-2 Infection in Golden Syrian Hamsters.","authors":"Teetat Kongratanapasert,&nbsp;Supasek Kongsomros,&nbsp;Nlin Arya,&nbsp;Kripitch Sutummaporn,&nbsp;Witthawat Wiriyarat,&nbsp;Yada Akkhawattanangkul,&nbsp;Tussapon Boonyarattanasoonthorn,&nbsp;Nithi Asavapanumas,&nbsp;Phongthon Kanjanasirirat,&nbsp;Ampa Suksatu,&nbsp;Khanit Sa-Ngiamsuntorn,&nbsp;Suparerk Borwornpinyo,&nbsp;Pornpun Vivithanaporn,&nbsp;Somchai Chutipongtanate,&nbsp;Suradej Hongeng,&nbsp;Boonsong Ongphiphadhanakul,&nbsp;Arunee Thitithanyanont,&nbsp;Phisit Khemawoot,&nbsp;Piyamitr Sritara","doi":"10.2147/JEP.S382895","DOIUrl":"https://doi.org/10.2147/JEP.S382895","url":null,"abstract":"<p><strong>Background: </strong>The outbreak of COVID-19 has led to the suffering of people around the world, with an inaccessibility of specific and effective medication. Fingerroot extract, which showed in vitro anti-SARS-CoV-2 activity, could alleviate the deficiency of antivirals and reduce the burden of health systems.</p><p><strong>Aim of study: </strong>In this study, we conducted an experiment in SARS-CoV-2-infected hamsters to determine the efficacy of fingerroot extract in vivo.</p><p><strong>Materials and methods: </strong>The infected hamsters were orally administered with vehicle control, fingerroot extract 300 or 1000 mg/kg, or favipiravir 1000 mg/kg at 48 h post-infection for 7 consecutive days. The hamsters (n = 12 each group) were sacrificed at day 2, 4 and 8 post-infection to collect the plasma and lung tissues for analyses of viral output, lung histology and lung concentration of panduratin A.</p><p><strong>Results: </strong>All animals in treatment groups reported no death, while one hamster in the control group died on day 3 post-infection. All treatments significantly reduced lung pathophysiology and inflammatory mediators, PGE<sub>2</sub> and IL-6, compared to the control group. High levels of panduratin A were found in both the plasma and lung of infected animals.</p><p><strong>Conclusion: </strong>Fingerroot extract was shown to be a potential of reducing lung inflammation and cytokines in hamsters. Further studies of the full pharmacokinetics and toxicity are required before entering into clinical development.</p>","PeriodicalId":15846,"journal":{"name":"Journal of Experimental Pharmacology","volume":"15 ","pages":"13-26"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/aa/9d/jep-15-13.PMC9869698.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9143313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacological Effects of the Lipidosterolic Extract from Kigelia africana Fruits in Experimental Benign Prostatic Hyperplasia Induced by Testosterone in Sprague Dawley Rats. 非洲栗子脂固醇提取物对实验性睾丸激素诱导的良性前列腺增生的药理作用。
Journal of Experimental Pharmacology Pub Date : 2023-01-01 DOI: 10.2147/JEP.S383699
Cristina Occhiuto, Giuseppe Santoro, Peter Quinto Tranchida, Giovanni Bono, Francesco Occhiuto
{"title":"Pharmacological Effects of the Lipidosterolic Extract from <i>Kigelia africana</i> Fruits in Experimental Benign Prostatic Hyperplasia Induced by Testosterone in Sprague Dawley Rats.","authors":"Cristina Occhiuto,&nbsp;Giuseppe Santoro,&nbsp;Peter Quinto Tranchida,&nbsp;Giovanni Bono,&nbsp;Francesco Occhiuto","doi":"10.2147/JEP.S383699","DOIUrl":"https://doi.org/10.2147/JEP.S383699","url":null,"abstract":"<p><strong>Background: </strong>The use of phytotherapics is very frequent in men with prostatic diseases, sexual disorders and infertility, and many associations are commercially available. Various vegetable products used as drugs or nutraceuticals are attributed to possess the capacity to exert benefic effects on the reproductive system, and most of these drugs have a rich and varied lipidosterolic fraction, primarily responsible for the effects related to the male genital sphere. <i>Kigelia africana</i> (Lam.) Benth. (Bignoniaceae) is a plant used in African folk medicine as a vegetal remedy for various diseases, including some disorders of the male reproductive system; however, its potential activities have not yet been fully explored. The aim of the present study was to investigate whether the lipidosterolic hexane extract (LHE) from <i>K. africana</i> fruits, analyzed by comprehensive two-dimensional gas chromatography-mass spectrometry/flame ionization detection (GC×GC-MS/FID), can prevent or reverse benign prostatic hyperplasia (BPH) in rats.