Journal of experimental zoology. Part A, Ecological and integrative physiology最新文献

More sleep for behavioral ecologists. 行为生态学家睡得更香

IF 1.9 3区生物学

Journal of experimental zoology. Part A, Ecological and integrative physiology Pub Date : 2024-12-01 Epub Date: 2024-07-21 DOI: 10.1002/jez.2856

Daniela C Rößler, Barrett A Klein

{"title":"More sleep for behavioral ecologists.","authors":"Daniela C Rößler, Barrett A Klein","doi":"10.1002/jez.2856","DOIUrl":"10.1002/jez.2856","url":null,"abstract":"From jellyfish to parrot fish and roundworms to homeotherms, all animals are thought to sleep. Despite its presumed universality, sleep is a poorly understood behavior, varying significantly in its expression across, and even within, animal lineages. There is still no consensus about the origin, architecture, ecology of sleep, or even its defining characters. The field of behavioral ecology has the potential to extend our knowledge of sleep behavior to nontraditional models and in ecologically relevant settings. Here, we highlight current efforts in diversifying the field to generate stronger synergies between historically human-focused sleep research and behavioral ecology. Our primary aim is for behavioral ecology to enhance sleep research by contributing crucial observations as well as by creating novel comparative and evolutionary frameworks. At the same time, sleep research can enhance behavioral ecology by exposing the relevance of sleep to wakeful behaviors. Nikolaas Tinbergen's four levels of analysis have served as a foundation for comprehensively addressing questions in behavior, and we introduce some Tinbergian approaches to examine the interplay between sleep and wake under ecologically meaningful conditions.","PeriodicalId":15711,"journal":{"name":"Journal of experimental zoology. Part A, Ecological and integrative physiology","volume":" ","pages":"1147-1156"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep in the East African root rat, Tachyoryctes splendens. 东非根鼠（Tachyoryctes splendens）的睡眠。

IF 1.9 3区生物学

Journal of experimental zoology. Part A, Ecological and integrative physiology Pub Date : 2024-12-01 Epub Date: 2024-06-03 DOI: 10.1002/jez.2839

Jean-Leigh Kruger, Adhil Bhagwandin, Jestina V Katandukila, Nigel C Bennett, Paul R Manger

{"title":"Sleep in the East African root rat, Tachyoryctes splendens.","authors":"Jean-Leigh Kruger, Adhil Bhagwandin, Jestina V Katandukila, Nigel C Bennett, Paul R Manger","doi":"10.1002/jez.2839","DOIUrl":"10.1002/jez.2839","url":null,"abstract":"The present study reports the results of an electrophysiological analysis of sleep in the East African root rat, Tachyoryctes splendens, belonging to the rodent subfamily Spalacinae. Telemetric electroencephalographic (EEG) and electromyographic recordings, with associated video recording, on three root rats over a continuous 72 h period (12 h light/12 h dark cycle) were analyzed. The analysis revealed that the East African root rat has a total sleep time (TST) of 8.9 h per day. Despite this relatively short total sleep time in comparison to fossorial rodents, nonrapid eye movement (non-REM) sleep and rapid eye movement (REM) sleep states showed similar physiological signatures to that observed in other rodents and no unusual sleep states were observed. REM occupied 19.7% of TST, which is within the range observed in other rodents. The root rats were extremely active during the dark period, and appeared to spend much of the light period in quiet wake while maintaining vigilance (as determined from both EEG recordings and behavioral observation). These recordings were made under normocapnic environmental conditions, which contrasts with the hypercapnic environment of their natural burrows.","PeriodicalId":15711,"journal":{"name":"Journal of experimental zoology. Part A, Ecological and integrative physiology","volume":" ","pages":"1111-1120"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxygen consumption rate of flatworms under the influence of wake- and sleep-promoting neurotransmitters. 扁形虫在唤醒神经递质和促进睡眠神经递质影响下的耗氧率

IF 1.9 3区生物学

Journal of experimental zoology. Part A, Ecological and integrative physiology Pub Date : 2024-12-01 Epub Date: 2024-05-27 DOI: 10.1002/jez.2828

Shauni E T Omond, Robert G Barker, Oana Sanislav, Paul R Fisher, Sarah J Annesley, John A Lesku

