Journal of Endocrinology最新文献_第10页

The alternate pathway of androgen metabolism and window of sensitivity. 雄激素代谢的替代途径和敏感性窗口。

IF 4 3区医学

Journal of Endocrinology Pub Date : 2023-08-01 Print Date: 2023-09-01 DOI: 10.1530/JOE-22-0296

Marilyn B Renfree, Geoff Shaw

{"title":"The alternate pathway of androgen metabolism and window of sensitivity.","authors":"Marilyn B Renfree, Geoff Shaw","doi":"10.1530/JOE-22-0296","DOIUrl":"10.1530/JOE-22-0296","url":null,"abstract":"Since the discovery in 1968 that dihydrotestosterone (DHT) is a major mediator of androgen action, a convincing body of evidence has accumulated to indicate that the major pathway of DHT formation is the 5α-reduction of circulating testosterone in androgen target tissues. However, we now know that DHT can also be formed in peripheral tissues by the oxidation of 5α-androstane-3α,17β-diol (adiol). This pathway is responsible for the formation of the male phenotype. We discuss the serendipitous discovery in the tammar wallaby of an alternate pathway by which adiol is formed in the testes, secreted into plasma and converted in peripheral tissues to DHT. This alternate pathway is responsible for virilisation of the urogenital system in this species and is present in the testes at the onset of male puberty of all mammals studied so far. This is the first clear-cut function for steroid 5α-reductase 1 in males. Unexpectedly, the discovery of this pathway in this Australian marsupial has had a major impact in understanding the pathophysiology of aberrant virilisation in female newborns. Overactivity of the alternate pathway appears to explain virilisation in congenital adrenal hyperplasia CAH, in X-linked 46,XY disorders of sex development. It also appears to be important in polycystic ovarian syndrome (PCOS) since PCOS ovaries have enhanced the expression of genes and proteins of the alternate pathway. It is now clear that normal male development in marsupials, rodents and humans requires the action of both the classic and the alternate (backdoor) pathways.","PeriodicalId":15740,"journal":{"name":"Journal of Endocrinology","volume":"258 3","pages":""},"PeriodicalIF":4.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9926204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brief overview: glucagon history and physiology. 简要概述:胰高血糖素的历史和生理。

IF 4 3区医学

Journal of Endocrinology Pub Date : 2023-08-01 DOI: 10.1530/JOE-22-0224

R Paul Robertson

{"title":"Brief overview: glucagon history and physiology.","authors":"R Paul Robertson","doi":"10.1530/JOE-22-0224","DOIUrl":"https://doi.org/10.1530/JOE-22-0224","url":null,"abstract":"Glucagon is a peptide hormone that is produced primarily by the alpha cells in the islet of Langerhans in the pancreas, but also in intestinal enteroendocrine cells and in some neurons. Approximately 100 years ago, several research groups discovered that pancreatic extracts would cause a brief rise in blood glucose before they observed the decrease in glucose attributed to insulin. An overall description of the regulation of glucagon secretion requires the inclusion of its sibling insulin because they both are made primarily by the islet and they both regulate each other in different ways. For example, glucagon stimulates insulin secretion, whereas insulin suppresses glucagon secretion. The mechanism of action of glucagon on insulin secretion has been identified as a trimeric guanine nucleotide-binding protein (G-protein)-mediated event. The manner in which insulin suppresses glucagon release from the alpha cell is thought to be highly dependent on the peri-portal circulation of the islet through which blood flows downstream from beta cells to alpha cells. In this scenario, it is via the circulation that insulin is thought to suppress the release of glucagon. However, high levels of glucose also have been shown to suppress glucagon secretion. Consequently, the glucose-lowering effect of insulin may be additive to the direct effects of insulin to suppress alpha cell function, so that in vivo both the discontinuation of the insulin signal and the condition of low glucose jointly are responsible for induction of glucagon secretion.","PeriodicalId":15740,"journal":{"name":"Journal of Endocrinology","volume":"258 2","pages":""},"PeriodicalIF":4.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9797283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Intercellular contacts affect secretion and biosynthesis of pancreatic islet cells. 细胞间接触影响胰岛细胞的分泌和生物合成。

