Journal of diabetes and its complications最新文献

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Prevalence and clinical implications of diabetes mellitus in autoimmune nodopathies: A systematic review 自身免疫性结节病中糖尿病的患病率和临床影响:系统综述。
IF 2.9 3区 医学
Journal of diabetes and its complications Pub Date : 2024-10-20 DOI: 10.1016/j.jdiacomp.2024.108883
Anastasios Tentolouris , Maria-Ioanna Stefanou , Anastasia V. Vrettou , Lina Palaiodimou , Christos Moschovos , Marianna Papadopoulou , Panagiotis Kokotis , Ioanna Eleftheriadou , Nikolaos Tentolouris , Georgios Tsivgoulis
{"title":"Prevalence and clinical implications of diabetes mellitus in autoimmune nodopathies: A systematic review","authors":"Anastasios Tentolouris ,&nbsp;Maria-Ioanna Stefanou ,&nbsp;Anastasia V. Vrettou ,&nbsp;Lina Palaiodimou ,&nbsp;Christos Moschovos ,&nbsp;Marianna Papadopoulou ,&nbsp;Panagiotis Kokotis ,&nbsp;Ioanna Eleftheriadou ,&nbsp;Nikolaos Tentolouris ,&nbsp;Georgios Tsivgoulis","doi":"10.1016/j.jdiacomp.2024.108883","DOIUrl":"10.1016/j.jdiacomp.2024.108883","url":null,"abstract":"<div><h3>Background and aims</h3><div>Autoimmune nodopathies comprise a newly-established subtype of immune-mediated peripheral neuropathies, characterized by circulating autoantibodies that target nodal-paranodal proteins, including contactin-1 (CNTN1), contactin-associated protein-1 (Caspr1), neurofascin-155 (NF155) and neurofascin-isoforms (NF140 and NF186). Emerging evidence suggests that diabetes mellitus (DM) may confer increased risk for autoimmune nodopathies.</div></div><div><h3>Methods</h3><div>A systematic search was performed including studies reporting on patients harboring nodal/paranodal antibodies (CNTN1, Caspr1, NF155, NF140 and NF186). We sought to evaluate: (1) the prevalence of DM among patients with autoimmune nodopathies; (2) the phenotype of DM-patients harboring different types of nodal/paranodal antibodies; (3) clinical features that allow distinction of autoimmune nodopathies from diabetic peripheral neuropathy (DPN).</div></div><div><h3>Results</h3><div>Five cohort studies, 3 case-reports and one case-series study were identified comprising 114 patients with autoimmune nodopathies. DM prevalence was documented to range between 10.5 % and 60 %. DM-patients harbored mostly paranodal antibodies; CNTN1: 58.3 %, followed by pan-neurofascin: 33.3 %, and Caspr1: 25 % antibodies. No significant differences in clinical phenotype were uncovered between DM-patients and their non-DM counterparts. Overall, DM patients were refractory to intravenous-immunoglobulins (IVIG), but responded well to escalation immunotherapies. Compared to DPN, distinctive features of autoimmune nodopathy comprised: (i) severe ataxia, tremor, and cranial nerve involvement; (ii) neurophysiological findings indicative of nodal-paranodal pathology, including (reversible) conduction failure and conduction velocity slowing, often accompanied by reduced compound muscle and sensory nerve action potentials; and (iii) marked protein-elevation or albuminocytological dissociation in cerebrospinal fluid analysis.</div></div><div><h3>Conclusions</h3><div>DM patients fall under the typical clinical phenotype of autoimmune nodopathy, displaying predominantly paranodal antibodies. Early suspicion is crucial, as unlike DPN, diagnosis of autoimmune nodopathy unfolds therapeutic perspectives.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 12","pages":"Article 108883"},"PeriodicalIF":2.9,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic value of pulse wave velocity for cardiovascular disease risk stratification in diabetic patients: A systematic review and meta-analysis 脉搏波速度对糖尿病患者心血管疾病风险分层的预后价值:系统回顾和荟萃分析。
IF 2.9 3区 医学
Journal of diabetes and its complications Pub Date : 2024-10-19 DOI: 10.1016/j.jdiacomp.2024.108894
Siao Suan Cheong , Nazirah Samah , Nur Aishah Che Roos , Azizah Ugusman , Mohd Shawal Faizal Mohamad , Boon Cong Beh , Isa Azzaki Zainal , Amilia Aminuddin
