Journal of Cosmetics, Dermatological Sciences and Applications最新文献

{"title":"Effective Treatment of Acne Fulminans with Oral Corticosteroids","authors":"I. Kurokawa","doi":"10.4236/jcdsa.2020.103012","DOIUrl":"https://doi.org/10.4236/jcdsa.2020.103012","url":null,"abstract":"An 18-year-old man had \u0000numerous multiple painful nodulocystic lesions, pustules, and necrotic hemorrhagic \u0000ulcerative lesions with crusts on the face, back, chest and upper arm two weeks \u0000ago. Systemic symptoms such as fever, general fatigue and arthralgia were not \u0000observed. Laboratory findings revealed an elevated white blood cell count with \u0000a neutrophilia and C-reactive protein. Oral antimicrobials did not respond. \u0000Consequently, oral prednisolone (20 mg/d) for two weeks induced remarkable \u0000improvement promptly. A case of acne fulminans without systemic symptoms \u0000successfully treated with oral corticosteroids has been reported.","PeriodicalId":15654,"journal":{"name":"Journal of Cosmetics, Dermatological Sciences and Applications","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74467142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Efficacy of Deeply Rooted® Nutraceutical for Hair Growth in Women","authors":"P. Maguiña","doi":"10.4236/jcdsa.2020.103016","DOIUrl":"https://doi.org/10.4236/jcdsa.2020.103016","url":null,"abstract":"Hair loss can significantly affect quality of life. \u0000Patients seeking treatment for hair loss find that many surgical or medication \u0000options involve significant risks or side effects. DEEPLY ROOTED® is a nutritional supplement that combines botanical \u0000and natural ingredients with the goal of effectively reducing hair loss and \u0000stimulating hair growth—without \u0000the side effects of many standard treatments. DEEPLY ROOTED’s active \u0000ingredients have both anti-inflammatory and adaptogenic properties, and inhibit \u0000dihydrotestosterone without the use of hormones, drugs, or industry \u0000by-products. This 3-month prospective study evaluates the effectiveness of \u0000DEEPLY ROOTED® for the prevention of hair loss. Healthy female subjects complaining of \u0000hair loss were enrolled, and supplied with three months of DEEPLY ROOTED®, without other compensation. The primary endpoint \u0000was a significant increase in hair growth. This was measured using anonymously \u0000collected patient data to evaluate hair growth and quality, as well as blinded \u0000Investigator hair assessment data. Patients \u0000who ingested DEEPLY ROOTED® over a three-month period reported noticeable improvement of hair growth (91%), increased \u0000hair volume (86%), and improved hair quality (86%). Subjects were noted to \u0000exhibit an increase in the number of new hairs, hair thickness and scalp \u0000coverage. No significant adverse effects were reported. DEEPLY ROOTED® safely helped over 90% of otherwise healthy women \u0000with self-perceived hair thinning to improve hair quality and quantity. The \u0000unique combination of botanical and natural ingredients provided a drug-free \u0000alternative for the management of hair loss.","PeriodicalId":15654,"journal":{"name":"Journal of Cosmetics, Dermatological Sciences and Applications","volume":"40 1","pages":"140-148"},"PeriodicalIF":0.0,"publicationDate":"2020-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79991873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Surgical Treatment with Chemical Peeling and Subsequent Vitamin C Iontophoresis for Rolling Scars in Acne Vulgaris","authors":"I. Kurokawa","doi":"10.4236/jcdsa.2020.103011","DOIUrl":"https://doi.org/10.4236/jcdsa.2020.103011","url":null,"abstract":"A 19-year-old man had atrophic scars on bilateral temple for several years. The atrophic scars were composed of rolling scars (three depressions, 8 × 4 mm in diameter), ice pick scars and boxcar scar. The patient was treated with chemical peeling (CP) using 20% glycolic acid (GA) (pH 3.2) and subsequent iontophoresis with vitamin C derivative at one month’s interval twice. Remarkable improvement was observed; the rolling scars almost disappeared with traces of hypopigmented macule. However, the ice pick scars and boxcar scar did not improve. CP and subsequent vitamin C iontophoresis can be an alternative non-surgical and non-invasive treatment for rolling scar in acne.","PeriodicalId":15654,"journal":{"name":"Journal of