IF 4 3区医学

Journal of Endocrinology Pub Date : 2023-08-01 DOI: 10.1530/JOE-22-0304

David Cottet-Dumoulin, Quentin Perrier, Vanessa Lavallard, David Matthey-Doret, Laura Mar Fonseca, Juliette Bignard, Reine Hanna, Geraldine Parnaud, Fanny Lebreton, Kevin Bellofatto, Ekaterine Berishvili, Thierry Berney, Domenico Bosco

{"title":"Intercellular contacts affect secretion and biosynthesis of pancreatic islet cells.","authors":"David Cottet-Dumoulin, Quentin Perrier, Vanessa Lavallard, David Matthey-Doret, Laura Mar Fonseca, Juliette Bignard, Reine Hanna, Geraldine Parnaud, Fanny Lebreton, Kevin Bellofatto, Ekaterine Berishvili, Thierry Berney, Domenico Bosco","doi":"10.1530/JOE-22-0304","DOIUrl":"https://doi.org/10.1530/JOE-22-0304","url":null,"abstract":"Cell protein biosynthesis is regulated by different factors, but implication of intercellular contacts on alpha and beta cell protein biosyntheses activity has not been yet investigated. Islet cell biosynthetic activity is essential in regulating not only the hormonal reserve within cells but also in renewing all the proteins involved in the control of secretion. Here we aimed to assess whether intercellular interactions affected similarly secretion and protein biosynthesis of rat alpha and beta cells. Insulin and glucagon secretion were analyzed by ELISA or reverse hemolytic plaque assay, and protein biosynthesis evaluated at single cell level using bioorthogonal noncanonical amino acid tagging. Regarding beta cells, we showed a positive correlation between insulin secretion and protein biosynthesis. We also observed that homologous contacts increased both activities at low or moderate glucose concentrations. By contrast, at high glucose concentration, homologous contacts increased insulin secretion and not protein biosynthesis. In addition, heterogeneous contacts between beta and alpha cells had no impact on insulin secretion and protein biosynthesis. Regarding alpha cells, we showed that when they were in contact with beta cells, they increased their glucagon secretion in response to a drop of glucose concentration, but, on the other hand, they decreased their protein biosynthesis under any glucose concentrations. Altogether, these results emphasize the role of intercellular contacts on the function of islet cells, showing that intercellular contacts increased protein biosynthesis in beta cells, except at high glucose, and decreased protein biosynthesis in alpha cells even when glucagon secretion is stimulated.","PeriodicalId":15740,"journal":{"name":"Journal of Endocrinology","volume":"258 2","pages":""},"PeriodicalIF":4.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10153357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Testosterone and type 2 diabetes prevention: translational lessons from the T4DM study. 睾酮与2型糖尿病预防：T4DM研究的转化经验教训。

IF 4 3区医学

Journal of Endocrinology Pub Date : 2023-08-01 Print Date: 2023-09-01 DOI: 10.1530/JOE-22-0223

