Journal of Drug Delivery and Therapeutics最新文献

{"title":"UV Spectrophotometric Method Development and Validation of Butorphanol Tartrate in Bulk Drug and Pharmaceutical Formulation","authors":"Sonu Ahirwar, Varsha Kashaw, Ravish Sahu, Surbhi Chourasia, Vaibhav Rajoria, Prakash Kushwaha","doi":"10.22270/jddt.v14i4.6521","DOIUrl":"https://doi.org/10.22270/jddt.v14i4.6521","url":null,"abstract":"The present research work discusses the development and validation of a UV spectrophotometric method for butorphanol tartrate. Simple, accurate and cost efficient spectrophotometric method has been developed for the estimation of butorphanol tartrate in tablet dosage form. The optimum conditions for the analysis of the drug were established. The maximum wavelength (λ max) was found to be 278nm. The percentage recovery of butorphanol tartrate was in the 100.016±0.68. Beers law was obeyed in the concentration range of 2-12μg/ml. Calibration curves shows a linear relationship between the absorbance and concentration. The line equation y = 0.0674x - 0.0057 with r2 of 0.9998was obtained. Validation was performed according to ICH guidelines for linearity, accuracy, precision, LOD and LOQ. The sample solution was stable up to 36 hours. The proposed method may be suitable for the analysis of butorphanol tartrate in tablet formulation for quality control purposes. \u0000Keywords: Butorphanol tartrate, Validation, Precision, Accuracy, LOQ, LOD, ICH guidelines.","PeriodicalId":15622,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"52 35","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140701368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Extraction Methods on the Physicochemical Properties and Biological Activities of heteroglycans from Hibiscus sabdariffa calyx","authors":"Judith Emery Kanemoto Ngomoyogoli, Fils Armand Ella, S. O. Kanemoto, T. Boudjeko, J. Ngondi, Nicolas Njintang Yanou","doi":"10.22270/jddt.v14i4.6436","DOIUrl":"https://doi.org/10.22270/jddt.v14i4.6436","url":null,"abstract":"The hot-water extraction method has been employed to enhance the diffusion rate of heteroglycans, thereby augmenting the extraction efficiency. This study investigates the antioxidant activities and immunological properties of water-soluble polysaccharides derived from the Hibiscus sabdariffa calyx (HWPF and LWPF). These polysaccharides were isolated through two distinct extraction methods involving hot water followed by ethanol precipitation. The physicochemical characterization was conducted through a series of experiments encompassing monosaccharide composition, ultraviolet-visible spectrum analysis, and Fourier-transform infrared (FT-IR) spectroscopy. The evaluation of antioxidative properties employed various techniques, including DPPH and ABTS radical scavenging activities, Ferric Reducing Antioxidant Power, ferrous chelating power, total reducing power, and protection against DNA damage. The assessment of anti-inflammatory potential involved the inhibition of hemolytic activity induced by a hypotonic solution and heat. Furthermore, the impact of the polysaccharides on the production of pro-inflammatory cytokines was analyzed through Luminex assay and RTPCR assay in PBMCs and LPS-stimulated RAW 264.7 cells, respectively. The findings revealed that heteroglycans (LWPF and HWPF) exhibit a content of Ara-Man-Rha-GluA-GalA (41.2:17.2:15.7:9.2:8.8) and Ara-Glu-Rha-Xyl-GluA-Man (31.5:23.8:12.16:10.4:7:6) with molecular weights of approximately 4.5 KDa and 41.3 KDa, respectively. HWPF demonstrated robust metal chelating and scavenging activities. Additionally, each fraction exhibited substantial protection of DNA against damage induced by H2O2. LWPF was observed to significantly down-regulate the expression of pro-inflammatory cytokines IL-6 and COX-2 at both transcriptional and translational levels, along with inhibiting NO production. In summary, these results indicate that the choice of extraction methods influences both the structure and biological activities of heteroglycans, providing valuable insights into the structure-activity relationship. \u0000Keywords: Hibiscus sabdariffa, heteroglycans, hot water extraction, physicochemical properties, Antioxidant activity, Pro-inflammatory cytokines.","PeriodicalId":15622,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"89 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140702225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical Minocycline Induced Bluish Black Hyperpigmentation in Acne