Journal of Experimental and Clinical Anatomy最新文献

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The effect of intake of palm wine on body weight and testicular microarchitecture in adult wistar rats 棕榈酒摄取量对成年wistar大鼠体重及睾丸微结构的影响
Journal of Experimental and Clinical Anatomy Pub Date : 2017-01-01 DOI: 10.4103/JECA.JECA_16_16
U. Isaac, F. Akpuaka, G. Ndukwe
{"title":"The effect of intake of palm wine on body weight and testicular microarchitecture in adult wistar rats","authors":"U. Isaac, F. Akpuaka, G. Ndukwe","doi":"10.4103/JECA.JECA_16_16","DOIUrl":"https://doi.org/10.4103/JECA.JECA_16_16","url":null,"abstract":"Background: The growing concerns about male reproductive dysfunction as well as obesity have necessitated the present study. Objective: The aim of this research was to investigate the effect of intake of palm wine on body weight, testis weight and microarchitecture of the testis in adult Wistar rats. Materials and Methods: Ten mature male rats weighing between 101 g and 180 g were assigned into two groups of A and B, consisting of five animals each that all had access to rat chow and water ad libitum. Fresh undiluted palm wine gotten as sap (juice) from oil palm trees was collected from a local palm wine tapper at every three days interval and often conserved in a refrigerator after every use before being replaced with a fresh collection on the 4th day. While group A served as control, group B animals were orally administered with 10ml/kg body weight per day of the palm wine for twenty-one days. The G&G(R) Electronic Scale (JJ1000 Capacity) was the instrument used for the assessment of the weight parameters. The analysis of variance was the statistical tool used to determine the weight differences between the two groups and P < 0.05 was taken as the statistically significant value; with the data presented as Mean ± SEM. Results: The outcome of the research on weight parameters showed non significant changes as the means for the initial and final body weights in group A were 108 g and 136 g ± 0.28 while those in group B were 138 g and 165 g ± 0.29 respectively. The testis mean weight of group A animals was 3.3 g ± 0.05 while that of group B was 3.8 g ± 0.07. Following routine histological processing, the micro-anatomic studies of testicular tissue samples from group B revealed focal disordered arrangement of sperm–producing cells. Conclusion: The findings therefore show that regular intake of fermented palm sap popularly known as palm wine may not significantly affect body weight nor testis weight, but can gradually distort testicular tissue architecture with abnormally structured cells.","PeriodicalId":15815,"journal":{"name":"Journal of Experimental and Clinical Anatomy","volume":"54 1","pages":"12 - 17"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78736851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Associations between birthweight, birth order, and age at menarche of schoolgirls in Niger Republic 尼日尔共和国女学生出生体重、出生顺序和初潮年龄之间的关系
Journal of Experimental and Clinical Anatomy Pub Date : 2017-01-01 DOI: 10.4103/JECA.JECA_27_16
Abdou Kaka Aboubacar Katiella, Monday Nwankwo, B. Danborno
{"title":"Associations between birthweight, birth order, and age at menarche of schoolgirls in Niger Republic","authors":"Abdou Kaka Aboubacar Katiella, Monday Nwankwo, B. Danborno","doi":"10.4103/JECA.JECA_27_16","DOIUrl":"https://doi.org/10.4103/JECA.JECA_27_16","url":null,"abstract":"Background: Few data are available on the association between birthweight, birth order (BO), and age at menarche. Previous studies have indicated a significant association between birthweight, BO, and age at menarche. Aim: this cross-sectional study examines the association between birthweight, BO, and age at menarche of Nigerien schoolgirls. Materials and Methods: Sociodemographic and anthropometric data were collected with questionnaires from a total of 487 adolescent schoolgirls aged 12–27 years. Results: Schoolgirls with low birthweight reach menarche earlier than those with normal birthweight (13.59 years vs. 13.94 years, P= 0.004). BO showed statistically significant impact on age at menarche with the first-born girls reaching menarche earlier than the later-born girls (F = 5.17,P< 0.001). Age at menarche was positively related to all the measured anthropometrics at P< 0.01. Multiple regression analyses revealed that only BO is a significant predictor of age at menarche (P < 0.000). Conclusion: Our results suggest an association between birthweight, BO, and age at menarche.","PeriodicalId":15815,"journal":{"name":"Journal of Experimental and Clinical Anatomy","volume":"79 1","pages":"18 - 24"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83758578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A cadaveric study on morphological variations of fissures and lobes in the human lungs and its clinical significance 人肺裂叶形态变化的尸体研究及其临床意义