{"title":"Prognostic value of pulse wave velocity for cardiovascular disease risk stratification in diabetic patients: A systematic review and meta-analysis","authors":"Siao Suan Cheong ,&nbsp;Nazirah Samah ,&nbsp;Nur Aishah Che Roos ,&nbsp;Azizah Ugusman ,&nbsp;Mohd Shawal Faizal Mohamad ,&nbsp;Boon Cong Beh ,&nbsp;Isa Azzaki Zainal ,&nbsp;Amilia Aminuddin","doi":"10.1016/j.jdiacomp.2024.108894","DOIUrl":"10.1016/j.jdiacomp.2024.108894","url":null,"abstract":"<div><h3>Aim</h3><div>Arterial stiffness, a significant cardiovascular risk marker, is particularly important in patients with diabetes mellitus (DM). Pulse wave velocity (PWV), a non-invasive measure of arterial stiffness, has emerged as an independent predictor of cardiovascular morbidity and mortality. However, its precise prognostic value in DM patients for cardiovascular risk stratification remains unclear. To address this, a systematic review was conducted.</div></div><div><h3>Method</h3><div>A thorough search of Ovid and Scopus databases was performed for cohort studies on PWV measurements for cardiovascular risk stratification in DM patients. Nine studies were included, examining the relationship between PWV and cardiovascular events or composite endpoints in DM patients asymptomatic of cardiovascular diseases (CVD).</div></div><div><h3>Results</h3><div>The review revealed that optimal PWV cutoffs to predict composite cardiovascular events ranged from 10 to 12.16 m/s (aortic PWV) and 14 to 16.72 m/s (brachial-ankle PWV). In addition, meta-analysis yielded a HR of 1.15 (95 % CI 1.07–1.24, <em>p</em> &lt; 0.001, <em>I</em><sup>2</sup> = 70 %) for aortic PWV in predicting cardiovascular events.</div></div><div><h3>Conclusion</h3><div>The assessment of arterial stiffness via PWV shows promise as an early diagnostic marker for CVD in DM patients, aiding in improved disease management. This underscores the potential of PWV in enhancing cardiovascular risk assessment and guiding clinical decisions in this high-risk population, without invasive procedures or radiation exposure.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 12","pages":"Article 108894"},"PeriodicalIF":2.9,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subcutaneous rapid-acting insulin analogues in mild to moderate diabetic ketoacidosis: A meta-analysis of randomized controlled trials 皮下速效胰岛素类似物治疗轻中度糖尿病酮症酸中毒:随机对照试验荟萃分析。
IF 2.9 3区 医学
Journal of diabetes and its complications Pub Date : 2024-10-16 DOI: 10.1016/j.jdiacomp.2024.108882
Maria L.R. Defante , Mariana de Moura de Souza , Beatriz Ximenes Mendes , Beatriz A. de A. De Hollanda Morais , Vitória M. Prizão , Salma Ali El Chab Parolin , Hugo Valinho Francisco
{"title":"Subcutaneous rapid-acting insulin analogues in mild to moderate diabetic ketoacidosis: A meta-analysis of randomized controlled trials","authors":"Maria L.R. Defante ,&nbsp;Mariana de Moura de Souza ,&nbsp;Beatriz Ximenes Mendes ,&nbsp;Beatriz A. de A. De Hollanda Morais ,&nbsp;Vitória M. Prizão ,&nbsp;Salma Ali El Chab Parolin ,&nbsp;Hugo Valinho Francisco","doi":"10.1016/j.jdiacomp.2024.108882","DOIUrl":"10.1016/j.jdiacomp.2024.108882","url":null,"abstract":"<div><h3>Introduction</h3><div>Diabetic Ketoacidosis (DKA) is commonly treated with intravenous (IV) regular insulin. However, patients with less severe DKA may benefit from a subcutaneous (SC) scheme.</div></div><div><h3>Methods</h3><div>We systematically searched PubMed, Cochrane, and Embase for randomized controlled trials (RCTs) comparing SC rapid-acting insulin analogue (RAIAs) with IV regular insulin. Risk ratios (RR) were used to compare treatment effects for binary outcomes and mean differences (MD) for continuous data with the corresponding 95 % confidence intervals (CI). <em>P</em> values &lt;0.05 were considered statistically significant. We used the R version 4.3.2 for statistical analyses.