</p><p><strong>Methods: </strong>BPH was induced in experimental groups by daily subcutaneous injections of testosterone propionate (TP) for four weeks. β-sitosterol (β-s) was used as positive control. On day 28, the animals were sacrificed by cervical dislocation after anesthesia. Prostates were excised, weighed, and used for macroscopic and histological studies. Testosterone and dihydrotestosterone (DHT) levels in prostate were measured.</p><p><strong>Results: </strong>The results showed that LHE significantly reduced the prostatic weight, prostatic index, prostatic levels of testosterone and DHT, and the histopathological alterations (including the epithelial thickness, stromal proliferation, and lumen area) induced by testosterone. These effects were superior to those demonstrated by β-s and appear to be due to a partial antiandrogenic activity of LHE.</p><p><strong>Conclusion: </strong>The results obtained showed that the LHE can prevent, and reverse testosterone induced prostatic hyperplasia, and support the traditional use of <i>Kigelia africana</i> in some disorders of the reproductive system.</p>","PeriodicalId":15846,"journal":{"name":"Journal of Experimental Pharmacology","volume":"15 ","pages":"41-50"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/db/07/jep-15-41.PMC9911901.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10703628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to Article "Evaluation of the Anti-Malarial Activity of the Crude Root Extract and Solvent Fraction of Sesamum indicum (Fabaceae)" [Letter]. 对《芝麻(豆科)粗根提取物和溶剂提取物抗疟疾活性评价》一文的回应(信)。
Journal of Experimental Pharmacology Pub Date : 2023-01-01 DOI: 10.2147/JEP.S418029
Putri Reno Intan, Ariyani Noviantari
{"title":"Response to Article \"Evaluation of the Anti-Malarial Activity of the Crude Root Extract and Solvent Fraction of <i>Sesamum indicum</i> (Fabaceae)\" [Letter].","authors":"Putri Reno Intan,&nbsp;Ariyani Noviantari","doi":"10.2147/JEP.S418029","DOIUrl":"https://doi.org/10.2147/JEP.S418029","url":null,"abstract":"","PeriodicalId":15846,"journal":{"name":"Journal of Experimental Pharmacology","volume":"15 ","pages":"215-216"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b0/58/jep-15-215.PMC10164382.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9498255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aloe adigratana Reynolds: Preliminary Phytochemical Screening, Proximate Content, Essential Oil Analysis, and In Vitro Antifungal Activity Studies of Its Leaf Peels and Gel. 芦荟叶皮和凝胶的初步植物化学筛选、近似含量、精油分析和体外抗真菌活性研究。
Journal of Experimental Pharmacology Pub Date : 2023-01-01 DOI: 10.2147/JEP.S420990
Abraha Gebremariam, Brhane Gebremedhin Gebrezgabher, Kebede Taye Desta, Desta Berhe Sbhatu, Goitom Gebreyohannes Berhe, Mahmud Abdirkadir, Ephrem Tsegay