Cosmetics, Dermatological Sciences and Applications","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81054725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Sequential Successful Therapy Comprising Chemical Peeling, Iontophoresis and Topical Vitamin C for Postinflammatory Hyperpigmentation in Acne Vulgaris","authors":"I. Kurokawa","doi":"10.4236/jcdsa.2020.93010","DOIUrl":"https://doi.org/10.4236/jcdsa.2020.93010","url":null,"abstract":"A 20-year-old man presented with for 6-month history of facial acne. He had erythema and red papules on the face secondary to BPO-induced contact dermatitis. He was administered topical corticosteroid. Contact dermatitis improved with this treatment, and he had red papules, comedones, prominent postinflammatory hyperpigmentation (PIH), postinflammatory erythema (PIE), erosions and erythema associated with acne vulgaris. He was subsequently treated with oral minocycline 100 mg/d and topical adapalene and ozenoxacin lotion once daily for 3 months. The inflammatory lesions and comedo subsided; however, PIH, PIE, atrophic scar and erosion persisted. During 3 months, the patient underwent chemical peeling using 20% glycolic acid (GA) and subsequent vitamin C iontophoresis twice at 1-month intervals. He showed almost disappearance of red papules and comedones but persistent PIH, PIE and erosion after 3 months of treatment. He was thereafter prescribed topical glyceryl-octyl-ascorbic acid/ascorbyl 2-phosphate 6-palmitate/DL-a-tocopherol phosphate complex for local application twice daily for 3 months. After 7 months of treatment, PIH, PIE, erosion and atrophic scar faded significantly with only trace residual erosions, atrophic scar and PIH. Subsequently, he was prescribed local application of 2% isostearyl-L-ascorbic acid gel vitamin C gel twice daily for 3 months. After 15 months, PIH, PIE, erosion and atrophic scar disappeared completely with significant improvement. Comprehensive sequential therapy resulted in significant improvement. It is suggested that medical treatment using systemic and topical antimicrobials and topical adapalene reduces inflammatory lesions and comedones initially. Subsequent chemical peeling using GA and vitamin C iontophoresis could improve PIH. These synergistic effects might have contributed to the significant improvement observed in this case. Comprehensive sequential treatment using chemical peeling, vitamin C iontophoresis and topical vitamin C can be a useful treatment strategy for PIH in acne vulgaris.","PeriodicalId":15654,"journal":{"name":"Journal of Cosmetics, Dermatological Sciences and Applications","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76075626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Commercially Available Skin Care Lotion with a pH of 4.5 and 10% Urea Improves Skin Surface pH, Stratum Corneum Hydration and Epidermal Barrier Function in Subjects with Dry Skin and Atopic Diathesis","authors":"J. Blaak, C. Theiß, M. Schleißinger, I. Simon, N. Schürer, P. Staib","doi":"10.4236/jcdsa.2020.103014","DOIUrl":"https://doi.org/10.4236/jcdsa.2020.103014","url":null,"abstract":"OBJECTIVE: The physiological skin surface pH is crucial for several epidermal \u0000barrier functions, like stratum corneum integrity, cohesion and restoration. \u0000Alterations of the “normal” acidic nature of the skin surface have been shown \u0000to correlate with specific skin conditions like aged or inflamed skin and are \u0000leading to impaired skin barrier function and formation. It is previously \u0000demonstrated that topical acidification in atopic dermatitis improves stratum \u0000corneum function, skin barrier structure and clinical signs in dermatitis. \u0000Against this background, we examined the impact of a slightly acidic skin care \u0000product containing urea on stratum corneum hydration, skin surface pH and \u0000epidermal barrier function in subjects with dry skin and atopic diathesis. METHODS: Stratum corneum hydration, skin surface pH and transepidermal water loss were \u0000biophysically measured before and after a 4-week treatment period with the test \u0000product (pH 4.5, 10% urea) compared to the reference product in 25 volunteers. \u0000In addition, dynamic epidermal barrier parameters like stratum corneum \u0000integrity, cohesion and recovery were investigated by using a previously \u0000described tape stripping approach. RESULTS: It was