Journal of diabetes and its complications最新文献

{"title":"Trends in mean serum insulin and hyperinsulinemia among US adults without diabetes 1999–2018","authors":"Tammie M. Johnson ,&nbsp;James R. Churilla","doi":"10.1016/j.jdiacomp.2025.109159","DOIUrl":"10.1016/j.jdiacomp.2025.109159","url":null,"abstract":"<div><h3>Purpose</h3><div>The purpose of this study is to examine trends for mean serum insulin concentration (pmol/L) and prevalence of hyperinsulinemia (≥4.358 pmol/L fasting insulin) in US adults without diabetes.</div></div><div><h3>Methods</h3><div>We used data from the 1999–2018 National Health and Nutrition Examination Survey (NHANES). Participants (<em>n</em> = 14,150) were ≥20 years of age, not pregnant, had no history of diabetes, had a fasting blood glucose measure of less than 126 mg/dL, and had valid responses to all study variables. Consecutive cycles of NHANES data from 1999 to 2018 (20 years) were aggregated into five four-year intervals.</div></div><div><h3>Results</h3><div>The Annual Percent Change (APC) for mean fasting insulin ranged from 5.64 (adjusted for body mass index) to 7.65 % when unadjusted (all <em>p</em>-values for trend &lt;0.0001). The APC for hyperinsulinemia prevalence ranged from 19.4 % (adjusted for waist circumference) to 22.3 % when unadjusted (all <em>p</em>-values for trend &lt;0.0001). The subanalyses by gender consistently revealed significant positive trends for both outcomes.</div></div><div><h3>Conclusions</h3><div>This study illustrates a significant positive trend for mean fasting insulin concentrations and hyperinsulinemia among US adults over 20 years. Monitoring serum insulin and hyperinsulinemia trends provides insights into the continuing rise in type 2 diabetes (T2D) and opportunities for T2D prevention.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 11","pages":"Article 109159"},"PeriodicalIF":3.1,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144997677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical complications and co-morbidities of type 1 diabetes in young adults","authors":"Steven James ,&nbsp;Rebecca Barber ,&nbsp;Jess Forster ,&nbsp;Lindsay Sawatsky ,&nbsp;Samantha Berry ,&nbsp;Olive James ,&nbsp;Kerrie Abel ,&nbsp;Claire Trigg ,&nbsp;Kim C. Donaghue ,&nbsp;Maria E. Craig ,&nbsp;Mahira Saiyed ,&nbsp;Sheryl S. Salis ,&nbsp;Jamie Wood ,&nbsp;Willem Staels","doi":"10.1016/j.jdiacomp.2025.109158","DOIUrl":"10.1016/j.jdiacomp.2025.109158","url":null,"abstract":"<div><h3>Aims</h3><div>Our review aimed to determine the prevalence of – and factors associated with – hearing loss, oral and olfactory disease, frozen shoulder, trigger finger, and hair loss in young adults with type 1 diabetes. These conditions were selected based on research team interests, existing literature, and group discussion.</div></div><div><h3>Methods</h3><div>We conducted a quantitative narrative review using a systematic process to identify cohort and cross-sectional studies involving young adults with type 1 diabetes (mean age 18–30 years). PubMed, CINAHL, and Cochrane were searched (January 2000–February 2024). Grey literature was not restricted, and quality appraisal was undertaken. Extracted data were synthesised and summarised narratively.</div></div><div><h3>Results</h3><div>The initial search found 3924 records and after title, abstract and full-text review, 19 records met inclusion criteria. Hearing loss prevalence ranged from 22.6 to 48.0 %, with age, diabetes duration, and systolic blood pressure identified as prominent associated features. For oral disease, peridontitis prevalence was 4.7 %, while alveolar bone loss ranged from 24.6 to 43.9 %; age was the primary associated factor. No eligible data were identified regarding frozen shoulder, trigger finger, or hair loss.</div></div><div><h3>Conclusions</h3><div>Further research is needed to characterize the prevalence and risk factors of atypical complications in type 1 diabetes. Clinical care should be guided by a robust understanding of these under-recognised comorbidities.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 11","pages":"Article 109158"},"PeriodicalIF":3.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145005097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex specific associations of sex hormones with brain volumes and cerebral blood flow: A cross sectional observational study within the look AHEAD type 2 diabetes cohort","authors":"Dhananjay Vaidya ,&nbsp;Yvette Yeboah-Kordieh ,&nbsp;Marjorie Howard ,&nbsp;Christina E. Hugenschmidt ,&nbsp;Paul A. Nyquist ,&nbsp;Erin D. Michos ,&nbsp;Rita R. Kalyani ,&nbsp;Sevil Yasar ,&nbsp;Brian Andres Robusto ,&nbsp;Hussein N. Yassine ,&nbsp;Jeanne M. Clark ,&nbsp;Mark A. Espeland ,&nbsp;Wendy L. Bennett","doi":"10.1016/j.jdiacomp.2025.109161","DOIUrl":"10.1016/j.jdiacomp.2025.109161","url":null,"abstract":"<div><h3>Background</h3><div>Females have greater brain volume and cerebral blood flow than males when controlling for intracranial volume and age. Brain volume decreases after menopause, suggesting a role of sex hormones. We studied the association of sex hormones with brain volume, white matter hyperintensity volumes and cerebral blood flow in people with Type 2 Diabetes and with overweight and obesity conditions that accelerate brain atrophy.