</div></div><div><h3>Results</h3><div>Our meta-analysis included eight RCTs encompassing 415 patients. No statistically significant differences were found between RAIAs and IV regular insulin in the treatment of mild to moderate DKA in the pediatric and adult population in the primary outcome of time until DKA resolution (MD 0.00 h; 95 % CI -1.27 to 1.28; <em>P</em> = 1.00). Both treatments showed comparable results in the secondary outcomes total insulin usage (<em>P</em> = 0.65), time until hyperglycemia resolution (<em>P</em> = 0.22), length of hospital stay (<em>P</em> = 0.11), the incidence of hypoglycemia (<em>P</em> = 0.15) and DKA recurrence (P = Not estimable). There were no reports of death, cerebral edema, or venous thrombosis in the studies.</div></div><div><h3>Conclusion</h3><div>In this meta-analysis of eight RCTs we found that SC RAIAs and regular IV insulin are comparable in resolving mild to moderate DKA in children and adults. PROSPERO registration: CRD42023485032.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 12","pages":"Article 108882"},"PeriodicalIF":2.9,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Individual and joint effects of diabetes and depression on incident cardiovascular diseases and all-cause mortality: Results from a population-based cohort study 糖尿病和抑郁症对心血管疾病和全因死亡率的个体和联合影响:基于人群的队列研究结果
IF 2.9 3区 医学
Journal of diabetes and its complications Pub Date : 2024-10-12 DOI: 10.1016/j.jdiacomp.2024.108878
Qiang Tu , Karice Hyun , Shuanglan Lin , Nashid Hafiz , Deborah Manandi , Qian Zhang , Xinzheng Wang , Na Zhang , Haisheng Wu , Julie Redfern
{"title":"Individual and joint effects of diabetes and depression on incident cardiovascular diseases and all-cause mortality: Results from a population-based cohort study","authors":"Qiang Tu ,&nbsp;Karice Hyun ,&nbsp;Shuanglan Lin ,&nbsp;Nashid Hafiz ,&nbsp;Deborah Manandi ,&nbsp;Qian Zhang ,&nbsp;Xinzheng Wang ,&nbsp;Na Zhang ,&nbsp;Haisheng Wu ,&nbsp;Julie Redfern","doi":"10.1016/j.jdiacomp.2024.108878","DOIUrl":"10.1016/j.jdiacomp.2024.108878","url":null,"abstract":"<div><h3>Aims</h3><div>To assess the individual and joint effects of diabetes and depression on all-cause mortality and cardiovascular disease (CVD) in the middle-aged and elderly Chinese populations.</div></div><div><h3>Methods</h3><div>9105 individuals without CVD from the China Health and Retirement Longitudinal Study (CHARLS) were included and followed up for 9 years. Participants were divided into four comparative groups: diabetes alone, depression alone, both conditions, and neither condition. Multivariate binary logistic regression models were performed to compare the risks of all-cause mortality and CVD among the four groups.</div></div><div><h3>Results</h3><div>When compared to those without diabetes and depression, the multivariate adjusted odds ratios (aORs) for CVD in individuals who had diabetes only, depression only, and both diabetes and depression were 1.245 (95 % CI 1.023 to 1.515), 1.318 (95 % CI 1.171 to 1.485) and 1.722 (95 % CI 1.361 to 2.178), respectively. The aORs for all-cause mortality were 1.366 (95 % CI 1.035–1.804) for diabetes alone, 1.082 (95 % CI 0.916–1.279) for depression alone, and 1.590 (95 % CI 1.152–2.195) for both conditions when compared with those with neither condition.</div></div><div><h3>Conclusions</h3><div>Individuals with both diabetes and depression had greater risk of CVD and all-cause mortality when compared to those with diabetes or depression alone, or those without either condition.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108878"},"PeriodicalIF":2.9,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142446166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
All-cause mortality and factors associated with it in Finnish patients with type 1 diabetes 芬兰 1 型糖尿病患者的全因死亡率及其相关因素。
IF 2.9 3区 医学