Journal of Experimental and Clinical Anatomy Pub Date : 2017-01-01 DOI: 10.4103/jeca.jeca_9_16
K. Gopalakrishna, S. Deepalaxmi, S. Somashekara, B. Rathna
{"title":"A cadaveric study on morphological variations of fissures and lobes in the human lungs and its clinical significance","authors":"K. Gopalakrishna, S. Deepalaxmi, S. Somashekara, B. Rathna","doi":"10.4103/jeca.jeca_9_16","DOIUrl":"https://doi.org/10.4103/jeca.jeca_9_16","url":null,"abstract":"Background: Knowledge of the anatomy and variations of the major fissures are essential to recognize pulmonary abnormalities, for segmental lung resection and radiological interpretations. Objective: To study the morphological variations of fissures and lobes in the human cadaveric lungs. Materials and Methods: One hundred specimens of formalin-fixed adult lungs of unknown gender were studied and the following parameters were measured bilaterally: (a) presence or absence of complete or incomplete fissure, (b) presence of accessory fissure, and (c) length of fissures. The observations and measurements were recorded, compiled, and tabulated and the result was compared with the other studies. Results: Length of oblique fissure was 29.36 ± 5.61cm with range of 17.9 - 42.0 cm on the right side and 26.81 ± 8.18 cm with range of 10.8–38.9 cm on the left side. Length of horizontal fissure was 10.2 ± 8.4 cm with range of 6.1–12.8 cm on the right side. Oblique fissure was complete in 84.0% cases on the right side and was in 82.0% cases on the right side. It was incomplete or absent in 16% (R) and 18% (L) cases. Horizontal fissure was complete in 74% and incomplete or absent in 26% of cases. Accessory fissure was found in a total of eight lung specimens. Conclusions: The knowledge of anatomy of fissures of the lung provides information on lobar anatomy with variations. The present study result and its comparison with other researches confirmed that lobar architecture is not constant. It emphasizes its usefulness in the diagnostic and surgical field.","PeriodicalId":15815,"journal":{"name":"Journal of Experimental and Clinical Anatomy","volume":"1 1","pages":"7 - 11"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89732473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Conference proceedings for the 15 th scientific conference of the society of experimental and clinical anatomists of Nigeria (SECAN), “ABRAKA 2016” 尼日利亚实验和临床解剖学家协会(SECAN)第15届科学会议论文集,“ABRAKA 2016”
Journal of Experimental and Clinical Anatomy Pub Date : 2016-10-18 DOI: 10.4314/jeca.v15i1
O. Egwu
{"title":"Conference proceedings for the 15 th scientific conference of the society of experimental and clinical anatomists of Nigeria (SECAN), “ABRAKA 2016”","authors":"O. Egwu","doi":"10.4314/jeca.v15i1","DOIUrl":"https://doi.org/10.4314/jeca.v15i1","url":null,"abstract":"","PeriodicalId":15815,"journal":{"name":"Journal of Experimental and Clinical Anatomy","volume":"11 1","pages":"60-72"},"PeriodicalIF":0.0,"publicationDate":"2016-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74672856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histomorphological changes in the cornea of the rat following monocular eyelid closure 大鼠单眼闭眼后角膜组织形态学的变化
Journal of Experimental and Clinical Anatomy Pub Date : 2016-08-25 DOI: 10.2399/ANA.16.010
F. Aseta, P. Mwachaka, P. Odula, A. Malek
{"title":"Histomorphological changes in the cornea of the rat following monocular eyelid closure","authors":"F. Aseta, P. Mwachaka, P. Odula, A. Malek","doi":"10.2399/ANA.16.010","DOIUrl":"https://doi.org/10.2399/ANA.16.010","url":null,"abstract":"Objectives: The aim of this study was to describe structural changes in the cornea of the rat after monocular eyelid closure. Methods: Twenty-six Rattus norvegicus male rats aged three months were used. The rats were randomly assigned into baseline (2), experimental (16) and control (8) groups. Unilateral eyelid closure was performed on the experimental animals by suture tarsorrhaphy. At experiment days 5, 10, 15 and 20, four rats from the experimental group and two rats from the control group were euthanized, their eyeballs harvested, and routine processing was done for paraffin embedding, sectioning and Masson’s trichrome staining. The photomicrographs were taken using a digital photomicroscope. Results: In the closed eyes, there was a time-dependent reduction in the stratification of the corneal epithelium with