Gary A Wittert, Mathis Grossmann, Bu B Yeap, David J Handelsman

{"title":"Testosterone and type 2 diabetes prevention: translational lessons from the T4DM study.","authors":"Gary A Wittert, Mathis Grossmann, Bu B Yeap, David J Handelsman","doi":"10.1530/JOE-22-0223","DOIUrl":"10.1530/JOE-22-0223","url":null,"abstract":"Testosterone acting via the androgen receptor, and via aromatisation to oestradiol, an activator of the oestrogen receptor, plays key roles in adipose tissue, bone and skeletal muscle biology. This is reflected in epidemiological studies associating obesity and disordered glucose metabolism with lower serum testosterone concentrations and an increased risk of type 2 diabetes (T2D) in men. Testosterone also modulates erythrocytosis and vascular endothelial and smooth muscle cell function, with potential impacts on haematocrit and the cardiovascular system. The Testosterone for the Prevention of Type 2 Diabetes (T4DM) study enrolled men aged 50 years and over with a waist circumference of 95 cm or over, impaired glucose tolerance or newly diagnosed T2D, and a serum testosterone concentration (as measured by chemiluminescence immunoassay) <14.0 nmol/L. The study reported that a 2-year treatment with testosterone undecanoate 1000 mg, administered 3-monthly intramuscularly, on the background of a lifestyle program, reduced the likelihood of T2D diagnosis by 40% compared to placebo. This effect was accompanied by a decrease in fasting serum glucose and associated with favourable changes in body composition, hand grip strength, bone mineral density and skeletal microarchitecture but not in HbA1c, a red blood cell-dependent measure of glycaemic control. There was no signal for cardiovascular adverse events. With the objective of informing translational science and future directions, this article discusses mechanistic studies underpinning the rationale for T4DM and translational implications of the key outcomes relating to glycaemia, and body composition, together with effects on erythrocytosis, cardiovascular risk and slow recovery of the hypothalamo-pituitary-testicular axis.","PeriodicalId":15740,"journal":{"name":"Journal of Endocrinology","volume":"258 3","pages":""},"PeriodicalIF":4.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9900932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

100 years of glucagon anniversary. 胰高血糖素100周年纪念。

IF 4 3区医学

Journal of Endocrinology Pub Date : 2023-07-28 Print Date: 2023-09-01 DOI: 10.1530/JOE-23-0138

James Cantley, Vincent Poitout, Rebecca L Hull-Meichle

{"title":"100 years of glucagon anniversary.","authors":"James Cantley, Vincent Poitout, Rebecca L Hull-Meichle","doi":"10.1530/JOE-23-0138","DOIUrl":"10.1530/JOE-23-0138","url":null,"abstract":"The year 2023 marks 100 years since publication of the first report of a hyperglycemic factor in pancreatic extracts which C P Kimball and John R Murlin named glucagon (from GLUCose AGONist). Glucagon has a range of profound effects on metabolism including, but not limited to, stimulation of hepatic glucose production. Dysregulation of glucagon secretion is a key feature of both major forms of diabetes, leading to the concept that diabetes is a bihormonal disorder. Still, the work to fully understand the production and biological effects of glucagon has proceeded at a slower pace compared to that of insulin. A recent resurgence of interest in the islet alpha (α) cell, the predominant site of glucagon production, has been facilitated in part by technological innovations. This work has led to significant developments in the field, from defining how alpha cells develop and how glucagon secretion from pancreatic alpha cells is regulated to determining the role of glucagon in metabolic homeostasis and the progression of both major forms of diabetes. In addition, glucagon is considered to be a promising target for diabetes therapy, with many new potential applications arising from research in this field. This collection of reviews, led by Guest Editors James Cantley, Vincent Poitout and Rebecca Hull-Meichle, is intended to capture the field's current understanding of glucagon and alpha cell biology, as well stimulate additional interest and research on this important hormone.","PeriodicalId":15740,"journal":{"name":"Journal of Endocrinology","volume":"258 3","pages":""},"PeriodicalIF":4.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9923057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do adipocytes serve as a reservoir for severe acute respiratory symptom coronavirus-2? 脂肪细胞是严重急性呼吸道症状冠状病毒-2的储存库吗?

IF 4 3区医学

Journal of Endocrinology Pub Date : 2023-07-12 Print Date: 2023-08-01 DOI: 10.1530/JOE-23-0027

Charlotte Steenblock, Nicole Bechmann, Felix Beuschlein, Christian Wolfrum, Stefan R Bornstein