{"title":"<i>Aloe adigratana</i> Reynolds: Preliminary Phytochemical Screening, Proximate Content, Essential Oil Analysis, and In Vitro Antifungal Activity Studies of Its Leaf Peels and Gel.","authors":"Abraha Gebremariam,&nbsp;Brhane Gebremedhin Gebrezgabher,&nbsp;Kebede Taye Desta,&nbsp;Desta Berhe Sbhatu,&nbsp;Goitom Gebreyohannes Berhe,&nbsp;Mahmud Abdirkadir,&nbsp;Ephrem Tsegay","doi":"10.2147/JEP.S420990","DOIUrl":"https://doi.org/10.2147/JEP.S420990","url":null,"abstract":"<p><strong>Background: </strong><i>Aloe</i> species are among the most significant plants with several applications. Many of the species, however, are underexplored, owing to their scarcity and limited geographical distribution. <i>A. adigratana</i> Reynolds, which is common in Ethiopia, is one of the little-studied and endangered <i>Aloe</i> species.</p><p><strong>Objective: </strong>This preliminary study focuses on the phytochemical screening, proximate analysis, essential oil content, and antifungal activities of <i>A. adigratana</i> leaf peels. Antifungal activities were also tested on the gels of the plant for comparison.</p><p><strong>Methods: </strong>Standard procedures were used for phytochemical and proximate composition studies. Essential oil analysis was performed using a gas chromatography-mass spectrometry instrument. Using the well-diffusion method, investigations on antifungal activity were performed on three clinically isolated specimens of dandruff-causing fungus; namely, <i>Malassezia furfur, Malassezia restricta</i>, and <i>Malassezia globosa</i>.</p><p><strong>Results: </strong>The leaf peels of <i>A. adigratana</i> contained alkaloids, flavonoids, tannins, and terpenes. The mean moisture, ash, and crude fat levels were 85.69, 92.20, and 8.00%, respectively, whereas the mean total protein and mean total carbohydrate values were 2.59 and 3.04%. Gas chromatography-mass spectrometry investigation confirmed the presence of fifteen essential oils. The most prevalent essential oil component was discovered to be phytol (33.78%), followed by decane (11.29%). In a dose-dependent way, the leaf latex and gel extracts prevented the growth of three dandruff-causing <i>Malassezia</i> fungal species (<i>M. furfur, M. restricta</i>, and <i>M. globosa</i>). Both the latex and gel demonstrated the maximum activity on <i>M. globosa</i>, the most prevalent fungus in the research area, with minimum inhibitory concentrations of 0.24 and 0.48 mg/mL and minimum fungicidal concentrations of 0.48 and 0.97 mg/mL, respectively.</p><p><strong>Conclusion: </strong>In general, the proximate and essential oil compositions of <i>A. adigratana</i> leaves were comparable to those of other <i>Aloe</i> species widely used in the food, cosmetic, and pharmaceutical industries, implying that <i>A. adigratana</i> could be a potential future plant for such industries.</p>","PeriodicalId":15846,"journal":{"name":"Journal of Experimental Pharmacology","volume":"15 ","pages":"321-332"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/eb/cf/jep-15-321.PMC10473414.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10155748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to Article "Antipyretic Potential of 80% Methanol Extract and Solvent Fractions of Bersama abyssinica Fresen. (Melianthaceae) Leaves Against Yeast-Induced Pyrexia in Mice" [Response to Letter]. 对“深草八成甲醇萃取物及溶剂馏分解热作用”一文的回应。(Melianthaceae)小鼠叶片抗酵母诱导的发热”[回复信件]。
Journal of Experimental Pharmacology Pub Date : 2023-01-01 DOI: 10.2147/JEP.S414817
Bantayehu Addis Tegegne, Agumas Alemu Alehegn
{"title":"Response to Article \"Antipyretic Potential of 80% Methanol Extract and Solvent Fractions of <i>Bersama abyssinica</i> Fresen. (Melianthaceae) Leaves Against Yeast-Induced Pyrexia in Mice\" [Response to Letter].","authors":"Bantayehu Addis Tegegne,&nbsp;Agumas Alemu Alehegn","doi":"10.2147/JEP.S414817","DOIUrl":"https://doi.org/10.2147/JEP.S414817","url":null,"abstract":"","PeriodicalId":15846,"journal":{"name":"Journal of Experimental Pharmacology","volume":"15 ","pages":"189-190"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fe/d3/jep-15-189.PMC10106797.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9383974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Anti-Inflammatory Activity of Ashwagandha Sustained-Release Formulation on Depression and Anxiety Induced by Chronic Unpredictable Stress: in vivo and in vitro Studies. Ashwagandha缓释制剂对慢性不可预测应激所致抑郁、焦虑的体内、体外研究