subsequent disintegration, and an increase in distribution of stromal keratocytes while the corneal endothelial cells showed slight enlargement from squamous shape. The contralateral and control eyes did not exhibit any significant changes through the experimental period. Conclusion: Monocular eyelid closure causes structural changes in the corneal epithelium, stroma and endothelium of the tarsorrhaphy eye. Therefore, tarsorrhaphy should not be prolonged due to risk of corneal diseases and diminution of vision as a result of the structural changes. Keywords: cornea; eyelid closure; rat; tarsorrhaphy","PeriodicalId":15815,"journal":{"name":"Journal of Experimental and Clinical Anatomy","volume":"11 1","pages":"87-93"},"PeriodicalIF":0.0,"publicationDate":"2016-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91544483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Prenatal ultrasound sex identification: Some factors that influence pregnant women's requests in Enugu, South-East Nigeria 产前超声性别鉴定:影响尼日利亚东南部埃努古孕妇要求的一些因素
Journal of Experimental and Clinical Anatomy Pub Date : 2016-07-01 DOI: 10.4103/1596-2393.200913
J. Ezugworie, A. Agu, Chimdimma Noelyn Onah, J. Nto, T. Okeke
{"title":"Prenatal ultrasound sex identification: Some factors that influence pregnant women's requests in Enugu, South-East Nigeria","authors":"J. Ezugworie, A. Agu, Chimdimma Noelyn Onah, J. Nto, T. Okeke","doi":"10.4103/1596-2393.200913","DOIUrl":"https://doi.org/10.4103/1596-2393.200913","url":null,"abstract":"Background: Mothers have always had cause to worry about the sex of their unborn child, but prenatal sex determination has continued to attract mixed feelings and reactions worldwide. This study was aimed at determining factors that influence pregnant women's requests for ultrasound sex identification of fetuses in Enugu, South-East Nigeria. Materials and Methods: A descriptive cross-sectional study of pregnant women attending antenatal clinic at University of Nigeria Teaching Hospital, Enugu, was done. A structured questionnaire was used to obtain information on the factors influencing their willingness to know the sex of their unborn children. Results: A total of 416 responses were obtained. Nearly 40.4% of the respondents were interested in knowing the sex of their children. Almost 56.3% preferred to have a male child, 8.7% preferred to have a female child while 25.5% of the respondents were indifferent. Those who had preference for a particular sex were more interested in requesting for prenatal sex determination than those who did not (54.2% vs. 24.0%). Those who had family pressure for a particular sex were more interested than those who were not pressured (65.9% vs. 33.1%). Other factors that influenced their desire to request for the prenatal sex of their children were preference for a male child, desire for more children dependent on the sex of the index fetus, and desire for more children (irrespective of the sex). Conclusions: Preference for a particular sex, desire to have more children, and family pressure for a particular sex were found to be the major factors that influence the desire for prenatal sex determination by pregnant women in this study.","PeriodicalId":15815,"journal":{"name":"Journal of Experimental and Clinical Anatomy","volume":"14 1","pages":"107 - 110"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79294933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Overexposure of rats to radiation from infrared lamp: Effects on blood parameters 大鼠过度暴露于红外灯辐射:对血液参数的影响
Journal of Experimental and Clinical Anatomy Pub Date : 2016-07-01 DOI: 10.4103/1596-2393.200916
A. Ibitoye, O. Afolabi, N. Irurhe, O. Ekun, A. Sowumi
{"title":"Overexposure of rats to radiation from infrared lamp: Effects on blood parameters","authors":"A. Ibitoye, O. Afolabi, N. Irurhe, O. Ekun, A. Sowumi","doi":"10.4103/1596-2393.200916","DOIUrl":"https://doi.org/10.4103/1596-2393.200916","url":null,"abstract":"Background: Previous reports showed that infrared radiation (IR) involved in photoaging, photocarcinogenesis, free radicals' production, and depletion of bone marrow cells. Beneficial effects of moderate exposure to infrared lamp have been itemized to include enhancement of blood circulation, relief from muscular pain, and wound healing acceleration with scarce information on biological effects when it is overexposed. Therefore, there is a need to investigate the possibility of its overexposure on biological system, especially blood parameters. Aim: This study was aimed to determine the biological effects of overexposure to radiation from infrared lamp on blood parameters. Materials and Methods: Infrared