Journal of diabetes and its complications Pub Date : 2024-10-12 DOI: 10.1016/j.jdiacomp.2024.108881
Elena Putula , Tuuli Kauppala , Sini Vanhamäki , Jaason Haapakoski , Tiina Laatikainen , Saara Metso
{"title":"All-cause mortality and factors associated with it in Finnish patients with type 1 diabetes","authors":"Elena Putula ,&nbsp;Tuuli Kauppala ,&nbsp;Sini Vanhamäki ,&nbsp;Jaason Haapakoski ,&nbsp;Tiina Laatikainen ,&nbsp;Saara Metso","doi":"10.1016/j.jdiacomp.2024.108881","DOIUrl":"10.1016/j.jdiacomp.2024.108881","url":null,"abstract":"<div><h3>Aims</h3><div>To assess the effect of comorbidities, risk classification for chronic kidney disease (CKD) according to albuminuria and eGFR, HbA1c and LDL-cholesterol levels on all-cause mortality in patients with type 1 diabetes (DM1).</div></div><div><h3>Methods</h3><div>The study included all 45,801 DM1 patients from the Finnish Diabetes Registry during 2018–2022. Mortality of patients with DM1 was compared with mortality in non-diabetic population in Finland by estimating standardized mortality rates (SMRs). Poisson regression model was used to estimate the effect of risk factors on the SMR.</div></div><div><h3>Results</h3><div>A total of 2469 patients died during follow-up. SMR for the total cohort was 1.84 (95 % CI 1.77–1.92) peaking at the age of 30–49 years. The coverage of HbA1c values was 98 %, that of LDL-cholesterol 94 %, and U-ACR and eGFR 80 %. In a multivariate analysis, assessing the effect on mortality, the rate ratio for end-stage renal disease was 2.66, cardiovascular diseases 1.92, mental and behavioural disorders 1.64, foot complications 1.51, high or very high risk for CKD 3.64, LDL-cholesterol ≥2.6 mmol/l 1.33, and HbA1c ≥8 % (64 mmol/mol) 1.27.</div></div><div><h3>Conclusions</h3><div>There's substantial excess mortality due to DM1 in Finland. Interventions should focus on addressing both renal and cardiovascular risk factors but also pay more attention to mental health.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 12","pages":"Article 108881"},"PeriodicalIF":2.9,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterizing the relationship between social determinants of health and risk of albuminuria among children with type 1 diabetes 描述 1 型糖尿病患儿健康的社会决定因素与白蛋白尿风险之间的关系
IF 2.9 3区 医学
Journal of diabetes and its complications Pub Date : 2024-10-09 DOI: 10.1016/j.jdiacomp.2024.108880
Jia Xin Huang , T. Charles Casper , Casey Pitts , Sage R. Myers , Rebecca Lynch , Lindsey Loomba , Janani Ramesh , Nathan Kuppermann , Elaine Ku , Nicole Glaser
{"title":"Characterizing the relationship between social determinants of health and risk of albuminuria among children with type 1 diabetes","authors":"Jia Xin Huang ,&nbsp;T. Charles Casper ,&nbsp;Casey Pitts ,&nbsp;Sage R. Myers ,&nbsp;Rebecca Lynch ,&nbsp;Lindsey Loomba ,&nbsp;Janani Ramesh ,&nbsp;Nathan Kuppermann ,&nbsp;Elaine Ku ,&nbsp;Nicole Glaser","doi":"10.1016/j.jdiacomp.2024.108880","DOIUrl":"10.1016/j.jdiacomp.2024.108880","url":null,"abstract":"<div><div>In a cohort of 2303 children with type 1 diabetes (T1D), we found that non-English speaking status (HR 2.82, 95% CI 1.54–5.18) and public insurance (HR 1.48, 95% CI 1.07–2.05) were associated with an increased risk of incident albuminuria, after adjusting for T1D-related variables (age, hemoglobin A1c, diabetic ketoacidosis episodes with acute kidney injury).</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 12","pages":"Article 108880"},"PeriodicalIF":2.9,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endothelial dysfunction markers syndecan-1 and thrombomodulin are associated with higher albuminuria levels in type 2 diabetes with no history of clinical cardiovascular disease 内皮功能障碍标志物辛迪加-1 和血栓调节蛋白与无临床心血管疾病史的 2 型糖尿病患者较高的白蛋白尿水平有关
IF 2.9 3区 医学
Journal of diabetes and its complications Pub Date : 2024-10-09 DOI: 10.1016/j.jdiacomp.2024.108879