{"title":"Oxygen consumption rate of flatworms under the influence of wake- and sleep-promoting neurotransmitters.","authors":"Shauni E T Omond, Robert G Barker, Oana Sanislav, Paul R Fisher, Sarah J Annesley, John A Lesku","doi":"10.1002/jez.2828","DOIUrl":"10.1002/jez.2828","url":null,"abstract":"Flatworms are among the best studied animal models for regeneration; however, they also represent an emerging opportunity to investigate other biological processes as well. For instance, flatworms are nocturnal and sleep during the day, a state that is regulated by sleep/wake history and the action of the sleep-promoting neurotransmitter gamma-aminobutyric acid (or GABA). Sleep is widespread across the animal kingdom, where it serves many nonexclusive functions. Notably, sleep saves energy by reducing metabolic rate and by not doing something more energetically taxing. Whether the conservation of energy is apparent in sleeping flatworms is unclear. We measured the oxygen consumption rate (OCR) of flatworms dosed with either (1) GABA (n = 29) which makes flatworms inactive or (2) dopamine (n = 20) which stimulates flatworms to move, or (3) day and night neurotransmitter-free controls (n = 28 and 27, respectively). While OCR did not differ between the day and night, flatworms treated with GABA used less oxygen than those treated with dopamine, and less than the day-time control. Thus, GABA affected flatworm physiology, ostensibly by enforcing energy-conserving sleep. Evidence that dopamine increased metabolism was less strong. This work broadens our understanding of flatworm physiology and expands the phylogenetic applicability of energy conservation as a function of sleep.","PeriodicalId":15711,"journal":{"name":"Journal of experimental zoology. Part A, Ecological and integrative physiology","volume":" ","pages":"1130-1136"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of melatonin supplementation upon parental care and nestling growth in arctic-breeding songbirds. 补充褪黑激素对北极繁殖鸣禽的父母照料和雏鸟成长的影响

IF 1.9 3区生物学

Journal of experimental zoology. Part A, Ecological and integrative physiology Pub Date : 2024-12-01 Epub Date: 2024-08-16 DOI: 10.1002/jez.2863

Keelee Pullum, Brett Hodinka, Zoe Ward, Greta Morrissette, Melanie M Richter, Kathleen E Hunt, Noah T Ashley

{"title":"Effect of melatonin supplementation upon parental care and nestling growth in arctic-breeding songbirds.","authors":"Keelee Pullum, Brett Hodinka, Zoe Ward, Greta Morrissette, Melanie M Richter, Kathleen E Hunt, Noah T Ashley","doi":"10.1002/jez.2863","DOIUrl":"10.1002/jez.2863","url":null,"abstract":"Arctic-breeding birds exhibit around-the-clock activity, and these activity cycles are postulated to maximize reproductive success during the short breeding season characteristic of high-latitude regions. Two closely related species of arctic-breeding songbirds, Lapland longspurs (Calcarius lapponicus; ground-nesting) and snow buntings (Plectrophenax nivalis; cavity-nesting) exhibit extended activity cycles throughout the polar day (71° N) except for 4-5 h of daily quiescence. Ground-nesting Lapland longspurs experience higher levels of nest predation than cavity-nesting snow buntings, and this difference is reflected in elevated nest vigilance in male longspurs compared with snow buntings. In this study, we examined the effect of melatonin supplementation upon male parental care, corresponding measures of nestling growth, and ability to reduce activity (and increase sleep). A pharmacological dose of melatonin in captive snow buntings dampened the amplitude of activity rhythms over the polar day with no detectable phase-shifting compared with control-implanted birds. Melatonin treatment reduced nest visits and overall time spent on the nest by male snow buntings compared with controls. There was no significant increase in time spent by female snow buntings on the nest to compensate for this, and there was no significant effect on offspring growth rates. There were no effects of melatonin supplementation on longspur adults or offspring, suggesting behavioral insensitivity to exogenous melatonin treatment. These differences in sensitivity underscore the importance of nest defense in ground-nesting longspurs compared with cavity-nesting snow buntings, which participate minimally in nest defense.","PeriodicalId":15711,"journal":{"name":"Journal of experimental zoology. Part A, Ecological and integrative physiology","volume":" ","pages":"1137-1146"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An electrophysiological correlate of sleep in a shark. 鲨鱼睡眠的电生理相关性。

IF 1.9 3区生物学

Journal of experimental zoology. Part A, Ecological and integrative physiology Pub Date : 2024-12-01 Epub Date: 2024-07-03 DOI: 10.1002/jez.2846

John A Lesku, Paul-Antoine Libourel, Michael L Kelly, Jan M Hemmi, Caroline C Kerr, Shaun P Collin, Craig A Radford

