Journal of electrocardiology最新文献

{"title":"The known high-risk p.R190Q KCNQ1-variant needs a second hit for QTc prolongation","authors":"Anton Karabinos ,&nbsp;Drahomira Schwartzova ,&nbsp;Renata Zemjarova Mezenska ,&nbsp;Miroslava Eckertova ,&nbsp;Ivana Lukacova ,&nbsp;Gabriela Magyarova ,&nbsp;Peter Krizan","doi":"10.1016/j.jelectrocard.2025.153924","DOIUrl":"10.1016/j.jelectrocard.2025.153924","url":null,"abstract":"<div><div>The heterozygous missense p.R190Q <em>KCNQ1</em> mutation represents one of the most frequent high-risk variants in long QT syndrome (LQTS). However, the presented case report and the data in literature led us to conclude that this heterozygous variant alone is associated with a low-penetrant clinical and electrocardiographical phenotype, while its co-inheritance with either the heterozygous p.E1053K <em>SCN5A</em> variant, some other LQTS-associated/modifying variant, or with some acquired QTc-inducing condition (like a specific leukaemia medication), may trigger QTc prolongation and thus a risk for arrhytmias.</div></div>","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"90 ","pages":"Article 153924"},"PeriodicalIF":1.3,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive T wave in lead aVR is associated with left atrial and ventricular function and cardiac outcomes in heart failure patients with preserved ejection fraction","authors":"Bektas Murat ,&nbsp;Selda Murat ,&nbsp;Fatih Aydın ,&nbsp;Muhammet Dural ,&nbsp;Halit Emre Yalvac ,&nbsp;Fatih Enes Durmaz ,&nbsp;Rabia Okumus ,&nbsp;Yuksel Cavusoglu","doi":"10.1016/j.jelectrocard.2025.153925","DOIUrl":"10.1016/j.jelectrocard.2025.153925","url":null,"abstract":"<div><h3>Background</h3><div>Heart failure with preserved ejection fraction (HFpEF) accounts for a significant proportion of heart failure cases and is associated with high morbidity and mortality. While echocardiography plays a central role in HFpEF assessment, the prognostic value of electrocardiographic (ECG) findings, particularly in lead aVR, remains underexplored. This study investigates the relationship between a positive T wave in lead aVR (TaVR) and left atrial (LA) and left ventricular (LV) function, as well as its prognostic significance in HFpEF patients.</div></div><div><h3>Methods</h3><div>This retrospective study included 231 HFpEF patients diagnosed according to ESC guidelines. Patients underwent comprehensive echocardiography and 12‑lead ECG evaluation. Positive TaVR was defined as a T-wave amplitude ≥1 mm in lead aVR. LA and LV functions were assessed using LA reservoir strain (LASr) and LV global longitudinal strain (GLS), respectively. Multivariate Cox regression and Kaplan-Meier survival analyses were performed to evaluate the prognostic significance of TaVR.</div></div><div><h3>Results</h3><div>Positive TaVR was observed in 34.6 % of patients and was associated with impaired LASr (15.02 ± 6.65 % vs. 17.78 ± 9.10 %, <em>p</em> = 0.023) and LV GLS (−13.66 ± 3.49 % vs. -15.19 ± 3.02 %, <em>p</em> = 0.001). Positive TaVR independently predicted 1-year all-cause mortality (HR = 6.02, <em>p</em> &lt; 0.001) and 6-month all-cause mortality (HR = 9.67, p &lt; 0.001). Patients with positive TaVR had higher hospitalization rates and worse clinical outcomes.</div></div><div><h3>Conclusion</h3><div>Positive TaVR is associated with LA dysfunction, LV remodeling, and poor prognosis in HFpEF. Incorporating this ECG parameter into routine clinical assessments could enhance risk stratification and guide management strategies for HFpEF patients.</div></div>","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"90 ","pages":"Article 153925"},"PeriodicalIF":1.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143785189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal P wave terminal force in lead V1 is correlated with adverse cardiac remodeling in patients with left ventricular noncompaction: A useful noninvasive indicator of disease severity","authors":"Huaibing Cheng MD ,&nbsp;Yangfei Xu MM ,&nbsp;Minjie Lu MD ,&nbsp;Gang Yin MS ,&nbsp;Fang Liu MM ,&nbsp;Wenxuan Zhai MM ,&nbsp;Jia He MM ,&nbsp;Lan Wang MB ,&nbsp;Chunfang Wang MM ,&nbsp;Hailan Chen MB ,&nbsp;Shihua Zhao MD ,&nbsp;Xiaohan Fan MD","doi":"10.1016/j.jelectrocard.2025.153923","DOIUrl":"10.1016/j.jelectrocard.2025.153923","url":null,"abstract":"<div><h3>Background</h3><div>Abnormal P wave terminal force in lead V1 (PTFV1) has been associated with adverse outcomes in various cardiovascular conditions. However, the potential role of PTFV1 in patients with left ventricular noncompaction (LVNC) has not been reported. Therefore, this study aims to investigate the prevalence of PTFV1 in patients with LVNC and explore its possible association with abnormalities in both the left atrium (LA) and left ventricle (LV).