Journal of environmental pathology and toxicology最新文献

Health and ecological assessment of polynuclear aromatic hydrocarbons. 多核芳烃的健康与生态评价。

Journal of environmental pathology and toxicology Pub Date : 1981-09-01

J Santodonato, P Howard, D Basu

引用次数: 0

Pheochromocytoma in rats: incidence, etiology, morphology and functional activity. 大鼠嗜铬细胞瘤:发病率、病因、形态和功能活性。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

L Cheng

引用次数: 0

Comparative in vitro metabolisms of dimethylnitrosamine in animals of six different species. 六种不同动物体内二甲基亚硝胺的体外代谢比较。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

E N Maduagwu, O Bassir

引用次数: 0

Technical problems in determining safe re-entry intervals. 确定安全再入间隔的技术问题。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

R C Spear

引用次数: 0

Subchronic toxicity of acrylamide administered to rats in the drinking water followed by up to 144 days of recovery. 丙烯酰胺的亚慢性毒性给予大鼠饮用水，随后长达144天的恢复。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

J D Burek, R R Albee, J E Beyer, T J Bell, R M Carreon, D C Morden, C E Wade, E A Hermann, S J Gorzinski

{"title":"Subchronic toxicity of acrylamide administered to rats in the drinking water followed by up to 144 days of recovery.","authors":"J D Burek, R R Albee, J E Beyer, T J Bell, R M Carreon, D C Morden, C E Wade, E A Hermann, S J Gorzinski","doi":"","DOIUrl":"","url":null,"abstract":"Groups of male and female Fischer 344 rats were administered acrylamide in their drinking water at 0, 0.05, 0.2, 1, 5, or 20 mg/kg/day for up to 93 days. Following the administration of acrylamide in the drinking water, male rats from each dose level were held for up to 144 days of recovery. The 20 mg/kg/day groups had definite treatment-related effects after 92 (males) and 93 (females) days. They were dragging the rear limbs, body weights were decreased, serum cholinesterase activity was decreased in top dose females, and packed cell volume, red blood cell, and hemoglobin values were slightly decreased in males and females. In the 20 mg/kg/day groups, the primary target tissue was the peripheral nerve with lesions consisting of severe degeneration characterized by demyelinization and axonal loss. Slight spinal cord degeneration was observed. Other effects included atrophy of skeletal muscle, testicular atrophy, and distended urinary bladders; these were probably secondary to the nerve degeneration. After 144 days of recovery, the lesions had partially or completely reversed. Parameters affected at the 5 mg/kg/day dose level after 92 (males) and 93 (females) days consisted of peripheral nerve degeneration which were of a lesser degree of severity than those seen in the 20 mg/kg/day groups and appeared to have completely reversed after 111 days of recovery. In rats given 1 mg/kg/day, a minimal treatment-related effect was observed in males after 92 days, and this was limited to very slight nerve degeneration using electron microscopy (females were not examined by electron microscopy). This observed effect appeared to have reversed after 25 days of recovery. No treatment-related effects were seen in any of the parameters monitored in the rats given 0.05 or 0.2 mg/kg/day of acrylamide.","PeriodicalId":15790,"journal":{"name":"Journal of environmental pathology and toxicology","volume":"4 5-6","pages":"157-82"},"PeriodicalIF":0.0,"publicationDate":"1980-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18233153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of sulfur dioxide on the morphology and mucin biosynthesis by the rat trachea. 二氧化硫对大鼠气管形态及粘蛋白生物合成的影响。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

J N Clark, W E Dalbey, K B Stephenson

引用次数: 0

Linear interpolation algorithm for low dose risk assessment of toxic substances. 有毒物质低剂量风险评估的线性插值算法。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

D W Gaylor, R L Kodell

引用次数: 0

Dietary nutrients and contaminants in laboratory animal experimentation. 实验室动物实验中的膳食营养素和污染物。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

P M Newberne, R G McConnell

引用次数: 0

Effect of cigarette smoke inhalation during pregnancy in Sprague-Dawley rats. Sprague-Dawley大鼠妊娠期吸入香烟的影响。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