Luis F. Ferreira-Divino , Christina G. Poulsen , Viktor Rotbain Curovic , Oliver B. Pedersen , Nete Tofte , Marie Frimodt-Møller , Tine W. Hansen , Anne-Mette Hvas , Peter Rossing
{"title":"Endothelial dysfunction markers syndecan-1 and thrombomodulin are associated with higher albuminuria levels in type 2 diabetes with no history of clinical cardiovascular disease","authors":"Luis F. Ferreira-Divino ,&nbsp;Christina G. Poulsen ,&nbsp;Viktor Rotbain Curovic ,&nbsp;Oliver B. Pedersen ,&nbsp;Nete Tofte ,&nbsp;Marie Frimodt-Møller ,&nbsp;Tine W. Hansen ,&nbsp;Anne-Mette Hvas ,&nbsp;Peter Rossing","doi":"10.1016/j.jdiacomp.2024.108879","DOIUrl":"10.1016/j.jdiacomp.2024.108879","url":null,"abstract":"<div><h3>Introduction</h3><div>Individuals with type 2 diabetes and increased albuminuria, a well-established marker of microvascular complications, are at a higher risk for cardiovascular disease (CVD) and premature mortality. Therefore, a better understanding of the underlying pathophysiology is needed to improve risk stratification and tailor prevention and intervention.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional study including 463 individuals with type 2 diabetes, various degrees of albuminuria and without CVD. We analysed the association between albuminuria and markers of endothelial function (thrombomodulin and syndecan-1), thrombin generation (thrombin-antithrombin complex, prothrombin fragment 1 + 2), fibrinogen, platelet function (activation using soluble plasma selectin and aggregation using Multiplate® Analyzer) using regression models.</div></div><div><h3>Results</h3><div>In the study cohort 33 % were women, the mean ± SD age was 65 ± 9 years, and median [IQR] diabetes duration was 15 [9–20] years. In total, 344 (74 %) individuals had normal albuminuria, 87 (19 %) moderately- and 32 (7 %) severely increased albuminuria levels. Higher markers of endothelial function and fibrinogen were independently associated with higher albuminuria levels (<em>p</em> &lt; 0.01). No association between albuminuria and markers of thrombin generation and platelet was demonstrated.</div></div><div><h3>Conclusion</h3><div>We demonstrated an independent association between albuminuria and markers of endothelial function and fibrinogen in individuals with type 2 diabetes and no history of CVD.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108879"},"PeriodicalIF":2.9,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The importance of arterial stiffness in pediatric patients with type 1 diabetes mellitus: What's new? 1 型糖尿病儿童患者动脉僵化的重要性:有什么新发现?
IF 2.9 3区 医学
Journal of diabetes and its complications Pub Date : 2024-10-01 DOI: 10.1016/j.jdiacomp.2024.108877
Evangelos C. Rizos , Evangelia E. Ntzani , Imran Rashid Rangraze , Mohamed El-Tanani , Manfredi Rizzo
{"title":"The importance of arterial stiffness in pediatric patients with type 1 diabetes mellitus: What's new?","authors":"Evangelos C. Rizos ,&nbsp;Evangelia E. Ntzani ,&nbsp;Imran Rashid Rangraze ,&nbsp;Mohamed El-Tanani ,&nbsp;Manfredi Rizzo","doi":"10.1016/j.jdiacomp.2024.108877","DOIUrl":"10.1016/j.jdiacomp.2024.108877","url":null,"abstract":"<div><div>Youths with type 1 diabetes (T1D) exhibits higher levels of pulse wave velocity (PWV) compared to healthy controls. Higher PWV in T1D subjects is associated with increased hazard of progression in albuminuria, decline in eGFR, cardiovascular (CV) events and mortality. In the recently published work by Georeli et al., increased PWV was associated with poor glycemic control as expressed by time-in-range (TIR) &lt; 50 % in T1D children, adolescents and young adults. This finding is of great interest, since it is well known that glycemic control, as measured by TIR, is an important contributor of CV risk. The duration of TIR &lt; 50 % is not reported by the authors, but is of importance, knowing that CGM provide data for the last 3–6 months, depending on the CGM model. In conclusion, PWV looks promising for risk stratification in T1D, but its exact role in T1D still remains to be fully explored.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108877"},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lower extremity amputation rates in patients with chronic kidney disease: A database study comparing patients with and without diabetes mellitus 慢性肾病患者的下肢截肢率:一项比较有糖尿病和无糖尿病患者的数据库研究。