shown that the test \u0000product (pH 4.5, 10% urea) significantly elevated stratum corneum hydration and \u0000improved the acidic nature of the skin surface by lowering the skin surface pH \u0000to a greater extent compared to the reference product. After the 4-week \u0000treatment period a significant faster barrier restoration was detected on the \u0000test site treated with the test product compared to the reference product. \u0000Moreover, the test product strengthens the skin barrier integrity and cohesion. CONCLUSION: The present marketed skin care lotion was shown to increase \u0000epidermal barrier function after 4 weeks of application. Balancing and \u0000controlling the skin surface pH in subjects with dry and atopic-prone skin by \u0000application of the herein tested o/w emulsion with a given pH of 4.5, in \u0000combination with a 10% urea content seems to be effective and beneficial. The \u0000results are important for the formulation of topical products for dry and \u0000atopic-prone skin.","PeriodicalId":15654,"journal":{"name":"Journal of Cosmetics, Dermatological Sciences and Applications","volume":"114 1","pages":"116-133"},"PeriodicalIF":0.0,"publicationDate":"2020-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74865456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Sign of Terra Firma-Forme Dermatosis","authors":"F. Ali, Waqas S. Abdulwahhab, Fatima A. Qaderi","doi":"10.4236/jcdsa.2020.103013","DOIUrl":"https://doi.org/10.4236/jcdsa.2020.103013","url":null,"abstract":"Background: Terra Firma-Forme Dermatosis (TFFD), a benign skin condition which \u0000presents with asymptomatic brown to black plaques which resemble dirty skin. Aim: To document a new case presentation with TFFD in the Arab region which is \u0000considered as one of the differential diagnoses of dirty neck. Case presentation: A 15-year-old \u0000girl presented with a history of asymptomatic brownish dirt-like lesion on the \u0000nape and sides of the neck for 4-years duration, not resolved by wash with \u0000water and soap and confused with other dermatoses like acanthosis nigricans or atopic dermatitis. \u0000The diagnosis of TFFD was confirmed when the lesions were completely resolved after \u0000gentle swabbing with 70% isopropyl alcohol. Conclusion: TFFD is rarely \u0000reported in Arab region and should be considered when evaluating cases of dirty \u0000neck-like presentation of atopic dermatitis or acanthosis nigricans.","PeriodicalId":15654,"journal":{"name":"Journal of Cosmetics, Dermatological Sciences and Applications","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79744362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modern Mild Skin Cleansing","authors":"Zheng-Jian Li","doi":"10.4236/jcdsa.2020.102009","DOIUrl":"https://doi.org/10.4236/jcdsa.2020.102009","url":null,"abstract":"Surfactant, an abbreviation for the surface-active agent, is utilized in almost every industry. It brings two immiscible phases such as oil and water into one single homogeneous phase, leading to various industrial applications such as food, painting, coating, drug delivery as well as cosmetics. The use of surfactants in skin cleansing is very common to keep skin healthy. Their function herein is to lower the interfacial tension at the dirt/water and skin/water interfaces, thereby detaching dirt, extra sebum or oils from the skin surface. But this application could bring side effects attributed to the penetration of surfactants into the skin, including skin proteins denaturation, stratum corneum lipids removal or even lipids organization disruption in the stratum corneum. This review summarizes modern mild skin cleansing technologies, which address the side effects brought by the surfactants.","PeriodicalId":15654,"journal":{"name":"Journal of Cosmetics, Dermatological Sciences and Applications","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83771385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safe Retinol-Like Skin Biological Effect by a New Complex, Enriched with Retinol Precursors","authors":"Z. Ma'or, Dror Cohen, Ya’ara La’or-Costa, M. Portugal-Cohen","doi":"10.4236/jcdsa.2020.102007","DOIUrl":"https://doi.org/10.4236/jcdsa.2020.102007","url":null,"abstract":"Background: Retinol (RE) is deeply involved in skin processes, therefore it is widely \u0000formulated in cosmetics, primarily as an anti-aging ingredient. Despite its