Journal of environmental pathology and toxicology最新文献_第3页

Histopathologic study of adverse effects of linoleic acid on rat lung. 亚油酸对大鼠肺不良反应的组织病理学研究。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

W R Anderson, W C Tan, T Takatori, H Shimasaki, O S Privett

引用次数: 0

Effects of lead, cadmium and methylmercury on immunological memory. 铅、镉和甲基汞对免疫记忆的影响。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

L D Koller, J G Roan

引用次数: 0

Neoplastic and preneoplastic lesions induced in female C3H mice by diets containing diethylstilbestrol or 17 beta-estradiol. 含有己烯雌酚或17 -雌二醇的饮食诱导的雌性C3H小鼠的肿瘤和肿瘤前病变。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

B Highman, D L Greenman, M J Norvell, J Farmer, T E Shellenberger

{"title":"Neoplastic and preneoplastic lesions induced in female C3H mice by diets containing diethylstilbestrol or 17 beta-estradiol.","authors":"B Highman, D L Greenman, M J Norvell, J Farmer, T E Shellenberger","doi":"","DOIUrl":"","url":null,"abstract":"To study the long term effects of estrogenic diets, 2160 virgin female C3H/Hel mice, having a high titer to the mammary tumor virus factor (MMTV), were fed diets containing 0, 10, 100, 500, or 1000 ppb diethylstilbestrol (DES) or 100, 1000, or 5000 ppb 17 beta-estradiol (E2) from 6 to 110 weeks of age; 1368 virgin female C3HeB/FeJ mice, having a low titer to the MMTV, were fed diets containing 0, 10, 1000, or 500 ppb DES from 6 to 136 weeks. In estrogen-treated mice, the incidence of cervical adenosis and of mammary hyperplastic alveolar nodules was increased and the time to development of mammary adenocarcinomas was shortened. These changes tended to increase with dose and time and appeared earlier in the C3H/HeJ mice. Other tumors observed included 32 cervical and 20 endometrial adenocarcinomas, 16 cervical granular cell myoblastomas, 12 peritoneal mesotheliomas involving the uterus, 2 cervical and 4 vaginal squamous cell carcinomas, 2 ovarian teratomas, 6 osteosarcomas, 25 pheochromocytomas and 3 thyroid carcinomas. Of these tumors, 1 cervical and 2 endometrial adenocarcinomas, and 4 pheochromocytomas occurred in C3HeB/FeJ control mice at 104-130 weeks; none occurred in C3H/HeJ controls. This study indicates that the MMTV facilitates the development of mammary lesions in C3H mice, that estrogens predispose C3H mice to endometrial and cervical adenocarcinomas, and that cervical adenosis may be a precursor of cervical adenocarcinoma in C3H mice and serve as an early indicator of the potential uterine carcinogenicity of a test compound. It supports the view that the C3H mouse may serve as an animal model for uterine adenocarcinomas and adenosis in women exposed to estrogens.","PeriodicalId":15790,"journal":{"name":"Journal of environmental pathology and toxicology","volume":"4 5-6","pages":"81-95"},"PeriodicalIF":0.0,"publicationDate":"1980-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18232820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of bis(p-chlorophenyl) acetic acid on the renal function of the rat. 双(对氯苯)乙酸对大鼠肾功能的影响。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

F J Koschier, P J Gigliotti, S K Hong

{"title":"The effect of bis(p-chlorophenyl) acetic acid on the renal function of the rat.","authors":"F J Koschier, P J Gigliotti, S K Hong","doi":"","DOIUrl":"","url":null,"abstract":"The principle water-soluble metabolite of DDT in mammals has been shown to be DDA (bis(p-chlorophenyl)acetic acid). Previous studies suggested that DDA was secreted by the renal proximal tubule and was reabsorbed at an unspecified site in the nephron. Since DDA has been known to produce alterations in cellular functions, the present study examined the possibility that the renal transport of DDA was capable of causing acute nephrotoxicity. When 100 mg/kg of DDA was infused iv into the rat during a 90 min period, there was a significant decrease (congruent to 20%) in the glomerular filtration rate (GFR) after 110 min from the start of administration. During these experiments, there was no change in the mean arterial blood pressure (MABP), urine flow rate (V), renal clearance of tetraethylammonium (CTEA) or fractional reabsorption of Na (FRNa). After 200 mg/kg of DDA was infused iv into the rat during a 90 min period, there was a 60% decrease in the GFR, CTEA and V. However, the decrease in renal function was accompanied by a dramatic reduction in MABP (125 to 60 mmHg). To determine whether DDA could have produced acute renal failure when the perfusion pressure was kept constant, isolated kidney experiments were performed. In these experiments, DDA (1.0 mM) was present in a dextran perfusate and the perfusion pressure was kept constant at 90 mmHg. During these experiments, the GFR, V and FRNa were decreased significantly. The results indicated that a high perfusate concentration of DDA caused acute renal failure in the isolated kidney which was produced even when the perfusion pressure was kept constant. In conclusion, DDA produced renal failure in vivo which was associated with a reduction in renal perfusion pressure; however, perfused kidney experiments indicated that DDA could have caused a direct effect on nephron function.","PeriodicalId":15790,"journal":{"name":"Journal of environmental pathology and toxicology","volume":"4 5-6","pages":"209-17"},"PeriodicalIF":0.0,"publicationDate":"1980-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18233155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mutagenicity of secalonic acid D in mice. 二氯膦酸D对小鼠的致突变性。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