lamp of 100 W acts as a source of the IR. Twenty male healthy Wistar rats of the age range between 10 and 12 weeks and weigh between 100 and 250 g were studied. All the animals studied also acts as a control group with their blood samples taken and recorded as initial counting values. The animals were later divided into three groups: A, B, and C according to their hours of exposure according to their weight. Animals in Groups A, B, and C were exposed to IR for 1, 3, and 5 h, respectively. Blood samples of each animal in the group were taken 24, 48, and 96 h after exposure. The total number of erythrocytes, leukocytes, lymphocyte, and neutrophils were counted and compared with the initial samples. Results: The results revealed that packed cell volume, white blood cell, and lymphocytes of all the exposed animals averagely decreased by 17.4%, 17.5%, and 11.3%, respectively, whereas neutrophil increased by 19.0% after exposure to infrared. Conclusion: This study established that overexposure to radiation from infrared lamp affects hematological parameters.","PeriodicalId":15815,"journal":{"name":"Journal of Experimental and Clinical Anatomy","volume":"26 1","pages":"85 - 89"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73880644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predicting high blood pressure among adults in Southeastern Nigeria using anthropometric variables 使用人体测量变量预测尼日利亚东南部成年人的高血压
Journal of Experimental and Clinical Anatomy Pub Date : 2016-07-01 DOI: 10.4103/1596-2393.200912
C. J. Okamkpa, Monday Nwankwo, B. Danborno
{"title":"Predicting high blood pressure among adults in Southeastern Nigeria using anthropometric variables","authors":"C. J. Okamkpa, Monday Nwankwo, B. Danborno","doi":"10.4103/1596-2393.200912","DOIUrl":"https://doi.org/10.4103/1596-2393.200912","url":null,"abstract":"Background: Epidemiological studies on high blood pressure revealed that it has become a global public health concern. Efforts are being made to uncover other indicators of hypertension than the traditional and crude one popularly used, i.e. BMI. Obesity and overweight are common causes of most cardiovascular diseases. Aim: The study examined which anthropometric variable better predicts hypertension among adults in Enugu State of Nigeria. Materials and Methods: Sample of the present cross-sectional study included 540 (288 females and 258 males) adults aged 28-74 years old. Five anthropometric variables (weight, height, chest, waist, and hip circumferences) and blood pressure were measured. Data were collected by means of questionnaires from patients attending Korean Enugu State University Teaching Hospital. Subject is classified as being hypertensive if systolic blood pressure (SBP) >140 mmHg and/or diastolic blood pressure (DBP) >90 mmHg. Results: The overall prevalence rate of hypertension was found to be 26.30% while 24.4% and 28% were recorded for males and females respectively. The prevalence was not significantly associated with gender (χ2 = 0.899, P = 0.343). Hypertension was found to be related to age, weight, chest, waist, and hip circumferences, and waist-hip ratio (P < 0.05) but not height (P > 0.05). Waist circumference with the largest area under the ROC curve was the best predictor of hypertension for all sample population, males and females respectively 0.67, 0.68 and 0.66. Logistic regression model revealed that CC, WC, HC and WHR are predictors of hypertension. Conclusion: Waist circumference appears to be a better predictor of hypertension than other anthropometrics in this sample population.","PeriodicalId":15815,"journal":{"name":"Journal of Experimental and Clinical Anatomy","volume":"87 1","pages":"111 - 117"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85935727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Normal values of foot arch parameters in adult Hausa population of Nigeria 尼日利亚成年豪萨人足弓参数的正常值
Journal of Experimental and Clinical Anatomy Pub Date : 2016-07-01 DOI: 10.4103/1596-2393.200917
A. Gwani, A. Khan, M. Asari, Z. M. Mohd Ismail