{"title":"An electrophysiological correlate of sleep in a shark.","authors":"John A Lesku, Paul-Antoine Libourel, Michael L Kelly, Jan M Hemmi, Caroline C Kerr, Shaun P Collin, Craig A Radford","doi":"10.1002/jez.2846","DOIUrl":"10.1002/jez.2846","url":null,"abstract":"Sleep is a prominent physiological state observed across the animal kingdom. Yet, for some animals, our ability to identify sleep can be masked by behaviors otherwise associated with being awake, such as for some sharks that must swim continuously to push oxygenated seawater over their gills to breathe. We know that sleep in buccal pumping sharks with clear rest/activity cycles, such as draughtsboard sharks (Cephaloscyllium isabellum, Bonnaterre, 1788), manifests as a behavioral shutdown, postural relaxation, reduced responsiveness, and a lowered metabolic rate. However, these features of sleep do not lend themselves well to animals that swim nonstop. In addition to video and accelerometry recordings, we tried to explore the electrophysiological correlates of sleep in draughtsboard sharks using electroencephalography (EEG), electromyography, and electrooculography, while monitoring brain temperature. The seven channels of EEG activity had a surprising level of (apparent) instability when animals were swimming, but also when sleeping. The amount of stable EEG signals was too low for replication within- and across individuals. Eye movements were not measurable, owing to instability of the reference electrode. Based on an established behavioral characterization of sleep in draughtsboard sharks, we offer the original finding that muscle tone was strongest during active wakefulness, lower in quietly awake sharks, and lowest in sleeping sharks. We also offer several critical suggestions on how to improve techniques for characterizing sleep electrophysiology in future studies on elasmobranchs, particularly for those that swim continuously. Ultimately, these approaches will provide important insights into the evolutionary confluence of behaviors typically associated with wakefulness and sleep.","PeriodicalId":15711,"journal":{"name":"Journal of experimental zoology. Part A, Ecological and integrative physiology","volume":" ","pages":"1121-1129"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introduction to the Special Issue on Comparative Biology of Sleep and Circadian Rhythms. 睡眠和昼夜节律比较生物学特刊导言。

IF 1.9 3区生物学

Journal of experimental zoology. Part A, Ecological and integrative physiology Pub Date : 2024-12-01 Epub Date: 2024-10-07 DOI: 10.1002/jez.2869

Noah T Ashley, John A Lesku

引用次数: 0

Postprandial Sleep in Short-Sleeping Mexican Cavefish. 短眠的墨西哥洞穴鱼的餐后睡眠

IF 1.9 3区生物学

Journal of experimental zoology. Part A, Ecological and integrative physiology Pub Date : 2024-12-01 Epub Date: 2024-11-13 DOI: 10.1002/jez.2880

Kathryn Gallman, Aakriti Rastogi, Owen North, Morgan O'Gorman, Pierce Hutton, Evan Lloyd, Wesley C Warren, Johanna E Kowalko, Erik R Duboue, Nicolas Rohner, Alex C Keene

{"title":"Postprandial Sleep in Short-Sleeping Mexican Cavefish.","authors":"Kathryn Gallman, Aakriti Rastogi, Owen North, Morgan O'Gorman, Pierce Hutton, Evan Lloyd, Wesley C Warren, Johanna E Kowalko, Erik R Duboue, Nicolas Rohner, Alex C Keene","doi":"10.1002/jez.2880","DOIUrl":"10.1002/jez.2880","url":null,"abstract":"Interactions between sleep and feeding behaviors are critical for adaptive fitness. Diverse species suppress sleep when food is scarce to increase the time spent foraging. Postprandial sleep, an increase in sleep time following a feeding event, has been documented in vertebrate and invertebrate animals. While interactions between sleep and feeding appear to be highly conserved, the evolution of postprandial sleep in response to changes in food availability remains poorly understood. Multiple populations of the Mexican cavefish, Astyanax mexicanus, have independently evolved sleep loss and increased food consumption compared to surface-dwelling fish of the same species, providing the opportunity to investigate the evolution of interactions between sleep and feeding. Here, we investigate the effects of feeding on sleep in larval and adult surface fish, and in two parallelly evolved cave populations of A. mexicanus. Larval surface and cave populations of A. mexicanus increase sleep immediately following a meal, providing the first evidence of postprandial sleep in a fish model. The amount of sleep was not correlated to meal size and occurred independently of feeding time. In contrast to larvae, postprandial sleep was not detected in adult surface or cavefish, which can survive for months without food. Together, these findings reveal that postprandial sleep is present in multiple short-sleeping populations of cavefish, suggesting sleep-feeding interactions are retained despite the evolution of sleep loss. These findings raise the possibility that postprandial sleep is critical for energy conservation and survival in larvae that are highly sensitive to food deprivation.","PeriodicalId":15711,"journal":{"name":"Journal of experimental zoology. Part A, Ecological and integrative physiology","volume":" ","pages":"1084-1096"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of group size on sleep in a neotropical bat, Artibeus jamaicensis. 新热带蝙蝠 Artibeus jamaicensis 的群体大小对睡眠的影响。