C S Reddy, R V Reddy, P K Chan, A W Hayes

引用次数: 0

Inhibition of microsomal metabolism and chemical oncogenesis in culture by naphthalene quinones. 萘醌对培养中微粒体代谢和化学致癌的抑制作用。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

S Nesnow, H Bergman, H Garland, M Morris

{"title":"Inhibition of microsomal metabolism and chemical oncogenesis in culture by naphthalene quinones.","authors":"S Nesnow, H Bergman, H Garland, M Morris","doi":"","DOIUrl":"","url":null,"abstract":"A series of naphthalene diols, quinones, and related compounds were examined for their ability to inhibit mixed-function oxidase in liver microsomes obtained from rats which had been pretreated with 3-methylcholanthrene (3-Mc) or phenobarbital (PB). Using benzo(a)pyrene monooxygenase as a measure of mixed-function oxidase activity, it was found that phenanthrene-9, 10-quinone was the most active compound tested with a K1 = 0.79 microM. Phenanthrene-9, 10-quinone did not affect cytochrome c reductase but did inhibit aminopyrine N-demethylase and p-nitroanisole-O-demethylase in both 3-MC and PB-induced microsome with almost identical inhibition constants. 1,2-Naphthoquinone exerted similar effects as phenanthrene-9,10-quinone on cytochrome c reductase, aminopyrine N-demethylase and p-nitroanisole-O-demethylase. Both quinones stimulated NADPH oxidase activity but the extent of this stimulation did not explain their inhibition of microsomal oxidation. Kinetic studies using benzo(a)-pyrene monooxygenase with phenanthrene-9, 10-quinone and 1,2-naphthoquinone indicated that they were noncompetitive with benzo(a)pyrene and mixed noncompetitive with NADPH. Both of these quinones inhibited benzo(a)pyrene induced oncogenic transformation in C3H10T1/2CL8 cells in culture in a dose response manner, presumably by inhibition of the cellular microsomal enzyme which activate benzo(a)pyrene. Phenanthrene-9, 10-quinone and 1,2-naphthoquinone seem to inhibit microsomal oxidative processes by interaction at the level of cytochrome P-450 possibly with a cytochrome P-450-substrate-oxygen complex.","PeriodicalId":15790,"journal":{"name":"Journal of environmental pathology and toxicology","volume":"4 5-6","pages":"17-30"},"PeriodicalIF":0.0,"publicationDate":"1980-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18233154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic analysis of adenine-3 mutants induced by hycanthone, lucanthone and their indazole analogs in Neurospora crassa. 刺草神经孢子虫腺嘌呤-3突变体的遗传分析。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

T Ong, F J de Serres

引用次数: 0

Null effect of dietary Aroclor 1254 on hepatocellular carcinoma incidence in rainbow trout (Salmo gairdneri) exposed to aflatoxin B1 as embryos. 饲料中添加Aroclor 1254对黄曲霉毒素B1暴露的虹鳟鱼胚胎肝癌发病率无影响。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

J D Hendricks, T P Putnam, R O Sinnhuber

{"title":"Null effect of dietary Aroclor 1254 on hepatocellular carcinoma incidence in rainbow trout (Salmo gairdneri) exposed to aflatoxin B1 as embryos.","authors":"J D Hendricks, T P Putnam, R O Sinnhuber","doi":"","DOIUrl":"","url":null,"abstract":"Four lots of 200 rainbow trout embryos were exposed to 200 ml solutions of aqueous 0.5 ppm aflatoxin B1 (AFB1) for 1 hr, and 4 lots of 200 rainbow trout embryos were sham-treated for 1 hr. After hatching and swimup, 100 fry from each group were selected for a feeding trial. Two groups of AFB1-treated and 2 groups of sham-treated fry were fed a control diet, while corresponding groups of AFB1-treated and sham-treated fry were fed the control diet plus 100 ppm Aroclor 1254 for 1 year. Samples were taken at 9 and 12 mon to monitor tumor incidence, Aroclor 1254 accumulation and histopathology. At the end of 12 mon, the liver cancer incidences in the combined AFB1-treated, control diet groups and the AFB1-treated, Aroclor 1254 diet groups were essentially the same. 65.8% and 63.9%, respectively. One trout in the sham-control, Aroclor 1254 diet group had a single liver cancer, but the sham-control, control diet group had none. The Aroclor 1254 fed groups had significantly higher liver to body weight ratios at 12 noon but not at 9 mon. Levels of accumulated Aroclor 1254 were similar to those reported previously, approximately 75 ppm on a whole fish basis at 12 mon. Glycogen depletion of hepatocytes and splenic hyperemia were the only tissue changes induced by Aroclor 1254.","PeriodicalId":15790,"journal":{"name":"Journal of environmental pathology and toxicology","volume":"4 5-6","pages":"9-16"},"PeriodicalIF":0.0,"publicationDate":"1980-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17837341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amikacin nephrotoxicity in the rat. 阿米卡星对大鼠肾毒性。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

D C Houghton, C E Plamp, D N Gilbert, S J Kohlhepp, W M Bennett, G A Porter, J DeFehr, M Webb

引用次数: 0

Current status of benzene teratology: a brief review. 苯致畸学研究现状综述。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

M A Mehlman, C A Schreiner, C R Mackerer

引用次数: 0