Vulgaris Patient: The First Case Report of Topical Application","authors":"S. N. Sujaya, V. S. Ranganath, B. S. Girish, Joel M Johns, C. S. Meghana","doi":"10.22270/jddt.v14i4.6515","DOIUrl":"https://doi.org/10.22270/jddt.v14i4.6515","url":null,"abstract":"Minocycline induced hyperpigmentation is an aesthetically unsetting adverse drug event. Oral minocycline inducing hyperpigmentation is common course, keeping in line with this topical minocycline 4% was formulated. A moderately built woman diagnosed with acne was prescribed with topical minocycline 4% Gel and after 15 days of application she noticed dark patches on applied areas which progressed into macules. On examination, it was found that the topical minocycline has induced Type I (Bluish Black) Hyperpigmentation. To the best of clinician’s knowledge, the drug was withdrawn and observed over a period of month. Post-withdrawal for 30-days the skin started to regain its original tone. Regardless of the fact that the topical formulation has been designed to reduce the drug contact with the systemic circulation and to decrease the side-effects, will the formulation succeed in providing the effective and safe therapy in acne patients? \u0000Keywords: Topical Minocycline 4%, Hyperpigmentation, Type I, Bluish Black Pigmentation, Acne Vulgaris","PeriodicalId":15622,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"291 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140703783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Withania somnifera: A potential rejuvenator of medicinal system for healthcare","authors":"Vibhuti Sharma, Rutika Sehgal, Reena Gupta","doi":"10.22270/jddt.v14i4.6536","DOIUrl":"https://doi.org/10.22270/jddt.v14i4.6536","url":null,"abstract":"Medicinal herbs have been used since the time of the Vedas. The plants have therapeutic qualities in every part. Secondary metabolites of extensive variety are present in medicinal plants and are utilised in the production of medications as well as in the treatment of many different ailments. Withania somnifera is a medicinal plant, have various properties.  'Ashwagandha' is the popular name of Withania somnifera.   It is offered as churna, a finely sieved powder that can be combined with ghee, water or honey. It has memory-enhancing, anti-oxidant, anti-stress, anti-venom, anti-inflammatory and anti-tumor effects. It is employed to treat a variety of clinical problems. In addition to being used as a suppressant in HIV/AIDS patients, Withania somnifera is used to treat ulcers, emaciation, colds, coughs, diabetes, conjunctivitis, insomnia, senile dementia, epilepsy, leprosy, Parkinson's disease, nervous disorders, rheumatism, arthritis, intestinal infections, bronchitis and asthma. The review article concentrates on the Withania somnifera plant's different pharmacological qualities. \u0000Keywords: Withania somnifera, Ayurveda, Anti-oxidant, Anti-inflammatory, Anti-tumour","PeriodicalId":15622,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140702506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticonvulsants in Hepatic Encephalopathy","authors":"Sona Jose, Amal Roy, N. M. Amala, C. S. Vidhya, Lincy George","doi":"10.22270/jddt.v14i4.6506","DOIUrl":"https://doi.org/10.22270/jddt.v14i4.6506","url":null,"abstract":"Hepatic encephalopathy (HE) is a complex neurological syndrome that arises as a complication of liver dysfunction. The primary focus in HE management has traditionally been on ammonia detoxification, but recent research has paved light on the potential role of anticonvulsant medications in improving the cognitive impairment and preventing seizures associated with HE. This review mainly aims to provide a comprehensive analysis of the use of anticonvulsants in hepatic encephalopathy, by taking a looking at their mechanisms of action, efficacy, and safety profiles. \u0000Keywords: Hepatic encephalopathy, Anticonvulsants, Cognitive impairment","PeriodicalId":15622,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"47 47","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140701841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Amenorrhoea (Ihtibas-al-Tamth) in Unani System of Medicine: A Review","authors":"Ayesha Raza, Farheen Zehra, Mohd Nayab","doi":"10.22270/jddt.v14i4.6500","DOIUrl":"https://doi.org/10.22270/jddt.v14i4.6500","url":null,"abstract":"Menstrual patterns can be an indicator of overall health and self-perception of well-being. Amenorrhoea is the absence of menses in women of