</div></div><div><h3>Methods</h3><div>We analyzed data from 215 participants with overweight or obesity and Type 2 Diabetes from the Look AHEAD Brain Magnetic Resonance Imaging ancillary study (mean age 68 years, 73 % postmenopausal female). Estradiol and total testosterone levels were measured with electrochemoluminescence assays. The ratio of brain measurements to intracranial volume was analyzed to account for body size. We analyzed sex hormones as quantitative measures in males, whereas in females we grouped those with detectable vs. undetectable hormone levels (Estradiol &lt;73 pmol/L [20 pg/mL]: 79 %; Total Testosterone &lt;0.07 mmol/L [0.02 ng/mL]: 37 % undetectable in females).</div></div><div><h3>Results</h3><div>Females with detectable total testosterone levels had higher brain volume to intracranial volume ratio (median [25th, 75th percentile]: 0.85 [0.84, 0.86]) as compared to those with undetectable Total Testosterone levels (0.84 [0.83, 0.86]; rank sum <em>p</em> = 0.04). This association was attenuated after age and body mass index adjustment (<em>p</em> = 0.08). Neither white matter hyperintensity volumes or cerebral blood flow in females, nor any brain measures in males, were significantly associated with Estradiol or Total Testosterone.</div></div><div><h3>Conclusions</h3><div>In postmenopausal females with Type 2 Diabetes with overweight and obesity, detectable levels of total testosterone were associated greater brain volume relative to intracranial volume, suggesting a protective role for testosterone in female brain health. Our findings are limited by a small sample size and low sensitivity of hormone assays. Our suggestive findings can be combined with future larger studies to assess clinically important differences.</div></div><div><h3>Trial registration</h3><div><span><span>NCT00017953</span><svg><path></path></svg></span></div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 10","pages":"Article 109161"},"PeriodicalIF":3.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Retention and outcomes of National Diabetes Prevention Program enrollees and non-enrollees with prediabetes: The University of Michigan experience\" [J. Diabetes Complicat. (2023) 108527].","authors":"William H Herman, Claudia Villatoro, Kevin L Joiner, Laura N McEwen","doi":"10.1016/j.jdiacomp.2025.109157","DOIUrl":"https://doi.org/10.1016/j.jdiacomp.2025.109157","url":null,"abstract":"","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":" ","pages":"109157"},"PeriodicalIF":3.1,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the letter to the editor.","authors":"Fernando Sebastian-Valles","doi":"10.1016/j.jdiacomp.2025.109160","DOIUrl":"https://doi.org/10.1016/j.jdiacomp.2025.109160","url":null,"abstract":"","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":" ","pages":"109160"},"PeriodicalIF":3.1,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor \"The role of artificial intelligence in diabetic retinopathy screening in type 1 diabetes: A systematic review\".","authors":"Leibing Ji, Reyisai Abudulam, Ming Li","doi":"10.1016/j.jdiacomp.2025.109155","DOIUrl":"https://doi.org/10.1016/j.jdiacomp.2025.109155","url":null,"abstract":"","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":" ","pages":"109155"},"PeriodicalIF":3.1,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of and risk factors for normoalbuminuric diabetic kidney disease","authors":"Jeeyoung Kim ,&nbsp;Sohyun Bae ,&nbsp;Donghwan Yun ,&nbsp;Sehoon Park ,&nbsp;Yong Chul Kim ,&nbsp;Dong Ki Kim ,&nbsp;Kook-Hwan Oh ,&nbsp;Kwon Wook Joo ,&nbsp;Yon Su Kim ,&nbsp;Seung Seok Han","doi":"10.1016/j.jdiacomp.2025.109154","DOIUrl":"10.1016/j.jdiacomp.2025.109154","url":null,"abstract":"<div><h3>Background</h3><div>Albuminuria is a key prognostic marker of diabetic kidney disease (DKD), but some patients experience disease progression without developing albuminuria, a condition referred to as normoalbuminuric DKD. This study aimed to evaluate the prognosis of normoalbuminuric DKD and identify factors associated with progression.</div></div><div><h3>Methods</h3><div>A total of 24,558 patients with type 2 diabetes and no baseline albuminuria were enrolled. Kidney function and albuminuria were monitored. Patients were classified into two groups: the normoalbuminuria group (no albuminuria until estimated glomerular filtration rate [eGFR] declined to 30 mL/min/1.73 m²) and the incident albuminuria group (albuminuria developed before eGFR declined below 30). Kidney disease progression, defined as &gt;50 % eGFR decline or end-stage kidney disease, was compared after propensity score matching.</div></div><div><h3>Results</h3><div>After matching, 6575 patients included per group. Median follow-up was 139 months (interquartile range, 72–204; maximum, 21 years). The incident albuminuria group had a higher risk of progression (adjusted hazard ratio, 2.39 [2.05–2.79]). Among normoalbuminuric patients, older age, poor glycemic control, cardiovascular comorbidities, and diuretic use were linked to higher risk, while metformin, statins were protective.