{"title":"Do adipocytes serve as a reservoir for severe acute respiratory symptom coronavirus-2?","authors":"Charlotte Steenblock, Nicole Bechmann, Felix Beuschlein, Christian Wolfrum, Stefan R Bornstein","doi":"10.1530/JOE-23-0027","DOIUrl":"10.1530/JOE-23-0027","url":null,"abstract":"Obesity is associated with a higher risk of severe coronavirus disease 2019 (COVID-19) and increased mortality. In the current study, we have investigated the expression of ACE2, NRP1, and HMGB1, known to facilitate severe acute respiratory symptom coronavirus-2 (SARS-CoV-2) cell entry, in adipose tissue from non-COVID-19 control patients with normal weight, overweight, and obesity. All factors were expressed, but no significant differences between the groups were observed. Furthermore, diabetes status and medications did not affect the expression of ACE2. Only in obese men, the expression of ACE2 in adipose tissue was higher than in obese women. In the adipose tissue from patients who died from COVID-19, SARS-CoV-2 was detected in the adipocytes even though the patients died more than 3 weeks after the acute infection. This suggests that adipocytes may act as reservoirs for the virus. In COVID-19 patients, the expression of NRP1 was increased in COVID-19 patients with overweight and obesity. Furthermore, we observed an increased infiltration with macrophages in the COVID-19 adipose tissues compared to control adipose tissue. In addition, crown-like structures of dying adipocytes surrounded by macrophages were observed in the adipose tissue from COVID-19 patients. These data suggest that in obese individuals, in addition to an increased mass of adipose tissue that could potentially be infected, increased macrophage infiltration due to direct infection with SARS-CoV-2 and sustained viral shedding, rather than preinfection ACE2 receptor expression, may be responsible for the increased severity and mortality of COVID-19 in patients with obesity.","PeriodicalId":15740,"journal":{"name":"Journal of Endocrinology","volume":"258 2","pages":""},"PeriodicalIF":4.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9795040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Insights into isoform-specific mineralocorticoid receptor action in the hippocampus. 洞察海马中矿质皮质激素受体的特异性作用

IF 3.4 3区医学

Journal of Endocrinology Pub Date : 2023-07-12 Print Date: 2023-08-01 DOI: 10.1530/JOE-22-0293

Carolina Gaudenzi, Karen R Mifsud, Johannes M H M Reul

{"title":"Insights into isoform-specific mineralocorticoid receptor action in the hippocampus.","authors":"Carolina Gaudenzi, Karen R Mifsud, Johannes M H M Reul","doi":"10.1530/JOE-22-0293","DOIUrl":"10.1530/JOE-22-0293","url":null,"abstract":"The mineralocorticoid receptor (MR) plays a critical role in the mammalian brain as a mediator of appropriate cellular and behavioural responses under both baseline and stressful conditions. In the hippocampus, the MR has been implicated in several processes, such as neuronal maintenance, adult neurogenesis, inhibitory control of the hypothalamic-pituitary-adrenal axis, and learning and memory. Because of its high affinity for endogenous glucocorticoid hormones, the MR has long been postulated to mediate tonic actions in the brain, but more recent data have expanded on this view, indicating that the MR elicits dynamic responses as well. The complexity of the diverse molecular, cellular, and physiological functions fulfilled by the human, rat and mouse MR could at least partially be explained by the existence of different isoforms of the receptor. The structural and functional characteristics of these isoforms, however, have remained largely unexplored. The present article will review the current knowledge concerning human, rat, and mouse MR isoforms and evaluate seminal studies concerning the roles of the brain MR, with the intent to shed light on the function of its specific isoforms.","PeriodicalId":15740,"journal":{"name":"Journal of Endocrinology","volume":"258 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7616738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9785401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RISING STARS: Endocrine regulation of metabolic homeostasis via the intestine and gut microbiome. 新星：通过肠道和肠道微生物组对代谢稳态的内分泌调节。

IF 4 3区医学

Journal of Endocrinology Pub Date : 2023-07-11 Print Date: 2023-08-01 DOI: 10.1530/JOE-23-0019

Rachel K Meyer, Frank A Duca

引用次数: 0

Not the second fiddle: α cell development, identity, and function in health and diabetes. 不是次要因素：α细胞的发育、身份和在健康和糖尿病中的功能。

IF 3.4 3区医学

Journal of Endocrinology Pub Date : 2023-07-11 Print Date: 2023-08-01 DOI: 10.1530/JOE-22-0297