</div></div><div><h3>Methods</h3><div>From January 2016 to December 2017, 93 patients diagnosed with LVNC via cardiovascular magnetic resonance (CMR) were enrolled in the study. Clinical, echocardiographic, CMR, and electrocardiogram data were retrospectively collected and analyzed independently.</div></div><div><h3>Results</h3><div>The mean age of the 93 patients at diagnosis was 44.3 ± 13.9 years, with 64.5 % being male. Abnormal PTFV1 was present in 23.6 % of the patients. Those with abnormal PTFV1 had significantly higher rates of NYHA functional class III or IV (86.4 % vs. 19.7 %, <em>p</em> &lt; 0.001), LV thrombus (9.0 % vs. 4.2 %, <em>p</em> = 0.049), and late gadolinium enhancement (63.6 % vs. 33.8 %, <em>p</em> = 0.013). These patients also had significantly greater mitral regurgitation grades, larger LA and LV volume indices, and lower LV ejection fraction (LVEF). Receiver operating characteristic curve analysis showed moderate-to-high area under the curve (AUC) values (ranging from 0.72 to 0.83) for various indices in identifying abnormal PTFV1, with LVEF showing the highest AUC of 0.83. Binary logistic regression identified LVEF as the only independent factor associated with abnormal PTFV1 (OR = 0.89, <em>p</em> = 0.003).</div></div><div><h3>Conclusion</h3><div>Abnormal PTFV1, observed in approximately one-quarter of LVNC patients, is linked to more severe cardiac remodeling and dysfunction, and its presence can be predicted by a reduced LVEF.</div></div>","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"90 ","pages":"Article 153923"},"PeriodicalIF":1.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fentanyl-induced Brugada phenocopy: A case report","authors":"Serhat Kesriklioglu ,&nbsp;Sener Gur ,&nbsp;Ahmet Taha Sahin ,&nbsp;Ahmet Lutfu Sertdemir ,&nbsp;Enes Elvin Gul","doi":"10.1016/j.jelectrocard.2025.153922","DOIUrl":"10.1016/j.jelectrocard.2025.153922","url":null,"abstract":"<div><div>Brugada Syndrome (BrS) is a genetic condition characterized by specific electrocardiographic (ECG) findings and an increased risk of life-threatening arrhythmias. Brugada phenocopy (BrP) refers to reversible ECG changes mimicking BrS caused by external factors, such as drugs or metabolic disturbances. Here, we present a case of a 45-year-old male with Brugada phenocopy due to high-dose of fentanyl transdermal patch.</div></div>","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"90 ","pages":"Article 153922"},"PeriodicalIF":1.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An unclassifiable case of advanced interatrial block after dialysis treatment","authors":"Marco Marano ,&nbsp;Luigi Senigalliesi ,&nbsp;Vincenzo Russo","doi":"10.1016/j.jelectrocard.2025.153910","DOIUrl":"10.1016/j.jelectrocard.2025.153910","url":null,"abstract":"","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"90 ","pages":"Article 153910"},"PeriodicalIF":1.3,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on “can electrocardiographic repolarization predict diabetes incidence: The Atherosclerosis Risk in Communities Study”","authors":"Bektas Murat ,&nbsp;Ayberk Beral ,&nbsp;Selda Murat","doi":"10.1016/j.jelectrocard.2025.153909","DOIUrl":"10.1016/j.jelectrocard.2025.153909","url":null,"abstract":"","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"90 ","pages":"Article 153909"},"PeriodicalIF":1.3,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maximally preexcited tachycardia in a patient with ventricular preexcitation via a right posteroseptal accessory pathway. What is the diagnosis?","authors":"Utkarsh Kohli MD ,&nbsp;Jeffrey K. Harris MD ,&nbsp;Jack R. Stines MD","doi":"10.1016/j.jelectrocard.2025.153911","DOIUrl":"10.1016/j.jelectrocard.2025.153911","url":null,"abstract":"","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"90 ","pages":"Article 153911"},"PeriodicalIF":1.3,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143601681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A simple electrocardiographic model for an improved detection of chronic thromboembolic pulmonary hypertension after pulmonary embolism","authors":"Lukas Ley MD ,&nbsp;Christoph B. Wiedenroth MD ,&nbsp;Stefan Guth MD ,&nbsp;Christian Gold MD ,&nbsp;Athiththan Yogeswaran MD ,&nbsp;Hossein Ardeschir Ghofrani MD ,&nbsp;Dirk Bandorski MD, PhD","doi":"10.1016/j.jelectrocard.2025.153908","DOIUrl":"10.1016/j.jelectrocard.2025.153908","url":null,"abstract":"<div><h3>Introduction</h3><div>Chronic thromboembolic pulmonary hypertension (CTEPH) is considered a late sequelae of a preceding pulmonary embolism (PE). There is reasonable suspicion that the majority of CTEPH patients are currently not detected. The aim of the present study was to evaluate the potential utility of a simple electrocardiographic (ECG) model for an improved detection of CTEPH after PE.