IF 1.9 3区生物学

Journal of experimental zoology. Part A, Ecological and integrative physiology Pub Date : 2024-12-01 Epub Date: 2024-07-25 DOI: 10.1002/jez.2860

Alexis M Heckley, Christian D Harding, Rachel A Page, Barrett A Klein, Yossi Yovel, Clarice A Diebold, Hannah B Tilley

{"title":"The effect of group size on sleep in a neotropical bat, Artibeus jamaicensis.","authors":"Alexis M Heckley, Christian D Harding, Rachel A Page, Barrett A Klein, Yossi Yovel, Clarice A Diebold, Hannah B Tilley","doi":"10.1002/jez.2860","DOIUrl":"10.1002/jez.2860","url":null,"abstract":"Sleep is associated with many costs, but is also important to survival, with a lack of sleep impairing cognitive function and increasing mortality. Sleeping in groups could alleviate sleep-associated costs, or could introduce new costs if social sleeping disrupts sleep. Working with the Jamaican fruit bat (Artibeus jamaicensis), we aimed to: (1) describe sleep architecture, (2) assess how sleeping in groups affects sleep, and (3) quantify total sleep time and identify rapid eye movement (REM) sleep using behavioral indicators that complement physiological evidence of sleep. Twenty-five adult bats were captured in Panama and recorded sleeping in an artificial roost enclosure. Three bats were fitted with an electromyograph and accelerometer and video recorded sleeping alone in controlled laboratory settings. The remaining 22 bats were assigned to differing social configurations (alone, dyad, triad, and tetrad) and video recorded sleeping in an outdoor flight cage. We found that sleep was highly variable among individuals (ranging from 2 h 53 min to 9 h 39 min over a 12-h period). Although we did not detect statistically significant effects and our sample size was limited, preliminary trends suggest that male bats may sleep longer than females, and individuals sleeping in groups may sleep longer than individuals sleeping alone. We also found a high correspondence between total sleep time quantified visually and quantified using actigraphy (with a 2-min immobility threshold) and identified physiological correlates of behaviorally-defined REM. These results serve as a starting point for future work on the ecology and evolution of sleep in bats and other wild mammals.","PeriodicalId":15711,"journal":{"name":"Journal of experimental zoology. Part A, Ecological and integrative physiology","volume":" ","pages":"1097-1110"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimentally Elevated Levels of Testosterone Advance Daily Onset of Activity in Short-Day Housed Male House Sparrows (Passer domesticus). 实验性睾酮水平升高会提前短日饲养雄性家雀（Passer domesticus）的每日活动开始时间。

IF 1.9 3区生物学

Journal of experimental zoology. Part A, Ecological and integrative physiology Pub Date : 2024-12-01 Epub Date: 2024-10-07 DOI: 10.1002/jez.2871

Holland Galante, Samuel J Lane, Emily K Elderbrock, Geoffrey Brown, Timothy J Greives