G Reznik, G Marquard

{"title":"Effect of cigarette smoke inhalation during pregnancy in Sprague-Dawley rats.","authors":"G Reznik, G Marquard","doi":"","DOIUrl":"","url":null,"abstract":"Pregnant 9 weeks old Sprague-Dawley rats were exposed to the smoke of different research cigarettes (C1-C7). The cigarettes were different in smoke nicotine, condensate and carbon monoxide. The animals were divided in groups inhaling different smoke concentrations, numbers of inhalations per day and time periods per pregnancy. Carbon monoxide and dioxide content in the inhalation chamber increased dependent on time and concentration of smoke inhalation. Both parameters were highest after inhalation of smoke from cigarette C2. The weight of the pregnant rats was reduced after inhalation of high concentrations of smoke from cigarette C1 and c2. Weight and length of fetuses were reduced dependent on number and duration of smoke inhalation. High concentrations of cigarette smoke, twice daily for 21 days were more effective than smoke inhalation in the second part of the pregnancy. Inhalation of cigarette smoke during the second half of the pregnancy was more effective than smoke inhalation in the first ten days of pregnancy. cigarette C1 reduced the length and weight of fetuses more than cigarette C2 when concentration and number of inhalations per day were the same. The vapor phase in both cigarettes was not as effective as the total smoke. Resorptions and stillbirths were independent of treatment. Malformations were diagnosed only in one fetus.","PeriodicalId":15790,"journal":{"name":"Journal of environmental pathology and toxicology","volume":"4 5-6","pages":"141-52"},"PeriodicalIF":0.0,"publicationDate":"1980-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18233151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute and subchronic toxicity of pentachlorobenzene. 五氯苯的急性和亚慢性毒性。

Journal of environmental pathology and toxicology Pub Date : 1980-11-01

R Linder, T Scotti, J Goldstein, K McElroy, D Walsh

{"title":"Acute and subchronic toxicity of pentachlorobenzene.","authors":"R Linder, T Scotti, J Goldstein, K McElroy, D Walsh","doi":"","DOIUrl":"","url":null,"abstract":"Oral LD50 values for pentachlorobenzene (QCB) in rats were 1125, 1080, and 940 mg/kg for adult males, adult females, and weanling females, respectively. The oral LD50 values in mice were 1175 mg/kg for males and 1370 mg/kg for females. Clinical signs of toxicity included tremors and narcosis. Dermal application of 2500 mg/kg did not produce clinical signs in rats. In subchronic studies weanling male rats were fed 0, 125, or 1000 ppm QCB for 100 days and weanling females fed 0, 125, 250, 500, or 1000 ppm for 180 days. No clinical signs of toxicity or effects on growth were observed in these rats throughout the exposures. QCB accumulated in adipose tissues at approximately 1.5-2.2 times the dietary concentrations. Porphyrin measurements were made only in females. Terminal values for urinary uro-and coproporphyrin and accumulation of liver porphyrins were not remarkably different in control and QCB-treated groups. In groups fed 1000 ppm, the WBC was increased and red blood cell indices were generally decreased compared to controls. The rats were pair-bred with untreated partners after 67 days of treatment. Fertility and fecundity were unaffected in either sex; however, suckling pups of QCB-treated mothers fed 250 ppm or more developed tremors and at 1000 ppm most died before weaning. Adrenal weights in males and kidney weights in both sexes were increased in adults fed 1000 ppm. In groups fed 250 ppm or more liver/body weight ratios were increased in both adults and in weanling offspring of QCB-treated dams. Hepatocellular enlargement was particularly evident in the 500 and 1000 ppm groups. In the kidneys of adult males, more numerous and larger foci of tubular atrophy and lymphocytic infiltration were seen at 1000 ppm than were seen in controls and dose-related increases in hyaline droplet formation occurred at 125 and 1000 ppm.","PeriodicalId":15790,"journal":{"name":"Journal of environmental pathology and toxicology","volume":"4 5-6","pages":"183-96"},"PeriodicalIF":0.0,"publicationDate":"1980-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18207768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0