</div></div><div><h3>Material and methods</h3><div>The present study was conducted as a bicentric, retrospective cross-sectional study in two German high volume referral centres for pulmonary hypertension (PH) between February 2011 and September 2023. A total of 100 patients with CTEPH and 100 patients with excluded PH were included. An ECG model for detecting CTEPH consisting of a screening test and confirmatory test was developed and subsequently tested on the present CTEPH cohort and a hypothetical cohort of PE survivors from Germany.</div></div><div><h3>Results</h3><div>Applying this ECG model to the present CTEPH cohort, 79 % of CTEPH patients were correctly identified (sensitivity: 79 %) and only 8 % of non-PH patients were incorrectly identified as PH patients (specificity: 92 %). When theoretically applying this model in CTEPH screening of a hypothetical cohort of persistently symptomatic PE survivors, a total 70 % of CTEPH patients could potentially be detected (sensitivity: 70 %) and right heart catheterisations (RHC) without pathological findings would only be performed on 2.5 % of non-CTEPH patients (specificity: 97.5 %) without the application of echocardiography. Compared to the current estimated CTEPH detection rate this would be about a threefold increase (from 24 % to 70 %).</div></div><div><h3>Conclusion</h3><div>Electrocardiographic CTEPH screening could potentially increase the CTEPH detection rate significantly, without the application of echocardiography and with performance of only very few RHCs without pathological findings, if all persistently symptomatic PE survivors were given a simple ECG as standard follow-up. However, the present approach remains largely hypothetical for now and must be validated externally.</div></div>","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"90 ","pages":"Article 153908"},"PeriodicalIF":1.3,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on Age-dependent influence of T wave amplitude on short period temporal dispersion in healthy subjects","authors":"Bektas Murat (Assoc. Prof.) ,&nbsp;Selda Murat (Assoc. Prof) ,&nbsp;Bulent Gorenek (Prof.)","doi":"10.1016/j.jelectrocard.2025.153905","DOIUrl":"10.1016/j.jelectrocard.2025.153905","url":null,"abstract":"","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"90 ","pages":"Article 153905"},"PeriodicalIF":1.3,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sudden cardiac arrest in patients with hypertrophic cardiomyopathy: Are there electrocardiographic predictors?","authors":"Jashan Gill MD ,&nbsp;Rezwan Munshi MD ,&nbsp;Jobin Varghese MD ,&nbsp;Michael T. Spooner MD ,&nbsp;Brian Olshansky MD","doi":"10.1016/j.jelectrocard.2025.153907","DOIUrl":"10.1016/j.jelectrocard.2025.153907","url":null,"abstract":"<div><h3>Background</h3><div>Hypertrophic cardiomyopathy (HCM) predisposes patients to cardiac arrest (CA). While established major risk factors may warrant the need for primary prevention by implantable cardioverter-defibrillator (ICD), it is unknown if specific electrocardiographic predictors are associated with CA. Our objective was to determine the risk of CA in patients with HCM based on the presence of identified electrocardiographic arrhythmias and conduction disorders.</div></div><div><h3>Methods</h3><div>We queried the National Inpatient Sample (NIS) from 4th quarter 2015 to 2020 to identify adult hospitalizations with HCM via ICD-10 codes excluding those presenting with syncope and those who had an ICD implant. We compared the odds of having CA in those with atrioventricular (AV) block, bundle branch block (BBB), atrial fibrillation (AF), atrial flutter (AFL), supraventricular tachycardia (SVT), and premature ventricular contractions (PVCs). Regression models were used to adjust for underlying medical comorbidities and patient demographics.</div></div><div><h3>Results</h3><div>Of 251,450 HCM hospitalizations, 12,573 (5 %) were associated with CA. Those who had CA were younger (63 vs 65 years, <em>p</em> &lt; 0.001) and had fewer comorbidities based on their Charlson Comorbidity Index score (2.49 vs 2.83, p &lt; 0.001) versus those without CA. The HCM cohort with first-, second- and third-degree AV block, left or right BBB, AF, AFL, SVT, or PVCs had increased odds of CA.</div></div><div><h3>Conclusion</h3><div>From the NIS database AV block, BBB, AF, AFL, SVT, and PVCs increased the odds of CA in HCM patients. Further prospective studies are warranted to determine if these predictors can pinpoint who may benefit from primary SCD prevention independent of other risk factors.</div></div>","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"90 ","pages":"Article 153907"},"PeriodicalIF":1.3,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}