{"title":"Normal values of foot arch parameters in adult Hausa population of Nigeria","authors":"A. Gwani, A. Khan, M. Asari, Z. M. Mohd Ismail","doi":"10.4103/1596-2393.200917","DOIUrl":"https://doi.org/10.4103/1596-2393.200917","url":null,"abstract":"Background: Deformities of foot arches have been implicated in various lower extremity injuries. Normal values of foot arch parameters have been studied in various populations. However, studies in Nigerian population are very limited and therefore require attention. Objective: The objectives of this study were to establish the normal values of foot arch parameters in adult Hausa population of Nigeria, to find the effect of gender on these parameters and to make comparison with previous studies in other populations. Materials and Methods: A total of 59 consented subjects (44 males, 15 females) that have no history of lower extremity deformity were recruited. Lateral radiograph of the right foot of each participant was taken in a bilateral standing position. For the medial longitudinal arch, navicular height (NH), first cuneiform height (FCH), calcaneal inclination angle (CIA), and calcaneal- first metatarsal angle (C1MA) were measured. Cuboid height (CH) and calcaneal-fifth metatarsal angle (C5MA) were measured for the lateral longitudinal arch. Measurements for angles and heights were performed using a universal plastic goniometer and a plastic ruler, respectively. Results: The mean (standard deviation [SD]) value of the NH was found to be 2.89 (0.54) cm, FCH 2.08 (0.44) cm, CIA 16.57° (3.30°), and C1MA 140.05° (5.63°). The mean (SD) of CH and C5MA was found to be 1.19 (0.31) cm and 160.96° (4.69°), respectively. There was no significant mean difference in those parameters between males and females. Conclusion: The mean values of foot arch parameters in adult Hausa population of Nigeria is comparable to previous studies on other populations, but generally lower than those of Caucasians. Similarly, our findings showed that gender has no significant effect on foot arch parameters.","PeriodicalId":15815,"journal":{"name":"Journal of Experimental and Clinical Anatomy","volume":"16 1","pages":"90 - 95"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88216055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histological and biochemical studies of Tamarindus indica pulp extract on the cerebral cortex in prenatal ethanol exposure in Wistar rats 产前乙醇暴露Wistar大鼠大脑皮层柽柳果肉提取物的组织学和生化研究
Journal of Experimental and Clinical Anatomy Pub Date : 2016-07-01 DOI: 10.4103/1596-2393.200919
Usman M. Ibe, A. Buraimoh, A. Ibegbu
{"title":"Histological and biochemical studies of Tamarindus indica pulp extract on the cerebral cortex in prenatal ethanol exposure in Wistar rats","authors":"Usman M. Ibe, A. Buraimoh, A. Ibegbu","doi":"10.4103/1596-2393.200919","DOIUrl":"https://doi.org/10.4103/1596-2393.200919","url":null,"abstract":"Introduction: Ethanol consumption during pregnancy has been shown to jeopardize the health of the mother and the embryo. Aim: The aim of the present study was to evaluate the histological and biochemical changes associated with the administration of Tamarindus indica pulp extract (TIPE) on the cerebral cortex in prenatal ethanol exposed Wistar rats. Methodology: Twenty four (24) pregnant rats were divided into 7 groups. Group 1 received 1ml of distilled water, Group 2 received 200mg/kg of body weight (bw) of TIPE only, Group 3 received 300mg/kg bw of Vitamin E only, Group 4 received 0.1ml of olive oil only, Group 5 received 2ml (30%v/v) of ethanol only, Group 6 received 2ml (30% v/v) of ethanol and 200mg/kg bw of TIPE while Group 7 received 2ml (30% v/v) of ethanol and 300mg/kg bw of Vitamin E. All administrations were via gastric intubation and lasted from prenatal day (PD) 7 to 14. The dams were allowed to litter and the brain tissues of the pups were collected for biochemical and histological studies. Results: The result of oxidative stress studies showed significant decrease in the mean levels of catalase and glutathione concentration in Groups 5, 6 and 7 respectively when compared with the Control (P < 0.05), while the mean concentration of malondialdehyde showed significant increase in Group 5 when compared to the Control (P < 0.05) and there was no significant difference in the mean level of superoxide dismutase in all the Groups. The result of sialic acid assay showed significant decrease in the mean level of free, bound and total sialic acid contents in Group 5 when compared to the Control (P < 0.001). The histological studies of the cerebral cortex showed normal architecture in Groups 1, 2, 3 and 4, while Group 5 showed degenerative changes with light staining of Nissl substances when compared to the Control and Groups 6 and 7 showed mild degenerative changes when compared to the Control. Conclusion: Treatment with TIPE has been shown to have potential protective effect on the Cerebral cortex of Wistar rats during prenatal ethanol exposure.","PeriodicalId":15815,"journal":{"name":"Journal of Experimental and Clinical Anatomy","volume":"12 1","pages":"96 - 101"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87391812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
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