Journal of environmental pathology and toxicology最新文献_第2页

Subchronic oral toxicity of BaCl2 in rats. BaCl2对大鼠的亚慢性口服毒性。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

R G Tardiff, M Robinson, N S Ulmer

引用次数: 0

The future challenge for anatomic pathology. 解剖病理学未来的挑战。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

J Stasney

引用次数: 0

Immunotoxicology studies of sodium arsenate-effects of exposure on tumor growth and cell-mediated tumor immunity. 砷化钠对肿瘤生长和细胞介导的肿瘤免疫的免疫毒理学研究。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

N I Kerkvliet, L B Steppan, L D Koller, J H Exon

引用次数: 0

Reproductive capacities of control mallard ducks (Anas platyrhynchos) during a one-generation reproduction study. 对照绿头鸭一代繁殖能力的研究。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

V J Piccirillo, R P Quesenberry

{"title":"Reproductive capacities of control mallard ducks (Anas platyrhynchos) during a one-generation reproduction study.","authors":"V J Piccirillo, R P Quesenberry","doi":"","DOIUrl":"","url":null,"abstract":"The Mallard duck (Anas Platyrhynchos) is the waterfowl model of choice for testing the reproductive impairment of pesticides and environmental contaminants. The literature contains numerous reports on the effects of pesticides on egg shell development for mallards, quail and other avian species. Limited control data for reproductive evaluation of pesticides can be found. This paper summarizes one generation reproduction results from 75 control female mallard ducks. One male and five female adult ducks were housed in clean pens with tap water and game bird breeder ration available ad libitum. The pre-egg laying cycle was ten weeks in duration. For the first eight weeks, the photoperiod was seven hours light per day, after which the photoperiod was increased to 17 hours to induce egg laying. Eggs were collected daly for eight weeks and incubated. Shell thickness was measured on one egg from each pen bi-weekly. The mean reproductive indices are as follows: Eggs Cracked/Eggs Laid - 2.18%; Viable 11-Day Embryos/Eggs Set-85.2%; Live 21-Day Embryos/Viable 11-Day Survivors-97.6%; Hatchlings/Live 21-Day Embryos-80.6%; and 14-Day Survivors/Hatchlings-89.3%. The mean egg shell thickness for 60 eggs is 0.378 millimeters.","PeriodicalId":15790,"journal":{"name":"Journal of environmental pathology and toxicology","volume":"4 5-6","pages":"133-9"},"PeriodicalIF":0.0,"publicationDate":"1980-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18233150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GLP problems from the point of view of the university. 从大学的角度看GLP问题。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

A E Munson

引用次数: 0

Epidemiology of field re-entry poisoning. 野外再入中毒流行病学。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

E Kahn

引用次数: 0

Influence of diet on hexachlorobenzene accumulation in Osborne Mendel rats. 饮食对奥斯本孟德尔大鼠六氯苯积累的影响。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

M E Zabik, R Schemmel

引用次数: 0

Immunocompetence over the lifespan of mice exposed in utero to carbofuran or diazinon: I. Changes in serum immunoglobulin concentrations. 子宫内暴露于呋喃或二嗪农的小鼠的免疫能力:1 .血清免疫球蛋白浓度的变化。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

J B Barnett, J M Spyker-Cranmer, D L Avery, A M Hoberman

{"title":"Immunocompetence over the lifespan of mice exposed in utero to carbofuran or diazinon: I. Changes in serum immunoglobulin concentrations.","authors":"J B Barnett, J M Spyker-Cranmer, D L Avery, A M Hoberman","doi":"","DOIUrl":"","url":null,"abstract":"Pregnant F2 dihybrid mice received either a vehicle-control or 1 of 2 doses of the anticholinesterase pesticides Carbofuran (0.01 or 0.50 mg/kg) or Diazinon (0.18 or 9.00 mg/kg) in the diet daily throughout gestation. All mothers gave birth to viable, overtly normal offspring at term. However, a significant number (12%) of pups born to dams who received 9.00 mg/kg Diazinon died prior to weaning on day 28; necropsy findings were consistent with death from respiratory infection. There was no significant difference in mortality between control and pesticide-exposed offspring once they reached 28 days of age. Determinations of 5 different classes of serum immunoglobulin (Ig) concentrations (IgG1,IgG2a,IgG2b, IgA, IgM) at 101, 400 and 800 days of age indicated transient but consistent disturbances of 2 Ig classes in offspring as a result of prenatal pesticide exposure. IgG1 concentrations of male offspring exposed to 0.50 mg/kg Carbofuran or 0.18 mg/kg Diazinon were significantly elevated at 101 days but not at 400 or 800 days of age. IgG1 concentrations of female offspring exposed to 0.01 mg/kg Carbofuran or 9.00 mg/kg Diazinon were significantly depressed at 101 days but not different from controls at 400 or 800 days of age. Changes in IgG2b levels generally were similar to those recorded for IgG1 but of smaller magnitude. There were no significant effects on serum IgG2b or IgM concentrations, and only equivocal effects on IgA, as a consequence of prenatal exposure to either pesticide.","PeriodicalId":15790,"journal":{"name":"Journal of environmental pathology and toxicology","volume":"4 5-6","pages":"53-63"},"PeriodicalIF":0.0,"publicationDate":"1980-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18232818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short-term in vivo initiation/promotion bioassay for hepatocarcinogens. 短期体内肝癌起始/促进生物测定。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

J O Ford, M A Pereira

引用次数: 0

Ultrastructure of spontaneous neoplasms induced by diethylnitrosamine and dieldrin in the C3H mouse. 二乙基亚硝胺和狄氏剂致C3H小鼠自发性肿瘤的超微结构。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

B H Ruebner, M E Gershwin, L Hsieh, P Dunn

{"title":"Ultrastructure of spontaneous neoplasms induced by diethylnitrosamine and dieldrin in the C3H mouse.","authors":"B H Ruebner, M E Gershwin, L Hsieh, P Dunn","doi":"","DOIUrl":"","url":null,"abstract":"The spontaneous hepatocellular neoplasms of C3H (MTV-ve) male mice were compared with the hepatic tumors induced in these animals by diethylnitrosamine (DEN) and dieldrin. No morphologic differences could be detected by light or electron microscopy between the spontaneous and induced lesions. However, the animals given diethylnitrosamine or dieldrin developed the lesions earlier, in greater numbers and of larger size. The earliest change was the development of foci composed of clear cells. Later nodules appeared which were composed of clear or basophilic cells. These lesions were followed by and presumably progressed to nodules of trabecular hepatocellular carcinomas. It is postulated that in this series, the first morphological step in the neoplastic transformation is the appearance of unusually clear hepatocytes. Ultrastructurally, the clear cells had increased glycogen and lipid droplets and a decrease in smooth endoplasmic reticulum. The basophilic cells seen later resembled the clear cells except for having a greatly increased rough endoplasmic reticulum. Trabecular hepatocellular carcinomas differed from benign nodules in the greater secretory activity of the rough endoplasmic reticulum, in the development of basement membranes at the vascular pole and of microvilli along the lateral cell membranes. The stepwise progression of normal hepatocytes to hepatocellular carcinoma is discussed on the basis of these sequential light microscopic and ultrastructural observations.","PeriodicalId":15790,"journal":{"name":"Journal of environmental pathology and toxicology","volume":"4 5-6","pages":"237-54"},"PeriodicalIF":0.0,"publicationDate":"1980-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18231956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0