{"title":"Experimentally Elevated Levels of Testosterone Advance Daily Onset of Activity in Short-Day Housed Male House Sparrows (Passer domesticus).","authors":"Holland Galante, Samuel J Lane, Emily K Elderbrock, Geoffrey Brown, Timothy J Greives","doi":"10.1002/jez.2871","DOIUrl":"10.1002/jez.2871","url":null,"abstract":"Seasonal changes in sleep/wake cycles and behaviors related to reproduction often co-occur with seasonal fluctuations in sex hormones. Experimental studies have established that fluctuations in circulating testosterone mediate circadian rhythms. However, most studies are performed under constant lighting conditions and fail to investigate the effects of testosterone on the phenotypic output of circadian rhythms, that is, chronotype (daily activity patterns under light:dark cycles). Here, we experimentally elevated testosterone with implants during short nonbreeding daylengths in male house sparrows (Passer domesticus) to test if observed seasonal changes in chronotype are directly in response to photoperiod or to testosterone. We fitted individuals with accelerometers to track activity across treatment periods. Birds experienced three treatments periods: short day photoperiods before manipulation (SD), followed by testosterone implants while still on short days (SD + T). Implants were then removed. After a decrease in cloacal protuberance size, an indicator of low testosterone levels, birds were then photostimulated on long days (LD). Blood samples were collected at night, when testosterone peaks, to compare testosterone levels to daily onset/offset activity for experimental periods. Our results indicate that experimentally elevated testosterone under short nonbreeding photoperiods significantly advanced daily onset of activity and total daily activity relative to daylength. This suggests that testosterone, independent of photoperiod, is responsible for seasonal shifts in chronotypes and daily activity rhythms. These findings suggest that sex steroid hormone actions regulate timing of daily behaviors, likely coordinating expression of reproductive behaviors to appropriate times of the day.","PeriodicalId":15711,"journal":{"name":"Journal of experimental zoology. Part A, Ecological and integrative physiology","volume":" ","pages":"1073-1083"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant and Antiapoptotic Effects of Selenium And Nano Selenium-Loaded Exosomes on Hepatic Dysfunction of Type 1 Diabetic Rats. 硒和纳米硒载体外泌体对1型糖尿病大鼠肝功能异常的抗氧化和抗凋亡作用

IF 1.9 3区生物学

Journal of experimental zoology. Part A, Ecological and integrative physiology Pub Date : 2024-11-13 DOI: 10.1002/jez.2881

Layla A Alahmari, Lashin S Ali, Hoda A Fansa, Dalal S Alshaya, Fawziah A Al-Salmi, Ehab I El-Hallous, Mamdouh Eldesoqui, Fahmy Gad Elsaid, Eman Fayad, Ahmed A El-Mansy, Ghadi Alsharif, Dlovan Y Khalil, Maryam Bakir Mahmood, Rozhan Yassin Khalil, Hanan M Rashwan, Shady G El-Sawah

{"title":"Antioxidant and Antiapoptotic Effects of Selenium And Nano Selenium-Loaded Exosomes on Hepatic Dysfunction of Type 1 Diabetic Rats.","authors":"Layla A Alahmari, Lashin S Ali, Hoda A Fansa, Dalal S Alshaya, Fawziah A Al-Salmi, Ehab I El-Hallous, Mamdouh Eldesoqui, Fahmy Gad Elsaid, Eman Fayad, Ahmed A El-Mansy, Ghadi Alsharif, Dlovan Y Khalil, Maryam Bakir Mahmood, Rozhan Yassin Khalil, Hanan M Rashwan, Shady G El-Sawah","doi":"10.1002/jez.2881","DOIUrl":"https://doi.org/10.1002/jez.2881","url":null,"abstract":"Mesenchymal stem cells-derived exosomes (MSCs-EXs) applications have brought a key breakthrough in treating type 1 diabetes mellitus (T1DM) and its diabetic complications. However, various recent strategies aimed to construct prominent engineered EXs with greater precision and higher efficiency for diabetes syndrome were conducted. In this research, we seek to enhance the medicinal potentialities of MSCs-EXs on type 1 diabetic rats' hepatic complications, via loading with either selenium (Se) or nano selenium (NSe) particles. For consecutive 4-weeks, rats were divided into 8 groups as; control, EXs, EXs + Se, EXs + NSe, STZ-diabetic (D), D + EXs, D + EXs + Se, and D + EXs + NSe groups. The three diabetic-treated groups manifested a significant reduction in hepatic contents of oxidative stress (OS) (MDA, NO, and H2O2) inflammatory (IL-6, TNF-α, and TGF-β), and apoptotic (P53, BAX, caspase-3, and Bcl2) markers, with marked elevation in hepatic antioxidant levels (GSH, GPX, SOD, and CAT). Such results were supported by the marked diminish in serum total proteins, liver function enzymes (AST, ALT, and bilirubin), and both serum and liver lipid profile fractions. In addition, hepatic histological examination showed marked improvement in liver architecture of all treated diabetic rats' groups, compared to diabetic untreated rats. Significantly, diabetic rats with EXs loaded with NSe exhibited the most therapeutic superiority.","PeriodicalId":15711,"journal":{"name":"Journal of experimental zoology. Part A, Ecological and integrative physiology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0