IF 2.9 3区 医学
Journal of diabetes and its complications Pub Date : 2024-09-28 DOI: 10.1016/j.jdiacomp.2024.108876
Dhruv Nandakumar , Matthew J. Johnson , Lawrence A. Lavery , Benjamin M. Conover , Katherine M. Raspovic , David H. Truong , Dane K. Wukich
{"title":"Lower extremity amputation rates in patients with chronic kidney disease: A database study comparing patients with and without diabetes mellitus","authors":"Dhruv Nandakumar ,&nbsp;Matthew J. Johnson ,&nbsp;Lawrence A. Lavery ,&nbsp;Benjamin M. Conover ,&nbsp;Katherine M. Raspovic ,&nbsp;David H. Truong ,&nbsp;Dane K. Wukich","doi":"10.1016/j.jdiacomp.2024.108876","DOIUrl":"10.1016/j.jdiacomp.2024.108876","url":null,"abstract":"<div><div>Lower extremity amputation (LEA) is one of the most feared consequences of diabetes mellitus (DM). The purpose of this study was to evaluate the impact of DM on LEA rates in patients at various stages of chronic kidney disease (CKD).</div><div>A commercially available de-identified database was searched for patients undergoing LEA and for CKD patients, from 2010 to 2023. Patients with DM and patients without DM who were followed for at least 5 years were included. LEA rates were then compared for patients at all 5 CKD stages in patients with and without diabetes.</div><div>Rates of all LEA were found to be significantly higher at all CKD stages for patients with diabetes (overall, minor and major LEA). Compared to patients without DM who have CKD stage 5 (end stage renal disease), patients with DM and CKD stage 5 have a 30 fold increased likelihood of undergoing overall LEA [OR 30.2 (24.48–37.19), <em>p</em> &lt; 0.001], 29 fold increased likelihood of undergoing minor LEA [28.9i (22.91–36.35), <em>p</em> &lt; 0.001] and 40 times fold increased likelihood of undergoing major LEA [40.1 (26.59–60.42), p &lt; 0.001]. For all stages of CKD, independent of diabetes status, minor LEA were performed with greater frequency than major LEA. In patients with DM, LEA rates significantly increased with CKD progression between stages 2–5 with a substantial jump between stages 4 and 5 [OR 2.6 (CI 2.49–2.74), <em>p</em> &lt; 0.001]. However, CKD progression between stages 1 and 2 was not significantly associated with increased LEA rates (OR 1.1 (CI 0.92–1.21), <em>p</em> = 0.24) in patients with diabetes.</div><div>Patients with comorbid diabetes have elevated risk for LEA at all stages of CKD compared to those without diabetes.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108876"},"PeriodicalIF":2.9,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monitoring the liver as a part of the cardio-renal-metabolic continuum – What is cooking and burning with non-invasive tests and treatment options? 监测肝脏是心-肾-代谢连续体的一部分--无创检测和治疗方案的烹饪和燃烧是什么?
IF 2.9 3区 医学
Journal of diabetes and its complications Pub Date : 2024-09-24 DOI: 10.1016/j.jdiacomp.2024.108875
Špela Volčanšek , Andrej Janež , Manfredi Rizzo , Emir Muzurović
{"title":"Monitoring the liver as a part of the cardio-renal-metabolic continuum – What is cooking and burning with non-invasive tests and treatment options?","authors":"Špela Volčanšek ,&nbsp;Andrej Janež ,&nbsp;Manfredi Rizzo ,&nbsp;Emir Muzurović","doi":"10.1016/j.jdiacomp.2024.108875","DOIUrl":"10.1016/j.jdiacomp.2024.108875","url":null,"abstract":"","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 12","pages":"Article 108875"},"PeriodicalIF":2.9,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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