Elliott P Brooks, Lori Sussel

{"title":"Not the second fiddle: α cell development, identity, and function in health and diabetes.","authors":"Elliott P Brooks, Lori Sussel","doi":"10.1530/JOE-22-0297","DOIUrl":"10.1530/JOE-22-0297","url":null,"abstract":"Historic and emerging studies provide evidence for the deterioration of pancreatic α cell function and identity in diabetes mellitus. Increased access to human tissue and the availability of more sophisticated molecular technologies have identified key insights into how α cell function and identity are preserved in healthy conditions and how they become dysfunctional in response to stress. These studies have revealed evidence of impaired glucagon secretion, shifts in α cell electrophysiology, changes in α cell mass, dysregulation of α cell transcription, and α-to-β cell conversion prior to and during diabetes. In this review, we outline the current state of research on α cell identity in health and disease. Evidence in model organisms and humans suggests that in addition to β cell dysfunction, diabetes is associated with a fundamental dysregulation of α cell identity. Importantly, epigenetic studies have revealed that α cells retain more poised and open chromatin at key cell-specific and diabetes-dysregulated genes, supporting the model that the inherent epigenetic plasticity of α cells makes them susceptible to the transcriptional changes that potentiate the loss of identity and function seen in diabetes. Thus, additional research into the maintenance of α cell identity and function is critical to fully understanding diabetes. Furthermore, these studies suggest α cells could represent an alternative source of new β cells for diabetes treatment.","PeriodicalId":15740,"journal":{"name":"Journal of Endocrinology","volume":"258 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10524258/pdf/nihms-1904140.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9793479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulation of adipose tissue development and energy metabolism by VEGFB isoforms. vegf异构体对脂肪组织发育和能量代谢的调节。

IF 4 3区医学

Journal of Endocrinology Pub Date : 2023-07-01 DOI: 10.1530/JOE-22-0329

Yang Chen, Xin Li, Jing Zhang, Mingjiao Zhang, Salah Adlat, Xiaodan Lu, Dan Li, Honghong Jin, Chenhao Wang, Zin Mar Oo, Farooq Hayel, Quangang Chen, Xufeng Han, Renjin Chen, Xuechao Feng, Luqing Zhang, Yaowu Zheng

{"title":"Regulation of adipose tissue development and energy metabolism by VEGFB isoforms.","authors":"Yang Chen, Xin Li, Jing Zhang, Mingjiao Zhang, Salah Adlat, Xiaodan Lu, Dan Li, Honghong Jin, Chenhao Wang, Zin Mar Oo, Farooq Hayel, Quangang Chen, Xufeng Han, Renjin Chen, Xuechao Feng, Luqing Zhang, Yaowu Zheng","doi":"10.1530/JOE-22-0329","DOIUrl":"https://doi.org/10.1530/JOE-22-0329","url":null,"abstract":"Obesity is caused by imbalanced energy intake and expenditure. Excessive energy intake and storage in adipose tissues are associated with many diseases. Several studies have demonstrated that vascular growth endothelial factor B (VEGFB) deficiency induces obese phenotypes. However, the roles of VEGFB isoforms VEGFB167 and VEGFB186 in adipose tissue development and function are still not clear. In this study, genetic mouse models of adipose-specific VEGFB167 and VEGFB186 overexpression (aP2-Vegfb167 tg/+and aP2-Vegfb186tg/+) were generated and their biologic roles were investigated. On regular chow, adipose-specific VEGFB186 is negatively associated with white adipose tissues (WATs) and positively regulates brown adipose tissues (BATs). VEGFB186 upregulates energy metabolism and metabolism-associated genes. In contrast, VEGFB167 has a nominal role in adipose development and function. On high-fat diet, VEGFB186 expression can reverse the phenotypes of VEGFB deletion. VEGFB186 overexpression upregulates BAT-associated genes and downregulates WAT-associated genes. VEGFB186 and VEGFB167 have very distinct roles in the regulation of adipose development and energy metabolism. As a key regulator of adipose tissue development and energy metabolism, VEGFB186 may be a target for obesity prevention and treatment.","PeriodicalId":15740,"journal":{"name":"Journal of Endocrinology","volume":"258 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10056661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0