</div></div><div><h3>Conclusions</h3><div>Although normoalbuminuria generally indicates favorable prognosis, some patients remain at risk and require close monitoring and individualized care.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 10","pages":"Article 109154"},"PeriodicalIF":3.1,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144889374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to \"Impact of remnant cholesterol and triglycerides on diabetes foot and disease in type 1 diabetes: A propensity score-matched case-control study\".","authors":"XiaoMei Wang, SongQian Yang","doi":"10.1016/j.jdiacomp.2025.109156","DOIUrl":"https://doi.org/10.1016/j.jdiacomp.2025.109156","url":null,"abstract":"","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":" ","pages":"109156"},"PeriodicalIF":3.1,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden and progression of arterial calcification in type 1 diabetes predicts future cardiovascular disease","authors":"Henrik Ø. Hjortkjær ,&nbsp;Peter Rossing ,&nbsp;Klaus F. Kofoed","doi":"10.1016/j.jdiacomp.2025.109152","DOIUrl":"10.1016/j.jdiacomp.2025.109152","url":null,"abstract":"<div><h3>Aims</h3><div>Even in the absence of kidney disease in persons with type 1 diabetes, there is an increased risk of cardiovascular (CV) disease through mechanisms not fully understood. This study aims to investigate whether evaluating arterial calcification can augment CV risk stratification in people with type 1 diabetes.</div></div><div><h3>Methods</h3><div>Persons with type 1 diabetes included in previous studies evaluating subclinical CV disease with CT scans of arterial beds in 75 persons without kidney disease were assessed for major adverse CV events (MACE) defined as CV-death, ischemic heart disease, heart failure, stroke, coronary interventions, and/or peripheral artery intervention. CT allowed for evaluation of coronary artery calcium score (CACS), progression of coronary artery calcium and generalised arterial calcification in multiple arterial beds. Cox regression was used for survival analyses.</div></div><div><h3>Results</h3><div>Seventy-three persons were available for endpoint evaluation and 16 (22 %) experienced a MACE after a median follow-up of 12.4 years (IQR 9.1–12.8). In unadjusted analyses, MACE was associated with baseline CACS &gt; 10 (<em>p</em> = 0.003), progression of coronary artery calcium (<em>p</em> = 0.03) and generalised arterial calcification (<em>p</em> = 0.006). After adjustment for diabetes duration, baseline CACS &gt; 10 remained associated with increased risk of MACE (<em>p</em> = 0.04).</div></div><div><h3>Conclusions</h3><div>This study shows that increased CACS entails increased risk of future MACE in persons with type 1 diabetes without kidney- or prior CV disease. This finding suggests that CACS evaluation may help differentiate CV risk management in persons with long-term type 1 diabetes without evidence of kidney disease and thus may be another step towards individualised medicine.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 10","pages":"Article 109152"},"PeriodicalIF":3.1,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk assessment modeling for diabetes-related lower extremity amputation using socioeconomic and behavioral health indicators","authors":"Kelsey A. Schmittling","doi":"10.1016/j.jdiacomp.2025.109153","DOIUrl":"10.1016/j.jdiacomp.2025.109153","url":null,"abstract":"<div><div>Lower extremity amputation (LEA) is a costly complication of diabetes, with disproportionate impacts among socially and medically vulnerable populations. While clinical predictors of LEA are well established, the role of behavioral health comorbidities, particularly alongside socioeconomic disparities, in amputation risk is unexplored. To evaluate sociodemographic and behavioral health predictors of LEA, a retrospective analysis of adult patients with diabetes was performed utilizing the Nationwide Inpatient Sample from 2018 to 2022. Sociodemographic and behavioral health characteristics were compared between patients that did and did not undergo LEA. Multivariable logistic regression was used to identify independent predictors of LEA using 2018–2021 data and was then tested on the 2022 validation cohort. Among 7.5 million adult patients with diabetes with inpatient events, patients undergoing LEA were significantly younger, more likely to be male, from lower income quartiles, and disproportionately Black, Hispanic, and Native American (<em>p</em> &lt; 0.001). Substance use disorder was significantly more common among LEA patients (16.0 % vs 11.6 %). In adjusted analysis, several behavioral health conditions were independently associated with increased LEA risk. The model demonstrated modest predictive performance in the testing cohort (AUC = 0.658). While not yet suitable for standalone clinical use, this model highlights that behavioral risk factors, especially in the context of sociodemographic characteristics, warrants increased attention in limb preservation strategies.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 10","pages":"Article 109153"},"PeriodicalIF":3.1,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144863837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}