Journal of Experimental Pharmacology Pub Date : 2023-01-01 DOI: 10.2147/JEP.S407906
Alluri Venkata KrishnaRaju, Venkateswarlu Somepalli, Shefali Thanawala, Rajat Shah
{"title":"Efficacy and Anti-Inflammatory Activity of Ashwagandha Sustained-Release Formulation on Depression and Anxiety Induced by Chronic Unpredictable Stress: in vivo and in vitro Studies.","authors":"Alluri Venkata KrishnaRaju,&nbsp;Venkateswarlu Somepalli,&nbsp;Shefali Thanawala,&nbsp;Rajat Shah","doi":"10.2147/JEP.S407906","DOIUrl":"https://doi.org/10.2147/JEP.S407906","url":null,"abstract":"<p><strong>Background: </strong>Stress is the psychological, physiological, and behavioral response of an individual's body when they perceive a lack of equilibrium between the demands placed upon them and their ability to meet those demands. Adaptogens are herbs that help with stress management, and Ashwagandha is one such safe and effective adaptogen.</p><p><strong>Objective: </strong>We evaluated the anti-neuroinflammatory potential of Ashwagandha sustained-release formulation (AshwaSR) by estimating the in vitro expression of pro-inflammatory cytokines, and its efficacy on anxiety and depression in an in vivo study.</p><p><strong>Methods: </strong>Our in vitro study investigated the anti-inflammatory potential of AshwaSR by estimating the expression of tumour necrosis factor [TNF]-α and interleukin [IL]-1β levels in LPS-induced THP-1 human monocytes, and the antioxidant effects by its potential to inhibit the superoxide [SO] generation in PMA-induced HL-60 human monocytic cells. The in vivo study assessed the efficacy of AshwaSR on chronic unpredictable stress (CUS)-induced comorbid anxiety and depression in <i>Sprague Dawley</i> rats. Antidepressant and anxiolytic effects of AshwaSR were evaluated by open field test (OFT), elevated plus maze (EPM), forced swim test (FST), and Morris water maze (MWM) test.</p><p><strong>Results: </strong>AshwaSR inhibited TNF-α, IL-1β and superoxide production in a dose-dependent manner in the in vitro study. The in vivo CUS model induced depression-like and anxiety-like behaviour. Treatments with AshwaSR and escitalopram showed improvement in the EPM and MWM models compared to the CUS-group.</p><p><strong>Conclusion: </strong>In vitro study demonstrated that AshwaSR inhibits expressions of pro-inflammatory cytokines, IL-1β and TNF-α, and superoxide production. Further, the in vivo study confirmed its anxiolytic and stress-relieving effects in the CUS model that confirmed AshwaSR's potential in managing stress and stress-related symptoms.</p>","PeriodicalId":15846,"journal":{"name":"Journal of Experimental Pharmacology","volume":"15 ","pages":"291-305"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8e/96/jep-15-291.PMC10386834.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9919708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum: Pharmacological Activities of Fingerroot Extract and Its Phytoconstituents Against SARS-CoV-2 Infection in Golden Syrian Hamsters [Corrigendum]. 勘误:指根提取物及其植物成分对金色叙利亚仓鼠SARS-CoV-2感染的药理活性[勘误]。
Journal of Experimental Pharmacology Pub Date : 2023-01-01 DOI: 10.2147/JEP.S411939
{"title":"Erratum: Pharmacological Activities of Fingerroot Extract and Its Phytoconstituents Against SARS-CoV-2 Infection in Golden Syrian Hamsters [Corrigendum].","authors":"","doi":"10.2147/JEP.S411939","DOIUrl":"https://doi.org/10.2147/JEP.S411939","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.2147/JEP.S382895.].</p>","PeriodicalId":15846,"journal":{"name":"Journal of Experimental Pharmacology","volume":"15 ","pages":"137-138"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c0/8a/jep-15-137.PMC10024502.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9146807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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