efficacy, the safety profile of RE is \u0000controversial. Objectives: Pretinol (PRE) complex was formulated with \u0000two RE precursors, β-Carotene and \u0000Niacinamide, in order to \u0000deliver retinol-like skin benefits with healthier characteristics, assuming that skin enzymes will enable safe RE \u0000supply on spot. Methods: The expression levels of hyaluronic acid, Tumor Necrosis Factor alpha (TNFα) and Interleukin 1 alpha (IL-1α), \u0000were measured using various skin models before and after \u0000exposure to PRE and RE. Full genome microarray was performed and the affected genes and pathways were analyzed. Results: Following fibroblasts exposure to PRE, the natural synthesis of hyaluronic acid \u0000is significantly elevated. Skin \u0000safety, demonstrated via cytokines expression on ex-vivo skin, results \u0000with TNFα and IL-1α elevation by RE application. In \u0000contrary PRE significantly reduces TNFα while IL-1α is not \u0000affected. These results establish skin safety advantage of PRE vs RE. \u0000Microarray results examined on skin equivalents reveal the involvement of PRE in inflammatory attenuation. Conclusions: Formulating \u0000RE precursors as a safe source for RE is partially supported. PRE presents a \u0000skin benefit in parallel to RE, while PRE characteristics are suggested to be \u0000safer to skin.","PeriodicalId":15654,"journal":{"name":"Journal of Cosmetics, Dermatological Sciences and Applications","volume":"87 1","pages":"59-75"},"PeriodicalIF":0.0,"publicationDate":"2020-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85584288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asian Case of Metastatic Melanoma in Which a Complete Response Was Maintained after Discontinuation of Dabrafenib and Trametinib","authors":"R. Deno, A. Tanemura, Madoka Takafuji, Yuma Hanaoka, E. Kiyohara, N. Arase, M. Wataya-Kaneda, M. Fujimoto","doi":"10.4236/JCDSA.2020.102006","DOIUrl":"https://doi.org/10.4236/JCDSA.2020.102006","url":null,"abstract":"A 54-year-old man diagnosed with metastatic melanoma of the right inguinal node with occult primary developed liver and bone metastases. The combination of dabrafenib plus trametinib was initiated, and a complete response (CR) was achieved 24 months after starting treatment. One month later, the target therapy was discontinued at the patient’s decision, and he has remained free from progression for 21 months since discontinuation. To the extent of our knowledge, real-world data in Asian melanoma concerning the discontinuation of dabrafenib plus trametinib after achieving CR have not been published; therefore, our case is a meaningful one for considering to cease target drugs and to rescue their financial toxicity.","PeriodicalId":15654,"journal":{"name":"Journal of Cosmetics, Dermatological Sciences and Applications","volume":"1 1","pages":"55-58"},"PeriodicalIF":0.0,"publicationDate":"2020-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90102740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement of Atrophic Acne Scar and Skin Complexity by Combination of Aqueous Human Placenta Extract and Mesenchymal Stem Cell Mesotherapy","authors":"Ruchee Phonchai, P. Naigowit, Bunchob Ubonsaen, Supansa Nilubol, Supaluk Brameld, Parinya Noisa","doi":"10.4236/jcdsa.2020.101001","DOIUrl":"https://doi.org/10.4236/jcdsa.2020.101001","url":null,"abstract":"Atrophic scars, a permanent complication of severe acne, have negative effect on psychology in adolescent. The treatment of atrophic scar is depended on types of scar and it is difficult to improve by a single treatment. Mesenchymal stem cell is a scientific approval for surgery scar treatment and wound healing. We present a case report of female presented with atrophic acne scar distributed on both cheeks. The case aims to prove that the combination of MSCs and aqueous human placenta extract (RGF®) contained bioactive therapeutic molecules obviously promoted the improvement of skin scar to reach the optimal outcomes. We first found that MSCs-contained human placenta extract solution combination subcision improves the atrophic acne scar and skin complexity by enhancement of skin cell regeneration.","PeriodicalId":15654,"journal":{"name":"Journal of Cosmetics, Dermatological Sciences and Applications","volume":"131 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76122009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}