reproductive agewhich may be primary or secondary. Primary amenorrhoea refers to the absence of menarche at the age of 16 and secondary amenorrhoea is the cessation of menses for at least 6 months in already cycling women. Secondary amenorrhoea is more common than primary amenorrhea. Ihtibas al-Tamth (amenorrhoea) is defined in the Unani system of medicine as the absence of monthly bleeding for more than 2 months or a decrease in the quantity of menstrual blood. The etiologies of amenorrhoea may be considered categorically as outflow tract abnormalities, primary ovarian insufficiency, hypothalamic or pituitary disorders, other endocrine gland disorders, sequelae of chronic disease, physiologic, or induced. The causes of Ihtibas al-Tamth are related to Quwwat Dafia al-Badan, Madda and Johar Khun-i-Hayd, or Ala Makhraj -i-Hayd. Su’-i-Mizaj Barid, Yabis, Harr or Harr wa Yabis, Su’-i-Mizaj Maddi or Sada can lead to Du’f al-Quwwat-i-Dafia. Abnormality in quality and quantity of Madda in Su’-i-Mizaj Maddi can also lead to ihtibas al-tamth. Amenorrhoea is not a diagnosis but a symptom indicating anatomical, genetic and neuroendocrine abnormalities. It can be determined by two different groups of causes: (a) anatomical defects of the genital organs; (b) endocrine dysfunctions. Both congenital and acquired anomalies in the structure of the uterus and vagina could produce amenorrhoea; nevertheless, in most patients, amenorrhoea is related to an ovarian malfunction. Symptoms usually associated with amenorrhoea are headache, nausea, back ache and lower abdominal pain, tiredness, and some respiratory problems. Main principle of treatment includes Tawleed-i-Dam, Tanqiya-i-Akhlat Ghaleeza, Talteef-i-Khilt, Tafteeh-i-Uruq Raham and Tahzeel if obesity is the cause. Surgical intervention if hymen is imperforated. Some regimenal therapies are also beneficial in amenorrhoea, such as Fasd-i-Safin, Hammam-i-Murattib and Hijama-i-Nariya on calf area. Some Unani drugs, which are beneficial in amenorrhoea, are Habb-i-Mudir, Safoof-i-Baboona, Kushta Faulad, and Safoof Muhazzil. In the present scenario, it is utmost important to educate the patients to live a healthy and hygienic life and to avoid those factors which cause amenorrhoea. \u0000 ","PeriodicalId":15622,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"48 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140698948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological changes in the placentas of pregnant women with Gestational Diabetes Mellitus","authors":"Süleyman Cemil Oğlak, M. Obut, F. Aşır, Emine Zeynep Yılmaz, Gökhan Bolluk, Elif Ağaçayak, Murat Akkuş","doi":"10.22270/jddt.v14i4.6499","DOIUrl":"https://doi.org/10.22270/jddt.v14i4.6499","url":null,"abstract":"Objectives: Placental damage might be the primary underlying cause of the high rates of fetal adverse outcomes in cases with gestational diabetes mellitus (GDM). Histopathological changes were considered to be associated with GDM in the literature. However, there are also studies showing no changes in the placenta in some gestational diabetic women. The pathophysiology of these placental alterations remains elusive. Therefore, this study aimed to examine the histopathological changes in the placentas of patients with GDM and compare them with the placentas of the healthy control group. \u0000Material and methods: This experimental non-randomized case-control study was conducted with 40 GDM patients and 40 healthy pregnant women at Dicle University Faculty of Medicine between March 2023 and December 2023. Placental tissues obtained following cesarean delivery were subjected to routine tissue processing. Placental samples were stained with hematoxylin-eosin and examined histopathologically using a light microscope. \u0000Results: When histopathological findings were compared between the GDM and control groups, villous degeneration, congestion in blood vessels, fibrinoid accumulation, inflammation and intervillous hemorrhage were higher in the GDM group than in the control group (p<0.001). \u0000Conclusion: The intricate relationship between GDM and placental pathology underscores the profound impact of metabolic changes on placental structure and function throughout pregnancy. Understanding these pathological changes is crucial for elucidating the progression of GDM and its implications for maternal and fetal health, highlighting the importance of comprehensive placental analysis in managing pregnancies complicated by GDM. \u0000Keywords: Gestational diabetes, hematoxylin-eosin staining, histopathological examination","PeriodicalId":15622,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"46 29","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140701671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation Development of Medicated Chewing Gum by Direct Compression utilizing the SeDeM Diagram Expert System","authors":"P. Karade, Sonal Jadhav (Mali), Rohit Ramesh Shah","doi":"10.22270/jddt.v14i4.6545","DOIUrl":"https://doi.org/10.22270/jddt.v14i4.6545","url":null,"abstract":"The main objective of this study was to prepare and characterize the MCG of Ondan HCl which helps to improve the effectivity of the drug and to investigate the applicability of the SeDeM system for the formulation of MCG. The Ondan HCl was formulated into directly compressed MCG utilizing the SeDeM Diagram Expert System. The MCG was optimized using 32 factorial design. Performance evaluation was carried out by evaluating different parameters. Statistical analysis showed that micromeritic properties were improved after inclusion of appropriate excipient in optimum amount. In-vitro drug release study showed 90.01% drug release whereas ex vivo buccal permeation study exhibited significant drug permeation within 15 min indicating its potential for increasing bioavailability. It was concluded that various characteristics of powder material at pre formulation level can be successfully predicted by SeDeM diagram expert system. The developed medicated chewing gum is more effective than mouth dissolving and conventional tablet formulation. \u0000Keywords: Ondansetron HCl; Medicated chewing gum; direct compression; SeDeM diagram expert system.","PeriodicalId":15622,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"18 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140700965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superporous Hydrogel: A Novel Approach for Safe Gastroretentive Drug Delivery System","authors":"Darshana Pawar, Darshan Jamindar, N. Farooqui, Nimita Manocha","doi":"10.22270/jddt.v14i4.6458","DOIUrl":"https://doi.org/10.22270/jddt.v14i4.6458","url":null,"abstract":"Superporous hydrogel are developed initially as novel drug delivery system to retain dosage form in upper gastrointestinal tract, and absorbs drug in gastric medium. The generation-based classification of superporous hydrogel is covered in this review. The hydrophilic polymer networks formed by the molecular entanglements which absorb water up to thousands of times to their dry weight. These systems swells quickly and resist in an extremely acidic condition in stomach. This hydrogel is instantly swell through capillary force which is driven by absorption of water through an open porous structure. This system provides better solubility and bioavailability by targeting the specific site of absorption.  The conventional superporous hydrogels have the poor mechanical strength which is overcome by developing the second superporous hydrogel generation composites and the third-generation superporous hydrogel hybrids. This article has mainly focused on the classification, techniques, drug loading, research papers, characterizations and applications of superporous hydrogel. \u0000Keywords: Gastric retention, Cross-linking, Superporous hydrogel, Swelling rate, Elastic property, Hydrophilic polymer networks.","PeriodicalId":15622,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"19 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140700167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Binge drinking and the risks to adolescent health","authors":"L. D. Del Ciampo, Ieda Regina Lopes Del Ciampo","doi":"10.22270/jddt.v14i4.6534","DOIUrl":"https://doi.org/10.22270/jddt.v14i4.6534","url":null,"abstract":"Adolescence is a phase characterized by physical, emotional and social changes that make adolescents more susceptible to risky practices and behaviors. One of these common practices is excessive alcohol consumption, known as “binge drinking”, which causes numerous acute and chronic health problems. This article presents some characteristics observed in adolescent development and the consequences of excessive alcohol consumption for physical and emotional health, and its repercussions on community life. \u0000Keywords: Adolescence, Alcohol, Binge Drinking, Adolescent Health","PeriodicalId":15622,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140700130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}